Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Anopheles gambiae | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 737 aa | 651 aa | 34.6 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 737 aa | 636 aa | 24.2 % |
Schistosoma mansoni | gliotactin | Acetylcholinesterase | 737 aa | 616 aa | 27.3 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 737 aa | 650 aa | 34.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0205 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0205 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 77.5 nM | Inhibition of recombinant human AChE after 10 mins by Ellman assay | ChEMBL. | 26386602 |
IC50 (binding) | = 121 nM | Inhibition of recombinant human AChE after 60 mins by Ellman assay | ChEMBL. | 26386602 |
IC50 (binding) | = 142 nM | Inhibition of recombinant Anopheles gambiae wild type AChE after 10 mins by Ellman assay | ChEMBL. | 26386602 |
IC50 (binding) | = 285 nM | Inhibition of recombinant Anopheles gambiae wild type AChE after 60 mins by Ellman assay | ChEMBL. | 26386602 |
Inhibition (binding) | Inhibition of recombinant human AChE by Ellman assay | ChEMBL. | 26386602 | |
Inhibition (binding) | Inhibition of recombinant Anopheles gambiae wild type AChE by Ellman assay | ChEMBL. | 26386602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.