Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.1759 | 0.2778 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.435 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.6334 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2206 | 0.0542 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.435 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.6334 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0214 | 0.8611 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.1759 | 0.2043 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.0842 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.6334 | 0.7355 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.0842 | 1 |
Schistosoma mansoni | patched 1 | 0.0068 | 0.1759 | 0.2778 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0237 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.0842 | 0.133 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.6334 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.1759 | 0.2778 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.3768 | 0.8342 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0237 | 0.5 |
Brugia malayi | glutathione reductase | 0.0049 | 0.0842 | 0.0978 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.1759 | 0.2043 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.6334 | 0.7355 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.6334 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.6334 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.6334 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.6334 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0237 | 0.0374 |
Brugia malayi | Pre-SET motif family protein | 0.0214 | 0.8611 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0237 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.0842 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0237 | 0.0275 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.0842 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.0842 | 0.133 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1759 | 0.2043 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.1759 | 0.2778 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2206 | 0.0542 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.1759 | 0.2778 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.6334 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.3768 | 0.8342 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.0842 | 0.0978 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0237 | 0.0374 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.1759 | 0.2778 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0237 | 0.0374 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.3768 | 0.8342 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0237 | 0.0374 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.3768 | 0.8342 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.3768 | 0.8342 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.1759 | 0.2778 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.0842 | 0.0978 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.435 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2206 | 0.0542 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.435 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0243 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.1759 | 0.2778 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.0842 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.3768 | 0.8342 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.0842 | 0.0978 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.2206 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.1759 | 0.2778 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0237 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 nM | Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR) | ChEMBL. | 8246233 |
IC50 (binding) | = 13 nM | Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR) | ChEMBL. | 8246233 |
IC50 (functional) | = 15.8 nM | Tested for ability to inhibit the incorporation of [14C]- acetate in to cholesterol in HepG2 cells | ChEMBL. | 8246233 |
IC50 (functional) | = 15.8 nM | Tested for ability to inhibit the incorporation of [14C]- acetate in to cholesterol in HepG2 cells | ChEMBL. | 8246233 |
logD (ADMET) | = 0.73 | Partition coefficient (logD7.4) | ChEMBL. | 8246233 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8246233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.