TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 281.352 | Formula: C17H19N3O
H donors: 0 H acceptors: 2 LogP: 1.92 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)C(=O)/C=C/c1ccc2c(n1)cccc2
InChi: 1S/C17H19N3O/c1-19-10-12-20(13-11-19)17(21)9-8-15-7-6-14-4-2-3-5-16(14)18-15/h2-9H,10-13H2,1H3/b9-8+
InChiKey: DRVFIGNLVZILDH-CMDGGOBGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0046	0.0088	0.0131
Schistosoma mansoni	protein kinase	0.0063	0.0159	0.0142
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0042	0.0339
Leishmania major	glucose transporter, lmgt3	0.0064	0.0162	0.027
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.0827	0.0812
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0042	0.0025
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0196	0.0333
Schistosoma mansoni	alpha-glucosidase	0.0136	0.0464	0.0448
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0062	0.0154	0.0154
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0162	0.027
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0042	0.0025
Brugia malayi	mbt repeat family protein	0.0048	0.0095	0.0095
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0042	0.0348
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0104	0.0088
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0162	0.027
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0158	0.0556	0.0556
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0162	0.027
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0042	0.0025
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0206	0.0755	0.0739
Leishmania major	protein kinase, putative	0.0063	0.0159	0.0264
Brugia malayi	beta-NAC-like protein	0.0035	0.0043	0.0043
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0042	0.0025
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0046	0.0088	0.0071
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.1323	0.5412	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0105	0.0332	0.0585
Brugia malayi	mbt repeat family protein	0.0048	0.0095	0.0095
Loa Loa (eye worm)	dihydrofolate reductase	0.2423	1	1
Trichomonas vaginalis	esterase, putative	0.0035	0.0042	0.0339
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0062	0.0154	0.0112
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0042	0.0048
Mycobacterium tuberculosis	Hypothetical protein	0.0105	0.0332	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0095	0.0079
Brugia malayi	hypothetical protein	0.0105	0.0332	0.0332
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0123	0.0106
Mycobacterium ulcerans	thymidylate synthase	0.022	0.0813	0.0797
Echinococcus granulosus	geminin	0.0506	0.2005	0.1991
Brugia malayi	major facilitator superfamily protein	0.0029	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0162	0.1973
Echinococcus granulosus	calcium dependent protein kinase	0.0059	0.0143	0.0126
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0042	0.0339
Entamoeba histolytica	hypothetical protein	0.0046	0.0088	0.3885
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0188	0.0681	0.0666
Brugia malayi	beta-lactamase family protein	0.0035	0.0042	0.0042
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0035	0.0042	0.0348
Toxoplasma gondii	facilitative glucose transporter GT1	0.0206	0.0755	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0074	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0043	0.0361
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0072	0.0196	0.0333
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0123	0.0123
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0042	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0104	0.0088
Plasmodium falciparum	hexose transporter	0.0206	0.0755	0.1368
Mycobacterium ulcerans	lipase LipD	0.0035	0.0042	0.0025
Toxoplasma gondii	NAC domain-containing protein	0.0035	0.0043	0.0049
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0042	0.0025
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0874	0.3541	0.6533
Loa Loa (eye worm)	thymidylate synthase	0.022	0.0813	0.0811
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.022	0.0813	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0042	0.004
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0047	0.0093	0.0076
Echinococcus granulosus	dihydrofolate reductase	0.2423	1	1
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0162	0.027
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0039	0.0059	0.0042
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0158	0.0556	0.0554
Trypanosoma cruzi	hexose transporter	0.0064	0.0162	0.027
Brugia malayi	Dihydrofolate reductase	0.2423	1	1
Onchocerca volvulus		0.0035	0.0042	0.0315
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0047	0.0093	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0063	0.0159	0.0264
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0042	0.0025
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0042	0.0025
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0042	0.0348
Onchocerca volvulus		0.0035	0.0042	0.0315
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0046	0.0029
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0062	0.0154	0.9543
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Brugia malayi	Cam kinase protein 1	0.0063	0.0159	0.0159
Leishmania major	glucose transporter, lmgt2	0.0064	0.0162	0.027
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0041	0.0046
Loa Loa (eye worm)	sugar transporter	0.0206	0.0755	0.0753
Schistosoma mansoni	glucose transport protein	0.0206	0.0755	0.0739
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0159	0.0142
Schistosoma mansoni	transcription factor btf3	0.0035	0.0043	0.0027
Brugia malayi	Isocitrate dehydrogenase	0.0047	0.0093	0.0093
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0039	0.0059	0.0017
Brugia malayi	Sugar transporter family protein	0.0029	0.0017	0.0017
Toxoplasma gondii	ABC1 family protein	0.0035	0.0042	0.0046
Schistosoma mansoni	lysyl-tRNA synthetase	0.0046	0.0088	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0042	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.1323	0.5412	1
Schistosoma mansoni	glucose transport protein	0.0206	0.0755	0.0739
Leishmania major	lysyl-tRNA synthetase, putative	0.0046	0.0088	0.0131
Trichomonas vaginalis	CAMK family protein kinase	0.0063	0.0159	0.1927
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0159	0.0142
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0017	0.0015
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0042	0.0025
Onchocerca volvulus		0.022	0.0813	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0042	0.0042
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0158	0.0556	0.054
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0063	0.0159	0.0264
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0072	0.0196	0.0333
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0123	0.0106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0104	0.0088
Brugia malayi	beta-lactamase	0.0035	0.0042	0.0042
Leishmania major	alpha glucosidase II subunit, putative	0.0035	0.0042	0.0048
Toxoplasma gondii	lysine-tRNA ligase	0.0046	0.0088	0.0131
Onchocerca volvulus		0.0092	0.0278	0.3277
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0104	0.0103
Toxoplasma gondii	protein kinase, putative	0.0582	0.2322	0.4274
Brugia malayi	hypothetical protein	0.0029	0.0017	0.0017
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0159	0.0142
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0042	0.0339
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0095	0.0079
Brugia malayi	Bromodomain containing protein	0.0075	0.0209	0.0209
Plasmodium falciparum	basic transcription factor 3b, putative	0.0035	0.0043	0.0049
Brugia malayi	major facilitator superfamily protein	0.0029	0.0017	0.0017
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0196	0.0333
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.022	0.0813	0.0797
Brugia malayi	Sugar transporter family protein	0.0029	0.0017	0.0017
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0162	0.027
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0408	0.0406
Brugia malayi	hypothetical protein	0.0123	0.0408	0.0408
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0206	0.0755	0.0739
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0042	0.0046
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0042	0.0025
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0042	0.0025
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0042	0.0025
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0123	0.0106
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0188	0.0681	0.0666
Echinococcus multilocularis	isocitrate dehydrogenase	0.0047	0.0093	0.0076
Echinococcus granulosus	lysyl tRNA synthetase	0.0046	0.0088	0.0071
Brugia malayi	hypothetical protein	0.0029	0.0017	0.0017
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0043	0.0049
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0047	0.0093	0.0141
Entamoeba histolytica	transcription factor BTF3, putative	0.0035	0.0043	0.0087
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0162	0.027
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.0755	0.0739
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0062	0.0154	0.0137
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0095	0.0079
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0035	0.0042	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Brugia malayi	thymidylate synthase	0.022	0.0813	0.0813
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0042	0.0025
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0158	0.0556	0.054
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0095	0.0987
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0196	0.0333
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0063	0.0159	0.0264
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0042	0.004
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0042	0.004
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0162	0.1973
Schistosoma mansoni	hypothetical protein	0.0506	0.2005	0.1991
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0066	0.0064
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.0145	0.0129
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0104	0.0088
Entamoeba histolytica	protein kinase, putative	0.0063	0.0159	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0046	0.0088	0.5182
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0042	0.0042
Onchocerca volvulus		0.0035	0.0042	0.0315
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0042	0.0025
Echinococcus multilocularis	dihydrofolate reductase	0.2423	1	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0063	0.0159	0.0264
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0017	0.0017
Plasmodium vivax	basic transcription factor 3b, putative	0.0035	0.0043	0.0049
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0046	0.0088	0.0131
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0042	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Schistosoma mansoni	glucose transport protein	0.0206	0.0755	0.0739
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0042	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0043	0.0361
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.0755	0.0739
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0062	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0191	0.019
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0095	0.0094
Schistosoma mansoni	lysyl-tRNA synthetase	0.0046	0.0088	0.0071
Brugia malayi	Bromodomain containing protein	0.0038	0.0056	0.0056
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0063	0.0159	0.0264
Entamoeba histolytica	hypothetical protein	0.0035	0.0043	0.0087
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0042	0.004
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0063	0.0159	0.0142
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0095	0.0094
Toxoplasma gondii	isocitrate dehydrogenase	0.0047	0.0093	0.0141
Echinococcus multilocularis	geminin	0.0506	0.2005	0.1991
Brugia malayi	hypothetical protein	0.0029	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0206	0.0755	0.0739
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.0755	0.0739
Schistosoma mansoni	protein kinase	0.0063	0.0159	0.0142
Plasmodium vivax	proline--tRNA ligase, putative	0.0072	0.0196	0.0333
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0043	0.0049
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0159	0.0142
Trichomonas vaginalis	glucose transporter, putative	0.0064	0.0162	0.1973
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0333	0.1284	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0042	0.004
Plasmodium vivax	hexose transporter	0.0206	0.0755	0.1368
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0042	0.0348
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0042	0.0348
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0017	0.0015
Toxoplasma gondii	isocitrate dehydrogenase	0.0047	0.0093	0.0141
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0063	0.0159	0.0159
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0042	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0042	0.0026
Leishmania major	hypothetical protein, conserved	0.0035	0.0042	0.0046
Schistosoma mansoni	dihydrofolate reductase	0.2423	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0332	0.4273
Giardia lamblia	Prolyl-tRNA synthetase	0.0062	0.0154	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0104	0.0104
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0095	0.0079
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0046	0.0088	0.0046
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0062	0.0154	0.0137
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0042	0.0025
Echinococcus multilocularis	thymidylate synthase	0.022	0.0813	0.0797
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0042	0.0046
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0159	0.0142
Schistosoma mansoni	protein kinase	0.0063	0.0159	0.0142
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.022	0.0813	0.0797
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.1323	0.5412	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0063	0.0159	0.0264
Onchocerca volvulus		0.0048	0.0095	0.0987
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0063	0.0159	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0042	0.0348
Schistosoma mansoni	alpha-glucosidase	0.0136	0.0464	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0206	0.0755	0.0739
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0047	0.0093	0.0141
Onchocerca volvulus	Huntingtin homolog	0.0123	0.0408	0.4915
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.0145	0.0129
Schistosoma mansoni	alpha glucosidase	0.0035	0.0042	0.0026
Plasmodium falciparum	protein kinase 7	0.0582	0.2322	0.4274
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0162	0.1973
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0063	0.0159	0.0264
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0072	0.0196	0.0333
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0095	0.0079
Entamoeba histolytica	protein kinase, putative	0.0063	0.0159	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0059	0.0143	0.0126
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0063	0.0159	0.0264
Loa Loa (eye worm)	ICD-1 protein	0.0035	0.0043	0.0042
Onchocerca volvulus	Huntingtin homolog	0.0123	0.0408	0.4915
Loa Loa (eye worm)	MBCTL1	0.0054	0.0123	0.0121
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0159	0.0142
Schistosoma mansoni	hypothetical protein	0.0291	0.1108	0.1093
Schistosoma mansoni	hypothetical protein	0.0206	0.0755	0.0739
Schistosoma mansoni	bromodomain containing protein	0.0063	0.016	0.0144
Brugia malayi	Sugar transporter family protein	0.0206	0.0755	0.0755
Echinococcus multilocularis	transcription factor btf3	0.0035	0.0043	0.0027
Trypanosoma brucei	transcription factor BTF3, putative	0.0035	0.0043	0.0049
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0333	0.1284	0.2348
Loa Loa (eye worm)	sugar transporter	0.0029	0.0017	0.0015
Echinococcus multilocularis	lysyl tRNA synthetase	0.0046	0.0088	0.0071
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0046	0.0088	0.0071
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0162	0.027
Leishmania major	glucose transporter, lmgt1	0.0064	0.0162	0.027
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0159	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0042	0.004
Trypanosoma brucei	glucose transporter 2A	0.0064	0.0162	0.027
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0104	0.0088
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0046	0.0029
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0123	0.0106
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.0755	0.0739
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0162	0.027
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0088	0.0086
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0047	0.0093	0.0076
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.2423	1	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0105	0.0104
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0162	0.027
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0123	0.0121
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0047	0.0093	0.0076
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0042	0.0048
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0042	0.0042
Plasmodium vivax	lysine--tRNA ligase, putative	0.0046	0.0088	0.0131
Plasmodium falciparum	lysine--tRNA ligase	0.0046	0.0088	0.0131
Plasmodium falciparum	proline--tRNA ligase	0.0072	0.0196	0.0333
Echinococcus granulosus	transcription factor btf3	0.0035	0.0043	0.0027
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.0755	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0042	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0154	0.0152
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0042	0.0348
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0042	0.0025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0104	0.0088
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0017	0.5
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0039	0.0059	0.0042
Echinococcus granulosus	thymidylate synthase	0.022	0.0813	0.0797
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0064	0.0162	0.027
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0062	0.0154	0.1855
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0047	0.0093	0.0076
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0042	0.0339
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0042	0.0046
Echinococcus multilocularis	General substrate transporter	0.0177	0.0634	0.0618
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0062	0.0154	0.0137
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0043	0.0361
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0042	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0154	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0042	0.004
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.004	0.0064	0.0641
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0162	0.027
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0063	0.0159	0.0264
Trichomonas vaginalis	glucose transporter, putative	0.0064	0.0162	0.1973
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0063	0.0159	0.0157
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0095	0.0079
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0062	0.0154	0.0137
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0042	0.0041
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.1323	0.5412	1
Leishmania major	basic transcription factor 3a, putative	0.0035	0.0043	0.0049
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0047	0.0093	0.0091
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0046	0.0088	0.0961
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0095	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0408	0.0406
Brugia malayi	isocitrate dehydrogenase	0.0047	0.0093	0.0093
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0017	0.0017
Plasmodium falciparum	protein kinase 6	0.0874	0.3541	0.6533
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0063	0.0159	0.0264
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0047	0.0093	0.0141
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0047	0.0093	0.0141
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0047	0.0093	0.0076
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0047	0.0093	0.0076
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.1323	0.5412	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0333	0.1284	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.2423	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0162	0.1973
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0162	0.027
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0042	0.0025
Schistosoma mansoni	hypothetical protein	0.0506	0.2005	0.1991
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0104	0.0088
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0063	0.0159	0.0264
Brugia malayi	lysyl-tRNA synthetase	0.0046	0.0088	0.0088
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0047	0.0093	0.0076
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0047	0.0093	0.0141
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0063	0.0159	0.0264
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0162	0.027
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0162	0.027
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0123	0.0106
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0063	0.0159	0.0157
Trypanosoma brucei	glucose transporter 1E	0.0064	0.0162	0.027
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0047	0.0093	0.0141
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0159	0.0142
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.2423	1	1
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.1323	0.5412	1
Chlamydia trachomatis	dihydrofolate reductase	0.2423	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Trypanosoma brucei	glucosidase, putative	0.0035	0.0042	0.0048
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0162	0.027
Echinococcus granulosus	lysosomal alpha glucosidase	0.0158	0.0556	0.054
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0017	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0159	0.0157
Echinococcus granulosus	General substrate transporter	0.0177	0.0634	0.0618
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.0042	0.0048
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0162	0.1973
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0017	0.0017

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 32 uM	In vitro anti protozoal activity against Trypanosoma brucei strain S427 was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	In vitro anti protozoal activity against Trypanosoma cruzi strain Tulahuen CL2 was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	In vitro anti protozoal activity against Leishmania infantum strain MHOM-ET-67/L82 was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	In vitro anti protozoal activity against Leishmania amazonensis strain MHOM/ET/L82/LV9 was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	Cytotoxicity of the compound was determined in macrophages	ChEMBL.	15203133
IC50 (functional)	> 32 uM	In vitro anti protozoal activity against Plasmodium falciparum sensitive strain W2 was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	In vitro anti protozoal activity of the compound against Plasmodium falciparum resistant strain Ghana was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	Cytotoxicity of the compound was determined in MRC-5 cells	ChEMBL.	15203133
IC50 (functional)	> 32 uM	In vitro anti protozoal activity against Trypanosoma brucei strain S427 was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	In vitro anti protozoal activity against Trypanosoma cruzi strain Tulahuen CL2 was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	In vitro anti protozoal activity against Leishmania infantum strain MHOM-ET-67/L82 was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	Cytotoxicity of the compound was determined in macrophages	ChEMBL.	15203133
IC50 (functional)	> 32 uM	In vitro anti protozoal activity against Plasmodium falciparum sensitive strain W2 was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	In vitro anti protozoal activity of the compound against Plasmodium falciparum resistant strain Ghana was determined	ChEMBL.	15203133
IC50 (functional)	> 32 uM	Cytotoxicity of the compound was determined in MRC-5 cells	ChEMBL.	15203133
Inhibition (functional)	= 0 %	Inhibitory activity against proliferationof HTLV-1 transformed cell lines (HUT-102) at 10 microM	ChEMBL.	15203133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL121434

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 210823