Detailed information for compound 210903

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.729 | Formula: C8H11ClN6O3S
  • H donors: 0 H acceptors: 4 LogP: 0.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCn1nnc2n(c1=O)cnc2S(=O)(=O)N(C)C
  • InChi: 1S/C8H11ClN6O3S/c1-13(2)19(17,18)7-6-11-12-15(4-3-9)8(16)14(6)5-10-7/h5H,3-4H2,1-2H3
  • InChiKey: YJQJSSZIAYYUEO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.1724 0.5664
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0052 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0417
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0118 0.0307
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0026 0.0062 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0032 0.0062
Echinococcus granulosus GPCR family 2 0.0069 0.0329 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0417
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0032 0.0062
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0285 0.2456
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0035 0.0118 0.0307
Brugia malayi Zinc finger, C2H2 type family protein 0.0196 0.1123 0.3231
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0026 0.0062 0.0062
Schistosoma mansoni pyruvate kinase 0.0033 0.0107 0.0107
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1724 0.5664
Giardia lamblia DINP protein human, muc B family 0.0042 0.016 1
Schistosoma mansoni glutamate receptor kainate 0.0054 0.0238 0.0238
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0026 0.0062 0.0163
Loa Loa (eye worm) hypothetical protein 0.0035 0.0118 0.0307
Echinococcus multilocularis geminin 0.0164 0.0923 0.0918
Loa Loa (eye worm) hypothetical protein 0.0038 0.0134 0.0352
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0032 0.0062
Brugia malayi Augmenter of liver regeneration 0.0034 0.0114 0.0294
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0044 0.0282
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0285 0.0902
Loa Loa (eye worm) hypothetical protein 0.0054 0.0238 0.0654
Echinococcus multilocularis GPCR, family 2 0.0069 0.0329 0.0324
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0146 0.1196
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0044 0.0091
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0115 0.0297
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0052 0.0129
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0026 0.0062 0.0143
Leishmania major hypothetical protein, conserved 0.0025 0.0052 0.0129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0059 0.0417
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0062 0.0444
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0074 0.0069
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0118 0.0307
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0352 0.1124
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0352 0.3059
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0762 0.2481
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0026 0.0062 0.0163
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0059 0.0417
Loa Loa (eye worm) hypothetical protein 0.0149 0.083 0.2378
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0114 0.0357
Brugia malayi Pip kinase protein 1 0.0026 0.0062 0.0143
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0238 0.0766
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0032 0.0062
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0052 0.0152
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0196 0.1123 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0352 0.0988
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0107 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0175 0.0175
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0501 0.3035 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0092 0.0261
Schistosoma mansoni mixed-lineage leukemia protein mll 0.024 0.1403 0.1403
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0032 0.0062
Trypanosoma brucei unspecified product 0.0055 0.0244 0.0765
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Schistosoma mansoni ap endonuclease 0.0018 0.0013 0.0013
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0107 0.0313
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0196 0.1123 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0118 0.035
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0032 0.0062
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0032 0.0062
Trichomonas vaginalis helicase, putative 0.0026 0.0059 0.0417
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0062 0.0163
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0039 0.0142 0.0137
Brugia malayi hypothetical protein 0.0229 0.133 0.3834
Schistosoma mansoni inositol monophosphatase 0.004 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0054 0.0238 0.0654
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0501 0.3035 1
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.4084 0.408
Schistosoma mansoni dihydroorotate dehydrogenase 0.0501 0.3035 0.3035
Brugia malayi Pip kinase protein 2 0.0326 0.1938 0.5602
Brugia malayi Inositol-1 0.004 0.0146 0.0386
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0146 0.014
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0052 0.0152
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0107 0.0313
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0107 0.0313
Toxoplasma gondii hypothetical protein 0.0047 0.0193 0.0618
Giardia lamblia Pyruvate kinase 0.0033 0.0107 0.6593
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0026 0.0062 0.0056
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0196 0.1123 0.1118
Echinococcus granulosus dna polymerase eta 0.0035 0.0118 0.0113
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0052 0.0129
Leishmania major pyruvate kinase 0.0033 0.0107 0.0313
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0352 0.0988
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0032 0.0086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0059 0.0417
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0238 0.0744
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0026 0.0062 0.0143
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0052 0.0129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0059 0.0417
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0352 0.1124
Leishmania major hypothetical protein, conserved 0.0034 0.0114 0.0334
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0032 0.0062
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0146 0.0439
Onchocerca volvulus 0.0429 0.2585 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0175 0.0169
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0032 0.0062
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0196 0.1123 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0196 0.1123 0.1118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0055
Schistosoma mansoni cpg binding protein 0.0113 0.0608 0.0608
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0074 0.0074
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0032 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0113
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0352 0.3059
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0092 0.0261
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0032 0.0055
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0032 0.017
Echinococcus granulosus pyruvate kinase 0.0033 0.0107 0.0102
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0329 0.0324
Schistosoma mansoni DNA polymerase eta 0.0035 0.0118 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0352 0.1124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0059 0.0417
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0352 0.1124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0091
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.012 0.0293
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0285 0.2456
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0146 0.0439
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0079 0.0074
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.0267 0.0261
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0074 0.0069
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0032 0.0062
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0032 0.0062
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0026 0.0062 0.0062
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0155 0.0471
Schistosoma mansoni ap endonuclease 0.0018 0.0013 0.0013
Echinococcus multilocularis pyruvate kinase 0.0026 0.0063 0.0058
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0146 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0417
Schistosoma mansoni lozenge 0.0054 0.0235 0.0235
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0238 0.0766
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0501 0.3035 0.8794
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0026 0.0062 0.0186
Mycobacterium ulcerans hypothetical protein 0.0073 0.0352 0.1124
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.1261 0.3633
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0501 0.3035 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0107 0.0102
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0107 0.0296
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0032 0.0062
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0032 0.0086
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0118 0.035
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0114 0.0108
Brugia malayi hypothetical protein 0.0025 0.0052 0.0113
Schistosoma mansoni ATP-binding cassette transporter 0.0024 0.005 0.005
Leishmania major DNA polymerase eta, putative 0.0035 0.0118 0.035
Brugia malayi sulfakinin receptor protein 0.0229 0.133 0.3834
Schistosoma mansoni hypothetical protein 0.0149 0.083 0.083
Echinococcus multilocularis cpg binding protein 0.012 0.0648 0.0643
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0352 0.1124
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0026 0.0062 0.0163
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0026 0.0062 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0032 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0417
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0762 0.2481
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1724 0.5664
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0055
Schistosoma mansoni inositol monophosphatase 0.004 0.0146 0.0146
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0501 0.3035 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0329 0.0922
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0026 0.0062 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0501 0.3035 1
Loa Loa (eye worm) FYVE zinc finger family protein 0.0026 0.0062 0.0143
Brugia malayi polk-prov protein 0.0038 0.0134 0.0352
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0032 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0417
Loa Loa (eye worm) histone methyltransferase 0.0035 0.0118 0.0306
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0032 0.0055
Echinococcus multilocularis Protein lozenge 0.0054 0.0235 0.023
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0107 0.0336
Echinococcus multilocularis pyruvate kinase 0.0033 0.0107 0.0102
Loa Loa (eye worm) hypothetical protein 0.0429 0.2585 0.7484
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0032 0.0062
Schistosoma mansoni terminal deoxycytidyl transferase 0.0035 0.0118 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0417
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0032 0.017
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0062 0.3657
Onchocerca volvulus 0.0113 0.0608 0.2256
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0059 0.0417
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0026 0.0062 0.0163
Echinococcus granulosus glutamate NMDA receptor subunit 0.0024 0.005 0.0045
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0501 0.3035 1
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0114 0.0357
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.0267 0.0261
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0039 0.0142 0.0137
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0146 0.0439
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.086 0.2804
Echinococcus multilocularis glutamate receptor 2 0.0024 0.005 0.0045
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0032 0.0062
Toxoplasma gondii histone lysine methyltransferase SET1 0.0215 0.1242 0.4082
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0352 0.1068
Echinococcus multilocularis NMDA receptor 0.0039 0.0142 0.0137
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.012 0.0354
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0196 0.1123 1
Echinococcus multilocularis dnaJ subfamily B 0.1614 1 1
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0032 0.0062
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0032 0.0062
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0032 0.0062
Loa Loa (eye worm) glutamate receptor 1 0.0024 0.005 0.011
Loa Loa (eye worm) glutamate receptor 2 0.0024 0.005 0.011
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0026 0.0062 0.0163
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0114 0.0334
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0501 0.3035 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0032 0.0062
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.005 0.005
Schistosoma mansoni hypothetical protein 0.1614 1 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0146 0.1196
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0107 0.0275
Loa Loa (eye worm) hypothetical protein 0.0069 0.0329 0.0922
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0059 0.0417
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0114 0.0334
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0114 0.0357
Toxoplasma gondii exonuclease III APE 0.0018 0.0013 0.0024
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0062 0.0186
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.0267 0.0261
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0285 0.028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0074 0.0069
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0155 0.0471
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0062 0.0186
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0329 0.0922
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0026 0.0062 0.0163
Schistosoma mansoni glutamate receptor NMDA 0.0029 0.0079 0.0079
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0035 0.0118 0.0113
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0114 0.0334
Plasmodium falciparum dihydroorotate dehydrogenase 0.0501 0.3035 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0146 0.0462
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0026 0.0062 0.0056
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0013 0.0465
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0032 0.0062
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0032 0.0062
Loa Loa (eye worm) oxidoreductase 0.0021 0.0032 0.0055
Loa Loa (eye worm) pip kinase 2 0.0326 0.1938 0.5602
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Schistosoma mansoni hypothetical protein 0.0069 0.0329 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0762 0.2481
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0032 0.017
Schistosoma mansoni glutamate receptor kainate 0.0024 0.005 0.005
Echinococcus granulosus geminin 0.0164 0.0923 0.0918
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0062 0.0163
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0026 0.0062 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0175 0.0175
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0013 0.0024
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0013 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0013 0.0007
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0107 0.0275
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0329 0.0324
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0175 0.0169
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0326 0.1938 0.1938
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0329 0.0922
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0419 0.2517 0.2513
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0032 0.0026
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0155 0.0471
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0107 0.0296
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.016 0.0487
Schistosoma mansoni pyruvate kinase 0.0017 0.0006 0.0006
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0107 0.0275
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0035 0.0118 0.0113
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0062 0.0163
Echinococcus granulosus dna polymerase kappa 0.0062 0.0285 0.028
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.4084 0.4084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0175 0.0175
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0026 0.0062 0.0163
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0024 0.005 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0175 0.0472
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.083 0.2378
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0175 0.0169
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0352 0.1124
Echinococcus granulosus glutamate receptor 2 0.002 0.0023 0.0017
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0032 0.0062
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.016 0.0487
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0032 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.016 0.0487
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0219 0.0683
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0074 0.0069
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0146 0.1196
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Onchocerca volvulus 0.0326 0.1938 0.7466
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0026 0.0062 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0417
Loa Loa (eye worm) hypothetical protein 0.0073 0.0352 0.0988
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0107 0.0336
Schistosoma mansoni hypothetical protein 0.0164 0.0923 0.0923
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0352 0.0988
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0285 0.0902
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0107 0.0275
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0026 0.0062 0.0186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0275
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0026 0.0062 0.0056
Brugia malayi CXXC zinc finger family protein 0.0113 0.0608 0.1731
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0032 0.0062
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0114 0.0108
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0035 0.0118 0.0112
Schistosoma mansoni hypothetical protein 0.0069 0.0329 0.0329
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0285 0.0902
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0326 0.1938 0.1933
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0326 0.1938 0.1938
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0107 0.0252
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0013 0.0024
Loa Loa (eye worm) hypothetical protein 0.0054 0.0238 0.0654
Loa Loa (eye worm) hypothetical protein 0.0054 0.0238 0.0654
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0032 0.0055
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0029 0.0079 0.0074
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0032 0.0055
Giardia lamblia Hypothetical protein 0.0026 0.0062 0.3657
Schistosoma mansoni hypothetical protein 0.0069 0.0329 0.0329
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0352 0.1124
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0352 0.1124
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0146 0.0439
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0196 0.1123 0.1118
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.0267 0.0261
Loa Loa (eye worm) inositol-1 0.004 0.0146 0.0386
Loa Loa (eye worm) hypothetical protein 0.0567 0.3449 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0035 0.0118 0.0112
Echinococcus granulosus cpg binding protein 0.012 0.0648 0.0643
Loa Loa (eye worm) pip kinase 1 0.0026 0.0062 0.0143
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0032 0.0062
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0146 0.1196
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0501 0.3035 1
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0026 0.0062 0.0186
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0013 0.0001
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0501 0.3035 0.8794
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0419 0.2517 0.2513
Schistosoma mansoni cpg binding protein 0.012 0.0648 0.0648
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0146 0.0439
Loa Loa (eye worm) hypothetical protein 0.0054 0.0238 0.0654
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0032 0.0062
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0032 0.0062
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0238 0.0744
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0035 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0429 0.2585 0.7484
Leishmania major pyruvate kinase 0.0033 0.0107 0.0313
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0032 0.0055
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0146 0.0439
Loa Loa (eye worm) hypothetical protein 0.0073 0.0352 0.0988
Onchocerca volvulus 0.0073 0.0352 0.1256
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0417
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0032 0.0062
Schistosoma mansoni glutamate receptor kainate 0.0054 0.0238 0.0238
Entamoeba histolytica deoxycytidyl transferase, putative 0.0035 0.0118 0.0952
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0032 0.0062
Loa Loa (eye worm) hypothetical protein 0.0326 0.1938 0.5602
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0352 0.1124
Entamoeba histolytica phosphoinositide kinase, putative 0.0026 0.0062 0.0444
Schistosoma mansoni glutamate receptor NMDA 0.0024 0.005 0.005
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.0267 0.0261
Schistosoma mansoni pyruvate kinase 0.0033 0.0107 0.0107
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.1724 0.5664
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0175 0.0472
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0013 0.0007
Schistosoma mansoni hypothetical protein 0.0164 0.0923 0.0923
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0026 0.0062 0.0444
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0107 0.0313
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0032 0.0086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0219 0.0683
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0092 0.0261
Loa Loa (eye worm) CXXC zinc finger family protein 0.0113 0.0608 0.1731
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0032 0.0062
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.0267 0.0261
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0175 0.0169
Echinococcus granulosus pyruvate kinase 0.0033 0.0107 0.0102
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0032 0.0055
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0026 0.0062 0.0062
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0196 0.1123 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0032 0.0055
Echinococcus granulosus glutamate receptor 2 0.0029 0.0079 0.0074
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0326 0.1938 0.1933
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0032 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0285 0.0902
Brugia malayi Glutamate receptor 2 precursor 0.0024 0.005 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0059 0.0417
Trypanosoma brucei unspecified product 0.0024 0.005 0.0124
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0352 0.3059
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0062 0.0163
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0114 0.0294
Echinococcus granulosus microtubule associated protein 2 0.0669 0.4084 0.408
Echinococcus multilocularis dna polymerase eta 0.0035 0.0118 0.0113
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0032 0.0062
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0032 0.0055
Mycobacterium ulcerans hypothetical protein 0.0154 0.086 0.2804
Loa Loa (eye worm) hypothetical protein 0.0229 0.133 0.3834
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.005 0.005
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0107 0.0296
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0352 0.1124
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0352 0.1068
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0107 0.0852
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0501 0.3035 1
Schistosoma mansoni cpg binding protein 0.012 0.0648 0.0648
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0155 0.0471
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0032 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0134 0.04
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0032 0.0086
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0196 0.1123 0.1118
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0238 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0032 0.0086
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0114 0.0357
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0026 0.0062 0.0444
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0352 0.0988
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0039 0.0142 0.0137
Schistosoma mansoni hypothetical protein 0.0069 0.0329 0.0329
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.1261 0.3633
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0059 0.0417
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0107 0.0852
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0052 0.0152
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0118 0.035
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0196 0.1123 1
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0026 0.0062 0.0186
Brugia malayi hypothetical protein 0.0429 0.2585 0.7484
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0107 0.0313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0219 0.0683
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0026 0.0062 0.0062
Echinococcus multilocularis glutamate receptor 2 0.002 0.0023 0.0017
Plasmodium falciparum pyruvate kinase 0.0033 0.0107 0.0336
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0352 0.1124
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0032 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0134 0.04
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0211 0.0657
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0032 0.0062
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0285 0.0902
Leishmania major dihydroorotate dehydrogenase 0.0501 0.3035 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0352 0.1124
Leishmania major DNA polymerase kappa, putative 0.0042 0.016 0.0487
Trypanosoma brucei unspecified product 0.0024 0.005 0.0124
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0114 0.0334
Brugia malayi Glutamate receptor 1 precursor 0.0024 0.005 0.011
Trypanosoma brucei DNA polymerase IV, putative 0.0055 0.0244 0.0765
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0029 0.0079 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0219 0.0683
Loa Loa (eye worm) runx1 0.0054 0.0235 0.0648
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0196 0.1123 0.3674
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0039 0.0142 0.0137
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0062 0.0163
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0032 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0567 0.3449 1
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0032 0.0062
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0501 0.3035 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0196 0.1123 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0107 0.0313

Activities

Activity type Activity value Assay description Source Reference
Survivors (functional) = 3 Antitumor activity was assessed against TLX5 tumors in CBA/CA mouse by inoculation of 2 x 10e5 tumor cells through sc route and number of survivors was reported at 40 mg/kg ip dose; 3/5 ChEMBL. 3806616
Survivors (functional) = 3 Antitumor activity was assessed against TLX5 tumors in CBA/CA mouse by inoculation of 2 x 10e5 tumor cells through sc route and number of survivors was reported at 20 mg/kg ip dose; 3/5 ChEMBL. 3806616
Survivors (functional) = 7 Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through iv route and number of Survivors to duration was reported at 40 mg/kg po dose; 7/7 ChEMBL. 3806616
T/C (functional) = 68 % Antitumor activity was assessed against TLX5 tumors in CBA/CA mouse by inoculation of 2 x 10e5 tumor cells through sc route and mean death of animals (treated/control) was reported at 80 mg/kg dose ChEMBL. 3806616
T/C (functional) = 152 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through iv route and mean death of animals (treated/control) was reported at 10 mg/kg po dose ChEMBL. 3806616
T/C (functional) = 152 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through iv route and mean death of animals (treated/control) was reported at 10 mg/kg po dose ChEMBL. 3806616
T/C (functional) = 222 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through iv route and mean death of animals (treated/control) was reported at 20 mg/kg po dose ChEMBL. 3806616
T/C (functional) = 222 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through iv route and mean death of animals (treated/control) was reported at 20 mg/kg po dose ChEMBL. 3806616
T/C (functional) > 381 % Antitumor activity was assessed against TLX5 tumors in CBA/CA mouse by inoculation of 2 x 10e5 tumor cells through sc route and mean death of animals (treated/control) was reported at 40 mg/kg dose ChEMBL. 3806616
T/C (functional) > 385 % Antitumor activity was assessed against TLX5 tumors in CBA/CA mouse by inoculation of 2 x 10e5 tumor cells through sc route and mean death of animals (treated/control) was reported at 20 mg/kg dose ChEMBL. 3806616
T/C (functional) > 750 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through iv route and mean death of animals (treated/control) was reported at 40 mg/kg po dose ChEMBL. 3806616
T/C (functional) > 750 % Antitumor activity was assessed against L1210 tumors in B6D2F1 mouse by inoculation of 10e5 tumor cells through iv route and mean death of animals (treated/control) was reported at 40 mg/kg po dose ChEMBL. 3806616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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