Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.016 ug ml-1 | Minimum inhibitory concentration(MIC)against S. pyogenes by 2-fold microdilution technique | ChEMBL. | 3373488 |
MIC (functional) | = 0.03 ug ml-1 | Minimum inhibitory concentration(MIC) against S. pneumoniae by 2-fold microdilution technique | ChEMBL. | 3373488 |
MIC (functional) | = 0.03 ug ml-1 | Minimum inhibitory concentration(MIC) was determined as oral therapeutic efficacy against S. pneumoniae. | ChEMBL. | 3373488 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration(MIC) against S. aureus by 2-fold microdilution technique. | ChEMBL. | 3373488 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration(MIC) against S. faecalis by 2-fold microdilution technique. | ChEMBL. | 3373488 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration(MIC) against P. mirabilis by 2-fold microdilution technique. | ChEMBL. | 3373488 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration(MIC) against E. coli by 2-fold microdilution technique. | ChEMBL. | 3373488 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration(MIC)was determined as oral therapeutic efficacy against E. coli. | ChEMBL. | 3373488 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration(MIC) against E. coli by 2-fold microdilution technique. | ChEMBL. | 3373488 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration(MIC)was determined as oral therapeutic efficacy against E. coli. | ChEMBL. | 3373488 |
MIC (functional) | = 8 ug ml-1 | Minimum inhibitory concentration(MIC) against H. influenzae by 2-fold microdilution technique. | ChEMBL. | 3373488 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory concentration(MIC) against K. pneumoniae by 2-fold microdilution technique. | ChEMBL. | 3373488 |
PD50 (functional) | = 3.6 mg kg-1 | Protective dose (PD50) against S. pneumoniae infected mice | ChEMBL. | 3373488 |
PD50 (functional) | > 50 mg kg-1 | Protective dose (PD50) against E. coli infected mice | ChEMBL. | 3373488 |
PD50 (functional) | > 50 mg kg-1 | Protective dose (PD50) against E. coli infected mice | ChEMBL. | 3373488 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.