Detailed information for compound 2107176

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 560.492 | Formula: C27H27Cl2N3O4S
  • H donors: 2 H acceptors: 4 LogP: 4.27 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@]1(CSC2=C1C(=O)c1c(C2=O)cccc1)C(=O)NCc1ccc(cc1)Cl)CN1CCCCC1.Cl
  • InChi: 1S/C27H26ClN3O4S.ClH/c28-18-10-8-17(9-11-18)14-29-26(35)27(30-21(32)15-31-12-4-1-5-13-31)16-36-25-22(27)23(33)19-6-2-3-7-20(19)24(25)34;/h2-3,6-11H,1,4-5,12-16H2,(H,29,35)(H,30,32);1H/t27-;/m0./s1
  • InChiKey: JEUNFIVMHNCMAB-YCBFMBTMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Leishmania major 3-keto-dihydrosphingosine reductase 0.007 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.007 1 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.007 1 1
Onchocerca volvulus 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Echinococcus granulosus retinol dehydrogenase 11 0.007 1 1
Mycobacterium ulcerans ketoacyl reductase 0.007 1 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.007 1 1
Entamoeba histolytica hypothetical protein 0.007 1 0.5
Leishmania major hypothetical protein, conserved 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.007 1 1
Leishmania major pteridine reductase 1 0.007 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.007 1 1
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Echinococcus multilocularis conserved hypothetical protein 0.007 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.007 1 1
Schistosoma mansoni carbonyl reductase 0.007 1 1
Schistosoma mansoni carbonyl reductase 0.007 1 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.9064 0.9064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.007 1 1
Plasmodium falciparum steroid dehydrogenase, putative 0.007 1 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.007 1 1
Onchocerca volvulus 0.007 1 1
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.007 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.007 1 1
Brugia malayi hypothetical protein 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.487 0.487
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.007 1 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.007 1 1
Mycobacterium ulcerans dehydrogenase/reductase 0.007 1 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Echinococcus granulosus calpain A 0.0066 0.9064 0.9064
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Leishmania major short chain dehydrogenase, putative 0.007 1 1
Onchocerca volvulus 0.007 1 1
Trypanosoma brucei oxidoreductase-like protein 0.007 1 1
Brugia malayi dehydrogenases, short chain protein 9 0.007 1 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.007 1 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Echinococcus multilocularis calpain family protein 1, d 0.0046 0.487 0.487
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.007 1 1
Brugia malayi Dehydrogenases, short chain protein 30 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Loa Loa (eye worm) dehydrogenase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.007 1 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.007 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.6911 0.6911
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans oxidoreductase 0.007 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Onchocerca volvulus Sepiapterin reductase homolog 0.007 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.007 1 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Echinococcus multilocularis retinol dehydrogenase 11 0.007 1 1
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.007 1 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.007 1 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.007 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Entamoeba histolytica hypothetical protein, conserved 0.007 1 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.845 0.845
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.007 1 0.5
Brugia malayi hypothetical protein 0.007 1 1
Entamoeba histolytica hypothetical protein, conserved 0.007 1 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.007 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.007 1 0.5
Leishmania major dehydrogenase-like protein 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.007 1 0.5
Leishmania major oxidoreductase-like protein 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.007 1 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Schistosoma mansoni short-chain dehydrogenase/reductase 0.007 1 1
Echinococcus granulosus hypothetical protein 0.007 1 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Brugia malayi calpain family protein 1 0.0063 0.845 0.845
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Schistosoma mansoni carbonyl reductase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.007 1 1
Schistosoma mansoni retinal dehydrogenase 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.007 1 0.5
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.9064 0.9064
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium ulcerans ketoacyl reductase 0.007 1 0.5
Plasmodium vivax hypothetical protein, conserved 0.007 1 1
Toxoplasma gondii oxidoreductase, putative 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.007 1 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Brugia malayi Dehydrogenases, short chain protein 2 0.007 1 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Mycobacterium tuberculosis Possible ketoacyl reductase 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Leishmania major hypothetical protein, conserved 0.007 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.007 1 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.007 1 1
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.007 1 0.5
Brugia malayi calpain family protein 1 0.0063 0.845 0.845
Leishmania major hypothetical protein, conserved 0.007 1 1
Echinococcus multilocularis calpain A 0.0066 0.9064 0.9064
Brugia malayi Retinol dehydrogenase 12 0.007 1 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.007 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.007 1 1
Echinococcus granulosus oxidoreductase 0.007 1 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.007 1 1
Mycobacterium ulcerans oxidoreductase 0.007 1 0.5
Mycobacterium leprae Probable oxidoreductase 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Echinococcus granulosus retinol dehydrogenase 11 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.845 0.845
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Onchocerca volvulus 0.007 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.007 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Giardia lamblia Hypothetical protein 0.007 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.007 1 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.007 1 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Echinococcus multilocularis steroid dehydrogenase 0.007 1 1
Onchocerca volvulus 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Leishmania major short chain dehydrogenase-like protein 0.007 1 1
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.007 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.007 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.007 1 0.5
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.007 1 1
Echinococcus multilocularis oxidoreductase 0.007 1 1
Leishmania major hypothetical protein, conserved 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Echinococcus multilocularis steroid dehydrogenase 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.007 1 1
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Toxoplasma gondii oxidoreductase, putative 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.3332 0.3332
Mycobacterium tuberculosis Possible oxidoreductase 0.007 1 0.5
Giardia lamblia Reductase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 1 1
Brugia malayi oxidoreductase 0.007 1 1
Onchocerca volvulus 0.007 1 1
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Trichomonas vaginalis steroid dehydrogenase, putative 0.007 1 0.5
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.9064 0.9064
Mycobacterium ulcerans short-chain type oxidoreductase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Mycobacterium ulcerans dehydrogenase 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.9064 0.9064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Leishmania major short chain dehydrogenase, putative 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.007 1 0.5
Mycobacterium ulcerans ketoacyl reductase 0.007 1 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Brugia malayi dehydrogenases, short chain protein 2 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.007 1 1
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.007 1 0.5
Loa Loa (eye worm) calpain family protein 1 0.0046 0.487 0.487
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Echinococcus granulosus hypothetical protein 0.007 1 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.007 1 1
Leishmania major hypothetical protein, conserved 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Loa Loa (eye worm) dehydrogenase 0.007 1 1
Onchocerca volvulus 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Onchocerca volvulus 0.007 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.007 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 1 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.007 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 1 1
Onchocerca volvulus 0.007 1 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.007 1 0.5
Loa Loa (eye worm) calpain family protein 1 0.0063 0.845 0.845
Onchocerca volvulus 0.007 1 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Echinococcus granulosus steroid dehydrogenase 0.007 1 1
Echinococcus multilocularis retinol dehydrogenase 11 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.007 1 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.007 1 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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