Detailed information for compound 21164

Basic information

Technical information
  • TDR Targets ID: 21164
  • Name: 1-[[4-[[6-hydroxy-2-[4-(2-pyrrolidin-1-yletho xy)phenyl]-1-benzothiophen-3-yl]methyl]-2-met hylphenyl]methyl]pyrrolidin-2-one
  • MW: 540.716 | Formula: C33H36N2O3S
  • H donors: 1 H acceptors: 2 LogP: 6.39 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1ccc2c(c1)sc(c2Cc1ccc(c(c1)C)CN1CCCC1=O)c1ccc(cc1)OCCN1CCCC1
  • InChi: 1S/C33H36N2O3S/c1-23-19-24(6-7-26(23)22-35-16-4-5-32(35)37)20-30-29-13-10-27(36)21-31(29)39-33(30)25-8-11-28(12-9-25)38-18-17-34-14-2-3-15-34/h6-13,19,21,36H,2-5,14-18,20,22H2,1H3
  • InChiKey: RRMBAANCMNHLRD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[[4-[[6-hydroxy-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]benzothiophen-3-yl]methyl]-2-methyl-phenyl]methyl]pyrrolidin-2-one
  • 1-[[4-[[6-hydroxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-3-benzothiophenyl]methyl]-2-methylphenyl]methyl]-2-pyrrolidinone
  • 1-[[4-[[6-hydroxy-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1-benzothiophen-3-yl]methyl]-2-methyl-phenyl]methyl]pyrrolidin-2-one
  • 1-[4-[[6-hydroxy-2-[4-(2-pyrrolidinoethoxy)phenyl]benzothiophen-3-yl]methyl]-2-methyl-benzyl]-2-pyrrolidone
  • 1-[[4-[[6-hydroxy-2-[4-(2-1-pyrrolidinylethoxy)phenyl]-3-benzothiophenyl]methyl]-2-methylphenyl]methyl]-2-pyrrolidinone
  • 1-[4-[[6-hydroxy-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]benzothiophen-3-yl]methyl]-2-methyl-benzyl]-2-pyrrolidone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GnHR receptor homolog 0.0024 0.0192 0.0251
Echinococcus granulosus tyrosine protein kinase Src64B 0.0039 0.0408 0.0405
Brugia malayi hypothetical protein 0.0021 0.0144 0.0188
Schistosoma mansoni hypothetical protein 0.0024 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Onchocerca volvulus 0.0024 0.0192 0.0911
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0139 0.0185
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.014 0.006
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0821 0.0819
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0192 0.0189
Mycobacterium ulcerans integral membrane transport protein 0.0077 0.0933 0.1254
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0553 0.0734
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.014 0.0137
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0192 0.0189
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0192 0.0189
Schistosoma mansoni hypothetical protein 0.0039 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Trypanosoma brucei glucose transporter, putative 0.0169 0.2234 0.8185
Trichomonas vaginalis glucose transporter, putative 0.0169 0.2234 0.2752
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Schistosoma mansoni blooms syndrome DNA helicase 0.0039 0.0401 0.0401
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0003 0.0004
Onchocerca volvulus 0.0077 0.0933 0.4487
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0299 0.0296
Brugia malayi G-protein coupled receptor 0.0024 0.0192 0.0251
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0821 0.0821
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0198 0.0263
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0139 0.0175
Trypanosoma cruzi hexose transporter 0.0169 0.2234 0.8192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Brugia malayi Serotonin receptor 0.0024 0.0192 0.0251
Loa Loa (eye worm) hypothetical protein 0.0037 0.0375 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0192 0.0189
Onchocerca volvulus 0.0087 0.1077 0.518
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0408 0.0405
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0192 0.0192
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis solute carrier family 22 0.0077 0.0933 0.093
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Schistosoma mansoni opsin-like receptor 0.0024 0.0192 0.0192
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0546 0.7527 0.7526
Echinococcus granulosus solute carrier family 22 0.0077 0.0933 0.093
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0096 0.035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0095 0.0123
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0192 0.0251
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Trypanosoma brucei glucose transporter, putative 0.0169 0.2234 0.8185
Loa Loa (eye worm) TK protein kinase 0.0036 0.0354 0.047
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0093
Onchocerca volvulus 0.0077 0.0933 0.4487
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0192 0.0192
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0546 0.7527 0.7526
Loa Loa (eye worm) SRC-1 0.0039 0.0408 0.0542
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0095 0.0092
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0096 0.035
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0192 0.0189
Onchocerca volvulus Putative transporter 0.0077 0.0933 0.4487
Brugia malayi MH2 domain containing protein 0.013 0.1677 0.2225
Echinococcus granulosus sex peptide receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0192
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0192 0.0255
Schistosoma mansoni sugar transporter 0.0077 0.0933 0.0933
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus granulosus GPCR family 2 0.0017 0.0095 0.0092
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0192 0.0189
Trypanosoma brucei THT1 - hexose transporter, putative 0.0169 0.2234 0.8185
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0408 0.0405
Schistosoma mansoni hypothetical protein 0.0024 0.0192 0.0192
Onchocerca volvulus 0.0077 0.0933 0.4487
Loa Loa (eye worm) RNA binding protein 0.0069 0.0821 0.1091
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0144 0.0141
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0535 0.7367 1
Schistosoma mansoni cytochrome P450 0.0011 0.001 0.001
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.001 0.0008
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0192 0.0189
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.015 0.1959 0.2603
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0192 0.0189
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0096 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0192 0.0192
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Schistosoma mansoni polycystin 1-related 0.0021 0.0144 0.0144
Onchocerca volvulus 0.0077 0.0933 0.4487
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0192 0.0192
Brugia malayi follicle stimulating hormone receptor 0.0265 0.3574 0.4746
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.001 0.0038
Echinococcus multilocularis synaptic vesicle 2 protein 0.0077 0.0933 0.093
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0408 0.0405
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Chlamydia trachomatis dihydrofolate reductase 0.0535 0.7367 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0192 0.0251
Brugia malayi hypothetical protein 0.0024 0.0192 0.0251
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0408 0.0405
Brugia malayi TAR-binding protein 0.0069 0.0821 0.1088
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0144 0.0065
Trichomonas vaginalis DNA helicase recq1, putative 0.0049 0.0547 0.0442
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0192 0.0189
Onchocerca volvulus 0.0077 0.0933 0.4487
Schistosoma mansoni glucose transporter 0.0077 0.0933 0.0933
Schistosoma mansoni microtubule-associated protein tau 0.0722 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis bloom syndrome protein 0.0049 0.0547 0.0544
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus granulosus solute carrier family 22 0.0077 0.0933 0.093
Loa Loa (eye worm) RecQ helicase 0.0049 0.0547 0.0726
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0033 0.0322 0.0305
Onchocerca volvulus 0.0077 0.0933 0.4487
Onchocerca volvulus 0.0024 0.0192 0.0911
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.0354 0.0351
Onchocerca volvulus 0.0024 0.0192 0.0911
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0096 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0553 0.0553
Loa Loa (eye worm) TK protein kinase 0.0032 0.0299 0.0397
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0096 0.0093
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0096 0.0313
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Schistosoma mansoni biogenic amine receptor 0.0024 0.0192 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0192 0.0192
Echinococcus granulosus General substrate transporter 0.0469 0.6448 0.6447
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0192 0.0192
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Schistosoma mansoni hypothetical protein 0.0017 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0192 0.0192
Loa Loa (eye worm) sugar transporter 0.0077 0.0933 0.124
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0096 0.0093
Brugia malayi Major Facilitator Superfamily protein 0.0077 0.0933 0.1236
Brugia malayi Sugar transporter family protein 0.0546 0.7527 1
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1677 0.2228
Trypanosoma brucei glucose transporter, putative 0.0169 0.2234 0.8185
Plasmodium falciparum hexose transporter 0.0546 0.7527 1
Brugia malayi major facilitator superfamily protein 0.0077 0.0933 0.1236
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1677 0.2228
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Schistosoma mansoni hypothetical protein 0.0546 0.7527 0.7527
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0192 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0003 0.0004
Brugia malayi ORL1-like opioid receptor 0.0024 0.0192 0.0251
Loa Loa (eye worm) dihydrofolate reductase 0.0535 0.7367 0.9788
Trichomonas vaginalis myo-inositol transporter, putative 0.0077 0.0933 0.0971
Brugia malayi RE15519p 0.0024 0.0192 0.0251
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0198 0.0255
Brugia malayi major facilitator superfamily protein 0.0077 0.0933 0.1236
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0192 0.0251
Trypanosoma cruzi glucose transporter, putative 0.0077 0.0933 0.3422
Toxoplasma gondii facilitative glucose transporter GT1 0.0546 0.7527 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0198 0.0691
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis serotonin receptor 0.0024 0.0192 0.0189
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.014 0.0182
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0192 0.0189
Toxoplasma gondii sugar transporter ST1 0.0077 0.0933 0.124
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.0354 0.0351
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0003 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.1077 0.1427
Trichomonas vaginalis sugar transporter, putative 0.0169 0.2234 0.2752
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.1077 0.1077
Echinococcus granulosus tyrosine protein kinase Lyn 0.0039 0.0408 0.0405
Echinococcus granulosus RUN 0.0021 0.0144 0.0141
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0821 0.1088
Schistosoma mansoni hypothetical protein 0.0037 0.0375 0.0375
Brugia malayi Sugar transporter family protein 0.0077 0.0933 0.1236
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Echinococcus granulosus tyrosine protein kinase Src42A 0.0034 0.0338 0.0336
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0077 0.0933 0.3397
Schistosoma mansoni neuropeptide receptor 0.0024 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0017 0.0095 0.0095
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0546 0.7527 0.7526
Echinococcus granulosus g protein coupled receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0192 0.0189
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.2234 0.2752
Trichomonas vaginalis glucose transporter, putative 0.0169 0.2234 0.2752
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0095 0.0092
Echinococcus multilocularis solute carrier family 22 0.0077 0.0933 0.093
Brugia malayi G protein-coupled receptor 0.0024 0.0192 0.0251
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0192 0.0192
Brugia malayi neuropeptide F receptor 0.0024 0.0192 0.0251
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.1077 0.1074
Brugia malayi protein-tyrosine kinase 0.0036 0.0354 0.0466
Brugia malayi hypothetical protein 0.0039 0.0404 0.0533
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0003 0.0003
Schistosoma mansoni opsin-like receptor 0.0024 0.0192 0.0192
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0003 0.0003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0144 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0821 0.0821
Brugia malayi Cytochrome P450 family protein 0.002 0.0139 0.0181
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0933 0.0971
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0192 0.0189
Brugia malayi RNA binding protein 0.0069 0.0821 0.1088
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.1077 0.1074
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0192 0.0189
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0093
Plasmodium vivax hexose transporter 0.0546 0.7527 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0096 0.0123
Schistosoma mansoni hypothetical protein 0.0024 0.0192 0.0192
Trypanosoma brucei THT1 - hexose transporter, putative 0.0169 0.2234 0.8185
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Trypanosoma brucei glucose transporter, putative 0.0169 0.2234 0.8185
Brugia malayi putative neuropeptide receptor 0.0024 0.0192 0.0251
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0077 0.0933 0.1254
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0077 0.0933 0.1254
Echinococcus multilocularis microtubule associated protein 2 0.0722 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0192 0.0192
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0192 0.0189
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0192 0.0189
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Onchocerca volvulus 0.0024 0.0192 0.0911
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.014 0.0186
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0192 0.0189
Entamoeba histolytica protein kinase, putative 0.0032 0.0299 0.7397
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Onchocerca volvulus 0.0158 0.2076 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0077 0.0933 0.1127
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0933 0.0971
Brugia malayi Cytochrome P450 family protein 0.0011 0.001 0.001
Brugia malayi dihydrofolate reductase family protein 0.0535 0.7367 0.9788
Echinococcus granulosus fmrfamide receptor 0.0024 0.0192 0.0189
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0144 0.0141
Onchocerca volvulus 0.0024 0.0192 0.0911
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0615 0.0818
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0192 0.0255
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0192 0.0189
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0192 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0192 0.0192
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0003 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0192 0.0189
Brugia malayi hypothetical protein 0.0077 0.0933 0.1236
Trypanosoma cruzi hexose transporter, putative 0.0169 0.2234 0.8192
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Brugia malayi Bloom's syndrome protein homolog 0.0049 0.0547 0.0723
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0192 0.0192
Onchocerca volvulus 0.0077 0.0933 0.4487
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Mycobacterium ulcerans sugar transporter 0.0077 0.0933 0.1254
Brugia malayi Dopamine receptor 0.0024 0.0192 0.0251
Entamoeba histolytica recQ family helicase, putative 0.0026 0.0224 0.5554
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0192 0.0192
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0003 0.0004
Brugia malayi Melatonin receptor type 1A 0.0024 0.0192 0.0251
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Brugia malayi hypothetical protein 0.0024 0.0192 0.0251
Brugia malayi hypothetical protein 0.0158 0.2076 0.2755
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0192 0.0189
Brugia malayi hypothetical protein 0.0024 0.0192 0.0251
Onchocerca volvulus 0.0024 0.0192 0.0911
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0204 0.2727 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0198 0.0255
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus granulosus allatostatin A receptor 0.0024 0.0192 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.014 0.0137
Brugia malayi hypothetical protein 0.0024 0.0192 0.0251
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Schistosoma mansoni hypothetical protein 0.0021 0.0144 0.0144
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0666 0.0663
Brugia malayi hypothetical protein 0.0077 0.0933 0.1236
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0204 0.2727 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0192 0.0189
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0192 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0198 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0039 0.0408 0.0405
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0039 0.0408 0.0405
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Brugia malayi isocitrate dehydrogenase 0.0017 0.0096 0.0123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0039 0.0408 0.0405
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0095 0.0092
Trichomonas vaginalis sugar transport protein, putative 0.0077 0.0933 0.0971
Onchocerca volvulus 0.0024 0.0192 0.0911
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Onchocerca volvulus 0.0024 0.0192 0.0911
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0192 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0553 0.0553
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0003 0.0003
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.014 0.0137
Trichomonas vaginalis DNA helicase recq, putative 0.0049 0.0547 0.0442
Echinococcus granulosus solute carrier family 22 0.0077 0.0933 0.093
Loa Loa (eye worm) hypothetical protein 0.0158 0.2076 0.2758
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.001 0.0038
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0198 0.0255
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.014 0.0186
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0192 0.0189
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0077 0.0933 0.1254
Schistosoma mansoni hypothetical protein 0.0017 0.0095 0.0095
Onchocerca volvulus 0.0077 0.0933 0.4487
Schistosoma mansoni glucose transport protein 0.0546 0.7527 0.7527
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0192 0.0189
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0192 0.0189
Trypanosoma brucei glucose transporter 2A 0.0169 0.2234 0.8185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Schistosoma mansoni hypothetical protein 0.0017 0.0095 0.0095
Onchocerca volvulus 0.0024 0.0192 0.0911
Schistosoma mansoni hypothetical protein 0.0024 0.0192 0.0192
Schistosoma mansoni glucose transport protein 0.0546 0.7527 0.7527
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) sugar transporter 0.0546 0.7527 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0077 0.0933 0.3397
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0192 0.0189
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0003 0.0003
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0093
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.0354 0.0351
Trypanosoma brucei glucose transporter, putative 0.0169 0.2234 0.8185
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.001 0.0014
Schistosoma mansoni neuropeptide receptor 0.0024 0.0192 0.0192
Echinococcus multilocularis dihydrofolate reductase 0.0535 0.7367 0.7366
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0546 0.7527 0.7526
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus granulosus g protein coupled receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.0186
Brugia malayi AKH receptor 0.0024 0.0192 0.0251
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0144 0.0141
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0408 0.0405
Schistosoma mansoni myosin xvIII 0.0024 0.0192 0.0192
Brugia malayi hypothetical protein 0.0024 0.0192 0.0251
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0933 0.0971
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0192 0.0251
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0204 0.2727 0.3541
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0204 0.2727 0.3623
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0408 0.0405
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0192 0.0255
Onchocerca volvulus 0.0077 0.0933 0.4487
Schistosoma mansoni amine GPCR 0.0024 0.0192 0.0192
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0192 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0192 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0933 0.0971
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.001
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0039 0.0408 0.0405
Echinococcus granulosus synaptic vesicle 2 protein 0.0077 0.0933 0.093
Brugia malayi hypothetical protein 0.0024 0.0192 0.0251
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0093
Onchocerca volvulus 0.0077 0.0933 0.4487
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0192 0.0251
Echinococcus granulosus g protein coupled receptor 0.0024 0.0192 0.0189
Echinococcus granulosus orexin receptor type 2 0.0024 0.0192 0.0189
Brugia malayi hypothetical protein 0.0077 0.0933 0.1236
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0192 0.0189
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0077 0.0933 1
Schistosoma mansoni DNA helicase recq1 0.002 0.014 0.014
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0139 0.0511
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0095 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0553 0.0731
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0192 0.0189
Brugia malayi hypothetical protein 0.0024 0.0192 0.0251
Echinococcus granulosus dihydrofolate reductase 0.0535 0.7367 0.7366
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0198 0.0138
Schistosoma mansoni amine GPCR 0.0024 0.0192 0.0192
Entamoeba histolytica hypothetical protein 0.0024 0.0198 0.4909
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0192 0.0251
Leishmania major glucose transporter, lmgt2 0.0169 0.2234 0.8185
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0003 0.0003
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0546 0.7527 0.7526
Trypanosoma cruzi hexose transporter, putative 0.0169 0.2234 0.8192
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0192 0.0255
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Brugia malayi G-protein coupled receptor 0.0024 0.0192 0.0251
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0043 0.0463 0.0494
Schistosoma mansoni rab6-interacting 0.0021 0.0144 0.0144
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0192 0.0189
Trypanosoma brucei glucose transporter, putative 0.0169 0.2234 0.8185
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0192 0.0189
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0144 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Entamoeba histolytica hypothetical protein 0.0039 0.0404 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Onchocerca volvulus 0.0077 0.0933 0.4487
Schistosoma mansoni histamine h1 receptor 0.0024 0.0192 0.0192
Echinococcus granulosus neuropeptide receptor 0.0024 0.0192 0.0189
Leishmania major glucose transporter/membrane transporter D2, putative 0.0169 0.2234 0.8185
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0033 0.0317 0.0421
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.001 0.0038
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0192 0.0189
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0003 0.0003
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0198 0.0263
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0192 0.0192
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0224 0.0822
Brugia malayi Dopamine receptor protein 1 0.0024 0.0192 0.0251
Brugia malayi Sugar transporter family protein 0.0077 0.0933 0.1236
Schistosoma mansoni neuropeptide receptor 0.0024 0.0192 0.0192
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0404 0.0401
Schistosoma mansoni amine GPCR 0.0024 0.0192 0.0192
Onchocerca volvulus 0.0077 0.0933 0.4487
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0192 0.0189
Brugia malayi Serotonin receptor 0.0024 0.0192 0.0251
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0546 0.7527 0.7526
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0003 0.0003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0096 0.0313
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0192 0.0189
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0408 0.0405
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0198 0.0138
Schistosoma mansoni opsin-like receptor 0.0024 0.0192 0.0192
Echinococcus multilocularis solute carrier family 22 0.0077 0.0933 0.093
Schistosoma mansoni adenoreceptor 0.0024 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Echinococcus granulosus tyrosine kinase 0.0036 0.0354 0.0351
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0821 0.0821
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0192 0.0192
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0192 0.0255
Schistosoma mansoni amine GPCR 0.0024 0.0192 0.0192
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0192 0.0255
Brugia malayi hypothetical protein 0.0021 0.0144 0.0188
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0546 0.7527 0.7526
Trypanosoma cruzi hexose transporter, putative 0.0077 0.0933 0.3422
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0003 0.0003
Schistosoma mansoni DNA helicase recq5 0.002 0.014 0.014
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0192 0.0251
Echinococcus granulosus neuropeptide receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Echinococcus granulosus somatostatin receptor 0.0024 0.0192 0.0189
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0039 0.0408 0.0405
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0192 0.0192
Loa Loa (eye worm) CYP4Cod1 0.002 0.0139 0.0185
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0192 0.0192
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.0354 0.0351
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Trypanosoma brucei sugar transporter, putative 0.0077 0.0933 0.3397
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0192 0.0255
Echinococcus granulosus Sugar transporter ERD6 protein 0.0077 0.0933 0.093
Echinococcus granulosus tar DNA binding protein 0.0069 0.0821 0.0819
Toxoplasma gondii transporter, major facilitator family protein 0.0077 0.0933 0.124
Onchocerca volvulus 0.0021 0.0144 0.0682
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0192 0.0255
Onchocerca volvulus 0.0024 0.0192 0.0911
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Leishmania major hypothetical protein, conserved 0.0077 0.0933 0.3397
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0139 0.0511
Schistosoma mansoni lipoxygenase 0.0021 0.0144 0.0144
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0535 0.7367 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0666 0.0663
Onchocerca volvulus 0.0024 0.0192 0.0911
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Trypanosoma brucei THT1 - hexose transporter, putative 0.0169 0.2234 0.8185
Plasmodium vivax sugar transporter, putative 0.0077 0.0933 0.1127
Giardia lamblia Hexose transporter 0.0077 0.0933 1
Brugia malayi cytochrome P450 0.0011 0.001 0.001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0192 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0192 0.0192
Trichomonas vaginalis glucose transporter, putative 0.0077 0.0933 0.0971
Trypanosoma cruzi sugar transporter, putative 0.0077 0.0933 0.3422
Brugia malayi Major Facilitator Superfamily protein 0.0077 0.0933 0.1236
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0224 0.0787
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0535 0.7367 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0192 0.0911
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0077 0.0933 0.0933
Schistosoma mansoni coup transcription factor 0.0011 0.0003 0.0003
Echinococcus multilocularis RUN 0.0021 0.0144 0.0141
Loa Loa (eye worm) major facilitator superfamily transporter 0.0077 0.0933 0.124
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0404 0.0401
Loa Loa (eye worm) hypothetical protein 0.0087 0.1077 0.143
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0192 0.0189
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0192 0.0189
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0039 0.0408 0.0405
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.3574 0.4748
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0204 0.2727 0.3541
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0553 0.055
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Echinococcus granulosus solute carrier family 22 0.0077 0.0933 0.093
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0192 0.0189
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0192 0.0911
Toxoplasma gondii sugar transporter ST3 0.0077 0.0933 0.124
Brugia malayi Dopamine receptor protein 2 0.0024 0.0192 0.0251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0192 0.0192
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0192 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0192 0.0189
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0192 0.0189
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0546 0.7527 0.7526
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0095 0.0126
Schistosoma mansoni sugar transporter 0.0077 0.0933 0.0933
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0192 0.0255
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Trypanosoma brucei glucose transporter, putative 0.0169 0.2234 0.8185
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0096 0.0127
Schistosoma mansoni tyrosine kinase 0.0039 0.0408 0.0408
Entamoeba histolytica hypothetical protein 0.0039 0.0404 1
Echinococcus granulosus bloom syndrome protein 0.0049 0.0547 0.0544
Loa Loa (eye worm) hypothetical protein 0.0054 0.0615 0.0818
Trypanosoma cruzi hexose transporter, putative 0.0093 0.1155 0.4236
Schistosoma mansoni sugar transporter 0.0077 0.0933 0.0933
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0192 0.0255
Schistosoma mansoni lipoxygenase 0.0058 0.0666 0.0666
Trichomonas vaginalis sugar transporter, putative 0.0169 0.2234 0.2752
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Leishmania major glucose transporter, lmgt1 0.0169 0.2234 0.8185
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0192 0.0189
Brugia malayi hypothetical protein 0.0024 0.0192 0.0251
Brugia malayi hypothetical protein 0.0024 0.0192 0.0251
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Onchocerca volvulus 0.0024 0.0192 0.0911
Brugia malayi Doublecortin family protein 0.0021 0.0144 0.0188
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Brugia malayi SRC-1 0.0039 0.0408 0.0538
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0096 0.0313
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0192 0.0189
Onchocerca volvulus 0.0024 0.0192 0.0911
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0553 0.055
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0198 0.0691
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0077 0.0933 0.1254
Loa Loa (eye worm) cytochrome P450 0.0011 0.001 0.0014
Toxoplasma gondii sugar transporter ST2 0.0077 0.0933 0.124
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0192 0.0189
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0144 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.2234 0.2752
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0821 0.0821
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0224 0.0787
Schistosoma mansoni loxhd1 0.0021 0.0144 0.0144
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0192 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0003 0.0004
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0204 0.2727 1
Onchocerca volvulus 0.0024 0.0192 0.0911
Brugia malayi Cytochrome P450 family protein 0.0011 0.001 0.001
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Schistosoma mansoni glucose transport protein 0.0546 0.7527 0.7527
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0192 0.0189
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0034 0.0338 0.0336
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.014 0.0137
Brugia malayi neuropeptide F receptor 0.0024 0.0192 0.0251
Schistosoma mansoni neuropeptide receptor 0.0024 0.0192 0.0192
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0821 0.1091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0039 0.0408 0.0405
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0408 0.0405
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0553 0.055
Brugia malayi larval opioid receptor 0.0024 0.0192 0.0251
Schistosoma mansoni dihydrofolate reductase 0.0535 0.7367 0.7367
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0933 0.0971
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0192 0.0192
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.014 0.0182
Echinococcus multilocularis GPCR, family 2 0.0017 0.0095 0.0092
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0144 0.0192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis sex peptide receptor 0.0024 0.0192 0.0189
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0553 0.055
Onchocerca volvulus 0.0024 0.0192 0.0911
Echinococcus multilocularis somatostatin receptor 0.0024 0.0192 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0553 0.0553
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0096 0.0096
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0354 0.0351
Brugia malayi sulfakinin receptor protein 0.0024 0.0192 0.0251
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0615 0.0814
Schistosoma mansoni sugar transporter 0.0077 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0255
Echinococcus multilocularis solute carrier family 22 0.0077 0.0933 0.093
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0615 0.0814
Trypanosoma brucei glucose transporter, putative 0.0169 0.2234 0.8185
Leishmania major cytochrome p450-like protein 0.002 0.0139 0.0474
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0192 0.0189
Entamoeba histolytica hypothetical protein 0.0039 0.0404 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0192
Onchocerca volvulus 0.0021 0.0144 0.0682
Onchocerca volvulus 0.0024 0.0192 0.0911
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.014 0.0186
Giardia lamblia Sugar-proton symporter 0.0077 0.0933 1
Trypanosoma brucei cytochrome P450, putative 0.002 0.0139 0.0474
Echinococcus multilocularis General substrate transporter 0.0469 0.6448 0.6447
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0095 0.0123
Onchocerca volvulus 0.0077 0.0933 0.4487
Brugia malayi Major Facilitator Superfamily protein 0.0077 0.0933 0.1236
Schistosoma mansoni biogenic amine receptor 0.0024 0.0192 0.0192
Onchocerca volvulus 0.0077 0.0933 0.4487
Entamoeba histolytica hypothetical protein 0.0039 0.0404 1
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0192 0.0189
Echinococcus multilocularis serotonin receptor 0.0024 0.0192 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0169 0.2234 0.2752
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Echinococcus granulosus hypothetical protein 0.0024 0.0192 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0821 0.0821
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0933 0.0971
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0096 0.0127
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0077 0.0933 0.093
Echinococcus granulosus serotonin receptor 0.0024 0.0192 0.0189
Onchocerca volvulus 0.0024 0.0192 0.0911
Schistosoma mansoni biogenic amine receptor 0.0024 0.0192 0.0192
Brugia malayi Dihydrofolate reductase 0.0535 0.7367 0.9788
Onchocerca volvulus 0.0077 0.0933 0.4487
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0299 0.0296
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0126
Echinococcus multilocularis 0.0011 0.001 0.0008
Leishmania major glucose transporter, lmgt3 0.0169 0.2234 0.8185
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0375 0.0494
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0144 0.0065
Brugia malayi Cytochrome P450 family protein 0.002 0.0139 0.0181
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0404 0.0404
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0192 0.0189
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0192 0.0192
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.001 0.0014
Brugia malayi hypothetical protein 0.0024 0.0192 0.0251
Schistosoma mansoni rab6-interacting 0.0021 0.0144 0.0144
Loa Loa (eye worm) major facilitator superfamily transporter 0.0077 0.0933 0.124
Schistosoma mansoni tyrosine kinase 0.0039 0.0408 0.0408
Trypanosoma cruzi hexose transporter, putative 0.0169 0.2234 0.8192
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0192 0.0189
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0198 0.0255
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0821 0.1091
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0077 0.0933 0.124
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0139 0.0185
Onchocerca volvulus 0.0077 0.0933 0.4487
Trypanosoma brucei glucose transporter 1E 0.0169 0.2234 0.8185
Trichomonas vaginalis conserved hypothetical protein 0.0546 0.7527 1
Schistosoma mansoni amine GPCR 0.0024 0.0192 0.0192

Activities

Activity type Activity value Assay description Source Reference
K ass (binding) = 525 10e6 l M-1 Inhibition of thrombin ChEMBL. 10866380
K ass (binding) = 525 10e6 l M-1 Inhibition of thrombin ChEMBL. 10866380

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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