Detailed information for compound 2107176

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 560.492 | Formula: C27H27Cl2N3O4S
  • H donors: 2 H acceptors: 4 LogP: 4.27 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@]1(CSC2=C1C(=O)c1c(C2=O)cccc1)C(=O)NCc1ccc(cc1)Cl)CN1CCCCC1.Cl
  • InChi: 1S/C27H26ClN3O4S.ClH/c28-18-10-8-17(9-11-18)14-29-26(35)27(30-21(32)15-31-12-4-1-5-13-31)16-36-25-22(27)23(33)19-6-2-3-7-20(19)24(25)34;/h2-3,6-11H,1,4-5,12-16H2,(H,29,35)(H,30,32);1H/t27-;/m0./s1
  • InChiKey: JEUNFIVMHNCMAB-YCBFMBTMSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.007 1 0.5
Leishmania major pteridine reductase 1 0.007 1 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.007 1 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 1 1
Echinococcus granulosus retinol dehydrogenase 11 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.845 0.845
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.007 1 0.5
Brugia malayi Retinol dehydrogenase 12 0.007 1 1
Brugia malayi oxidoreductase 0.007 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.007 1 1
Echinococcus multilocularis calpain family protein 1, d 0.0046 0.487 0.487
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Leishmania major oxidoreductase-like protein 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.007 1 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.007 1 1
Brugia malayi dehydrogenases, short chain protein 9 0.007 1 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.007 1 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.9064 0.9064
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Brugia malayi hypothetical protein 0.007 1 1
Onchocerca volvulus 0.007 1 1
Schistosoma mansoni carbonyl reductase 0.007 1 1
Loa Loa (eye worm) calpain family protein 1 0.0063 0.845 0.845
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.007 1 0.5
Leishmania major hypothetical protein, conserved 0.007 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.007 1 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.007 1 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.007 1 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Toxoplasma gondii carbonyl reductase 1, putative 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.007 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Loa Loa (eye worm) dehydrogenase 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Mycobacterium ulcerans ketoacyl reductase 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Echinococcus multilocularis retinol dehydrogenase 13 0.007 1 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.007 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans dehydrogenase 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Leishmania major dehydrogenase-like protein 0.007 1 1
Plasmodium falciparum steroid dehydrogenase, putative 0.007 1 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Giardia lamblia Reductase, putative 0.007 1 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Echinococcus granulosus oxidoreductase 0.007 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.845 0.845
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Echinococcus multilocularis steroid dehydrogenase 0.007 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 1 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.007 1 1
Mycobacterium ulcerans ketoacyl reductase 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Onchocerca volvulus Sepiapterin reductase homolog 0.007 1 1
Echinococcus multilocularis steroid dehydrogenase 0.007 1 1
Entamoeba histolytica hypothetical protein, conserved 0.007 1 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.007 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.3332 0.3332
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Leishmania major hypothetical protein, conserved 0.007 1 1
Mycobacterium ulcerans short-chain type oxidoreductase 0.007 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.007 1 1
Trypanosoma brucei oxidoreductase-like protein 0.007 1 1
Echinococcus granulosus hypothetical protein 0.007 1 1
Onchocerca volvulus 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.007 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Echinococcus multilocularis calpain A 0.0066 0.9064 0.9064
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.007 1 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.007 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.007 1 1
Onchocerca volvulus 0.007 1 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.007 1 1
Mycobacterium leprae Probable oxidoreductase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.007 1 1
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.007 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.007 1 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.007 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.007 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.007 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.007 1 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.007 1 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.007 1 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.007 1 1
Echinococcus granulosus steroid dehydrogenase 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Schistosoma mansoni carbonyl reductase 0.007 1 1
Echinococcus multilocularis retinol dehydrogenase 11 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 1 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.007 1 1
Schistosoma mansoni short-chain dehydrogenase/reductase 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium ulcerans oxidoreductase 0.007 1 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.007 1 1
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.007 1 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.007 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.007 1 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Brugia malayi calpain family protein 1 0.0063 0.845 0.845
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Leishmania major hypothetical protein, conserved 0.007 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Schistosoma mansoni carbonyl reductase 0.007 1 1
Mycobacterium ulcerans oxidoreductase 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.007 1 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.007 1 0.5
Entamoeba histolytica hypothetical protein 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.007 1 1
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.007 1 0.5
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.9064 0.9064
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Echinococcus multilocularis oxidoreductase 0.007 1 1
Brugia malayi calpain family protein 1 0.0063 0.845 0.845
Echinococcus granulosus calpain A 0.0066 0.9064 0.9064
Mycobacterium tuberculosis Possible oxidoreductase 0.007 1 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.007 1 0.5
Entamoeba histolytica hypothetical protein, conserved 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Toxoplasma gondii oxidoreductase, putative 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.007 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Giardia lamblia Hypothetical protein 0.007 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Schistosoma mansoni retinal dehydrogenase 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Mycobacterium tuberculosis Possible ketoacyl reductase 0.007 1 0.5
Toxoplasma gondii oxidoreductase, putative 0.007 1 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.007 1 1
Trichomonas vaginalis steroid dehydrogenase, putative 0.007 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.007 1 1
Leishmania major short chain dehydrogenase, putative 0.007 1 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.007 1 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.007 1 1
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.007 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.487 0.487
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.007 1 1
Brugia malayi hypothetical protein 0.007 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 1 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.007 1 1
Mycobacterium ulcerans dehydrogenase/reductase 0.007 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Leishmania major short chain dehydrogenase, putative 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Leishmania major quinonoid dihydropteridine reductase 0.007 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.007 1 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.007 1 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.007 1 0.5
Leishmania major short chain dehydrogenase-like protein 0.007 1 1
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Echinococcus granulosus hypothetical protein 0.007 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Plasmodium vivax steroid dehydrogenase, putative 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Loa Loa (eye worm) dehydrogenase 0.007 1 1
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Echinococcus multilocularis conserved hypothetical protein 0.007 1 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.9064 0.9064
Plasmodium vivax hypothetical protein, conserved 0.007 1 1
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.007 1 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.007 1 1
Giardia lamblia Short-chain dehydrogenase, putative 0.007 1 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Leishmania major 3-keto-dihydrosphingosine reductase 0.007 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 1 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.007 1 1
Onchocerca volvulus 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.007 1 1
Echinococcus granulosus WW domain containing oxidoreductase 0.007 1 1
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Schistosoma mansoni steroid dehydrogenase 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.9064 0.9064
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.007 1 1
Brugia malayi Dehydrogenases, short chain protein 2 0.007 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 1 1
Echinococcus multilocularis carbonyl reductase 1 0.007 1 1
Loa Loa (eye worm) calpain family protein 1 0.0046 0.487 0.487
Loa Loa (eye worm) hypothetical protein 0.0056 0.6911 0.6911
Onchocerca volvulus 0.007 1 1
Loa Loa (eye worm) oxidoreductase 0.007 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 1 0.5
Onchocerca volvulus 0.007 1 1
Mycobacterium ulcerans ketoacyl reductase 0.007 1 0.5
Leishmania major hypothetical protein, conserved 0.007 1 1
Leishmania major hypothetical protein, conserved 0.007 1 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.007 1 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.007 1 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.007 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.007 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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