Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | selenide water dikinase | 0.0107 | 0.0096 | 0.0128 |
Echinococcus multilocularis | thymidylate synthase | 0.58 | 0.7403 | 1 |
Echinococcus multilocularis | geminin | 0.019 | 0.0203 | 0.0273 |
Onchocerca volvulus | 0.0252 | 0.0282 | 0.0367 | |
Leishmania major | folylpolyglutamate synthetase | 0.0216 | 0.0236 | 0.0236 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.58 | 0.7403 | 1 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0011 | 0.0026 |
Onchocerca volvulus | 0.0043 | 0.0014 | 0.0004 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.5216 | 0.6654 | 0.8986 |
Trypanosoma brucei | Selenophosphate synthetase 2 | 0.0107 | 0.0096 | 0.0095 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0011 | 0.0011 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0011 | 0.0009 |
Brugia malayi | FolC bifunctional protein | 0.0216 | 0.0236 | 0.0317 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0216 | 0.0236 | 0.0305 |
Brugia malayi | dihydrofolate reductase family protein | 0.5216 | 0.6654 | 0.8988 |
Mycobacterium tuberculosis | Hypothetical protein | 0.2759 | 0.35 | 0.472 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Plasmodium vivax | selenophosphate synthetase, putative | 0.0107 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | thiamine monophosphate kinase | 0.0064 | 0.0041 | 0.0056 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.5216 | 0.6654 | 0.8988 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0011 | 0.0026 |
Schistosoma mansoni | methionyl-tRNA formyltransferase | 0.0052 | 0.0026 | 0.0035 |
Chlamydia trachomatis | dihydrofolate reductase | 0.5216 | 0.6654 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Trypanosoma brucei | folylpolyglutamate synthase, putative | 0.0216 | 0.0236 | 0.0234 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Leishmania major | pteridine reductase 1 | 0.0212 | 0.0231 | 0.0231 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Toxoplasma gondii | bifunctional protein FolC subfamily protein | 0.0216 | 0.0236 | 0.0236 |
Mycobacterium leprae | PROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL (THIAMINE-PHOSPHATE KINASE) | 0.0064 | 0.0041 | 0.0041 |
Schistosoma mansoni | heat shock protein | 0.0033 | 0.0002 | 0.0002 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7824 | 1 | 1 |
Loa Loa (eye worm) | FolC protein | 0.0216 | 0.0236 | 0.0317 |
Echinococcus granulosus | dihydrofolate reductase | 0.5216 | 0.6654 | 0.8988 |
Mycobacterium ulcerans | thymidylate synthase | 0.58 | 0.7403 | 1 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0216 | 0.0236 | 0.0317 |
Trichomonas vaginalis | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0216 | 0.0236 | 0.067 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0216 | 0.0236 | 0.0317 |
Brugia malayi | selenium donor protein | 0.0107 | 0.0096 | 0.0128 |
Toxoplasma gondii | formyl transferase domain-containing protein | 0.0052 | 0.0026 | 0.0026 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0033 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0316 | 0.0365 | 0.0479 |
Mycobacterium ulcerans | methionyl-tRNA formyltransferase | 0.0052 | 0.0026 | 0.0035 |
Echinococcus multilocularis | 0.0107 | 0.0096 | 0.0128 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0011 | 0.0012 |
Mycobacterium tuberculosis | Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transfo | 0.0246 | 0.0275 | 0.0357 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Leishmania major | selenophosphate synthetase, putative | 0.0107 | 0.0096 | 0.0096 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0215 | 0.0235 | 0.0315 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0012 |
Mycobacterium ulcerans | phosphoribosylformylglycinamidine synthase II | 0.0107 | 0.0096 | 0.013 |
Leishmania major | methionyl-tRNA formyltransferase, putative | 0.0052 | 0.0026 | 0.0026 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0011 | 0.0026 |
Plasmodium vivax | endoplasmin, putative | 0.0033 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0052 | 0.0026 | 0.002 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0011 | 0.0015 |
Schistosoma mansoni | endoplasmin | 0.0033 | 0.0002 | 0.0002 |
Plasmodium falciparum | dihydrofolate synthase/folylpolyglutamate synthase | 0.0216 | 0.0236 | 0.0236 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0011 | 0.0012 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.1433 | 0.1798 | 0.2429 |
Mycobacterium tuberculosis | Probable formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase) | 0.0052 | 0.0026 | 0.002 |
Brugia malayi | thymidylate synthase | 0.58 | 0.7403 | 1 |
Trypanosoma cruzi | selenophosphate synthetase, putative | 0.0107 | 0.0096 | 0.0095 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.58 | 0.7403 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.7824 | 1 | 1 |
Plasmodium vivax | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0216 | 0.0236 | 0.0236 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0216 | 0.0236 | 0.0305 |
Schistosoma mansoni | tyrosine kinase | 0.0215 | 0.0235 | 0.0317 |
Wolbachia endosymbiont of Brugia malayi | folate-dependent phosphoribosylglycinamide formyltransferase PurN | 0.0052 | 0.0026 | 0.0143 |
Echinococcus granulosus | folylpolyglutamate synthase, mitochondrial | 0.0216 | 0.0236 | 0.0317 |
Trypanosoma brucei | pteridine reductase 1 | 0.021 | 0.0228 | 0.0226 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA formyltransferase | 0.0052 | 0.0026 | 0.0143 |
Mycobacterium tuberculosis | Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) | 0.0107 | 0.0096 | 0.0116 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylformylglycinamidine synthase domain-containing protein | 0.0107 | 0.0096 | 0.0536 |
Mycobacterium tuberculosis | Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt | 0.0209 | 0.0227 | 0.0293 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.7824 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0011 | 0.0015 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Schistosoma mansoni | tyrosine kinase | 0.021 | 0.0228 | 0.0309 |
Trypanosoma cruzi | methionyl-tRNA formyltransferase, putative | 0.0052 | 0.0026 | 0.0024 |
Plasmodium vivax | methionyl-tRNA formyltransferase, putative | 0.0052 | 0.0026 | 0.0026 |
Trypanosoma cruzi | folylpolyglutamate synthase, putative | 0.0216 | 0.0236 | 0.0234 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.5216 | 0.6654 | 0.8988 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Schistosoma mansoni | endoplasmin | 0.0033 | 0.0002 | 0.0002 |
Mycobacterium leprae | Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transf | 0.0246 | 0.0275 | 0.0357 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0011 | 0.0009 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0011 | 0.0012 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0011 | 0.0009 |
Plasmodium falciparum | heat shock protein 90 | 0.0033 | 0.0002 | 0.0002 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.1433 | 0.1798 | 1 |
Trypanosoma cruzi | folylpolyglutamate synthetase | 0.0216 | 0.0236 | 0.0234 |
Toxoplasma gondii | selenide, water dikinase | 0.0107 | 0.0096 | 0.0096 |
Mycobacterium leprae | PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) | 0.0107 | 0.0096 | 0.0116 |
Echinococcus granulosus | folylpolyglutamate synthase mitochondrial | 0.0216 | 0.0236 | 0.0317 |
Brugia malayi | beta-lactamase | 0.004 | 0.0011 | 0.0012 |
Loa Loa (eye worm) | selenium donor protein | 0.0107 | 0.0096 | 0.0128 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0011 | 0.0012 |
Mycobacterium ulcerans | phosphoribosylaminoimidazole synthetase | 0.0316 | 0.0365 | 0.0493 |
Echinococcus multilocularis | dihydrofolate reductase | 0.5216 | 0.6654 | 0.8988 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.7824 | 1 | 1 |
Mycobacterium ulcerans | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | 0.0246 | 0.0275 | 0.0371 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.58 | 0.7403 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) | 0.0316 | 0.0365 | 0.0479 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0011 | 0.0012 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylaminoimidazole synthetase | 0.0316 | 0.0365 | 0.2029 |
Plasmodium vivax | heat shock protein 86, putative | 0.0033 | 0.0002 | 0.0002 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0033 | 0.0002 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Trypanosoma cruzi | methionyl-tRNA formyltransferase, putative | 0.0052 | 0.0026 | 0.0024 |
Mycobacterium ulcerans | phosphoribosylglycinamide formyltransferase | 0.0052 | 0.0026 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0012 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0216 | 0.0236 | 0.0305 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0216 | 0.0236 | 1 |
Echinococcus granulosus | geminin | 0.019 | 0.0203 | 0.0273 |
Onchocerca volvulus | 0.58 | 0.7403 | 1 | |
Trypanosoma cruzi | selenophosphate synthetase, putative | 0.0107 | 0.0096 | 0.0095 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0033 | 0.0002 | 0.0002 |
Echinococcus granulosus | thymidylate synthase | 0.58 | 0.7403 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2759 | 0.35 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.58 | 0.7403 | 1 |
Trypanosoma brucei | methionyl-tRNA formyltransferase | 0.0052 | 0.0026 | 0.0024 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0033 | 0.0002 | 0.5 |
Schistosoma mansoni | selinide water dikinase | 0.0107 | 0.0096 | 0.013 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.2759 | 0.35 | 0.3499 |
Brugia malayi | Dihydrofolate reductase | 0.5216 | 0.6654 | 0.8988 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0259 | 0.0291 | 0.0379 |
Schistosoma mansoni | dihydrofolate reductase | 0.5216 | 0.6654 | 0.8988 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0011 | 0.0015 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7824 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0011 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0012 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0011 | 0.0012 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0011 | 0.0015 |
Schistosoma mansoni | folylpolyglutamate synthase | 0.0216 | 0.0236 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0012 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.5216 | 0.6654 | 0.8986 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.1433 | 0.1798 | 0.2418 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0033 | 0.0002 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0011 | 0.0015 |
Wolbachia endosymbiont of Brugia malayi | AICAR transformylase/IMP cyclohydrolase PurH | 0.0246 | 0.0275 | 0.1528 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0011 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0012 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0216 | 0.0236 | 0.0319 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.0203 | 0.0275 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0215 | 0.0235 | 0.0315 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0011 | 0.0026 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0011 | 0.0026 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0011 | 0.0015 |
Schistosoma mansoni | heat shock protein | 0.0033 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0012 |
Onchocerca volvulus | 0.0316 | 0.0365 | 0.0479 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0011 | 0.0012 |
Brugia malayi | hypothetical protein | 0.2759 | 0.35 | 0.4727 |
Plasmodium falciparum | methionyl-tRNA formyltransferase, putative | 0.0052 | 0.0026 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.0203 | 0.0275 |
Plasmodium falciparum | selenide water dikinase, putative | 0.0107 | 0.0096 | 0.0096 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Apoptosis index (functional) | = 1.09 | Apoptosis index was determined against human glioblastoma LNZ308 cells at 25 microM after total exposure time of 24 hours | ChEMBL. | 12904064 |
Apoptosis index (functional) | = 1.1 | Apoptosis index was determined against human glioblastoma LN18 cells at 25 microM after total exposure time of 24 hours | ChEMBL. | 12904064 |
IC50 (functional) | = 3.3 uM | Cytotoxicity measured for the growth inhibition of A-431 Human epidermoid carcinoma cell line | ChEMBL. | 10743943 |
IC50 (functional) | = 4.2 uM | Cytotoxicity of compound was measured for the growth inhibition of HT-29 human colon carcinoma cell line | ChEMBL. | 10743943 |
IC50 (functional) | = 8.5 uM | Glycomer activity determined as growth inhibition of human glioblastoma LNZ308 cells | ChEMBL. | 12904064 |
IC50 (functional) | = 12.5 uM | Glycomer activity determined as growth inhibition of human glioblastoma LN18 cells | ChEMBL. | 12904064 |
IC50 (functional) | = 18 uM | Glycomer activity determined as growth inhibition of human glioblastoma LNZ308 cells | ChEMBL. | 12904064 |
IC50 (functional) | = 18.5 uM | Glycomer activity determined as growth inhibition of human glioblastoma LN18 cells | ChEMBL. | 12904064 |
Inhibition (binding) | = 30 % | Compound was evaluated for the inhibitory activity against Growth factor receptor bound protein 2 SH2 at a concentration of 100 microM | ChEMBL. | 10743943 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.