Detailed information for compound 21021

Basic information

Technical information
  • TDR Targets ID: 21021
  • Name: N-(diaminomethylidene)-4,5-bis(4-methoxypheny l)-1,3-thiazole-2-carboxamide
  • MW: 382.436 | Formula: C19H18N4O3S
  • H donors: 2 H acceptors: 2 LogP: 3.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1sc(nc1c1ccc(cc1)OC)C(=O)N=C(N)N
  • InChi: 1S/C19H18N4O3S/c1-25-13-7-3-11(4-8-13)15-16(12-5-9-14(26-2)10-6-12)27-18(22-15)17(24)23-19(20)21/h3-10H,1-2H3,(H4,20,21,23,24)
  • InChiKey: KVKCLRUAOBJUMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(diaminomethylene)-4,5-bis(4-methoxyphenyl)thiazole-2-carboxamide
  • N-(diaminomethylene)-4,5-bis(4-methoxyphenyl)-2-thiazolecarboxamide
  • N-[bis(azanyl)methylidene]-4,5-bis(4-methoxyphenyl)-1,3-thiazole-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dnaJ subfamily B 0.2268 0.5887 0.5887
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0028 0.094
Brugia malayi N-terminal motif family protein 0.0209 0.0505 0.1665
Echinococcus granulosus lamin dm0 0.0122 0.0278 0.0278
Schistosoma mansoni cpg binding protein 0.0159 0.0376 0.0376
Echinococcus granulosus aldo keto reductase family 1 member B4 0.004 0.0063 0.0063
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0068 0.0136 0.0136
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0054 0.1286
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0071 0.1727
Trypanosoma brucei short-chain dehydrogenase, putative 0.0017 0.0004 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0204 0.231
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0194 0.0468 0.1544
Onchocerca volvulus 0.0068 0.0136 0.0438
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0016 0.0332
Echinococcus granulosus retinol dehydrogenase 11 0.0017 0.0004 0.0004
Trypanosoma brucei cytochrome P450, putative 0.0033 0.0045 0.0484
Mycobacterium tuberculosis Conserved protein 0.004 0.0063 0.1358
Echinococcus granulosus carbonyl reductase 1 0.0017 0.0004 0.0004
Brugia malayi MAP kinase sur-1 0.0167 0.0397 0.1309
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.001 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.005 0.0166
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0016 0.0186
Schistosoma mansoni DNA polymerase eta 0.0033 0.0046 0.0045
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0068 0.0136 0.0136
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0062 0.0062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0054 0.1286
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0068 0.0136 0.0438
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0036 0.0036
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0016 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0016 0.0318
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0194 0.0468 0.1544
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0088 0.0973
Echinococcus multilocularis nuclear receptor nhr 48 0.0068 0.0136 0.0136
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0024 0.0021 0.007
Brugia malayi hypothetical protein 0.0019 0.001 0.0031
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0004 0.0036
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0017 0.0004 0.0044
Echinococcus granulosus lamin 0.0122 0.0278 0.0278
Brugia malayi GH02984p 0.0356 0.089 0.2938
Loa Loa (eye worm) oxidoreductase 0.004 0.0063 0.0208
Echinococcus multilocularis FTZ F1 alpha 0.0194 0.0468 0.0468
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0049 0.0088 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0058 0.0632
Schistosoma mansoni cellular tumor antigen P53 0.0163 0.0384 0.0384
Echinococcus granulosus protein C ets 2 0.0024 0.0021 0.0021
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0088 0.1006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0054 0.1286
Loa Loa (eye worm) dehydrogenase 0.0017 0.0004 0.0012
Mycobacterium ulcerans DNA polymerase IV 0.0093 0.0204 0.4585
Echinococcus multilocularis solute carrier family 5 0.0039 0.0062 0.0062
Brugia malayi photoreceptor-specific nuclear receptor 0.0194 0.0468 0.1544
Schistosoma mansoni DNA helicase recq5 0.0022 0.0016 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0116 0.1328
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0127 0.0291 0.0291
Loa Loa (eye worm) oxidoreductase 0.004 0.0063 0.0208
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0068 0.0136 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0028 0.0092
Onchocerca volvulus 0.0122 0.0278 0.0907
Leishmania major quinonoid dihydropteridine reductase 0.0017 0.0004 0.0044
Entamoeba histolytica hypothetical protein 0.0019 0.001 0.0224
Echinococcus multilocularis lamin dm0 0.0122 0.0278 0.0278
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.012
Echinococcus multilocularis steroid dehydrogenase 0.0017 0.0004 0.0004
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0017 0.0004 0.0044
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0349 0.0871 1
Schistosoma mansoni lipoxygenase 0.0066 0.0133 0.0133
Echinococcus granulosus GA binding protein alpha chain 0.0163 0.0387 0.0387
Schistosoma mansoni z-protein (S1r protein) 0.0029 0.0036 0.0036
Echinococcus granulosus bloom syndrome protein 0.0022 0.0016 0.0016
Loa Loa (eye worm) RecQ helicase 0.0022 0.0016 0.0051
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0011 0.0159
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0046 0.0957
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0045 0.0518
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0062 0.0062
Leishmania major short chain dehydrogenase, putative 0.0017 0.0004 0.0044
Schistosoma mansoni nuclear receptor 0.0068 0.0136 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0194 0.0468 0.1544
Trypanosoma brucei unspecified product 0.0078 0.0164 0.1858
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0029 0.0036 0.012
Mycobacterium ulcerans hypothetical protein 0.004 0.0063 0.1358
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0186 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0017 0.0004 0.0004
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0167 0.0397 0.4551
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0164 0.1858
Leishmania major hypothetical protein, conserved 0.0017 0.0004 0.0044
Entamoeba histolytica hypothetical protein 0.0019 0.001 0.0224
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0194 0.0468 0.0468
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0017 0.0004 0.0007
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0072 0.0147 0.0147
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0016 0.0159
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Loa Loa (eye worm) ets-domain-containing protein 0.0024 0.0021 0.007
Plasmodium falciparum LCCL domain-containing protein 0.0066 0.0133 1
Echinococcus granulosus hypothetical protein 0.0017 0.0004 0.0004
Echinococcus granulosus WW domain containing oxidoreductase 0.0017 0.0004 0.0004
Schistosoma mansoni carbonyl reductase 0.0017 0.0004 0.0004
Leishmania major oxidoreductase-like protein 0.0017 0.0004 0.0044
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0046 0.0488
Echinococcus granulosus lipoxygenase domain containing protein 0.0066 0.0133 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0175
Loa Loa (eye worm) hypothetical protein 0.0049 0.0088 0.029
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0072 0.0147 0.3285
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0071 0.1714
Echinococcus multilocularis ewsr:fli fusion protein type 0.0024 0.0021 0.0021
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Echinococcus granulosus mitogen activated protein kinase 3 0.0167 0.0397 0.0396
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0167 0.0397 0.4551
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0028 0.0556
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0065 0.013 0.0429
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0071 0.2608
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.0147 0.0147
Echinococcus multilocularis expressed protein 0.0373 0.0936 0.0936
Schistosoma mansoni aldo-keto reductase 0.004 0.0063 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0139 0.0139
Brugia malayi Ets-domain containing protein 0.0163 0.0387 0.1277
Echinococcus granulosus thyroid hormone receptor alpha 0.0068 0.0136 0.0136
Loa Loa (eye worm) doublecortin family protein 0.0066 0.0133 0.0438
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0204 0.231
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0163
Trypanosoma brucei short-chain dehydrogenase, putative 0.0017 0.0004 0.0007
Onchocerca volvulus 0.004 0.0064 0.0198
Trichomonas vaginalis aldo/keto reductase, putative 0.004 0.0063 0.1522
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.1286
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0036 0.0036
Brugia malayi nuclear hormone receptor family member nhr-6 0.0068 0.0136 0.0449
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0194 0.0468 0.0468
Trypanosoma cruzi short chain dehydrogenase, putative 0.0017 0.0004 0.0044
Echinococcus granulosus survival motor neuron protein 1 0.1031 0.2654 0.2654
Echinococcus multilocularis voltage gated potassium channel subunit 0.004 0.0063 0.0063
Brugia malayi hypoxia-induced factor 1 0.0167 0.0395 0.1304
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0017 0.0004 0.0044
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0024 0.0021 0.0021
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.004 0.0063 0.0208
Schistosoma mansoni survival motor neuron protein 0.021 0.0509 0.0509
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0016 0.0302
Echinococcus granulosus ETS domain containing protein Elk 1 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0066 0.0133 0.0438
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0017 0.0004 0.0004
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0046 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0094
Brugia malayi ecdysone receptor 0.0068 0.0136 0.0449
Entamoeba histolytica hypothetical protein 0.004 0.0065 0.2372
Leishmania major DNA polymerase kappa, putative 0.0048 0.0085 0.0973
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0204 0.231
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0004 0.0006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0194 0.0468 0.0468
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0004 0.0004
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0017 0.0004 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0046 0.015
Echinococcus granulosus voltage gated potassium channel subunit 0.004 0.0063 0.0063
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0016 0.0317
Schistosoma mansoni intermediate filament proteins 0.0122 0.0278 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.1286
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0116 0.0262 0.0262
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.004 0.0063 0.4597
Trichomonas vaginalis CMGC family protein kinase 0.0167 0.0397 1
Brugia malayi dehydrogenases, short chain protein 2 0.0017 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Leishmania major quinonoid dihydropteridine reductase 0.0017 0.0004 0.0044
Echinococcus granulosus carbonyl reductase 1 0.0017 0.0004 0.0004
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.001 0.0009
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.0147 0.0147
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0017 0.0004 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0094
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.1286
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0071 0.0071
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.001 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0028 0.0092
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0167 0.0397 0.4551
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0017 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0066 0.0133 0.0133
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0194 0.0468 0.0468
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0139 0.0139
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Echinococcus granulosus hypothetical protein 0.0017 0.0004 0.0004
Trypanosoma brucei short-chain dehydrogenase, putative 0.0017 0.0004 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0087 0.0285
Brugia malayi Cytochrome P450 family protein 0.0033 0.0045 0.0149
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0017 0.0004 0.0016
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0017 0.0004 0.0004
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0016 0.0053
Schistosoma mansoni inositol transporter 0.0039 0.0062 0.0062
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0017 0.0004 0.0016
Entamoeba histolytica aldose reductase, putative 0.004 0.0063 0.2294
Brugia malayi beta-NAC-like protein 0.004 0.0065 0.0214
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0017 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0194 0.0468 0.1544
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0004 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Loa Loa (eye worm) oxidoreductase 0.0017 0.0004 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0194 0.0468 0.1544
Schistosoma mansoni coup transcription factor 0.0194 0.0468 0.0468
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Schistosoma mansoni carbonyl reductase 0.0017 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0204 0.231
Brugia malayi nuclear receptor NHR-88 0.0194 0.0468 0.1544
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0088 0.1006
Echinococcus multilocularis carbonyl reductase 1 0.0017 0.0004 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0139 0.0139
Trypanosoma cruzi DNA polymerase kappa, putative 0.0093 0.0204 0.2338
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0004 0.0004
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Echinococcus granulosus nuclear receptor nhr 48 0.0068 0.0136 0.0136
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Echinococcus multilocularis protein C ets 2 0.0024 0.0021 0.0021
Loa Loa (eye worm) oxidoreductase 0.0017 0.0004 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0194 0.0468 0.1544
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0004 0.0004
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0017 0.0004 0.0016
Echinococcus granulosus ewsr:fli fusion protein type 0.0024 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0194 0.0468 0.1544
Loa Loa (eye worm) hypothetical protein 0.1174 0.3029 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0062 0.0783
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0059 0.0113 0.0113
Echinococcus multilocularis GA binding protein alpha chain 0.0163 0.0387 0.0387
Brugia malayi Ets-domain containing protein 0.0163 0.0387 0.1277
Echinococcus granulosus RUN 0.0066 0.0133 0.0133
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0065 0.4752
Brugia malayi Doublecortin family protein 0.0066 0.0133 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0163
Onchocerca volvulus 0.004 0.0063 0.0196
Brugia malayi tailless protein 0.0068 0.0136 0.0449
Brugia malayi intermediate filament protein 0.0122 0.0278 0.0918
Echinococcus granulosus aldo keto reductase family 1 member B4 0.004 0.0063 0.0063
Brugia malayi hypothetical protein 0.0019 0.001 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0163
Trichomonas vaginalis CMGC family protein kinase 0.0167 0.0397 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0017 0.0004 0.0016
Brugia malayi hypothetical protein 0.0297 0.0736 0.2428
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0349 0.0871 1
Trypanosoma brucei protein kinase, putative 0.0167 0.0397 0.4531
Onchocerca volvulus 0.0194 0.0468 0.1534
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.0147 0.3285
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0194 0.0468 0.0468
Echinococcus granulosus Polycystic kidney disease protein 0.0066 0.0133 0.0133
Schistosoma mansoni nuclear receptor 0.0068 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0057 0.0107 0.0354
Echinococcus granulosus Nuclear hormone receptor HR96 0.0068 0.0136 0.0136
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0059 0.0113 0.0113
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0004 0.0006
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0356 0.089 0.2938
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Echinococcus multilocularis mitogen activated protein kinase 3 0.0167 0.0397 0.0396
Schistosoma mansoni ets-related 0.0024 0.0021 0.0021
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0045 0.0518
Echinococcus granulosus cpg binding protein 0.0168 0.0399 0.0399
Schistosoma mansoni lamin 0.0122 0.0278 0.0278
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Brugia malayi MH2 domain containing protein 0.013 0.0298 0.0984
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0127 0.0291 0.0291
Entamoeba histolytica aldose reductase, putative 0.004 0.0063 0.2294
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0016 0.0318
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0017 0.0004 0.0044
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0016 0.0285
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0194 0.0468 0.0468
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0127 0.0291 0.0291
Giardia lamblia DINP protein human, muc B family 0.0048 0.0085 0.2061
Trichomonas vaginalis CMGC family protein kinase 0.0167 0.0397 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0093 0.0204 0.231
Loa Loa (eye worm) oxidoreductase 0.0017 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0031
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Echinococcus granulosus aldo keto reductase family 1 member B4 0.004 0.0063 0.0063
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0016 0.0318
Loa Loa (eye worm) intermediate filament protein 0.0122 0.0278 0.0918
Echinococcus multilocularis high affinity choline transporter 1 0.0356 0.089 0.089
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0045 0.0149
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0028 0.0556
Schistosoma mansoni rab6-interacting 0.0066 0.0133 0.0133
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0046 0.0045
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Brugia malayi nuclear hormone receptor family member odr-7 0.0068 0.0136 0.0449
Plasmodium falciparum aldehyde reductase, putative 0.004 0.0063 0.4597
Trichomonas vaginalis DNA polymerase eta, putative 0.0093 0.0204 0.5097
Echinococcus multilocularis carbonyl reductase 1 0.0017 0.0004 0.0004
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0167 0.0397 0.5278
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.001 0.0009
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0017 0.0004 0.0044
Schistosoma mansoni hypothetical protein 0.0116 0.0262 0.0262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0194 0.0468 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0194 0.0468 0.1544
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.001 0.0163
Echinococcus multilocularis Polycystic kidney disease protein 0.0066 0.0133 0.0133
Entamoeba histolytica alcohol dehydrogenase, putative 0.004 0.0063 0.2294
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0036 0.0036
Loa Loa (eye worm) oxidoreductase 0.0017 0.0004 0.0012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0068 0.0136 0.0449
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.004 0.0063 0.1522
Onchocerca volvulus 0.0163 0.0384 0.1258
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0011 0.0536
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0031
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Leishmania major hypothetical protein, conserved 0.0017 0.0004 0.0044
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0062 0.0062
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0011 0.0159
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0016 0.0965
Trypanosoma cruzi aldo/keto reductase, putative 0.004 0.0063 0.0723
Giardia lamblia Kinase, CMGC MAPK 0.0167 0.0397 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0054 0.1286
Giardia lamblia Aldose reductase 0.004 0.0063 0.1508
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Leishmania major DNA polymerase eta, putative 0.0033 0.0046 0.0523
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Echinococcus granulosus mixed lineage leukemia protein mll 0.004 0.0063 0.0063
Trypanosoma brucei unspecified product 0.0023 0.0019 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0028 0.0556
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0017 0.0004 0.0044
Schistosoma mansoni ets-related 0.0496 0.1257 0.1257
Onchocerca volvulus 0.0122 0.0278 0.0907
Leishmania major quinonoid dihydropteridine reductase 0.0017 0.0004 0.0044
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0093 0.0204 0.5097
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0014 0.0013
Brugia malayi orphan nuclear receptor NR2E1 0.0068 0.0136 0.0449
Echinococcus granulosus axis inhibition protein axin 0.0019 0.001 0.0009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0194 0.0468 0.0468
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0167 0.0397 0.4551
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0208
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0017 0.0004 0.0007
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0065 0.0746
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0004 0.0004
Entamoeba histolytica aldose reductase, putative 0.004 0.0063 0.2294
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0139 0.0459
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0054 0.1286
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.001 0.0031
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.001 0.0175
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0071 0.0071
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0016 0.0053
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.088 0.2259 0.2259
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0017 0.0004 0.0044
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0028 0.0556
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Schistosoma mansoni aldo-keto reductase 0.004 0.0063 0.0063
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0017 0.0004 0.0044
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Echinococcus multilocularis aldo keto reductase 0.004 0.0063 0.0063
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0122 0.0278 0.0918
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0035
Echinococcus multilocularis oxidoreductase 0.0017 0.0004 0.0004
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.004 0.0063 0.1522
Loa Loa (eye worm) RNA binding protein 0.0069 0.0139 0.0459
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0017 0.0004 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0063 0.1522
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.001 0.0009
Echinococcus granulosus transcription factor btf3 0.004 0.0065 0.0065
Brugia malayi hypothetical protein 0.0127 0.0291 0.0961
Loa Loa (eye worm) DR-78 0.0068 0.0136 0.0449
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0004 0.0004
Toxoplasma gondii aldose reductase, putative 0.004 0.0063 0.0796
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0016 0.0186
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0205
Brugia malayi Nuclear hormone receptor E75 0.0068 0.0136 0.0449
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0194 0.0468 0.0468
Brugia malayi PXA domain containing protein 0.0019 0.001 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0003 0.00000000058918
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0016 0.0332
Schistosoma mansoni mixed-lineage leukemia protein mll 0.004 0.0063 0.0063
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.004 0.0063 0.0208
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0298 0.0984
Schistosoma mansoni nuclear receptor nhr-48 0.0068 0.0136 0.0136
Schistosoma mansoni single-minded 0.0054 0.01 0.01
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0016 0.0016
Echinococcus multilocularis ecdysone induced protein 78C 0.0194 0.0468 0.0468
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0014 0.0044
Leishmania major cytochrome p450-like protein 0.0033 0.0045 0.0518
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0088 0.029
Loa Loa (eye worm) hypothetical protein 0.0059 0.0113 0.0373
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0046 0.0523
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0004 0.0004
Echinococcus granulosus steroid dehydrogenase 0.0017 0.0004 0.0004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0016 0.0159
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0016 0.0016
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0011 0.0536
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0139 0.0139
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Schistosoma mansoni potassium channel beta 0.004 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0194 0.0468 0.1544
Echinococcus multilocularis aldo keto reductase 0.004 0.0063 0.0063
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0004 0.0013
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0016 0.0051
Echinococcus multilocularis tumor protein p63 0.1111 0.2862 0.2862
Brugia malayi bHLH-PAS transcription factor 0.004 0.0064 0.021
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0194 0.0468 0.1544
Trichomonas vaginalis helicase, putative 0.0036 0.0054 0.1286
Toxoplasma gondii aldo-keto reductase 0.004 0.0063 0.0796
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Brugia malayi Fli-1 protein 0.0496 0.1257 0.415
Echinococcus granulosus carbonyl reductase 1 0.0017 0.0004 0.0004
Trypanosoma brucei aldo/keto reductase, putative 0.004 0.0063 0.069
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0004 0.0044
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0071 0.0816
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0062 0.0062
Echinococcus granulosus lipoxygenase domain containing protein 0.0066 0.0133 0.0133
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0017 0.0004 0.0044
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Echinococcus granulosus oxidoreductase 0.0017 0.0004 0.0004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0391 0.4488
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0144 0.1626
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0004 0.0044
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0071 0.1727
Loa Loa (eye worm) hypothetical protein 0.0126 0.0288 0.0951
Brugia malayi regulator of G-protein signaling egl-10 0.0029 0.0036 0.012
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.001 0.0009
Brugia malayi PXA domain containing protein 0.0019 0.001 0.0031
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0016 0.0482
Echinococcus multilocularis ets variant gene 4 0.0024 0.0021 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0028 0.0092
Schistosoma mansoni hypothetical protein 0.0034 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0004 0.0014
Echinococcus multilocularis aldo keto reductase 0.004 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0127 0.0291 0.0961
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0062 0.0205
Echinococcus granulosus hypothetical protein 0.004 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0127 0.0291 0.0961
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0167 0.0397 0.4551
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.007
Leishmania major quinonoid dihydropteridine reductase 0.0017 0.0004 0.0044
Leishmania major aldo-keto reductase-like protein 0.004 0.0063 0.0723
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0014 0.0013
Echinococcus granulosus ETS transcription factor Elf 2 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0234
Echinococcus granulosus ETS transcription factor Elf 2 0.0024 0.0021 0.0021
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0298 0.0984
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0017 0.0004 0.0004
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0139 0.0459
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0016 0.0921
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0127 0.0291 0.0291
Brugia malayi TAR-binding protein 0.0069 0.0139 0.0459
Loa Loa (eye worm) hypoxia-induced factor 1 0.0167 0.0395 0.1304
Onchocerca volvulus 0.021 0.0509 0.167
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0071 0.0783
Toxoplasma gondii histone lysine methyltransferase SET1 0.0302 0.0748 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0017 0.0004 0.0012
Onchocerca volvulus 0.004 0.0063 0.0196
Echinococcus multilocularis RUN 0.0066 0.0133 0.0133
Echinococcus granulosus FTZ F1 alpha 0.0194 0.0468 0.0468
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.004 0.0063 0.0723
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0024 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0065 0.1572
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0139 0.0459
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0094
Schistosoma mansoni transcription factor btf3 0.004 0.0065 0.0065
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.004 0.0063 0.0208
Echinococcus granulosus dna polymerase eta 0.0033 0.0046 0.0045
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0092
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.2268 0.5887 0.5887
Trypanosoma brucei aldo-keto reductase, putative 0.004 0.0063 0.069
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0071 0.0816
Onchocerca volvulus 0.004 0.0063 0.0196
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0035
Leishmania major mitochondrial DNA polymerase beta 0.0349 0.0871 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0016 0.018
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Echinococcus granulosus aldo keto reductase 0.004 0.0063 0.0063
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0016 0.0016
Brugia malayi Dehydrogenases, short chain protein 2 0.0017 0.0004 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0194 0.0468 0.1544
Echinococcus multilocularis ETS transcription factor Elf 2 0.0024 0.0021 0.0021
Trypanosoma cruzi ISWI complex protein 0.0017 0.0003 0.0036
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0028 0.094
Trypanosoma brucei oxidoreductase-like protein 0.0017 0.0004 0.0007
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0065 0.0713
Echinococcus granulosus geminin 0.0908 0.2332 0.2332
Echinococcus granulosus solute carrier family 5 0.0039 0.0062 0.0062
Echinococcus multilocularis survival motor neuron protein 1 0.1031 0.2654 0.2654
Schistosoma mansoni transcription factor LCR-F1 0.0116 0.0262 0.0262
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0004 0.0044
Loa Loa (eye worm) hypothetical protein 0.0057 0.0107 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0065 0.1572
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0017 0.0004 0.0004
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0004 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0014 0.0013
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0017 0.0004 0.0016
Schistosoma mansoni hypothetical protein 0.0024 0.0021 0.0021
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0167 0.0397 0.4551
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Echinococcus granulosus aldo keto reductase family 1 member B4 0.004 0.0063 0.0063
Brugia malayi Cytochrome P450 family protein 0.0035 0.005 0.0166
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0209 0.0505 0.1655
Onchocerca volvulus 0.0025 0.0024 0.0067
Brugia malayi Retinol dehydrogenase 12 0.0017 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0908 0.2332 0.2332
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0014 0.0044
Brugia malayi Nuclear hormone receptor-like 1 0.0127 0.0291 0.0961
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0004 0.0004
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.004 0.0063 0.0723
Schistosoma mansoni elf1 0.0024 0.0021 0.0021
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0194 0.0468 0.1534
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0046 0.1617
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.0049
Trichomonas vaginalis aldo/keto reductase, putative 0.004 0.0063 0.1522
Schistosoma mansoni gabp alpha 0.0163 0.0387 0.0387
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0144 0.0476
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0028 0.0556
Schistosoma mansoni thyroid hormone receptor 0.0194 0.0468 0.0468
Echinococcus granulosus retinol dehydrogenase 11 0.0017 0.0004 0.0004
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0072 0.0147 0.0485
Echinococcus multilocularis lipoxygenase domain containing protein 0.0066 0.0133 0.0133
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0017 0.0004 0.0044
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0019 0.0019
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0016 0.0051
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0103 0.0339
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0042
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0035
Mycobacterium ulcerans oxidoreductase 0.004 0.0063 0.1358
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0194 0.0468 0.1544
Brugia malayi RNA binding protein 0.0069 0.0139 0.0459
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0004 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0028 0.0556
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0139 0.0139
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0016 0.0016
Brugia malayi hypothetical protein 0.0068 0.0136 0.0449
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0017 0.0004 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.1286
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.1286
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0088 0.1006
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.004 0.0063 0.0796
Trypanosoma brucei short-chain dehydrogenase, putative 0.0017 0.0004 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0204 0.231
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0046 0.0045
Leishmania major pteridine reductase 1 0.0017 0.0004 0.0044
Schistosoma mansoni hypothetical protein 0.021 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0127 0.0291 0.0961
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0163
Onchocerca volvulus 0.0066 0.0133 0.0426
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0028 0.0556
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.004 0.0063 0.0723
Giardia lamblia Aldose reductase 0.004 0.0063 0.1508
Schistosoma mansoni axis inhibition protein axin 0.0019 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.1286
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0016 0.0151
Brugia malayi hypothetical protein 0.0181 0.0432 0.1425
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0004 0.0044
Echinococcus multilocularis lipoxygenase domain containing protein 0.0066 0.0133 0.0133
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.001 0.0031
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0071 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0136 0.0136
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0049 0.0088 0.0088
Toxoplasma gondii hypothetical protein 0.0056 0.0107 0.138
Schistosoma mansoni pol-related 0.004 0.0063 0.0063
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.021 0.0509 0.168
Brugia malayi hypothetical protein 0.0066 0.0133 0.0438
Echinococcus granulosus aldo keto reductase family 1 member B4 0.004 0.0063 0.0063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0194 0.0468 0.0468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0194 0.0468 0.1544
Brugia malayi NADH-dependent xylose reductase 0.004 0.0063 0.0208
Brugia malayi nuclear receptor NHR-88 0.0068 0.0136 0.0449
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0017 0.0004 0.0044
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0016 0.0016
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0065 0.2372
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0088 0.029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Plasmodium falciparum aldo-keto reductase, putative 0.004 0.0063 0.4597
Echinococcus multilocularis lamin 0.0122 0.0278 0.0278
Mycobacterium ulcerans hypothetical protein 0.0184 0.044 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0035
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.0391 0.4468
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0071 0.0071
Brugia malayi polk-prov protein 0.0071 0.0144 0.0476
Echinococcus multilocularis aldo keto reductase 0.004 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0093 0.0204 0.2338
Loa Loa (eye worm) oxidoreductase 0.0017 0.0004 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0047 0.0156
Leishmania major short chain dehydrogenase/reductase, putative 0.0017 0.0004 0.0044
Echinococcus multilocularis ETS transcription factor Elf 5 0.0024 0.0021 0.0021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0194 0.0468 0.1544
Onchocerca volvulus 0.0039 0.0062 0.0193
Loa Loa (eye worm) oxidoreductase 0.0017 0.0004 0.0012
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.001 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.1286
Brugia malayi PAS domain containing protein 0.0054 0.01 0.033
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0016 0.0285
Trypanosoma brucei short-chain dehydrogenase, putative 0.0017 0.0004 0.0007
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0011 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.004 0.0063 0.0063
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0017 0.0004 0.0044
Echinococcus granulosus carbonyl reductase 1 0.0017 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0054 0.1286
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.004 0.0063 0.0208
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0204 0.231
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0004 0.0004
Mycobacterium leprae Possible oxidoreductase 0.004 0.0063 1
Toxoplasma gondii exonuclease III APE 0.0022 0.0016 0.0167
Echinococcus granulosus aldo keto reductase family 1 member B4 0.004 0.0063 0.0063
Trypanosoma brucei unspecified product 0.0023 0.0019 0.018
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0046 0.015
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0068 0.0136 0.0449
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0017 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0017 0.0004 0.0044
Loa Loa (eye worm) fli-1 protein 0.0496 0.1257 0.415
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0016 0.0051
Schistosoma mansoni cpg binding protein 0.0168 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.0051
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Toxoplasma gondii NAC domain-containing protein 0.004 0.0065 0.0823
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0009
Entamoeba histolytica hypothetical protein 0.0116 0.0262 1
Trichomonas vaginalis hypothetical protein 0.0019 0.001 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0194 0.0468 0.0468
Echinococcus multilocularis carbonyl reductase 1 0.0017 0.0004 0.0004
Brugia malayi Nuclear hormone receptor E75 0.0068 0.0136 0.0449
Mycobacterium ulcerans putative regulatory protein 0.004 0.0064 0.1372
Echinococcus granulosus aldo keto reductase 0.004 0.0063 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0085 0.094
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.004 0.0063 1
Schistosoma mansoni sodium/solute symporter 0.0039 0.0062 0.0062
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Loa Loa (eye worm) CYP4Cod1 0.0033 0.0045 0.0149
Onchocerca volvulus 0.004 0.0063 0.0196
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Schistosoma mansoni DNA helicase recq1 0.0022 0.0016 0.0016
Schistosoma mansoni microtubule-associated protein tau 0.3841 1 1
Brugia malayi hypothetical protein 0.0116 0.0262 0.0864
Brugia malayi Nuclear hormone receptor-like 1 0.0194 0.0468 0.1544
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Entamoeba histolytica alcohol dehydrogenase, putative 0.004 0.0063 0.2294
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0194 0.0468 0.0468
Echinococcus granulosus ecdysone induced protein 78C 0.0194 0.0468 0.0468
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0071 0.0071
Leishmania major hypothetical protein, conserved 0.0017 0.0004 0.0044
Leishmania major quinonoid dihydropteridine reductase 0.0017 0.0004 0.0044
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0156
Echinococcus granulosus ETS transcription factor Elf 1 0.0024 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0004 0.0044
Echinococcus multilocularis retinol dehydrogenase 11 0.0017 0.0004 0.0004
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0048 0.0085 0.1857
Schistosoma mansoni hypothetical protein 0.0908 0.2332 0.2332
Echinococcus granulosus ETS transcription factor Elf 5 0.0024 0.0021 0.0021
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.01 0.01
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0194 0.0468 0.0468
Schistosoma mansoni cpg binding protein 0.0168 0.0399 0.0399
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0028 0.0556
Trypanosoma brucei DNA polymerase IV, putative 0.0093 0.0204 0.231
Onchocerca volvulus Protein ultraspiracle homolog 0.0194 0.0468 0.1534
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.1286
Echinococcus multilocularis dna polymerase eta 0.0033 0.0046 0.0045
Loa Loa (eye worm) dehydrogenase 0.0017 0.0004 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0093 0.0204 0.2338
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0017 0.0004 0.0007
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0016 0.0921
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0017 0.0004 0.0004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0186 0.0444 0.0444
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0136 0.0136
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0016 0.0051
Loa Loa (eye worm) oxidoreductase 0.004 0.0063 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0194 0.0468 0.1544
Leishmania major protein kinase, putative 0.002 0.0012 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0397 0.0396
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.004 0.0063 0.0208
Brugia malayi glutamate-cysteine ligase modifier subunit 0.004 0.0063 0.0208
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0194 0.0468 0.0468
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0068 0.0136 0.0136
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.001 0.0009
Trypanosoma cruzi short chain dehydrogenase, putative 0.0017 0.0004 0.0044
Schistosoma mansoni carbonyl reductase 0.0017 0.0004 0.0004
Loa Loa (eye worm) D-ets-2 protein 0.0024 0.0021 0.007
Brugia malayi nuclear hormone receptor 0.0194 0.0468 0.1544
Loa Loa (eye worm) hypothetical protein 0.0127 0.0291 0.0961
Leishmania major dehydrogenase-like protein 0.0017 0.0004 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.1286
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Schistosoma mansoni RAR-like nuclear receptor 0.0194 0.0468 0.0468
Loa Loa (eye worm) histone methyltransferase 0.0049 0.0088 0.0291
Brugia malayi oxidoreductase 0.0017 0.0004 0.0012
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.001 0.0009
Entamoeba histolytica hypothetical protein 0.0019 0.001 0.0224
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0071 0.0234
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.0184
Trichomonas vaginalis steroid dehydrogenase, putative 0.0017 0.0004 0.0016
Echinococcus granulosus tumor protein p63 0.1111 0.2862 0.2862
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0058 0.0632
Brugia malayi transcription factor E74 isoform 0.0024 0.0021 0.007
Entamoeba histolytica hypothetical protein 0.0116 0.0262 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0065 0.1572
Schistosoma mansoni ap endonuclease 0.0022 0.0016 0.0016
Schistosoma mansoni ets 0.0024 0.0021 0.0021
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Brugia malayi nuclear receptor RXR 0.0068 0.0136 0.0449
Loa Loa (eye worm) oxidoreductase 0.0017 0.0004 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Echinococcus multilocularis musashi 0.0122 0.0278 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0058 0.0632
Echinococcus granulosus dna polymerase kappa 0.0093 0.0204 0.0204
Echinococcus granulosus aldo keto reductase family 1 member B4 0.004 0.0063 0.0063
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0004 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0045 0.0149
Brugia malayi hypothetical protein 0.0017 0.0004 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0016 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0167 0.0397 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.0468 0.1544
Schistosoma mansoni steroid hormone receptor ad4bp 0.0194 0.0468 0.0468
Schistosoma mansoni zinc finger protein 0.0068 0.0136 0.0136
Schistosoma mansoni nuclear hormone receptor 0.0194 0.0468 0.0468
Brugia malayi dehydrogenases, short chain protein 9 0.0017 0.0004 0.0012
Leishmania major hypothetical protein, conserved 0.0017 0.0004 0.0044
Leishmania major short chain dehydrogenase-like protein 0.0017 0.0004 0.0044
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0017 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Brugia malayi nuclear receptor RXR 0.0127 0.0291 0.0961
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0062 0.0062
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0017 0.0004 0.0016
Onchocerca volvulus 0.004 0.0063 0.0196
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0036 0.0036
Onchocerca volvulus 0.004 0.0063 0.0196
Loa Loa (eye worm) hypothetical protein 0.0194 0.0468 0.1544
Schistosoma mansoni axis inhibition protein axin 0.0019 0.001 0.0009
Trypanosoma cruzi aldo/keto reductase, putative 0.004 0.0063 0.0723
Plasmodium vivax aldehyde reductase, putative 0.004 0.0063 0.4597
Echinococcus multilocularis retinol dehydrogenase 11 0.0017 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0127 0.0291 0.0961
Plasmodium vivax multidomain scavenger receptor, putative 0.0066 0.0133 1
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0065 0.4752
Echinococcus granulosus dnaJ subfamily B 0.2268 0.5887 0.5887
Loa Loa (eye worm) hypothetical protein 0.0127 0.0291 0.0961
Leishmania major basic transcription factor 3a, putative 0.004 0.0065 0.0746
Echinococcus granulosus expressed protein 0.0373 0.0936 0.0936
Brugia malayi CXXC zinc finger family protein 0.0159 0.0376 0.124
Loa Loa (eye worm) ICD-1 protein 0.004 0.0065 0.0214
Loa Loa (eye worm) CXXC zinc finger family protein 0.0159 0.0376 0.124
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0014 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0194 0.0468 0.0468
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0004 0.0004
Brugia malayi hypothetical protein 0.1031 0.2654 0.8762
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Loa Loa (eye worm) RGS-3 protein 0.0019 0.001 0.0031
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0016 0.018
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.1031 0.2654 0.8762
Echinococcus granulosus intermediate filament protein 0.0122 0.0278 0.0278
Schistosoma mansoni retinoic acid receptor RXR 0.0194 0.0468 0.0468
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0009
Brugia malayi ecdysteroid receptor 0.1174 0.3029 1
Schistosoma mansoni myst-related protein 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0122 0.0278 0.0918
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.001 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0194 0.0468 0.1544
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0194 0.0468 0.1544
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0031
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0009
Onchocerca volvulus 0.0026 0.0028 0.008
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0017 0.0004 0.0012
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.004 0.0063 0.1522
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0016 0.0016
Onchocerca volvulus 0.0159 0.0376 0.1229
Trichomonas vaginalis aldo/keto reductase, putative 0.004 0.0063 0.1522
Brugia malayi DNA-binding protein D-ETS-3 0.0024 0.0021 0.007
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0035
Echinococcus multilocularis cpg binding protein 0.0168 0.0399 0.0399
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0194 0.0468 0.0468
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0028 0.4095
Echinococcus granulosus axis inhibition protein axin 0.0019 0.001 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0349 0.0871 1
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0004 0.0004
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Loa Loa (eye worm) nuclear hormone receptor 0.0068 0.0136 0.0449
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0025 0.029
Leishmania major quinonoid dihydropteridine reductase 0.0017 0.0004 0.0044
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0028 0.0322
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0017 0.0004 0.0012
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0072 0.0147 0.1688
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Leishmania major quinonoid dihydropteridine reductase 0.0017 0.0004 0.0044
Brugia malayi cytoplasmic intermediate filament protein 0.0065 0.013 0.0429
Brugia malayi hypothetical protein 0.0068 0.0136 0.0449
Brugia malayi Intermediate filament tail domain containing protein 0.0122 0.0278 0.0918
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.001 0.0009
Brugia malayi conserved hypotetical protein 0.0068 0.0136 0.0449
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0016 0.0144
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0167 0.0397 0.1309
Brugia malayi nuclear hormone receptor 0.0068 0.0136 0.0449
Echinococcus granulosus tar DNA binding protein 0.0069 0.0139 0.0139
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0016 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0144 0.1626
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0054 0.1286
Onchocerca volvulus 0.0066 0.0133 0.0426
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.044 1
Entamoeba histolytica hypothetical protein 0.0116 0.0262 1
Echinococcus multilocularis microtubule associated protein 2 0.3841 1 1
Onchocerca volvulus 0.004 0.0063 0.0196
Brugia malayi Cytochrome P450 family protein 0.0033 0.0045 0.0149
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.001 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0139 0.0139
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0017 0.0004 0.0016
Schistosoma mansoni polycystin 1-related 0.0066 0.0133 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0204 0.231
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Loa Loa (eye worm) nuclear receptor NHR-67 0.0068 0.0136 0.0449
Brugia malayi hypothetical protein 0.0127 0.0291 0.0961
Trypanosoma cruzi aldo-keto reductase 0.004 0.0063 0.0723
Loa Loa (eye worm) oxidoreductase 0.004 0.0063 0.0208
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0136 0.0136
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0071 0.0071
Echinococcus granulosus high affinity choline transporter 1 0.0356 0.089 0.089
Schistosoma mansoni hypothetical protein 0.0024 0.0021 0.0021
Schistosoma mansoni lipoxygenase 0.0186 0.0444 0.0444
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0062 0.0062
Plasmodium falciparum zinc finger protein, putative 0.0019 0.0009 0.0369
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0338 0.0842 0.0842
Brugia malayi Nuclear hormone receptor-like 1 0.0127 0.0291 0.0961
Echinococcus multilocularis thyroid hormone receptor alpha 0.0194 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0033 0.0046 0.015
Trichomonas vaginalis aldo-keto reductase, putative 0.004 0.0063 0.1522
Echinococcus multilocularis retinol dehydrogenase 13 0.0017 0.0004 0.0004
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0017 0.0004 0.0016
Echinococcus multilocularis ETS transcription factor Elf 2 0.0024 0.0021 0.0021
Echinococcus multilocularis mitogen activated protein kinase 0.0167 0.0397 0.0396
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0048 0.0085 0.0973
Echinococcus granulosus single minded 2 0.004 0.0064 0.0064
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0194 0.0468 0.0468
Schistosoma mansoni hypothetical protein 0.0061 0.0118 0.0118
Schistosoma mansoni ap endonuclease 0.0022 0.0016 0.0016
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0017 0.0004 0.0004
Schistosoma mansoni high-affinity choline transporter 0.0356 0.089 0.089
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0016 0.046
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Echinococcus multilocularis ETS transcription factor Elf 1 0.0024 0.0021 0.0021
Schistosoma mansoni retinal dehydrogenase 0.0017 0.0004 0.0004
Brugia malayi isocitrate dehydrogenase 0.0017 0.0004 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0204 0.231
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0046 0.0045
Brugia malayi hypothetical protein 0.0017 0.0004 0.0012
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0068 0.0136 0.0136
Schistosoma mansoni myst-related protein 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0181 0.0432 0.1425
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0194 0.0468 0.1544
Entamoeba histolytica hypothetical protein 0.0116 0.0262 1
Echinococcus granulosus aldo keto reductase 0.004 0.0063 0.0063
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0194 0.0468 0.1544
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0092
Brugia malayi hypothetical protein 0.0066 0.0133 0.0438
Echinococcus multilocularis conserved hypothetical protein 0.0017 0.0004 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0054 0.1286
Loa Loa (eye worm) hypothetical protein 0.0163 0.0384 0.1269
Leishmania major short chain dehydrogenase, putative 0.0017 0.0004 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0046 0.015
Echinococcus multilocularis carbonyl reductase 1 0.0017 0.0004 0.0004
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0071 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0204 0.231
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0062 0.0062
Schistosoma mansoni lamin 0.0122 0.0278 0.0278
Schistosoma mansoni thyroid hormone receptor 0.0194 0.0468 0.0468
Echinococcus granulosus aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Onchocerca volvulus 0.0068 0.0136 0.0438
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0092
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0028 0.4095
Onchocerca volvulus Bile acid receptor homolog 0.1174 0.3029 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.004 0.0063 0.1522
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0116 0.0262 0.0262
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0024 0.0021 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0194 0.0468 0.1544
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0391 0.4488
Loa Loa (eye worm) hypothetical protein 0.014 0.0325 0.1072
Brugia malayi nuclear receptor NHR-67 0.0068 0.0136 0.0449
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0071 0.0071
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0065 0.0746
Loa Loa (eye worm) oxidoreductase 0.004 0.0063 0.0208
Echinococcus multilocularis geminin 0.0908 0.2332 0.2332
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0194 0.0468 0.1544
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0028 0.094
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0028 0.0322
Echinococcus granulosus mitogen activated protein kinase 0.0167 0.0397 0.0396
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0004 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0093 0.0204 0.2338
Echinococcus multilocularis steroid dehydrogenase 0.0017 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0194 0.0468 0.1544
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.004 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0136 0.0136
Mycobacterium tuberculosis Probable oxidoreductase 0.004 0.0063 0.1358
Schistosoma mansoni inositol transporter 0.0039 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0071 0.1727
Brugia malayi Ets-domain containing protein 0.0024 0.0021 0.007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0194 0.0468 0.0468
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0017 0.0004 0.0007
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Loa Loa (eye worm) oxidoreductase 0.0017 0.0004 0.0012
Schistosoma mansoni loxhd1 0.0066 0.0133 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0194 0.0468 0.1544
Leishmania major short chain dehydrogenase/reductase, putative 0.0017 0.0004 0.0044
Leishmania major prostaglandin f synthase, putative 0.004 0.0063 0.0723
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0017 0.0004 0.0016
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0028 0.0556
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0068 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0194 0.0468 0.1544
Trypanosoma brucei prostaglandin f synthase 0.004 0.0063 0.069
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.004 0.0063 0.0796
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.004 0.0063 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0094
Echinococcus multilocularis dna polymerase kappa 0.0093 0.0204 0.0204
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0163 0.0387 0.1277
Brugia malayi steroid hormone receptor 0.0194 0.0468 0.1544
Loa Loa (eye worm) hypothetical protein 0.012 0.0272 0.0898
Echinococcus granulosus Nuclear hormone receptor HR96 0.0068 0.0136 0.0136
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0017 0.0004 0.0044
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.001 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0194 0.0468 0.1544
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0016 0.0965
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0004 0.0012
Leishmania major 3-keto-dihydrosphingosine reductase 0.0017 0.0004 0.0044
Brugia malayi Steroid receptor seven-up type 2 0.0194 0.0468 0.1544
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0068 0.0136 0.0136
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0071 0.0816
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0209 0.0505 0.1665
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0194 0.0468 0.0468
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0064 0.0064
Echinococcus multilocularis transcription factor btf3 0.004 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0031
Mycobacterium ulcerans DNA polymerase IV 0.0093 0.0204 0.4585
Loa Loa (eye worm) oxidoreductase 0.0017 0.0004 0.0012
Mycobacterium ulcerans hypothetical protein 0.0026 0.0028 0.0556
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.0147 0.3285
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0449
Loa Loa (eye worm) steroid hormone receptor 0.0194 0.0468 0.1544
Loa Loa (eye worm) hypothetical protein 0.0066 0.0133 0.0438
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0088 0.029
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0028 0.0322
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0167 0.0397 0.4531
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0036 0.0036
Echinococcus granulosus aldo keto reductase family 1 member B4 0.004 0.0063 0.0063
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0017 0.0004 0.0016
Schistosoma mansoni rab6-interacting 0.0066 0.0133 0.0133
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.004 0.0063 0.0063
Echinococcus multilocularis mixed lineage leukemia protein mll 0.004 0.0063 0.0063
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.0045 0.0948
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0068 0.0136 0.0438
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.001 0.0031

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 100 uM In vitro vasodilatory activity in isolated rat aorta ChEMBL. 8164261
IC50 (functional) > 0.1 uM In vitro antiplatelet activity against arachidonic acid induced malondialdehyde production ChEMBL. 8164261

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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