Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | FK506 binding protein 5 | Starlite/ChEMBL | References |
Homo sapiens | FK506 binding protein 1A, 12kDa | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | FK506 binding protein 1A, 12kDa | 108 aa | 107 aa | 48.6 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1 uM | Binding affinity to FKBP12 (unknown origin) by competitive fluorescence polarization assay | ChEMBL. | 26419422 |
Ki (binding) | = 3.4 uM | Binding affinity to FKBP51 (unknown origin) by competitive fluorescence polarization assay | ChEMBL. | 26419422 |
Ki (binding) | > 500 uM | Binding affinity to FKBP52 (unknown origin) by competitive fluorescence polarization assay | ChEMBL. | 26419422 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.