Detailed information for compound 2107175

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 560.492 | Formula: C27H27Cl2N3O4S
  • H donors: 2 H acceptors: 4 LogP: 4.27 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@@]1(CSC2=C1C(=O)c1c(C2=O)cccc1)C(=O)NCc1ccc(cc1)Cl)CN1CCCCC1.Cl
  • InChi: 1S/C27H26ClN3O4S.ClH/c28-18-10-8-17(9-11-18)14-29-26(35)27(30-21(32)15-31-12-4-1-5-13-31)16-36-25-22(27)23(33)19-6-2-3-7-20(19)24(25)34;/h2-3,6-11H,1,4-5,12-16H2,(H,29,35)(H,30,32);1H/t27-;/m1./s1
  • InChiKey: JEUNFIVMHNCMAB-HZPIKELBSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Onchocerca volvulus 0.007 1 1
Toxoplasma gondii carbonyl reductase 1, putative 0.007 1 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.007 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium ulcerans ketoacyl reductase 0.007 1 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Loa Loa (eye worm) dehydrogenase 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Mycobacterium ulcerans dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.007 1 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.007 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Echinococcus multilocularis retinol dehydrogenase 13 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Plasmodium falciparum steroid dehydrogenase, putative 0.007 1 0.5
Leishmania major dehydrogenase-like protein 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.007 1 1
Giardia lamblia Reductase, putative 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Echinococcus granulosus retinol dehydrogenase 11 0.007 1 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 1 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.007 1 0.5
Leishmania major pteridine reductase 1 0.007 1 1
Brugia malayi oxidoreductase 0.007 1 1
Brugia malayi Retinol dehydrogenase 12 0.007 1 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.845 0.845
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Leishmania major oxidoreductase-like protein 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Echinococcus multilocularis calpain family protein 1, d 0.0046 0.487 0.487
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.007 1 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.9064 0.9064
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.007 1 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.007 1 1
Brugia malayi dehydrogenases, short chain protein 9 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.007 1 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.007 1 1
Leishmania major hypothetical protein, conserved 0.007 1 1
Loa Loa (eye worm) calpain family protein 1 0.0063 0.845 0.845
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni carbonyl reductase 0.007 1 1
Onchocerca volvulus 0.007 1 1
Brugia malayi hypothetical protein 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.007 1 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.007 1 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.007 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.007 1 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Echinococcus granulosus retinol dehydrogenase 11 0.007 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.007 1 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.007 1 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.007 1 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.007 1 1
Echinococcus granulosus steroid dehydrogenase 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 1 0.5
Echinococcus granulosus oxidoreductase 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Echinococcus multilocularis steroid dehydrogenase 0.007 1 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.007 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.845 0.845
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.3332 0.3332
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Entamoeba histolytica hypothetical protein, conserved 0.007 1 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.007 1 0.5
Echinococcus multilocularis steroid dehydrogenase 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Onchocerca volvulus Sepiapterin reductase homolog 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Mycobacterium ulcerans ketoacyl reductase 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.007 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Leishmania major hypothetical protein, conserved 0.007 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Onchocerca volvulus 0.007 1 1
Echinococcus granulosus hypothetical protein 0.007 1 1
Trypanosoma brucei oxidoreductase-like protein 0.007 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.007 1 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.007 1 0.5
Echinococcus multilocularis calpain A 0.0066 0.9064 0.9064
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.007 1 1
Onchocerca volvulus 0.007 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.007 1 1
Echinococcus multilocularis retinol dehydrogenase 11 0.007 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.007 1 1
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.007 1 1
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.007 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium leprae Probable oxidoreductase 0.007 1 0.5
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.9064 0.9064
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.007 1 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Entamoeba histolytica hypothetical protein 0.007 1 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.007 1 0.5
Echinococcus granulosus calpain A 0.0066 0.9064 0.9064
Mycobacterium tuberculosis Possible oxidoreductase 0.007 1 0.5
Brugia malayi calpain family protein 1 0.0063 0.845 0.845
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Echinococcus multilocularis oxidoreductase 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Entamoeba histolytica hypothetical protein, conserved 0.007 1 0.5
Toxoplasma gondii oxidoreductase, putative 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni retinal dehydrogenase 0.007 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Giardia lamblia Hypothetical protein 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Toxoplasma gondii oxidoreductase, putative 0.007 1 0.5
Mycobacterium tuberculosis Possible ketoacyl reductase 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.007 1 1
Leishmania major short chain dehydrogenase, putative 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.007 1 1
Trichomonas vaginalis steroid dehydrogenase, putative 0.007 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.007 1 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.007 1 1
Schistosoma mansoni carbonyl reductase 0.007 1 1
Onchocerca volvulus 0.007 1 1
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.007 1 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.007 1 1
Mycobacterium ulcerans oxidoreductase 0.007 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.007 1 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.007 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 1 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.007 1 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.007 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.007 1 1
Onchocerca volvulus 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.007 1 0.5
Brugia malayi calpain family protein 1 0.0063 0.845 0.845
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium ulcerans oxidoreductase 0.007 1 0.5
Schistosoma mansoni carbonyl reductase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.007 1 1
Leishmania major hypothetical protein, conserved 0.007 1 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.007 1 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Onchocerca volvulus 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.007 1 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.9064 0.9064
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Brugia malayi Dehydrogenases, short chain protein 2 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.6911 0.6911
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Loa Loa (eye worm) calpain family protein 1 0.0046 0.487 0.487
Leishmania major hypothetical protein, conserved 0.007 1 1
Mycobacterium ulcerans ketoacyl reductase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.007 1 1
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.007 1 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.007 1 0.5
Leishmania major hypothetical protein, conserved 0.007 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.007 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.007 1 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.007 1 1
Brugia malayi hypothetical protein 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.487 0.487
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.007 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.007 1 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Leishmania major short chain dehydrogenase, putative 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Mycobacterium ulcerans dehydrogenase/reductase 0.007 1 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.007 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.007 1 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Echinococcus granulosus hypothetical protein 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.007 1 1
Leishmania major short chain dehydrogenase-like protein 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 1 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Loa Loa (eye worm) dehydrogenase 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Plasmodium vivax steroid dehydrogenase, putative 0.007 1 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.9064 0.9064
Plasmodium vivax hypothetical protein, conserved 0.007 1 1
Echinococcus multilocularis conserved hypothetical protein 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.007 1 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Leishmania major 3-keto-dihydrosphingosine reductase 0.007 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.007 1 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.007 1 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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