TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.34 | Formula: C20H15F3N2O3
H donors: 1 H acceptors: 2 LogP: 4.21 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1O[C@H](C(=O)N1Cc1cccc(c1)C(F)(F)F)Cc1c[nH]c2c1cccc2
InChi: 1S/C20H15F3N2O3/c21-20(22,23)14-5-3-4-12(8-14)11-25-18(26)17(28-19(25)27)9-13-10-24-16-7-2-1-6-15(13)16/h1-8,10,17,24H,9,11H2/t17-/m0/s1
InChiKey: QXCVZBAXCMOJRS-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tachykinin receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04224 tachykinin receptor 3, putative	Get druggable targets OG5_137770	All targets in OG5_137770

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0084	0.0041
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0658	1	1
Brugia malayi	RNA binding protein	0.0065	0.0764	0.0764
Loa Loa (eye worm)	hypothetical protein	0.005	0.0528	0.0528
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0232	0.3364	0.3364
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0118	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0123	0.0123
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0567	0.859	0.859
Schistosoma mansoni	hypothetical protein	0.0034	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.003
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0202	0.016
Brugia malayi	TAR-binding protein	0.0065	0.0764	0.0764
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0084	0.0055
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0764	0.0764
Schistosoma mansoni	peptidylglycine monooxygenase	0.0123	0.1672	0.1672
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0284	0.0284
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0658	1	1
Schistosoma mansoni	hypothetical protein	0.0307	0.4528	0.4528
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0043	0.0043
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0658	1	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0062	0.0728	0.0728
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0484	0.0484
Entamoeba histolytica	hypothetical protein	0.0023	0.0118	0.0075
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0091	0.1165	0.1127
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0658	1	1
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0084	0.0041
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30	0.0091	0.1165	0.1165
Giardia lamblia	Hypothetical protein	0.0091	0.1165	0.1127
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0123	0.0093
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0567	0.859	0.859
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0764	0.0764
Schistosoma mansoni	ran	0.0021	0.0084	0.0084
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0151	0.0151
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0123	0.008
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0764	0.0764
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0764	0.0764
Mycobacterium tuberculosis	Probable trigger factor (TF) protein Tig	0.0091	0.1165	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.003
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0091	0.1165	0.1127
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-30	0.0091	0.1165	0.1165
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0202	0.0202
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0202	0.0173
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase, putative	0.0091	0.1165	0.1139
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0567	0.859	0.859
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0484	0.0484
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0084	0.0084
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0123	0.008
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0658	1	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0232	0.3364	0.3364
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0658	1	1
Echinococcus granulosus	snurportin 1	0.0307	0.4528	0.4528
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0658	1	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0043	0.0043
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0764	0.0764
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0658	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0151	0.0108
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0528	0.0528
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0484	0.0484
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0484	0.0484
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-13	0.0091	0.1165	0.1165
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0484	0.0484
Trypanosoma brucei	hypothetical protein, conserved	0.0091	0.1165	0.1127
Onchocerca volvulus		0.0091	0.1165	1
Mycobacterium ulcerans	hypothetical protein	0.0091	0.1165	0.1139
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0123	0.0093
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0118	0.0075
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0118	0.0075
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0123	0.0938
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0658	1	1
Entamoeba histolytica	Ran family GTPase	0.0021	0.0084	0.0041
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0232	0.3364	0.3364
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0123	0.0123
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0118	0.0075
Trichomonas vaginalis	fk506-binding protein, putative	0.0091	0.1165	0.1127
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0123	0.008
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0123	0.008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0484	0.0484
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0658	1	1
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0091	0.1165	0.1127
Echinococcus multilocularis	FK506 binding protein 8, 38 kDa	0.0091	0.1165	0.1165
Leishmania major	peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative	0.0091	0.1165	0.1127
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0764	0.0764
Schistosoma mansoni	ran	0.0021	0.0084	0.0084
Echinococcus granulosus	FK506 binding protein 8 38 kDa	0.0091	0.1165	0.1165
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0764	0.0764
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0123	0.008
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0658	1	1
Trichomonas vaginalis	immunophilin, putative	0.0658	1	1
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0658	1	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0123	0.0093
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0658	1	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0084	0.0055
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0084	0.0041
Plasmodium falciparum	importin beta, putative	0.0029	0.0202	0.0173
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0091	0.1165	0.1127
Trichomonas vaginalis	fk506-binding protein, putative	0.0658	1	1
Trypanosoma brucei	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0091	0.1165	0.1127
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0019	0.0044	0.0001
Schistosoma mansoni	fk506 binding protein	0.0091	0.1165	0.1165
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0018	0.0043	0.0043
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0123	0.1672	0.1672
Loa Loa (eye worm)	FKBP5 protein	0.0658	1	1
Toxoplasma gondii	FATC domain-containing protein	0.0025	0.0151	0.0958
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0084	0.0084
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0123	0.0123
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0764	0.0764
Toxoplasma gondii	peptidyl-prolyl isomerase FKBP12, putative	0.0091	0.1165	1
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13	0.0091	0.1165	0.1165
Schistosoma mansoni	immunophilin	0.0567	0.859	0.859
Trichomonas vaginalis	ran, putative	0.0021	0.0084	0.0041
Entamoeba histolytica	hypothetical protein	0.0025	0.0151	0.0108
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0123	0.0093
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0084	0.0041
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0151	0.0108
Schistosoma mansoni	importin beta-1	0.0029	0.0202	0.0202
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0091	0.1165	1
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.1165	0.1127
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0118	0.0075
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0484	0.0484
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0764	0.0764
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0043	0.0043
Echinococcus multilocularis		0.0091	0.1165	0.1165
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0123	0.008
Mycobacterium leprae	PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG	0.0091	0.1165	1
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0764	0.0764
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0123	0.0093
Trypanosoma cruzi	macrophage infectivity potentiator, precursor, putative	0.0091	0.1165	0.1127
Echinococcus multilocularis	snurportin 1	0.0307	0.4528	0.4528
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0232	0.3364	0.3364
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0202	0.0202
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0484	0.0484
Trichomonas vaginalis	fk506-binding protein, putative	0.0091	0.1165	0.1127
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.0091	0.1165	1
Leishmania major	GTP-binding protein, putative	0.0021	0.0084	0.0041
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0123	0.0093
Schistosoma mansoni	hypothetical protein	0.0091	0.1165	0.1165
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0025	0.0151	0.0151
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33	0.0091	0.1165	0.1165
Brugia malayi	RNA, U transporter 1	0.0082	0.1027	0.1027
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0091	0.1165	0.1127
Plasmodium vivax	peptidyl-prolyl cis-trans isomerase, putative	0.0091	0.1165	0.1139
Loa Loa (eye worm)	hypothetical protein	0.0232	0.3364	0.3364
Trypanosoma brucei	macrophage infectivity potentiator, precursor, putative	0.0091	0.1165	0.1127
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.1165	0.1127
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0091	0.1165	0.1127
Echinococcus multilocularis	geminin	0.0142	0.1966	0.1966
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0091	0.1165	1
Leishmania major	fk506-binding protein 1-like protein	0.0658	1	1
Schistosoma mansoni	hypothetical protein	0.0142	0.1966	0.1966
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0658	1	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0043	0.0043
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0091	0.1165	0.1127
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.003	0.013
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1672	0.1672
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0658	1	1
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0091	0.1165	0.5
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0658	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0123	0.0123
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0025	0.0151	0.0108
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0084	0.0367
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0202	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0095	0.0095
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0658	1	1
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0658	1	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0123	0.0938
Echinococcus granulosus	geminin	0.0142	0.1966	0.1966
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0061	0.0699	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.003
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0043	0.0043
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0091	0.1165	0.1127
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0123	0.0093
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0202	0.016
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0019	0.0044	0.0001
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0658	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0123	0.0123
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0528	0.0528
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0091	0.1165	0.5
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0658	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0764	0.0764
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0084	0.0084
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0658	1	1
Trichomonas vaginalis	fk506 binding protein, putative	0.0091	0.1165	0.1127
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1165	0.1165
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0307	0.4528	0.4528
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.003
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0091	0.1165	0.1127
Leishmania major	peptidylprolyl isomerase-like protein	0.0658	1	1
Echinococcus multilocularis	fk506 binding protein	0.0658	1	1
Onchocerca volvulus		0.0091	0.1165	1
Echinococcus granulosus	serine protein kinase ATM	0.0025	0.0151	0.0151
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0123	0.1672	0.1672
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0091	0.1165	0.1127
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0043	0.0043
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0123	0.0093
Schistosoma mansoni	immunophilin	0.0658	1	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-33	0.0091	0.1165	0.1165
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0018	0.0043	0.0043
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0095	0.0052
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0091	0.1165	0.1127
Schistosoma mansoni	immunophilin	0.0658	1	1
Brugia malayi	Importin beta-1 subunit	0.0029	0.0202	0.0202
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0091	0.1165	1
Echinococcus multilocularis	serine protein kinase ATM	0.0025	0.0151	0.0151
Schistosoma mansoni	hypothetical protein	0.0142	0.1966	0.1966
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0018	0.0043	0.0043
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0202	0.1419
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0084	0.0084
Leishmania major	FKBP-type peptidyl-prolyl cis-trans isomerase, putative	0.0091	0.1165	0.1127
Echinococcus granulosus	FK506 binding protein 2	0.0091	0.1165	0.1165
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0123	0.0123
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0658	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.003

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.57	Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]-SP.	ChEMBL.	9733486
Log IC50 (binding)	= 5.57 M	Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]-SP.	ChEMBL.	9733486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 211163