Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Anopheles gambiae | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | gliotactin | Acetylcholinesterase | 737 aa | 616 aa | 27.3 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 737 aa | 650 aa | 34.5 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 737 aa | 636 aa | 24.2 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 737 aa | 651 aa | 34.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0205 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0205 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0205 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0205 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 591 nM | Inhibition of recombinant human AChE after 10 mins by Ellman assay | ChEMBL. | 26386602 |
IC50 (binding) | = 678 nM | Inhibition of recombinant human AChE after 60 mins by Ellman assay | ChEMBL. | 26386602 |
IC50 (binding) | = 950 nM | Inhibition of recombinant Anopheles gambiae wild type AChE after 10 mins by Ellman assay | ChEMBL. | 26386602 |
IC50 (binding) | = 1040 nM | Inhibition of recombinant Anopheles gambiae wild type AChE after 60 mins by Ellman assay | ChEMBL. | 26386602 |
Inhibition (binding) | Inhibition of recombinant Anopheles gambiae wild type AChE by Ellman assay | ChEMBL. | 26386602 | |
Inhibition (binding) | Inhibition of recombinant human AChE by Ellman assay | ChEMBL. | 26386602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.