TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 501.57 | Formula: C30H31NO6
H donors: 2 H acceptors: 5 LogP: 2.95 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(=O)O.CCN1CCC(=C(C1)C(=O)OCC(c1ccccc1)c1ccccc1)c1ccccc1
InChi: 1S/C28H29NO2.C2H2O4/c1-2-29-19-18-25(22-12-6-3-7-13-22)26(20-29)28(30)31-21-27(23-14-8-4-9-15-23)24-16-10-5-11-17-24;3-1(4)2(5)6/h3-17,27H,2,18-21H2,1H3;(H,3,4)(H,5,6)
InChiKey: OSKAUUHELWXKCH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholinergic receptor, muscarinic 1	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, muscarinic 5	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, muscarinic 4	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, muscarinic 2	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, muscarinic 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133264	All targets in OG5_133264
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133264	All targets in OG5_133264

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.0127	0.0167
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0034	0.0127	0.0167
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0085	0.0053
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.0127	0.0127
Schistosoma mansoni	hypothetical protein	0.0178	0.0921	0.1211
Echinococcus multilocularis	neuropeptide receptor A26	0.0014	0.0018	0.0023
Leishmania major	basic transcription factor 3a, putative	0.0037	0.0141	0.0141
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0018	0.0023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Schistosoma mansoni	hypothetical protein	0.0078	0.0368	0.0483
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0014	0.0018	0.0023
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0017	0.0032	0.0032
Loa Loa (eye worm)	TYRA-2 protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	tumor protein p63	0.0355	0.1898	0.2496
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0147	0.0194
Echinococcus granulosus	dnaJ subfamily B	0.043	0.2311	0.3038
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0219	0.0288
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0017	0.0032	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	hypothetical protein	0.0475	0.2558	0.3363
Plasmodium falciparum	basic transcription factor 3b, putative	0.0037	0.0141	0.011
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0179	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0017	0.0032	0.0042
Echinococcus granulosus	neuropeptide receptor A26	0.0014	0.0018	0.0023
Loa Loa (eye worm)	melatonin receptor type 1A	0.0014	0.0018	0.0023
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0018	0.0023
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0017	0.0032	0.0042
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0061	0.0273	0.0273
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0219	0.0288
Brugia malayi	nuclear receptor NHR-88	0.0014	0.0018	0.0023
Schistosoma mansoni	multidrug resistance protein	0.0036	0.0136	0.0179
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0017	0.0032	0.0042
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0085	0.0085
Mycobacterium tuberculosis	Hypothetical protein	0.0475	0.2558	0.3363
Schistosoma mansoni	RAR-like nuclear receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	hypothetical protein	0.0018	0.0035	0.0046
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0035	0.0046
Loa Loa (eye worm)	ICD-1 protein	0.0037	0.0141	0.0186
Trypanosoma brucei	oxidoreductase-like protein	0.0022	0.0061	0.0061
Brugia malayi	photoreceptor-specific nuclear receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0219	0.0288
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0018	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0141	0.0433
Mycobacterium ulcerans	thymidylate synthase	0.0999	0.5445	0.7159
Schistosoma mansoni	hypothetical protein	0.0012	0.0004	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0014	0.0018	0.0023
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0018	0.0023
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0085	0.0085
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0999	0.5445	0.7159
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0014	0.0018	0.0023
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0014	0.0018	0.0023
Plasmodium vivax	basic transcription factor 3b, putative	0.0037	0.0141	0.011
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0018	0.0023
Brugia malayi	hypothetical protein	0.0017	0.0033	0.0043
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.0051	0.0051
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0014	0.0018	0.0023
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0018	0.0023
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0034	0.0127	0.0167
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0014	0.0018	0.0023
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0017	0.0032	0.0042
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0017	0.0032	0.0032
Schistosoma mansoni	beta-hexosaminidase B	0.0188	0.0977	0.1284
Echinococcus granulosus	g-protein coupled receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0018	0.0023
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0014	0.0018	0.0023
Brugia malayi	CXXC zinc finger family protein	0.003	0.0105	0.0138
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0018	0.0023
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.1391	0.7607	1
Echinococcus granulosus	beta hexosaminidase subunit beta	0.0188	0.0977	0.1284
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0018	0.0023
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0017	0.0032	0.0032
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0014	0.0018	0.0023
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0014	0.0018	0.0023
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0034	0.0127	0.0127
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0014	0.0018	0.0023
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0197	0.1023	0.1345
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0014	0.0018	0.0023
Brugia malayi	G protein-coupled receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Schistosoma mansoni	cpg binding protein	0.0032	0.0114	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Trypanosoma brucei	membrane transporter protein, putative	0.0036	0.0136	0.0136
Loa Loa (eye worm)	oxidoreductase	0.0017	0.0032	0.0042
Echinococcus multilocularis	orexin receptor type 2	0.0014	0.0018	0.0023
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0014	0.0018	0.0023
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0034	0.0127	0.0095
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0999	0.5445	0.7159
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0018	0.0023
Entamoeba histolytica	beta-N-acetylhexosaminidase, beta subunit	0.0188	0.0977	0.953
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0014	0.0018	0.0023
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	coup transcription factor	0.0014	0.0018	0.0023
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0018	0.0023
Brugia malayi	putative neuropeptide receptor NPR1	0.0014	0.0018	0.0023
Trypanosoma brucei	pteridine reductase 1	0.0394	0.2114	0.2114
Brugia malayi	hypothetical protein	0.0249	0.131	0.1722
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0017	0.0032	0.0042
Brugia malayi	beta-NAC-like protein	0.0037	0.0141	0.0186
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0014	0.0018	0.0023
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0018	0.0023
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0017	0.0032	0.0042
Schistosoma mansoni	amine GPCR	0.0014	0.0018	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Schistosoma mansoni	hypothetical protein	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0052	0.0225	0.0383
Trypanosoma cruzi	membrane transporter protein, putative	0.0036	0.0136	0.0136
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.0127	0.0167
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Echinococcus granulosus	hypothetical protein	0.0014	0.0018	0.0023
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0034	0.0127	0.0167
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0014	0.0018	0.0023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.0127	0.0127
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0017	0.0032	0.0042
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0197	0.1023	0.3924
Onchocerca volvulus		0.0014	0.0018	0.000001165
Trichomonas vaginalis	conserved hypothetical protein	0.0475	0.2558	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	7tm_1 domain containing protein	0.0014	0.0018	0.0023
Schistosoma mansoni	hypothetical protein	0.0014	0.0018	0.0023
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.1824	1	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0014	0.0018	0.0023
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Schistosoma mansoni	growth hormone secretagogue receptor	0.0014	0.0018	0.0023
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0017	0.0032	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0014	0.0018	0.0023
Loa Loa (eye worm)	steroid hormone receptor	0.0014	0.0018	0.0023
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.0032	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0018	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0014	0.0018	0.0023
Echinococcus multilocularis	beta hexosaminidase subunit beta	0.0188	0.0977	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	allatostatin A receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	CYP4Cod1	0.002	0.0051	0.0067
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.1824	1	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0034	0.0127	0.0167
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0014	0.0018	0.0023
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0197	0.1023	0.1345
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0022	0.0061	0.008
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0018	0.0023
Schistosoma mansoni	retinoic acid receptor RXR	0.0014	0.0018	0.0023
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	transcription factor btf3	0.0037	0.0141	0.0186
Entamoeba histolytica	beta-N-acetylhexosaminidase, putative	0.0188	0.0977	0.953
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Echinococcus granulosus	somatostatin receptor	0.0014	0.0018	0.0023
Brugia malayi	Isocitrate dehydrogenase	0.0034	0.0127	0.0167
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0014	0.0018	0.0023
Echinococcus multilocularis	dnaJ subfamily B	0.043	0.2311	0.3038
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0085	0.0111
Leishmania major	hypothetical protein, conserved	0.0027	0.0085	0.0085
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0219	0.0288
Brugia malayi	Dopamine receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0018	0.0023
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0085	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0514	0.2775	0.3648
Echinococcus multilocularis	serotonin receptor	0.0014	0.0018	0.0023
Brugia malayi	GnHR receptor homolog	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0051	0.0067
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0014	0.0018	0.0023
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0197	0.1023	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0136	0.0136
Echinococcus multilocularis	ecdysone induced protein 78C	0.0014	0.0018	0.0023
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0218	0.0287
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0197	0.1023	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0035	0.0046
Schistosoma mansoni	amine GPCR	0.0014	0.0018	0.0023
Schistosoma mansoni	hypothetical protein	0.0018	0.0035	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0147	0.0194
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0018	0.0023
Schistosoma mansoni	myosin xvIII	0.0014	0.0018	0.0023
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0014	0.0018	0.0023
Leishmania major	hypothetical protein, conserved	0.0036	0.0136	0.0136
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0014	0.0018	0.0023
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0017	0.0032	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	putative neuropeptide receptor	0.0014	0.0018	0.0023
Brugia malayi	Dopamine receptor protein 1	0.0014	0.0018	0.0023
Echinococcus multilocularis	sex peptide receptor	0.0014	0.0018	0.0023
Mycobacterium ulcerans	oxidoreductase	0.0017	0.0032	0.0042
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0141	0.0433
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0141	0.0433
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	hypothetical protein	0.0054	0.0238	0.0313
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0017	0.0032	0.0042
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0017	0.0032	0.0032
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Brugia malayi	Steroid receptor seven-up type 2	0.0014	0.0018	0.0023
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.1391	0.7607	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0141	0.1102
Echinococcus multilocularis	somatostatin receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	adenoreceptor	0.0014	0.0018	0.0023
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0017	0.0032	0.0042
Brugia malayi	G-protein coupled receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0219	0.0288
Schistosoma mansoni	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	larval opioid receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	neuropeptide FF receptor 2	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0249	0.131	0.1722
Brugia malayi	RE15519p	0.0014	0.0018	0.0023
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0017	0.0032	0.0042
Onchocerca volvulus		0.0999	0.5445	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	Cytochrome P450 family protein	0.002	0.0051	0.0067
Mycobacterium tuberculosis	Possible oxidoreductase	0.0017	0.0032	0.0042
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0017	0.0032	0.0042
Trypanosoma brucei	MATE efflux family protein, putative	0.0036	0.0136	0.0136
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0014	0.0018	0.0023
Echinococcus multilocularis	g-protein coupled receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0105	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	transcription factor btf3	0.0037	0.0141	0.0186
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0022	0.0061	0.0061
Schistosoma mansoni	opsin-like receptor	0.0014	0.0018	0.0023
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0014	0.0018	0.0023
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0017	0.0032	0.0042
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0035	0.0046
Schistosoma mansoni	beta-hexosaminidase B	0.0188	0.0977	0.1284
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	glycosyl hydrolase family 20	0.0188	0.0977	0.1284
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0014	0.0018	0.0023
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0014	0.0018	0.0023
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0014	0.0018	0.0023
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0141	0.0141
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0225	0.0296
Schistosoma mansoni	amine GPCR	0.0014	0.0018	0.0023
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0014	0.0018	0.0023
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0018	0.0023
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0014	0.0018	0.0023
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0023
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0018	0.0023
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0061	0.0273	0.0954
Brugia malayi	dihydrofolate reductase family protein	0.1391	0.7607	1
Brugia malayi	Serotonin receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0018	0.0023
Echinococcus multilocularis	multidrug and toxin extrusion protein 2	0.0036	0.0136	0.0179
Leishmania major	hypothetical protein, conserved	0.0036	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus granulosus	multidrug and toxin extrusion protein 2	0.0036	0.0136	0.0179
Schistosoma mansoni	cpg binding protein	0.0032	0.0114	0.0151
Brugia malayi	G protein-coupled receptor F59B2.13	0.0014	0.0018	0.0023
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0017	0.0032	0.0027
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0035	0.0046
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0244	0.0321
Echinococcus multilocularis	beta hexosaminidase subunit alpha	0.0118	0.0587	0.0772
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0035	0.0046
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0197	0.1023	0.3924
Brugia malayi	AKH receptor	0.0014	0.0018	0.0023
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0197	0.1023	1
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0017	0.0032	0.0042
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0017	0.0032	0.0032
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0017	0.0032	0.0042
Echinococcus multilocularis	Multi antimicrobial extrusion protein MatE	0.0033	0.0119	0.0156
Echinococcus granulosus	ecdysone induced protein 78C	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Echinococcus granulosus	G protein coupled receptor 139	0.0014	0.0018	0.0023
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0034	0.0127	0.0127
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0014	0.0018	0.0023
Brugia malayi	steroid hormone receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0014	0.0018	0.0023
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0034	0.0127	0.0095
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.1824	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0014	0.0018	0.000001165
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0061	0.0273	0.0954
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus granulosus	GPCR family 2	0.0018	0.0035	0.0046
Echinococcus multilocularis	dro:myosuppressin receptor	0.0014	0.0018	0.0023
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0141	0.0141
Entamoeba histolytica	hypothetical protein	0.0078	0.0368	0.3386
Entamoeba histolytica	beta-N-acetylhexosaminidase, alpha subunit	0.0188	0.0977	0.953
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0017	0.0032	0.0042
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0078	0.0368	0.0483
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0244	0.0321
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.0127	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0034	0.0127	0.0167
Trichomonas vaginalis	beta-hexosaminidase, putative	0.0118	0.0587	0.2198
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0014	0.0018	0.0023
Schistosoma mansoni	dihydrofolate reductase	0.1391	0.7607	1
Echinococcus granulosus	neuropeptide s receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	thymidylate synthase	0.0999	0.5445	0.7159
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0034	0.0127	0.0167
Schistosoma mansoni	hypothetical protein	0.0014	0.0018	0.0023
Trichomonas vaginalis	beta-hexosaminidase, putative	0.0118	0.0587	0.2198
Chlamydia trachomatis	dihydrofolate reductase	0.1391	0.7607	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0085	0.0085
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0197	0.1023	0.3924
Brugia malayi	Dihydrofolate reductase	0.1391	0.7607	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0085	0.0053
Schistosoma mansoni	transcription factor btf3	0.0037	0.0141	0.0186
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0017	0.0032	0.0032
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0017	0.0032	0.0042
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0023
Schistosoma mansoni	cpg binding protein	0.003	0.0105	0.0138
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0017	0.0032	0.0042
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0018	0.0023
Echinococcus multilocularis	serotonin receptor	0.0014	0.0018	0.0023
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0017	0.0032	0.0042
Brugia malayi	Dopamine receptor protein 2	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0017	0.0032	0.0042
Onchocerca volvulus		0.0051	0.0218	0.037
Mycobacterium ulcerans	short chain dehydrogenase	0.0022	0.0061	0.008
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.1824	1	1
Onchocerca volvulus		0.0014	0.0018	0.000001165
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0014	0.0018	0.0023
Brugia malayi	Glycosyl hydrolase family 20, catalytic domain containing protein	0.0044	0.0179	0.0236
Schistosoma mansoni	hypothetical protein	0.0051	0.0218	0.0287
Schistosoma mansoni	hypothetical protein	0.043	0.2311	0.3038
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	amine GPCR	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0017	0.0032	0.0042
Echinococcus multilocularis	G protein coupled receptor 139	0.0014	0.0018	0.0023
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0219	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Loa Loa (eye worm)	MH2 domain-containing protein	0.0133	0.067	0.0881
Entamoeba histolytica	transcription factor BTF3, putative	0.0037	0.0141	0.1102
Echinococcus granulosus	cpg binding protein	0.0032	0.0114	0.0151
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	thyroid hormone receptor	0.0014	0.0018	0.0023
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0475	0.2558	0.2558
Onchocerca volvulus		0.0014	0.0018	0.000001165
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0035	0.0046
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0017	0.0032	0.0042
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0014	0.0018	0.0023
Leishmania major	pteridine reductase 1	0.04	0.2143	0.2143
Toxoplasma gondii	isocitrate dehydrogenase	0.0034	0.0127	0.0127
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0219	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0136	0.0136
Entamoeba histolytica	hypothetical protein	0.0078	0.0368	0.3386
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	nuclear hormone receptor	0.0014	0.0018	0.0023
Onchocerca volvulus		0.003	0.0105	0.0161
Trichomonas vaginalis	beta-hexosaminidase, putative	0.0118	0.0587	0.2198
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0014	0.0018	0.0023
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0014	0.0018	0.0023
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0014	0.0018	0.000001165
Brugia malayi	Cytochrome P450 family protein	0.002	0.0051	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0514	0.2775	0.3648
Brugia malayi	Serotonin receptor	0.0014	0.0018	0.0023
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0017	0.0032	0.0042
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0197	0.1023	0.3924
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0179	0.0236
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.002	0.0051	0.0067
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0018	0.0023
Schistosoma mansoni	hypothetical protein	0.0018	0.0035	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus granulosus	allatostatin A receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0244	0.0321
Echinococcus multilocularis	dihydrofolate reductase	0.1391	0.7607	1
Trypanosoma brucei	transcription factor BTF3, putative	0.0037	0.0141	0.0141
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0018	0.0023
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0273	0.0273
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0017	0.0032	0.0032
Echinococcus multilocularis	neuropeptide s receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0051	0.0067
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.1391	0.7607	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0014	0.0018	0.0023
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0017	0.0032	0.0032
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0004	0.0005
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0004	0.0005
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0197	0.1023	0.3924
Trypanosoma brucei	membrane transporter protein, putative	0.0036	0.0136	0.0136
Brugia malayi	isocitrate dehydrogenase	0.0034	0.0127	0.0167
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0017	0.0032	0.0042
Mycobacterium tuberculosis	Probable oxidoreductase	0.0022	0.0061	0.008
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0014	0.0018	0.0023
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0254	0.0254
Echinococcus granulosus	7TM GPCR rhodopsin	0.0014	0.0018	0.0023
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0014	0.0018	0.0023
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0014	0.0018	0.0023
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0035	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0022	0.0061	0.008
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0136	0.0136
Schistosoma mansoni	transcription factor LCR-F1	0.0078	0.0368	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Trichomonas vaginalis	beta-hexosaminidase B, putative	0.0118	0.0587	0.2198
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0014	0.0018	0.0023
Entamoeba histolytica	beta-N-acetylhexosaminidase, putative	0.0188	0.0977	0.953
Echinococcus granulosus	FTZ F1 alpha	0.0014	0.0018	0.0023
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0017	0.0032	0.5
Onchocerca volvulus		0.0014	0.0018	0.000001165
Brugia malayi	nuclear hormone receptor	0.0014	0.0018	0.0023
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0014	0.0018	0.0023
Brugia malayi	Melatonin receptor type 1A	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Schistosoma mansoni	hypothetical protein	0.0038	0.0147	0.0194
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0014	0.0018	0.0023
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0014	0.0018	0.0023
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0014	0.0018	0.0023
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0017	0.0032	0.0042
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0244	0.0321
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0197	0.1023	0.1345
Echinococcus multilocularis	FTZ F1 alpha	0.0014	0.0018	0.0023
Schistosoma mansoni	hypothetical protein	0.0178	0.0921	0.1211
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0017	0.0032	0.0042
Entamoeba histolytica	hypothetical protein	0.0078	0.0368	0.3386
Leishmania major	cytochrome p450-like protein	0.002	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Leishmania major	hypothetical protein, conserved	0.0061	0.0273	0.0273
Brugia malayi	follicle stimulating hormone receptor	0.0014	0.0018	0.0023
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0018	0.0023
Brugia malayi	thymidylate synthase	0.0999	0.5445	0.7159
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.0127	0.0127
Schistosoma mansoni	opsin-like receptor	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Echinococcus multilocularis	survival motor neuron protein 1	0.0249	0.131	0.1722
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0017	0.0032	0.0042
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0136	0.0689	0.0906
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0219	0.0288
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0018	0.0023
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0014	0.0018	0.0023
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	thymidylate synthase	0.0999	0.5445	0.7159
Loa Loa (eye worm)	dihydrofolate reductase	0.1391	0.7607	1
Onchocerca volvulus		0.0022	0.0061	0.008
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0014	0.0018	0.0023
Trypanosoma brucei	membrane transporter protein, putative	0.0036	0.0136	0.0136
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0014	0.0018	0.0023
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0017	0.0032	0.0042
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0018	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0014	0.0018	0.0023
Echinococcus granulosus	serotonin receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	dihydropteridine reductase	0.0017	0.0032	0.0042
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0078	0.0368	0.0483
Onchocerca volvulus		0.0014	0.0018	0.000001165
Mycobacterium ulcerans	short chain dehydrogenase	0.0017	0.0032	0.0042
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	ecdysteroid receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Onchocerca volvulus	Hexosaminidase D homolog	0.0044	0.0179	0.0298
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus granulosus	tumor protein p63	0.0355	0.1898	0.2496
Brugia malayi	sulfakinin receptor protein	0.0014	0.0018	0.0023
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0035	0.0046
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0014	0.0018	0.0023
Echinococcus granulosus	survival motor neuron protein 1	0.0249	0.131	0.1722
Echinococcus multilocularis	cpg binding protein	0.0032	0.0114	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0018	0.0023
Brugia malayi	neuropeptide F receptor	0.0014	0.0018	0.0023
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0085	0.0085
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0218	0.0287
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0136	0.0136
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Trypanosoma brucei	cytochrome P450, putative	0.002	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Brugia malayi	Glycosyl hydrolase family 20, catalytic domain containing protein	0.0188	0.0977	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0042
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	sex peptide receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Loa Loa (eye worm)	transcription factor SMAD2	0.0133	0.067	0.0881
Schistosoma mansoni	amine GPCR	0.0014	0.0018	0.0023
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0292	0.0384
Brugia malayi	neuropeptide F receptor	0.0014	0.0018	0.0023
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0018	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0014	0.0018	0.0023
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0022	0.0061	0.008
Echinococcus multilocularis	thymidylate synthase	0.0999	0.5445	0.7159
Brugia malayi	Glycosyl hydrolase family 20, catalytic domain containing protein	0.0044	0.0179	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0018	0.0023
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0018	0.0023
Brugia malayi	MH2 domain containing protein	0.0133	0.067	0.0881
Brugia malayi	Nuclear hormone receptor-like 1	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0018	0.0023
Schistosoma mansoni	opsin-like receptor	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0018	0.0023
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0014	0.0018	0.0023
Brugia malayi	G-protein coupled receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	hypothetical protein	0.0018	0.0035	0.0046
Echinococcus granulosus	fmrfamide receptor	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0197	0.1023	0.3924
Echinococcus multilocularis	geminin	0.0178	0.0921	0.1211
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0014	0.0018	0.0023
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0014	0.0018	0.0023
Entamoeba histolytica	hypothetical protein	0.0078	0.0368	0.3386
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0999	0.5445	0.7159
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0018	0.0023
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0014	0.0018	0.0023
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0014	0.0018	0.0023
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0014	0.0018	0.0023
Schistosoma mansoni	thyroid hormone receptor	0.0014	0.0018	0.0023
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0014	0.0018	0.000001165
Schistosoma mansoni	histamine h1 receptor	0.0014	0.0018	0.0023
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0273	0.0273
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0022	0.0061	0.0061
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0018	0.0023
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.1824	1	1
Echinococcus granulosus	orexin receptor type 2	0.0014	0.0018	0.0023
Toxoplasma gondii	NAC domain-containing protein	0.0037	0.0141	0.0141
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0017	0.0032	0.0042
Echinococcus granulosus	beta hexosaminidase subunit alpha	0.0118	0.0587	0.0772
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0014	0.0018	0.0023
Brugia malayi	ORL1-like opioid receptor	0.0014	0.0018	0.0023
Onchocerca volvulus		0.0197	0.1023	0.1853
Toxoplasma gondii	isocitrate dehydrogenase	0.0034	0.0127	0.0127
Schistosoma mansoni	neuropeptide f receptor 76f	0.0014	0.0018	0.0023
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0035	0.0046
Trichomonas vaginalis	beta-hexosaminidase, putative	0.0044	0.0179	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.0051	0.0051
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0225	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0017	0.0032	0.0032
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0014	0.0018	0.0023
Brugia malayi	hypothetical protein	0.0078	0.0368	0.0483
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0219	0.0288
Leishmania major	oxidoreductase-like protein	0.0022	0.0061	0.0061
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0018	0.0023
Brugia malayi	hypothetical protein	0.0027	0.0085	0.0111
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.0032	0.0042
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0014	0.0018	0.0023
Mycobacterium tuberculosis	Possible oxidoreductase	0.0017	0.0032	0.0042
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0014	0.0018	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus granulosus	geminin	0.0178	0.0921	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0023
Echinococcus granulosus	dihydrofolate reductase	0.1391	0.7607	1
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0018	0.0023
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0018	0.0023

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2573.4 nM	Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL.	9986705
IC50 (binding)	= 2573.4 nM	Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL.	9986705
IC50 (binding)	= 2829.7 nM	Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M1 using membranes from transfected CHO cells	ChEMBL.	9986705
IC50 (binding)	= 2829.7 nM	Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M1 using membranes from transfected CHO cells	ChEMBL.	9986705
IC50 (binding)	= 3108.6 nM	Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cells	ChEMBL.	9986705
IC50 (binding)	= 3108.6 nM	Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cells	ChEMBL.	9986705
IC50 (binding)	= 5051.5 nM	Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cells	ChEMBL.	9986705
IC50 (binding)	= 5051.5 nM	Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cells	ChEMBL.	9986705
IC50 (binding)	= 7708.4 nM	Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M4 using membranes from transfected CHO cells	ChEMBL.	9986705
IC50 (binding)	= 7708.4 nM	Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M4 using membranes from transfected CHO cells	ChEMBL.	9986705

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL120963

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 211014