Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 44.8 uM | Inhibition of electric eel AChE pretreated for 20 mins followed by acetylthiocholine iodide substrate addition measured for 5 mins by Ellman's method | LITERATURE. | 27688184 |
Inhibition (binding) | = 10 % | Inhibition of horse serum BChE at 10 uM pretreated for 20 mins followed by butyrylthiocholine iodide substrate addition measured for 5 mins by Ellman's method relative to control | LITERATURE. | 27688184 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.