Detailed information for compound 210300

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 244.595 | Formula: C6H5ClN6O3
  • H donors: 0 H acceptors: 4 LogP: 1.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCn1nnc2n(c1=O)cnc2[N+](=O)[O-]
  • InChi: 1S/C6H5ClN6O3/c7-1-2-12-6(14)11-3-8-4(13(15)16)5(11)9-10-12/h3H,1-2H2
  • InChiKey: OECAKUBSAPRQLL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0876 0.0834
Trichomonas vaginalis set domain proteins, putative 0.023 0.6917 0.8459
Mycobacterium ulcerans polyketide synthase 0.0026 0.0508 0.0513
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0508 0.0513
Brugia malayi PHD-finger family protein 0.0029 0.0591 0.0706
Brugia malayi MH2 domain containing protein 0.0118 0.339 0.4142
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0177 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2615 0.3126
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0436 0.1639
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0599 0.0715
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0309 0.0266
Trypanosoma brucei trypanothione reductase 0.0037 0.086 0.3039
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1137 0.1293
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1106 0.1065
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2615 0.3126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1234 0.1467
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0094 0.5
Plasmodium falciparum glutathione reductase 0.0037 0.086 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2615 0.3126
Schistosoma mansoni hypothetical protein 0.0011 0.0045 0.0035
Schistosoma mansoni jumonji domain containing protein 0.0075 0.2039 0.2483
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0165
Brugia malayi Pre-SET motif family protein 0.0202 0.6039 0.7396
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2615 0.3126
Loa Loa (eye worm) glutaminase 2 0.0269 0.816 1
Onchocerca volvulus 0.0043 0.1031 0.0956
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.2615 0.339
Onchocerca volvulus Alhambra homolog 0.0029 0.0591 0.028
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0591 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1137 0.1293
Plasmodium falciparum thioredoxin reductase 0.0037 0.086 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.2661 1
Treponema pallidum NADH oxidase 0.0013 0.0094 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0508 0.1908
Loa Loa (eye worm) glutathione reductase 0.0037 0.086 0.1007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1106 0.1065
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0177 0.0197
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.2615 0.3191
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.2615 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0485 0.5101
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0591 0.6564
Leishmania major hypothetical protein, conserved 0.0025 0.0485 0.155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0177 0.0132
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.086 0.1007
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0599 0.0556
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0599 0.0715
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.1151 0.1393
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0094 0.0049
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.086 1
Mycobacterium ulcerans polyketide synthase 0.0025 0.046 0.0453
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0782 0.074
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.2362 0.8878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1106 0.1337
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.046 0.1728
Giardia lamblia Kinase, PLK 0.0093 0.2615 1
Brugia malayi Bromodomain containing protein 0.0029 0.0591 0.0706
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1554 0.1861
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0409 0.1537
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0591 0.0706
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0177 0.0132
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0436 0.1639
Toxoplasma gondii thioredoxin reductase 0.0037 0.086 1
Schistosoma mansoni tar DNA-binding protein 0.0187 0.5569 0.6818
Onchocerca volvulus 0.0029 0.0599 0.0292
Schistosoma mansoni tar DNA-binding protein 0.0187 0.5569 0.6818
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0177 0.0197
Loa Loa (eye worm) hypothetical protein 0.0025 0.0485 0.0545
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0945 0.0904
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1106 0.1337
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.2615 1
Loa Loa (eye worm) TAR-binding protein 0.0187 0.5569 0.6808
Mycobacterium ulcerans glutaminase 0.0269 0.816 1
Loa Loa (eye worm) glutaminase 0.0269 0.816 1
Mycobacterium tuberculosis Probable reductase 0.0085 0.2362 0.8878
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0094 0.5
Brugia malayi hypothetical protein 0.0016 0.0202 0.0228
Schistosoma mansoni hypothetical protein 0.0016 0.0177 0.0197
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.2615 0.2582
Loa Loa (eye worm) hypothetical protein 0.0041 0.0985 0.116
Brugia malayi Pre-SET motif family protein 0.0029 0.0599 0.0715
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.046 0.0453
Loa Loa (eye worm) RNA binding protein 0.0187 0.5569 0.6808
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1106 0.1337
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0745 0.0894
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.086 0.3039
Brugia malayi RNA recognition motif domain containing protein 0.0187 0.5569 0.6818
Echinococcus granulosus GPCR family 2 0.0016 0.0177 0.0132
Plasmodium falciparum phd finger protein, putative 0.0029 0.0591 0.6491
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0508 0.5494
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.2647 0.2614
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.2362 0.8878
Loa Loa (eye worm) hypothetical protein 0.0049 0.1237 0.1471
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0198 0.0129
Loa Loa (eye worm) fatty acid synthase 0.0024 0.045 0.0501
Onchocerca volvulus 0.0048 0.1197 0.1211
Onchocerca volvulus 0.023 0.6917 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.046 0.0544
Schistosoma mansoni hypothetical protein 0.0167 0.494 0.6045
Echinococcus multilocularis tar DNA binding protein 0.0187 0.5569 0.5549
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0508 0.1908
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.2615 0.3169
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0094 0.0095
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0094 0.0049
Echinococcus multilocularis GPCR, family 2 0.0016 0.0177 0.0132
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0782 0.0939
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2615 0.3126
Schistosoma mansoni hypothetical protein 0.0016 0.0177 0.0197
Brugia malayi Thioredoxin reductase 0.0037 0.086 0.1036
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0242 0.0911
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0782 0.074
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.046 0.1728
Echinococcus granulosus peregrin 0.0029 0.0591 0.0549
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0599 0.0715
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0599 0.0556
Plasmodium vivax SET domain protein, putative 0.0029 0.0599 0.6588
Schistosoma mansoni hypothetical protein 0.0016 0.0177 0.0197
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.2362 0.8878
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.2362 0.8878
Loa Loa (eye worm) hypothetical protein 0.0048 0.1197 0.1422
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0094 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1234 0.1494
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.1079 0.103
Plasmodium vivax glutathione reductase, putative 0.0037 0.086 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0485 0.155
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0409 0.0482
Echinococcus granulosus geminin 0.0167 0.494 0.4917
Brugia malayi jmjC domain containing protein 0.0035 0.0782 0.0939
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.2661 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0485 0.155
Leishmania major trypanothione reductase 0.0037 0.086 0.3039
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.2615 0.5
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0409 0.0451
Loa Loa (eye worm) hypothetical protein 0.0034 0.0745 0.0865
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0599 0.0556
Schistosoma mansoni hypothetical protein 0.0029 0.0591 0.0706
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0782 0.091
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0782 0.0939
Giardia lamblia PHD finger protein 15 0.0029 0.0591 0.1972
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0189 0.1414
Echinococcus multilocularis tumor protein p63 0.0327 1 1
Schistosoma mansoni tar DNA-binding protein 0.0187 0.5569 0.6818
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.2661 1
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0094 0.0206
Schistosoma mansoni hypothetical protein 0.0034 0.0745 0.0894
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0842 0.3163
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.339 0.4123
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0508 0.1257
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0591 0.0676
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0485 0.5202
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.2615 0.2582
Mycobacterium ulcerans thioesterase TesA 0.002 0.0331 0.0294
Brugia malayi TAR-binding protein 0.0187 0.5569 0.6818
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0198 0.0129
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0842 0.2612
Brugia malayi glutathione reductase 0.0037 0.086 0.1036
Echinococcus granulosus jumonji domain containing protein 0.004 0.0945 0.0904
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.046 0.1062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0565 0.0522
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.046 0.0453
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0331 0.0539
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0319 0.1199
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.2661 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0187 0.5569 0.6808
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0508 0.1257
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0094 0.0354
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0237 0.2037
Schistosoma mansoni hypothetical protein 0.0167 0.494 0.6045
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.046 0.1062
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0842 0.0927
Schistosoma mansoni kinase 0.0047 0.1176 0.1423
Mycobacterium ulcerans thioesterase 0.002 0.0331 0.0294
Echinococcus multilocularis geminin 0.0167 0.494 0.4917
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.6039 0.7387
Schistosoma mansoni tar DNA-binding protein 0.0187 0.5569 0.6818
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0508 0.1908
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0309 0.0266
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1106 0.1309
Brugia malayi glutaminase DH11.1 0.0269 0.816 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0094 0.0206
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.1197 0.145
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0309 0.0449
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0591 0.6491
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0127 0.0476
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.2615 0.3191
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.2615 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0177 0.0132
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0331 0.1244
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2615 0.3126
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.046 0.0453
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0485 0.5101
Echinococcus granulosus tar DNA binding protein 0.0187 0.5569 0.5549
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.046 0.1728
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.046 0.0453
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.086 0.3233
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0876 0.0834
Trypanosoma brucei polo-like protein kinase 0.0093 0.2615 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0485 0.5101
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0508 0.1257
Loa Loa (eye worm) hypothetical protein 0.0049 0.1234 0.1467
Brugia malayi hypothetical protein 0.0025 0.0485 0.0575
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1234 0.1494
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0599 0.0715
Trichomonas vaginalis glutaminase, putative 0.0269 0.816 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0485 0.155
Schistosoma mansoni tar DNA-binding protein 0.0187 0.5569 0.6818
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.2647 0.2614
Schistosoma mansoni glutaminase 0.0269 0.816 1
Brugia malayi jmjC domain containing protein 0.0094 0.2647 0.323
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2615 0.3126
Brugia malayi RNA binding protein 0.0187 0.5569 0.6818
Loa Loa (eye worm) hypothetical protein 0.0029 0.0599 0.0685
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0508 0.0513
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0177 0.0165
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0094 0.0095
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0842 0.3163
Schistosoma mansoni hypothetical protein 0.0016 0.0177 0.0197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1106 0.1337
Loa Loa (eye worm) hypothetical protein 0.0014 0.012 0.0096
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0599 0.6659
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.2362 0.8788
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1106 0.1065
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.2362 0.8878
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1106 0.1065
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.339 0.4123
Loa Loa (eye worm) hypothetical protein 0.0029 0.0591 0.0676
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0591 0.6564
Echinococcus multilocularis peregrin 0.0029 0.0591 0.0549
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0591 0.0549

Activities

Activity type Activity value Assay description Source Reference
T/C (functional) = 98 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through intravenous route and mean death of animals (treated/control) was reported at 200 mg/kg peroral dose ChEMBL. 3806616
T/C (functional) = 98 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through intravenous route and mean death of animals (treated/control) was reported at 100 mg/kg peroral dose ChEMBL. 3806616
T/C (functional) = 98 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through intravenous route and mean death of animals (treated/control) was reported at 50 mg/kg peroral dose ChEMBL. 3806616
T/C (functional) = 98 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through intravenous route and mean death of animals (treated/control) was reported at 200 mg/kg peroral dose ChEMBL. 3806616
T/C (functional) = 98 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through intravenous route and mean death of animals (treated/control) was reported at 100 mg/kg peroral dose ChEMBL. 3806616
T/C (functional) = 98 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through intravenous route and mean death of animals (treated/control) was reported at 50 mg/kg peroral dose ChEMBL. 3806616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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