Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0162 | 0.2676 | 0.2671 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0558 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0162 | 0.2676 | 0.2194 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0558 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0558 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0558 | 1 | 1 |
Toxoplasma gondii | aldo-keto reductase | 0.0162 | 0.2676 | 0.2194 |
Echinococcus multilocularis | aldo keto reductase | 0.0558 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0617 | 0.0617 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0617 | 0.0617 |
Loa Loa (eye worm) | oxidoreductase | 0.0558 | 1 | 1 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0033 | 0.0299 | 0.0292 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0033 | 0.0306 | 0.0299 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.005 | 0.0617 | 0.061 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0558 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0033 | 0.0299 | 0.0292 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0558 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0033 | 0.0299 | 0.0292 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0558 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0558 | 1 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.005 | 0.0617 | 0.061 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0007 | 0.0007 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0617 | 0.0617 |
Toxoplasma gondii | aldose reductase, putative | 0.0558 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0558 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0162 | 0.2676 | 0.2676 |
Mycobacterium ulcerans | oxidoreductase | 0.0558 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0162 | 0.2676 | 0.2671 |
Onchocerca volvulus | 0.0558 | 1 | 1 | |
Giardia lamblia | Aldose reductase | 0.0558 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0033 | 0.0299 | 0.0292 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0558 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0617 | 0.061 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0033 | 0.0306 | 0.0299 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0558 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0558 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0558 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0558 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.005 | 0.0617 | 0.061 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Onchocerca volvulus | 0.0558 | 1 | 1 | |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0033 | 0.0306 | 0.0299 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0162 | 0.2676 | 0.2671 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0558 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0558 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0558 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0558 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0558 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0617 | 0.061 |
Echinococcus granulosus | aldo keto reductase | 0.0558 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0558 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0558 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0396 | 0.7013 | 0.7011 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0162 | 0.2676 | 0.2194 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0162 | 0.2676 | 0.2676 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0558 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0007 | 0.0007 |
Onchocerca volvulus | 0.0558 | 1 | 1 | |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0162 | 0.2676 | 0.2445 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0033 | 0.0306 | 0.0299 |
Echinococcus granulosus | nervana 2 | 0.0033 | 0.0299 | 0.0292 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0617 | 0.0617 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0162 | 0.2676 | 0.2671 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0558 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0617 | 0.0617 |
Loa Loa (eye worm) | oxidoreductase | 0.0558 | 1 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0033 | 0.0306 | 0.0299 |
Onchocerca volvulus | 0.0558 | 1 | 1 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0558 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0162 | 0.2676 | 0.2671 |
Brugia malayi | NADH-dependent xylose reductase | 0.0162 | 0.2676 | 0.2671 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0617 | 0.0617 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0162 | 0.2676 | 0.2676 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0162 | 0.2676 | 0.2671 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0617 | 0.0617 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0162 | 0.2676 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0007 | 0.0007 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0162 | 0.2676 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0558 | 1 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.0033 | 0.0306 | 0.0299 |
Echinococcus multilocularis | aldehyde reductase | 0.0396 | 0.7013 | 0.7011 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0558 | 1 | 1 |
Onchocerca volvulus | 0.0558 | 1 | 1 | |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0033 | 0.0299 | 0.0292 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0558 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0558 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0558 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0558 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0162 | 0.2676 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0558 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0558 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0162 | 0.2676 | 0.2671 |
Schistosoma mansoni | aldo-keto reductase | 0.0558 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.0033 | 0.0299 | 0.0292 |
Schistosoma mansoni | aldo-keto reductase | 0.0558 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0558 | 1 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0162 | 0.2676 | 0.2671 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0162 | 0.2676 | 0.2676 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0033 | 0.0306 | 0.0299 |
Trypanosoma cruzi | aldo-keto reductase | 0.0558 | 1 | 1 |
Onchocerca volvulus | 0.0558 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase | 0.0558 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0396 | 0.7013 | 0.5922 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0162 | 0.2676 | 0.2194 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0033 | 0.0306 | 0.0299 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0558 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0007 | 0.0007 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0558 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0558 | 1 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0033 | 0.0306 | 0.0299 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0162 | 0.2676 | 0.2676 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.005 | 0.0617 | 0.061 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0033 | 0.0306 | 0.0299 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0558 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0033 | 0.0299 | 0.0292 |
Leishmania major | prostaglandin f synthase, putative | 0.0558 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0558 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0558 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0558 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0162 | 0.2676 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0617 | 0.061 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (functional) | = 0.16 | Ratio of GH release stimulated by 300 ug/kg of compound to that of GH release stimulated by 300 ug/kg of hexarelin in infant rat (sc injection) | ChEMBL. | 12646029 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.