Detailed information for compound 211489

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 794.942 | Formula: C42H54N10O6
  • H donors: 9 H acceptors: 6 LogP: 2.07 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCC1CC(=O)N[C@@H](Cc2ccc3c(c2)cccc3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(=O)N[C@H](CCCCNC1=O)C(=O)N)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C42H54N10O6/c1-2-26-23-36(53)49-34(21-25-16-17-27-10-3-4-11-28(27)20-25)40(57)51-33(15-9-19-47-42(44)45)39(56)52-35(22-29-24-48-31-13-6-5-12-30(29)31)41(58)50-32(37(43)54)14-7-8-18-46-38(26)55/h3-6,10-13,16-17,20,24,26,32-35,48H,2,7-9,14-15,18-19,21-23H2,1H3,(H2,43,54)(H,46,55)(H,49,53)(H,50,58)(H,51,57)(H,52,56)(H4,44,45,47)/t26?,32-,33+,34+,35-/m1/s1
  • InChiKey: XFQWSJOXRAVFGY-YQEGVIHVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 3 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 5 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein melanocortin 5 receptor 325 aa 311 aa 20.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0201 0.0543
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0166
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0051
Brugia malayi nuclear hormone receptor 0.0013 0.0014 0.0032
Onchocerca volvulus 0.0013 0.0014 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0079 0.0208
Brugia malayi Muscleblind-like protein 0.0144 0.058 0.1561
Echinococcus multilocularis serotonin receptor 0.0057 0.0201 0.0201
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0201 0.0543
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0079 0.0215
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0022 0.0052 0.115
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Plasmodium falciparum glutathione reductase 0.0023 0.0056 0.1371
Schistosoma mansoni inositol transporter 0.0022 0.0054 0.0145
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus multilocularis protoporphyrinogen oxidase 0.0029 0.0081 0.0081
Toxoplasma gondii Na+/H+ exchanger NHE3 0.0011 0.0003 0.0066
Echinococcus multilocularis dro:myosuppressin receptor 0.0057 0.0201 0.0201
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0057 0.0201 0.0201
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.005 0.0127
Loa Loa (eye worm) TYRA-2 protein 0.0057 0.0201 0.0537
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0029 0.0081 0.1995
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0112 0.0303
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0201 0.0537
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0057 0.0201 0.0543
Onchocerca volvulus 0.0013 0.0014 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0865 0.3699 1
Loa Loa (eye worm) hypothetical protein 0.0516 0.219 0.5917
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0212
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0056 0.0199 0.0531
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0076 0.0285 0.0763
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0079 0.0215
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0022 0.0052 0.0283
Trypanosoma cruzi DNA polymerase eta, putative 0.0011 0.0005 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0079 0.0215
Echinococcus multilocularis dna polymerase kappa 0.0011 0.0005 0.0005
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0063 0.0231 0.0231
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0022 0.0052 0.1267
Brugia malayi Calcitonin receptor-like protein seb-1 0.0516 0.219 0.5917
Mycobacterium ulcerans oxidoreductase 0.0029 0.0081 0.0455
Brugia malayi hypothetical protein 0.0057 0.0201 0.0537
Schistosoma mansoni terminal deoxycytidyl transferase 0.0011 0.0005 0.0015
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0257 0.1069 0.1069
Echinococcus multilocularis neuropeptide s receptor 0.0057 0.0201 0.0201
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0079 0.0208
Echinococcus granulosus dna polymerase eta 0.0011 0.0005 0.0015
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0011 0.0005 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.024 0.0649
Schistosoma mansoni hypothetical protein 0.0163 0.0663 0.1793
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0061 0.0166
Onchocerca volvulus 0.0046 0.0154 0.079
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0023 0.0055
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0208
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0201 0.0543
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0107 0.0418 0.2164
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0353
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0057 0.0201 0.0537
Schistosoma mansoni hypothetical protein 0.0134 0.0535 0.1445
Brugia malayi Latrophilin receptor protein 2 0.0163 0.0663 0.1787
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0112 0.0303
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0003 0.0003
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0057 0.0201 0.0201
Plasmodium falciparum thioredoxin reductase 0.0023 0.0056 0.1371
Loa Loa (eye worm) hypothetical protein 0.0056 0.0199 0.0531
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus granulosus 7tm_1 domain containing protein 0.0057 0.0201 0.0543
Brugia malayi Intermediate filament tail domain containing protein 0.0076 0.0285 0.0763
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0022 0.0054 0.0145
Trypanosoma brucei PAB1-binding protein , putative 0.0104 0.0407 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0112 0.2755
Echinococcus multilocularis smad 0.0024 0.0061 0.0061
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0014 0.0016 0.0076
Brugia malayi MH2 domain containing protein 0.0011 0.0003 0.0002
Onchocerca volvulus 0.0029 0.0081 0.0408
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0201 0.0543
Trypanosoma cruzi DNA polymerase kappa, putative 0.0011 0.0005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0174 0.0711 0.1917
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0201 0.0201
Schistosoma mansoni amine GPCR 0.0057 0.0201 0.0543
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.002 0.0044 0.0366
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0056 0.0199 0.0538
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0079 0.04
Echinococcus granulosus tachykinin peptides receptor 99D 0.0057 0.0201 0.0543
Brugia malayi conserved hypotetical protein 0.0013 0.0014 0.0032
Schistosoma mansoni alkaline phosphatase 0.0257 0.1069 0.289
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0058 0.0208 0.1285
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0014 0.0039
Trichomonas vaginalis sucrase-isomaltase, putative 0.0018 0.0032 0.0272
Brugia malayi nuclear hormone receptor 0.0028 0.0079 0.0208
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0166 0.4034
Echinococcus granulosus L aminoadipate semialdehyde 0.0049 0.0167 0.0452
Echinococcus granulosus neutral alpha glucosidase AB 0.0018 0.0032 0.0088
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0057 0.0201 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Brugia malayi Inositol-1 0.0022 0.0052 0.0132
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0029 0.0081 0.0081
Brugia malayi ecdysone receptor 0.0013 0.0014 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.0407 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0166 0.4034
Trichomonas vaginalis set domain proteins, putative 0.0285 0.1192 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus granulosus sodium:myo inositol cotransporter 0.0022 0.0054 0.0145
Schistosoma mansoni hypothetical protein 0.0057 0.0201 0.0543
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0057 0.0201 0.0537
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0112 0.0303
Schistosoma mansoni neuropeptide f receptor 76f 0.0057 0.0201 0.0543
Loa Loa (eye worm) NHE-3 0.0056 0.0199 0.0531
Brugia malayi steroid hormone receptor 0.0028 0.0079 0.0208
Schistosoma mansoni biogenic amine receptor 0.0057 0.0201 0.0543
Schistosoma mansoni hypothetical protein 0.003 0.0086 0.0232
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0049 0.0167 0.0445
Toxoplasma gondii sodium/hydrogen exchanger 3 protein 0.0011 0.0003 0.0066
Schistosoma mansoni myelin transcription factor 1 myt1 0.0122 0.0482 0.1304
Echinococcus granulosus sex peptide receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) TAR-binding protein 0.0865 0.3699 1
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0025 0.0063 0.017
Mycobacterium ulcerans dehydrogenase 0.0029 0.0081 0.0455
Brugia malayi neuropeptide F receptor 0.0057 0.0201 0.0537
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0163 0.0663 0.1787
Echinococcus granulosus intestinal type alkaline phosphatase 0.0257 0.1069 0.289
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0014 0.0016 0.0387
Brugia malayi hypothetical protein 0.0015 0.0021 0.0051
Echinococcus multilocularis survival motor neuron protein 1 0.0146 0.059 0.059
Echinococcus multilocularis Furin 1 0.0025 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0014 0.0016 0.2667
Echinococcus multilocularis dna polymerase eta 0.0011 0.0005 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0516 0.219 0.5917
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0057 0.0201 0.0543
Echinococcus multilocularis solute carrier family 5 0.0022 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0014 0.0039
Plasmodium vivax SET domain protein, putative 0.0036 0.0112 0.2755
Trypanosoma cruzi UDP-galactopyranose mutase 0.0029 0.0081 0.1941
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0201 0.0543
Schistosoma mansoni sodium/solute symporter 0.0022 0.0054 0.0145
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0014 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0029 0.0081 0.049
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Brugia malayi ecdysteroid receptor 0.0028 0.0079 0.0208
Brugia malayi nuclear receptor RXR 0.0015 0.0021 0.0051
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0014 0.0016 0.0387
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Brugia malayi hypothetical protein 0.0015 0.0021 0.0051
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0201 0.0543
Trichomonas vaginalis alpha-glucosidase, putative 0.0018 0.0032 0.0272
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0057 0.0201 0.0537
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0061 0.0166
Schistosoma mansoni neuropeptide receptor 0.0057 0.0201 0.0543
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0106 0.0288
Echinococcus granulosus sodium:glucose cotransporter 2 0.0022 0.0054 0.0145
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0051
Schistosoma mansoni amine GPCR 0.0057 0.0201 0.0543
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0018 0.0032 0.0272
Toxoplasma gondii thioredoxin reductase 0.0023 0.0056 0.1371
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.0407 1
Schistosoma mansoni smad 0.0024 0.0061 0.0166
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0425 0.1796 0.1796
Onchocerca volvulus 0.0036 0.0112 0.057
Schistosoma mansoni growth hormone secretagogue receptor 0.0057 0.0201 0.0543
Onchocerca volvulus Neuropeptide F receptor homolog 0.0057 0.0201 0.1032
Echinococcus granulosus GPCR family 2 0.0163 0.0663 0.1793
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.002 0.0044 0.0366
Brugia malayi ORL1-like opioid receptor 0.0057 0.0201 0.0537
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0018 0.0032 0.008
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0003 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0014 0.0016 0.0634
Toxoplasma gondii histone lysine-specific demethylase 0.0029 0.0081 0.1995
Brugia malayi Melatonin receptor type 1A 0.0057 0.0201 0.0537
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0163 0.0663 0.0663
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0029 0.0081 0.1995
Schistosoma mansoni tar DNA-binding protein 0.0865 0.3699 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0057 0.0201 0.0537
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.002 0.0044 0.0366
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0201 0.0543
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0056 0.0199 0.0538
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0079 0.0215
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Onchocerca volvulus 0.0057 0.0201 0.1032
Echinococcus granulosus neuropeptide receptor 0.0057 0.0201 0.0543
Onchocerca volvulus 0.0022 0.0054 0.0265
Brugia malayi follicle stimulating hormone receptor 0.0057 0.0201 0.0537
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.005 0.1222
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0166
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0201 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0079 0.0208
Echinococcus granulosus neuropeptide receptor 0.0057 0.0201 0.0543
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0014 0.0014
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0011 0.0005 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0079 0.0208
Leishmania major hypothetical protein, conserved 0.0104 0.0407 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0029 0.0081 0.1995
Brugia malayi mbt repeat family protein 0.0107 0.0418 0.1125
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0201 0.0543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0201 0.0543
Onchocerca volvulus 0.0057 0.0201 0.1032
Brugia malayi MH1 domain containing protein 0.0024 0.0061 0.0159
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0022 0.0054 0.0054
Echinococcus multilocularis muscleblind protein 1 0.0144 0.058 0.058
Loa Loa (eye worm) glutathione reductase 0.0023 0.0056 0.0144
Plasmodium vivax sodium/hydrogen exchanger 1, putative 0.0011 0.0003 0.0066
Loa Loa (eye worm) endoprotease bli-4 0.0104 0.0407 0.1095
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0018 0.0032 0.1465
Loa Loa (eye worm) STAT protein 0.0098 0.0379 0.1019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0296
Brugia malayi RE15519p 0.0057 0.0201 0.0537
Giardia lamblia High cysteine membrane protein Group 2 0.0039 0.0124 0.6231
Echinococcus multilocularis sex peptide receptor 0.0057 0.0201 0.0201
Echinococcus granulosus survival motor neuron protein 1 0.0146 0.059 0.1595
Loa Loa (eye worm) hypothetical protein 0.0221 0.0911 0.2457
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0208
Entamoeba histolytica hypothetical protein 0.0061 0.0221 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0163 0.0663 0.1793
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0022 0.0052 0.0433
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0066 0.024 0.0649
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0166
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0023 0.0055
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0056 0.0199 0.0199
Schistosoma mansoni Smad4 0.0011 0.0003 0.0009
Brugia malayi RNA binding protein 0.0865 0.3699 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0014 0.0016 0.0387
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0066 0.024 0.024
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0425 0.1796 0.4854
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0166 0.4073
Brugia malayi isocitrate dehydrogenase 0.0048 0.0166 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Schistosoma mansoni alpha glucosidase 0.0018 0.0032 0.0088
Echinococcus granulosus alpha 1A adrenergic receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) latrophilin receptor protein 2 0.0163 0.0663 0.1787
Schistosoma mansoni tar DNA-binding protein 0.0865 0.3699 1
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0023 0.0507
Onchocerca volvulus Huntingtin homolog 0.0221 0.0911 0.4728
Schistosoma mansoni hypothetical protein 0.0653 0.2783 0.7525
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.005 0.2498
Echinococcus granulosus G protein coupled receptor 139 0.0057 0.0201 0.0543
Brugia malayi Dopamine receptor protein 1 0.0057 0.0201 0.0537
Schistosoma mansoni ap endonuclease 0.0022 0.005 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Echinococcus granulosus SAM and MBT domain containing protein 0.0107 0.0418 0.1131
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.002 0.0044 0.0118
Schistosoma mansoni coup transcription factor 0.0028 0.0079 0.0215
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.005 0.1105
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0066 0.024 0.0643
Echinococcus granulosus sodium:hydrogen exchanger 0.0056 0.0199 0.0538
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0079 0.0215
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0079 0.0208
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0029 0.0081 0.1995
Schistosoma mansoni opsin-like receptor 0.0057 0.0201 0.0543
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0201 0.0543
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0014 0.0016 0.0081
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0014 0.0061
Leishmania major trypanothione reductase 0.0023 0.0056 0.1313
Echinococcus multilocularis 0.0084 0.032 0.032
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0014 0.0032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0011 0.0005 0.0066
Giardia lamblia DINP protein human, muc B family 0.0011 0.0005 0.027
Echinococcus multilocularis muscleblind protein 0.0144 0.058 0.058
Brugia malayi hypothetical protein 0.0146 0.059 0.1589
Brugia malayi N-terminal motif family protein 0.0174 0.0711 0.1917
Onchocerca volvulus 0.0057 0.0201 0.1032
Onchocerca volvulus 0.003 0.0086 0.0432
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0061 0.0221 0.0598
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0057 0.0201 0.0201
Brugia malayi hypothetical protein 0.0057 0.0201 0.0537
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0011 0.0005 0.0015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0231 0.1935
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0166 0.4073
Brugia malayi Glycosyl hydrolases family 31 protein 0.0018 0.0032 0.008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0166 0.0166
Entamoeba histolytica hypothetical protein 0.0061 0.0221 1
Brugia malayi RNA recognition motif domain containing protein 0.0865 0.3699 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0166 0.3994
Brugia malayi G-protein coupled receptor 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0208
Loa Loa (eye worm) hypothetical protein 0.0122 0.0482 0.1298
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0061 0.0221 0.0221
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0201 0.0201
Schistosoma mansoni hypothetical protein 0.0057 0.0201 0.0543
Schistosoma mansoni hypothetical protein 0.0376 0.1583 0.4278
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0166 0.4073
Loa Loa (eye worm) hypothetical protein 0.0049 0.0167 0.0445
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0201 0.0201
Echinococcus granulosus hypothetical protein 0.0057 0.0201 0.0543
Entamoeba histolytica deoxycytidyl transferase, putative 0.0011 0.0005 0.0243
Entamoeba histolytica hypothetical protein 0.0061 0.0221 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0052 0.0183 0.877
Loa Loa (eye worm) hypothetical protein 0.0353 0.1483 0.4005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0063 0.0528
Brugia malayi hypothetical protein 0.0029 0.0081 0.0212
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0104 0.0407 0.1101
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.005 0.0134
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0056 0.0199 0.0531
Loa Loa (eye worm) hypothetical protein 0.0104 0.0407 0.1095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0079 0.0208
Schistosoma mansoni myosin xvIII 0.0057 0.0201 0.0543
Schistosoma mansoni hypothetical protein 0.0163 0.0663 0.1793
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.0763
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0063 0.0528
Onchocerca volvulus 0.0057 0.0201 0.1032
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0079 0.0215
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0079 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Schistosoma mansoni sex comb on midleg homolog 0.0107 0.0418 0.1131
Plasmodium vivax ataxin-2 like protein, putative 0.0104 0.0407 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0021 0.0058
Schistosoma mansoni opsin-like receptor 0.0057 0.0201 0.0543
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0052 0.0183 0.1127
Loa Loa (eye worm) MH2 domain-containing protein 0.0356 0.1497 0.4042
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0014 0.0039
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0201 0.0537
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0079 0.0215
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0021 0.0058
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0014 0.0032
Echinococcus multilocularis serotonin receptor 0.0057 0.0201 0.0201
Leishmania major DNA polymerase eta, putative 0.0011 0.0005 0.0066
Schistosoma mansoni lamin 0.0076 0.0285 0.077
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.005 0.0273
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0057 0.0201 0.0201
Echinococcus multilocularis neuropeptide receptor A26 0.0057 0.0201 0.0201
Trichomonas vaginalis inositol monophosphatase, putative 0.0022 0.0052 0.0433
Echinococcus granulosus neuropeptide s receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus multilocularis orexin receptor type 2 0.0057 0.0201 0.0201
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0022 0.0054 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0057 0.0201 0.0201
Loa Loa (eye worm) RNA binding protein 0.0865 0.3699 1
Brugia malayi endoprotease bli-4 precursor 0.0104 0.0407 0.1095
Schistosoma mansoni hypothetical protein 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus multilocularis G protein coupled receptor 139 0.0057 0.0201 0.0201
Brugia malayi SWIRM domain containing protein 0.0029 0.0081 0.0212
Brugia malayi putative neuropeptide receptor 0.0057 0.0201 0.0537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0201 0.0543
Schistosoma mansoni tar DNA-binding protein 0.0865 0.3699 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0201 0.0201
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0079 0.0215
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0018 0.0032 0.0272
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0208
Echinococcus granulosus intermediate filament protein 0.0076 0.0285 0.077
Brugia malayi Pre-SET motif family protein 0.0251 0.1042 0.2811
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0201 0.0201
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0066 0.024 0.0643
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0079 0.0215
Echinococcus granulosus g-protein coupled receptor 0.0057 0.0201 0.0543
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0516 0.219 0.5917
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0107 0.0418 0.1131
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0056 0.0199 0.0199
Echinococcus multilocularis musashi 0.0076 0.0285 0.0285
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0079 0.0215
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0079 0.0215
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0166 0.0166
Brugia malayi hypothetical protein 0.0057 0.0201 0.0537
Onchocerca volvulus 0.0057 0.0201 0.1032
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0057 0.0201 0.0543
Leishmania major DNA polymerase kappa, putative 0.0011 0.0005 0.0066
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0201 0.0543
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0122 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus g protein coupled receptor 0.0057 0.0201 0.0543
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.038 0.1603 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0063 0.0528
Brugia malayi Thioredoxin reductase 0.0023 0.0056 0.0144
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0007
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0023 0.0507
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0201 0.0201
Trypanosoma brucei trypanothione reductase 0.0023 0.0056 0.1256
Trichomonas vaginalis alpha-glucosidase, putative 0.0018 0.0032 0.0272
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.0407 1
Echinococcus multilocularis alkaline phosphatase 0.0257 0.1069 0.1069
Echinococcus multilocularis somatostatin receptor 0.0057 0.0201 0.0201
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0011 0.0005 0.0005
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0056 0.0199 0.1022
Echinococcus granulosus g protein coupled receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0079 0.0208
Echinococcus granulosus neuropeptide FF receptor 2 0.0057 0.0201 0.0543
Schistosoma mansoni DNA polymerase eta 0.0011 0.0005 0.0015
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0014 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0066 0.024 0.024
Echinococcus granulosus lysine specific histone demethylase 1A 0.0029 0.0081 0.0219
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0079 0.0208
Loa Loa (eye worm) hypothetical protein 0.0144 0.058 0.1561
Brugia malayi nuclear receptor NHR-88 0.0013 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0212
Mycobacterium tuberculosis Probable oxidoreductase 0.0058 0.0208 0.1285
Loa Loa (eye worm) hypothetical protein 0.0163 0.0663 0.1787
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0287
Leishmania major cytochrome p450-like protein 0.0015 0.0023 0.0507
Brugia malayi G-protein coupled receptor 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0208
Echinococcus granulosus dro:myosuppressin receptor 0.0057 0.0201 0.0543
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0201 0.0201
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0122 0.0482 0.1298
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0014 0.0039
Schistosoma mansoni hypothetical protein 0.0163 0.0663 0.1793
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0201 0.0543
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0257 0.1069 0.289
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0021 0.0051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.005 0.1163
Echinococcus granulosus muscleblind protein 0.0144 0.058 0.1567
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0057 0.0201 0.0201
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0014 0.0014
Echinococcus multilocularis thioredoxin glutathione reductase 0.0023 0.0056 0.0056
Plasmodium falciparum sodium/hydrogen exchanger, Na+, H+ antiporter 0.0011 0.0003 0.0066
Echinococcus multilocularis neutral alpha glucosidase AB 0.0018 0.0032 0.0032
Echinococcus multilocularis sodium:hydrogen exchanger 7 0.0011 0.0003 0.0003
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0057 0.0201 0.0537
Loa Loa (eye worm) MBCTL1 0.0122 0.0482 0.1298
Echinococcus granulosus peptide allatostatin:somatostatin 0.0057 0.0201 0.0543
Brugia malayi nuclear receptor NHR-88 0.0028 0.0079 0.0208
Brugia malayi hypothetical protein 0.0057 0.0201 0.0537
Brugia malayi Dopamine receptor protein 2 0.0057 0.0201 0.0537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0057 0.0201 0.0537
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0079 0.0079
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.0407 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0079 0.0215
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0021 0.0021
Brugia malayi Pre-SET motif family protein 0.0036 0.0112 0.0296
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0079 0.04
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0201 0.0201
Brugia malayi hypothetical protein 0.0057 0.0201 0.0537
Brugia malayi MH1 domain containing protein 0.0024 0.0061 0.0159
Brugia malayi hypothetical protein 0.0057 0.0201 0.0537
Brugia malayi amine oxidase, flavin-containing family protein 0.0029 0.0081 0.0212
Schistosoma mansoni nuclear receptor 0.0013 0.0014 0.0039
Echinococcus multilocularis GPCR, family 2 0.0163 0.0663 0.0663
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.0711 0.3689
Loa Loa (eye worm) melatonin receptor type 1A 0.0057 0.0201 0.0537
Brugia malayi nuclear receptor RXR 0.0013 0.0014 0.0032
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0158 0.0158
Onchocerca volvulus 0.0057 0.0201 0.1032
Echinococcus granulosus mitochondrial sodium:hydrogen exchanger 9B2 0.0011 0.0003 0.0007
Echinococcus multilocularis histone acetyltransferase MYST2 0.0122 0.0482 0.0482
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0166 0.0166
Onchocerca volvulus 0.0057 0.0201 0.1032
Echinococcus granulosus orexin receptor type 2 0.0057 0.0201 0.0543
Brugia malayi Dopamine receptor 0.0057 0.0201 0.0537
Schistosoma mansoni ap endonuclease 0.0022 0.005 0.0134
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0045 0.0153 0.0413
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0079 0.0215
Schistosoma mansoni nuclear receptor 0.0013 0.0014 0.0039
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Schistosoma mansoni alpha-glucosidase 0.0068 0.0251 0.0679
Loa Loa (eye worm) hypothetical protein 0.0144 0.058 0.1561
Onchocerca volvulus 0.0107 0.0418 0.2164
Echinococcus multilocularis 0.0029 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Schistosoma mansoni zinc finger protein 0.0013 0.0014 0.0039
Schistosoma mansoni neuropeptide receptor 0.0057 0.0201 0.0543
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0409 0.1727 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0061 0.0159
Onchocerca volvulus Huntingtin homolog 0.0221 0.0911 0.4728
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0201 0.0543
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0029 0.0081 0.3815
Schistosoma mansoni sodium/hydrogen exchanger 3 (nhe3) 0.0011 0.0003 0.0007
Schistosoma mansoni amine oxidase 0.0029 0.0081 0.0219
Loa Loa (eye worm) hypothetical protein 0.0074 0.0279 0.0747
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0063 0.0528
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.0056 0.0199 0.0531
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0231 0.1935
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0057 0.0201 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0201 0.0201
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0014 0.0016 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0079 0.0208
Loa Loa (eye worm) transcription factor SMAD2 0.0356 0.1497 0.4042
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0079 0.0208
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0201 0.0543
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0201 0.0543
Mycobacterium ulcerans DNA polymerase IV 0.0011 0.0005 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0018 0.0032 0.0272
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0021 0.0051
Echinococcus granulosus lysine specific histone demethylase 1A 0.0029 0.0081 0.0219
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus granulosus somatostatin receptor 0.0057 0.0201 0.0543
Brugia malayi putative neuropeptide receptor NPR1 0.0057 0.0201 0.0537
Brugia malayi hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus alkaline phosphatase 0.0257 0.1069 0.289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.024 0.0649
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0079 0.0215
Schistosoma mansoni opsin-like receptor 0.0057 0.0201 0.0543
Schistosoma mansoni tar DNA-binding protein 0.0865 0.3699 1
Brugia malayi cytoplasmic intermediate filament protein 0.0041 0.0132 0.0351
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0166 0.0448
Onchocerca volvulus 0.0028 0.0079 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0051
Brugia malayi celfurPC protein 0.0084 0.032 0.0859
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0014 0.0032
Echinococcus multilocularis high affinity choline transporter 1 0.0204 0.0838 0.0838
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0201 0.0201
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0014 0.0039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0138
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0081 0.1995
Onchocerca volvulus 0.0057 0.0201 0.1032
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0079 0.0079
Onchocerca volvulus 0.0057 0.0201 0.1032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0079 0.0208
Leishmania major UDP-galactopyranose mutase 0.0029 0.0081 0.1941
Mycobacterium ulcerans monoamine oxidase 0.0029 0.0081 0.0455
Echinococcus granulosus thioredoxin glutathione reductase 0.0023 0.0056 0.0151
Onchocerca volvulus 0.0057 0.0201 0.1032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0022 0.0052 0.0433
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0079 0.0215
Schistosoma mansoni inositol transporter 0.0022 0.0054 0.0145
Echinococcus multilocularis inositol monophosphatase 1 0.0022 0.0052 0.0052
Schistosoma mansoni adenoreceptor 0.0057 0.0201 0.0543
Echinococcus granulosus high affinity choline transporter 1 0.0204 0.0838 0.2265
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0201 0.0543
Echinococcus multilocularis SAM and MBT domain containing protein 0.0107 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0208
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0201 0.0201
Schistosoma mansoni inositol monophosphatase 0.0022 0.0052 0.0139
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0014 0.0014
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0014 0.0039
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus Furin 1 0.0025 0.0063 0.017
Trypanosoma brucei glucosidase, putative 0.0018 0.0032 0.0673
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0079 0.04
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0014 0.0039
Schistosoma mansoni hypothetical protein 0.0057 0.0201 0.0543
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Trichomonas vaginalis DNA polymerase eta, putative 0.0011 0.0005 0.0045
Brugia malayi G protein-coupled receptor F59B2.13 0.0057 0.0201 0.0537
Echinococcus multilocularis lysosomal alpha glucosidase 0.0079 0.0299 0.0299
Brugia malayi intermediate filament protein 0.0076 0.0285 0.0763
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0079 0.0079
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0079 0.0079
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.005 0.1222
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0079 0.0215
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0057 0.0201 0.0537
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.005 0.0294
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.005 0.9624
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0079 0.0208
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0066 0.024 0.0649
Entamoeba histolytica hypothetical protein 0.0014 0.0016 0.0711
Echinococcus multilocularis g-protein coupled receptor 0.0057 0.0201 0.0201
Plasmodium falciparum protoporphyrinogen oxidase 0.0029 0.0081 0.1995
Brugia malayi GnHR receptor homolog 0.0057 0.0201 0.0537
Echinococcus multilocularis mitochondrial sodium:hydrogen exchanger 9B2 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0104 0.0407 0.1093
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0201 0.0543
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0257 0.1069 0.289
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0079 0.0208
Loa Loa (eye worm) nuclear factor I 0.0013 0.0014 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0201 0.0543
Trichomonas vaginalis hypothetical protein 0.002 0.0044 0.0366
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.002 0.0042 0.0243
Toxoplasma gondii LsmAD domain-containing protein 0.0104 0.0407 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0021 0.0051
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0003 0.0002
Mycobacterium tuberculosis Probable reductase 0.0052 0.0183 0.1127
Brugia malayi hypothetical protein 0.0057 0.0201 0.0537
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0014 0.0014
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0023 0.0444
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0079 0.0208
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0204 0.0838 0.2259
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0014 0.0039
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0011 0.0005 0.0066
Leishmania major phosphopantetheinyl transferase-like protein 0.0014 0.0016 0.0322
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Mycobacterium tuberculosis Conserved hypothetical protein 0.0011 0.0005 0.0017
Brugia malayi hypothetical protein 0.0057 0.0201 0.0537
Schistosoma mansoni lamin 0.0076 0.0285 0.077
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0201 0.0543
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0166 0.3994
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0057 0.0201 0.0543
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0029 0.0081 0.0219
Plasmodium vivax glutathione reductase, putative 0.0023 0.0056 0.1371
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0057 0.0201 0.0537
Giardia lamblia Furin precursor putative serine protease 0.002 0.0044 0.2194
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0022 0.0052 0.1209
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0014 0.0039
Echinococcus granulosus neuropeptide receptor A26 0.0057 0.0201 0.0543
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0166 0.0166
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0409 0.1727 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0018 0.0032 0.0796
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0201 0.0543
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0014 0.0014
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0201 0.0537
Brugia malayi hypothetical protein 0.0067 0.0247 0.0661
Onchocerca volvulus 0.0057 0.0201 0.1032
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0201 0.0201
Brugia malayi hypothetical protein 0.0057 0.0201 0.0537
Echinococcus multilocularis lamin 0.0076 0.0285 0.0285
Echinococcus multilocularis tar DNA binding protein 0.0865 0.3699 0.3699
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0061 0.0061
Echinococcus multilocularis neuropeptide FF receptor 2 0.0057 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0079 0.0208
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0049 0.0167 0.0452
Giardia lamblia Sodium/hydrogen exchanger 3 0.0056 0.0199 1
Brugia malayi mbt repeat family protein 0.0107 0.0418 0.1125
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0079 0.0079
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.005 0.0417
Loa Loa (eye worm) Smad1 0.0024 0.0061 0.0159
Schistosoma mansoni sodium/hydrogen exchanger 0.0056 0.0199 0.0538
Onchocerca volvulus 0.0285 0.1192 0.619
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Brugia malayi MH2 domain containing protein 0.0024 0.0061 0.0159
Brugia malayi ImpB/MucB/SamB family protein 0.0011 0.0005 0.0007
Echinococcus multilocularis G-protein coupled receptor, putative 0.0057 0.0201 0.0201
Brugia malayi MH1 domain containing protein 0.0013 0.0014 0.0032
Echinococcus granulosus serotonin receptor 0.0057 0.0201 0.0543
Schistosoma mansoni hypothetical protein 0.0163 0.0663 0.1793
Echinococcus multilocularis polycomb protein SCMH1 0.0107 0.0418 0.0418
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0201 0.0543
Echinococcus granulosus fmrfamide receptor 0.0057 0.0201 0.0543
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0021 0.0058
Schistosoma mansoni alkaline phosphatase 0.0257 0.1069 0.289
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0257 0.1069 0.1069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0063 0.0528
Brugia malayi ImpB/MucB/SamB family protein 0.0011 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0057 0.0201 0.0201
Brugia malayi hypothetical protein 0.0013 0.0014 0.0032
Onchocerca volvulus 0.0057 0.0201 0.1032
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0037 0.0115 0.031
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0052 0.0183 0.1127
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0032 0.0735
Echinococcus granulosus tar DNA binding protein 0.0865 0.3699 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0029 0.0081 0.1995
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0122 0.0482 0.1304
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0208
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.024 0.0649
Schistosoma mansoni alpha-glucosidase 0.0068 0.0251 0.0679
Trichomonas vaginalis alpha-glucosidase, putative 0.0018 0.0032 0.0272
Echinococcus granulosus lamin 0.0076 0.0285 0.077
Schistosoma mansoni amine GPCR 0.0057 0.0201 0.0543
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0058 0.0208 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.002 0.0042 0.1891
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0055
Schistosoma mansoni intermediate filament proteins 0.0076 0.0285 0.077
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0079 0.0215
Loa Loa (eye worm) mbt repeat family protein 0.0107 0.0418 0.1125
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0011 0.0005 0.0045
Leishmania major alpha glucosidase II subunit, putative 0.0018 0.0032 0.0735
Schistosoma mansoni amine GPCR 0.0057 0.0201 0.0543
Mycobacterium tuberculosis Possible oxidoreductase 0.0029 0.0081 0.049
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0079 0.0208
Echinococcus multilocularis allatostatin A receptor 0.0057 0.0201 0.0201
Mycobacterium ulcerans DNA polymerase IV 0.0011 0.0005 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0201 0.0543
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0201 0.0201
Entamoeba histolytica sodium/proton antiporter, putative 0.0011 0.0003 0.0122
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0061 0.0159
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0014 0.0032
Brugia malayi neuropeptide F receptor 0.0057 0.0201 0.0537
Echinococcus granulosus dna polymerase kappa 0.0011 0.0005 0.0015
Brugia malayi G protein-coupled receptor 0.0057 0.0201 0.0537
Brugia malayi GH02984p 0.0204 0.0838 0.2259
Schistosoma mansoni survival motor neuron protein 0.003 0.0086 0.0232
Onchocerca volvulus 0.0049 0.0167 0.0857
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0037 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0051
Echinococcus granulosus g protein coupled receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0079 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0079 0.0208
Echinococcus granulosus geminin 0.0376 0.1583 0.4278
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0201 0.0543
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0057 0.0201 0.0543
Schistosoma mansoni Smad4 0.0011 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0007
Schistosoma mansoni biogenic amine receptor 0.0057 0.0201 0.0543
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0022 0.0052 0.2332
Onchocerca volvulus 0.0076 0.0285 0.1468
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0051
Schistosoma mansoni histamine h1 receptor 0.0057 0.0201 0.0543
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0022 0.0052 0.1209
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Brugia malayi Serotonin receptor 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Trypanosoma cruzi DNA polymerase kappa, putative 0.0011 0.0005 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0079 0.0079
Loa Loa (eye worm) sodium/hydrogen exchanger 0.0056 0.0199 0.0531
Onchocerca volvulus 0.0057 0.0201 0.1032
Brugia malayi hypothetical protein 0.0057 0.0201 0.0537
Echinococcus granulosus histone acetyltransferase MYST2 0.0122 0.0482 0.1304
Echinococcus granulosus furin 0.0104 0.0407 0.1101
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Trichomonas vaginalis maltase-glucoamylase, putative 0.0018 0.0032 0.0272
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0003 0.0002
Toxoplasma gondii sodium/hydrogen exchanger NHE2 0.0011 0.0003 0.0066
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0201 0.0201
Loa Loa (eye worm) intermediate filament protein 0.0076 0.0285 0.0763
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.005 0.0417
Loa Loa (eye worm) hypothetical protein 0.0146 0.059 0.1589
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Onchocerca volvulus 0.0057 0.0201 0.1032
Brugia malayi STAT protein, DNA binding domain containing protein 0.0098 0.0379 0.1019
Brugia malayi MH2 domain containing protein 0.0356 0.1497 0.4042
Brugia malayi latrophilin 2 splice variant baaae 0.0353 0.1483 0.4005
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0057 0.0201 0.0543
Schistosoma mansoni sex comb on midleg homolog 0.0107 0.0418 0.1131
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus multilocularis geminin 0.0376 0.1583 0.1583
Echinococcus granulosus inositol monophosphatase 1 0.0022 0.0052 0.0139
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0201 0.0201
Brugia malayi hypothetical protein 0.0104 0.0407 0.1093
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0029 0.0081 0.0455
Loa Loa (eye worm) proprotein convertase 2 0.0025 0.0063 0.0163
Brugia malayi Glycosyl hydrolases family 31 protein 0.0079 0.0299 0.0801
Onchocerca volvulus 0.0057 0.0201 0.1032
Echinococcus multilocularis neuroendocrine convertase 2 0.0065 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0061 0.0221 0.0598
Echinococcus granulosus 7TM GPCR rhodopsin 0.0057 0.0201 0.0543
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0003 0.0002
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0057 0.0201 0.0537
Echinococcus granulosus solute carrier family 5 0.0022 0.0054 0.0145
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0163 0.0663 0.0663
Schistosoma mansoni transcription factor LCR-F1 0.0061 0.0221 0.0598
Echinococcus granulosus lysosomal alpha glucosidase 0.0079 0.0299 0.0808
Toxoplasma gondii Na+/H+ exchanger NHE1 0.0011 0.0003 0.0066
Brugia malayi glutathione reductase 0.0023 0.0056 0.0144
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0056 0.0199 0.1022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0201 0.0543
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0056 0.0199 0.1022
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0201 0.0543
Entamoeba histolytica sodium/proton antiporter, putative 0.0011 0.0003 0.0122
Schistosoma mansoni hypothetical protein 0.0047 0.0158 0.0428
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0201 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Trichomonas vaginalis alpha-glucosidase, putative 0.0018 0.0032 0.0272
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.0056 0.0199 0.0538
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0063 0.0231 0.0623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0112 0.0303
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0022 0.0052 0.1209
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0201 0.0201
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0014 0.0016 0.0387
Echinococcus multilocularis sodium:hydrogen exchanger 0.0056 0.0199 0.0199
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0163 0.0663 0.1793
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0201 0.0201
Brugia malayi MH2 domain containing protein 0.0024 0.0061 0.0159
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.005 0.1163
Plasmodium vivax thioredoxin reductase, putative 0.0023 0.0056 0.1371
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.003 0.0086 0.0224
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0014 0.0039
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0045 0.0153 0.0153
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0056 0.0199 0.0531
Brugia malayi sulfakinin receptor protein 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0208
Mycobacterium tuberculosis Probable dehydrogenase 0.0052 0.0183 0.1127
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0454 0.1923 0.5197
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0079 0.0215
Echinococcus granulosus Smad4 0.0024 0.0061 0.0166
Toxoplasma gondii exonuclease III APE 0.0022 0.005 0.1222
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0166 0.0441
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0022 0.0052 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0212
Echinococcus multilocularis lysosomal alpha glucosidase 0.0079 0.0299 0.0299
Schistosoma mansoni amine oxidase 0.0029 0.0081 0.0219
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0018 0.0032 0.1465
Onchocerca volvulus 0.0057 0.0201 0.1032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus allatostatin A receptor 0.0057 0.0201 0.0543
Echinococcus granulosus sodium:glucose cotransporter 0.0022 0.0054 0.0145
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0166 0.0441
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus sodium:hydrogen exchanger 0.0056 0.0199 0.0538
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Echinococcus granulosus polycomb protein SCMH1 0.0107 0.0418 0.1131
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0056 0.0199 0.0199
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0079 0.0299 0.0801
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0056 0.1313
Onchocerca volvulus 0.0454 0.1923 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0079 0.0215
Trypanosoma cruzi UDP-galactopyranose mutase 0.0029 0.0081 0.1941
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0201 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0032 0.0735
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Schistosoma mansoni alpha-1 adrenergic receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0014 0.0032
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0166 0.0448
Brugia malayi hypothetical protein 0.0454 0.1923 0.5197
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0201 0.0543
Schistosoma mansoni smad 0.0011 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0212
Schistosoma mansoni furin-1 (S08 family) 0.0045 0.0153 0.0413
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0052 0.0183 0.1127
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0029 0.0081 0.0219
Loa Loa (eye worm) hypothetical protein 0.0221 0.0911 0.2457
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0166 0.4034
Echinococcus granulosus sodium:hydrogen exchanger 7 0.0011 0.0003 0.0007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0057 0.0201 0.0537
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0058 0.0208 0.1285
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0079 0.0079
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.005 0.1163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0079 0.0208
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0063 0.0528
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0023 0.0119
Schistosoma mansoni Smad4 0.0024 0.0061 0.0166
Echinococcus granulosus lamin dm0 0.0076 0.0285 0.077
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0032
Brugia malayi nuclear receptor NHR-67 0.0013 0.0014 0.0032
Brugia malayi AKH receptor 0.0057 0.0201 0.0537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0201 0.0201
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0023 0.0055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0115 0.0303
Chlamydia trachomatis protoporphyrinogen oxidase 0.0029 0.0081 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0011 0.0005 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0081 0.1995
Brugia malayi neuroendocrine convertase 1 precursor 0.0065 0.024 0.0642
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0003 0.0003
Brugia malayi Serotonin receptor 0.0057 0.0201 0.0537
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0201 0.0201
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0057 0.0201 0.1032
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0061 0.0166
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0003 0.0003
Brugia malayi proprotein convertase 2 0.0065 0.024 0.0642
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0112 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0112 0.0303
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0014 0.0032
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0079 0.0208
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0022 0.0054 0.0054
Brugia malayi hypothetical protein 0.0221 0.0911 0.2457
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.005 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0079 0.0208
Schistosoma mansoni neuropeptide receptor 0.0057 0.0201 0.0543
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0166 0.0166
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.005 0.0127
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0201 0.0201
Schistosoma mansoni inositol monophosphatase 0.0022 0.0052 0.0139
Loa Loa (eye worm) DR-78 0.0013 0.0014 0.0032
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0023 0.0056 0.0332
Brugia malayi TAR-binding protein 0.0865 0.3699 1
Schistosoma mansoni high-affinity choline transporter 0.0204 0.0838 0.2265
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0201 0.0543
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0041 0.0132 0.0351
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0079 0.0208
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0865 0.3699 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0201 0.0543
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0287
Loa Loa (eye worm) inositol-1 0.0022 0.0052 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0079 0.0208
Onchocerca volvulus 0.0057 0.0201 0.1032
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.005 0.2249
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1042 0.2811
Schistosoma mansoni Slc9a7 protein 0.0011 0.0003 0.0007
Loa Loa (eye worm) thioredoxin reductase 0.0023 0.0056 0.0144
Echinococcus multilocularis sodium:hydrogen exchanger 0.0056 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.0376 0.1583 0.4278
Schistosoma mansoni biogenic amine receptor 0.0057 0.0201 0.0543
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.005 0.005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0112 0.0112
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0014 0.0032
Brugia malayi Smad1 0.0024 0.0061 0.0159
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0079 0.0215
Echinococcus multilocularis lamin dm0 0.0076 0.0285 0.0285
Brugia malayi Sodium:solute symporter family protein 0.0022 0.0054 0.0138
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0079 0.0208
Brugia malayi MH1 domain containing protein 0.0013 0.0014 0.0032
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0166 0.4073
Brugia malayi hypothetical protein 0.0061 0.0221 0.0591
Entamoeba histolytica hypothetical protein 0.0061 0.0221 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0022 0.0054 0.1319
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0056 0.0199 0.0538
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0052 0.0183 0.1127
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0061 0.0061
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0057 0.0201 0.0543
Echinococcus multilocularis Smad4 0.0024 0.0061 0.0061
Echinococcus multilocularis L aminoadipate semialdehyde 0.0049 0.0167 0.0167
Echinococcus granulosus neuroendocrine convertase 2 0.0065 0.024 0.0648
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0201 0.0201
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0016 0.0258
Schistosoma mansoni hypothetical protein 0.0353 0.1483 0.401
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0201 0.0201
Onchocerca volvulus 0.0076 0.0285 0.1468
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0257 0.1069 0.1069
Schistosoma mansoni amine GPCR 0.0057 0.0201 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0366
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0201 0.0201
Brugia malayi tailless protein 0.0013 0.0014 0.0032
Schistosoma mansoni neuropeptide receptor 0.0057 0.0201 0.0543
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0166 0.1019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0011 0.0005 0.0007
Brugia malayi larval opioid receptor 0.0057 0.0201 0.0537
Loa Loa (eye worm) hypothetical protein 0.0107 0.0418 0.1125
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0158 0.0428
Echinococcus granulosus smad 0.0024 0.0061 0.0166
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0537

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 220 nM Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5. ChEMBL. 11606131
EC50 (functional) = 220 nM Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5. ChEMBL. 11606131
EC50 (functional) = 240 nM Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5. ChEMBL. 11606131
EC50 (functional) = 240 nM Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5. ChEMBL. 11606131
Ki (binding) = 0.58 nM Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 0.58 nM Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 1.5 nM Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 1.5 nM Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 120 nM Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 120 nM Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 140 nM Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 140 nM Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 240 nM Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 240 nM Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 400 nM Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Ki (binding) = 400 nM Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) ChEMBL. 11606131
Selectivity ratio (binding) = 160 Ratio of binding affinity against hMC-3R to hMC4R was determined ChEMBL. 11606131
Selectivity ratio (binding) = 210 Ratio of binding affinity against hMC-3R to hMC4R was determined ChEMBL. 11606131
Selectivity ratio (binding) = 240 Ratio of binding affinity against hMC4R to hMC5R was determined ChEMBL. 11606131
Selectivity ratio (binding) = 270 Ratio of binding affinity against hMC4R to hMC5R was determined ChEMBL. 11606131

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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