Detailed information for compound 211647

Basic information

Technical information
  • TDR Targets ID: 211647
  • Name: 6-chloro-8-piperazin-1-ylimidazo[1,2-a]pyrazi ne
  • MW: 237.689 | Formula: C10H12ClN5
  • H donors: 1 H acceptors: 2 LogP: 1.45 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cn2ccnc2c(n1)N1CCNCC1
  • InChi: 1S/C10H12ClN5/c11-8-7-16-6-3-13-9(16)10(14-8)15-4-1-12-2-5-15/h3,6-7,12H,1-2,4-5H2
  • InChiKey: NTXSQRDZZRTWHR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-chloro-8-piperazin-1-yl-imidazo[1,2-a]pyrazine
  • 6-chloro-8-(1-piperazinyl)imidazo[1,2-a]pyrazine
  • 6-chloro-8-piperazino-imidazo[1,2-a]pyrazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.008 0.0256 0.1021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0256 0.0238
Onchocerca volvulus 0.008 0.0256 0.1021
Schistosoma mansoni myosin xvIII 0.008 0.0256 0.0239
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0256 0.0238
Trypanosoma cruzi protein farnesyltransferase, putative 0.049 0.1904 0.4309
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.008 0.0256 0.0239
Schistosoma mansoni amine GPCR 0.008 0.0256 0.0239
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.008 0.0256 0.0239
Echinococcus granulosus neuropeptide FF receptor 2 0.008 0.0256 0.0238
Toxoplasma gondii hypothetical protein 0.06 0.2344 0.3704
Loa Loa (eye worm) follicle stimulating hormone receptor 0.008 0.0256 0.0238
Onchocerca volvulus 0.008 0.0256 0.1021
Plasmodium falciparum protein farnesyltransferase subunit beta 0.049 0.1904 0.2179
Echinococcus multilocularis neuropeptide FF receptor 2 0.008 0.0256 0.0238
Echinococcus multilocularis tyrosine protein kinase Blk 0.005 0.0139 0.0121
Schistosoma mansoni growth hormone secretagogue receptor 0.008 0.0256 0.0239
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0256 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0256 0.0239
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.008 0.0256 0.0239
Schistosoma mansoni biogenic amine (5HT) receptor 0.008 0.0256 0.0239
Brugia malayi Serotonin receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.0407 0.1571 0.1555
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0706 0.2769 0.2756
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0256 0.0238
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0256 0.0239
Echinococcus multilocularis c src tyrosine kinase 0.0027 0.0046 0.0027
Echinococcus multilocularis tyrosine protein kinase Srms 0.005 0.0139 0.0121
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.06 0.2344 0.233
Leishmania major farnesyltransferase beta subunit 0.049 0.1904 0.7831
Brugia malayi ORL1-like opioid receptor 0.008 0.0256 0.0238
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.1593 0.6329 0.5645
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Onchocerca volvulus 0.008 0.0256 0.1021
Schistosoma mansoni amine GPCR 0.008 0.0256 0.0239
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.008 0.0256 0.0238
Trypanosoma brucei lanosterol synthase 0.0501 0.1948 0.4884
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.2193 0.8737 0.8734
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0166 0.0148
Brugia malayi gonadotropin-releasing hormone receptor 2 0.008 0.0256 0.0238
Echinococcus multilocularis alpha 1A adrenergic receptor 0.008 0.0256 0.0238
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.2508 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0256 0.0239
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Brugia malayi Serotonin receptor 0.008 0.0256 0.0238
Plasmodium falciparum geranylgeranyltransferase, putative 0.0407 0.1571 0.1798
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.049 0.1904 0.0395
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.2193 0.8737 0.8734
Echinococcus multilocularis serotonin receptor 0.008 0.0256 0.0238
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.008 0.0256 0.1021
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0166 0.0148
Echinococcus multilocularis fmrfamide receptor 0.008 0.0256 0.0238
Brugia malayi protein-tyrosine kinase 0.005 0.0139 0.0121
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.2193 0.8737 0.8734
Schistosoma mansoni tyrosine kinase 0.0027 0.0046 0.0028
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0233 0.087 0.0853
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Brugia malayi Dopamine receptor protein 1 0.008 0.0256 0.0238
Echinococcus multilocularis tachykinin peptides receptor 99D 0.008 0.0256 0.0238
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0256 0.0239
Echinococcus granulosus tachykinin peptides receptor 99D 0.008 0.0256 0.0238
Schistosoma mansoni tyrosine kinase 0.0226 0.0842 0.0826
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.008 0.0256 0.0238
Brugia malayi Dopamine receptor 0.008 0.0256 0.0238
Entamoeba histolytica protein kinase, putative 0.0043 0.0111 0.0093
Echinococcus multilocularis neuropeptide receptor 0.008 0.0256 0.0238
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0256 0.0238
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0166 0.0148
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.008 0.0256 0.0239
Plasmodium vivax prenyltransferase alpha subunit, putative 0.2193 0.8737 1
Echinococcus granulosus g protein coupled receptor 0.008 0.0256 0.0238
Echinococcus multilocularis dro:myosuppressin receptor 0.008 0.0256 0.0238
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0256 0.0239
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.049 0.1904 0.1889
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0057 0.0166 0.0148
Schistosoma mansoni opsin-like receptor 0.008 0.0256 0.0239
Echinococcus multilocularis G protein coupled receptor 139 0.008 0.0256 0.0238
Echinococcus multilocularis tyrosine protein kinase HCK 0.0043 0.0111 0.0093
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.2193 0.8737 0.8734
Echinococcus multilocularis g protein coupled receptor 0.008 0.0256 0.0238
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0256 0.0238
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.049 0.1904 0.0395
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0027 0.0046 0.0028
Brugia malayi Tyrosine-protein kinase abl-1 0.0131 0.0463 0.0445
Schistosoma mansoni serine/threonine protein kinase 0.0719 0.2821 0.2809
Brugia malayi hypothetical protein 0.008 0.0256 0.0238
Echinococcus granulosus somatostatin receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.0705 0.2768 0.2754
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.008 0.0256 0.0238
Giardia lamblia Prenyltransferase 0.049 0.1904 0.0465
Trypanosoma brucei protein farnesyltransferase beta subunit 0.049 0.1904 0.4309
Echinococcus granulosus sex peptide receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) TK/ABL protein kinase 0.0233 0.087 0.0853
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0085 0.0067
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0407 0.1571 0.1555
Echinococcus granulosus neuropeptide receptor 0.008 0.0256 0.0238
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.2508 1 1
Onchocerca volvulus 0.008 0.0256 0.1021
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0256 0.0238
Brugia malayi hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Brugia malayi putative neuropeptide receptor 0.008 0.0256 0.0238
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0057 0.0166 0.0148
Echinococcus granulosus fmrfamide receptor 0.008 0.0256 0.0238
Schistosoma mansoni biogenic amine receptor 0.008 0.0256 0.0239
Onchocerca volvulus 0.008 0.0256 0.1021
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.2193 0.8737 0.8734
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0256 0.0238
Echinococcus granulosus alpha 1A adrenergic receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0407 0.1571 0.2482
Brugia malayi larval opioid receptor 0.008 0.0256 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0256 0.0238
Schistosoma mansoni tyrosine kinase 0.0057 0.0166 0.0149
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.049 0.1904 0.0395
Schistosoma mansoni neuropeptide receptor 0.008 0.0256 0.0239
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.2193 0.8737 0.8734
Schistosoma mansoni opsin-like receptor 0.008 0.0256 0.0239
Echinococcus granulosus thyrotropin releasing hormone receptor 0.008 0.0256 0.0238
Echinococcus granulosus neuropeptide s receptor 0.008 0.0256 0.0238
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0256 0.0238
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0256 0.0238
Brugia malayi neuropeptide F receptor 0.008 0.0256 0.0238
Echinococcus granulosus 7TM GPCR rhodopsin 0.008 0.0256 0.0238
Giardia lamblia Rab geranylgeranyltransferase 0.06 0.2344 0.1079
Echinococcus granulosus neuropeptide receptor 0.008 0.0256 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0256 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0256 0.0238
Schistosoma mansoni histamine h1 receptor 0.008 0.0256 0.0239
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.06 0.2344 0.2683
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.2508 1 1
Brugia malayi SRC-1 0.0057 0.0166 0.0148
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0256 0.0238
Schistosoma mansoni biogenic amine (5HT) receptor 0.008 0.0256 0.0239
Schistosoma mansoni amine GPCR 0.008 0.0256 0.0239
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0256 0.0239
Toxoplasma gondii hypothetical protein 0.1593 0.6329 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.2193 0.8737 0.8501
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0407 0.1571 0.1798
Onchocerca volvulus 0.06 0.2344 1
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0256 0.0238
Trypanosoma cruzi lanosterol synthase, putative 0.0501 0.1948 0.4884
Loa Loa (eye worm) hypothetical protein 0.0407 0.1571 0.1555
Onchocerca volvulus 0.008 0.0256 0.1021
Echinococcus granulosus tyrosine protein kinase Lyn 0.0057 0.0167 0.0149
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0027 0.0046 0.0027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0256 0.0239
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.06 0.2344 0.233
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.049 0.1904 0.1889
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0256 0.0239
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.008 0.0256 0.0238
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0706 0.2769 0.2756
Brugia malayi Tyrosine-protein kinase abl-1 0.0108 0.0371 0.0354
Brugia malayi Melatonin receptor type 1A 0.008 0.0256 0.0238
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0407 0.1571 0.1555
Schistosoma mansoni alpha-1 adrenergic receptor 0.008 0.0256 0.0239
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis serotonin receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.2193 0.8737 0.8734
Loa Loa (eye worm) hypothetical protein 0.0705 0.2768 0.2754
Schistosoma mansoni neuropeptide receptor 0.008 0.0256 0.0239
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0256 0.0238
Onchocerca volvulus 0.008 0.0256 0.1021
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis g protein coupled receptor 0.008 0.0256 0.0238
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.2193 0.8737 0.8501
Echinococcus granulosus tyrosine protein kinase HCK 0.0043 0.0111 0.0093
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.06 0.2344 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0256 0.0238
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0256 0.0238
Echinococcus multilocularis biogenic amine (5HT) receptor 0.008 0.0256 0.0238
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.049 0.1904 0.3008
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.049 0.1904 0.0395
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0166 0.0148
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.06 0.2344 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis allatostatin A receptor 0.008 0.0256 0.0238
Brugia malayi Serotonin/octopamine receptor family protein 7 0.008 0.0256 0.0238
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.008 0.0256 0.0239
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.2508 1 1
Schistosoma mansoni amine GPCR 0.008 0.0256 0.0239
Loa Loa (eye worm) TK protein kinase 0.005 0.0139 0.0121
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0057 0.0166 0.0148
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0407 0.1571 0.1556
Brugia malayi G protein-coupled receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.06 0.2344 0.233
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.06 0.2344 1
Loa Loa (eye worm) melatonin receptor type 1A 0.008 0.0256 0.0238
Echinococcus granulosus 7tm_1 domain containing protein 0.008 0.0256 0.0238
Loa Loa (eye worm) TKL/MLK/LZK protein kinase 0.0706 0.2769 0.2756
Brugia malayi neuropeptide F receptor 0.008 0.0256 0.0238
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.008 0.0256 0.0239
Echinococcus granulosus g protein coupled receptor 0.008 0.0256 0.0238
Echinococcus multilocularis somatostatin receptor 0.008 0.0256 0.0238
Schistosoma mansoni protein farnesyltransferase subunit beta 0.049 0.1904 0.189
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.008 0.0256 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0256 0.0239
Schistosoma mansoni tyrosine kinase 0.002 0.0018 0.0001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0166 0.0148
Trypanosoma cruzi lanosterol synthase, putative 0.0501 0.1948 0.4884
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0166 0.0148
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.008 0.0256 0.0238
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.049 0.1904 0.0395
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.2193 0.8737 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0057 0.0166 0.0148
Schistosoma mansoni adenoreceptor 0.008 0.0256 0.0239
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Brugia malayi Protein kinase domain containing protein 0.0706 0.2769 0.2756
Brugia malayi AKH receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) TK protein kinase 0.0043 0.0111 0.0093
Schistosoma mansoni hypothetical protein 0.008 0.0256 0.0239
Brugia malayi GnHR receptor homolog 0.008 0.0256 0.0238
Onchocerca volvulus 0.008 0.0256 0.1021
Trypanosoma cruzi hypothetical protein, conserved 0.06 0.2344 1
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0256 0.0238
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Schistosoma mansoni tyrosine kinase 0.0057 0.0166 0.0149
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0256 0.0238
Loa Loa (eye worm) SRC-1 0.0057 0.0166 0.0148
Plasmodium vivax farnesyltransferase beta subunit, putative 0.049 0.1904 0.2179
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0256 0.0238
Schistosoma mansoni opsin-like receptor 0.008 0.0256 0.0239
Brugia malayi hypothetical protein 0.008 0.0256 0.0238
Trypanosoma brucei hypothetical protein, conserved 0.06 0.2344 1
Brugia malayi G-protein coupled receptor 0.008 0.0256 0.0238
Onchocerca volvulus 0.008 0.0256 0.1021
Echinococcus multilocularis G-protein coupled receptor, putative 0.008 0.0256 0.0238
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus granulosus G protein coupled receptor 139 0.008 0.0256 0.0238
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.005 0.0139 0.0121
Schistosoma mansoni neuropeptide receptor 0.008 0.0256 0.0239
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0256 0.0238
Echinococcus granulosus tyrosine protein kinase Blk 0.005 0.0139 0.0121
Echinococcus multilocularis sex peptide receptor 0.008 0.0256 0.0238
Echinococcus granulosus c src tyrosine kinase 0.0027 0.0046 0.0027
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis tyrosine protein kinase Abl 0.0108 0.0371 0.0354
Schistosoma mansoni neuropeptide receptor 0.008 0.0256 0.0239
Echinococcus granulosus dro:myosuppressin receptor 0.008 0.0256 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0256 0.0239
Brugia malayi hypothetical protein 0.008 0.0256 0.0238
Brugia malayi hypothetical protein 0.008 0.0256 0.0238
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.008 0.0256 0.0239
Onchocerca volvulus 0.008 0.0256 0.1021
Echinococcus granulosus protein prenyltransferase alpha subunit 0.06 0.2344 0.233
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Brugia malayi Dopamine receptor protein 2 0.008 0.0256 0.0238
Echinococcus granulosus protein farnesyltransferase subunit beta 0.049 0.1904 0.1889
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0256 0.0239
Plasmodium vivax geranylgeranyltransferase, putative 0.0407 0.1571 0.1798
Echinococcus multilocularis g protein coupled receptor 0.008 0.0256 0.0238
Echinococcus granulosus g protein coupled receptor 0.008 0.0256 0.0238
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.06 0.2344 0.0918
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.06 0.2344 0.233
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0027 0.0046 0.0027
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0501 0.1948 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.008 0.0256 0.0238
Echinococcus granulosus g-protein coupled receptor 0.008 0.0256 0.0238
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0256 0.0238
Brugia malayi RE15519p 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Brugia malayi hypothetical protein 0.008 0.0256 0.0238
Echinococcus granulosus hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.06 0.2344 0.233
Brugia malayi G protein-coupled receptor F59B2.13 0.008 0.0256 0.0238
Schistosoma mansoni neuropeptide f receptor 76f 0.008 0.0256 0.0239
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.2193 0.8737 0.8501
Echinococcus granulosus allatostatin A receptor 0.008 0.0256 0.0238
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.06 0.2344 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.049 0.1904 0.1889
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0256 0.0239
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis neuropeptide receptor 0.008 0.0256 0.0238
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0407 0.1571 0.2482
Brugia malayi hypothetical protein 0.008 0.0256 0.0238
Echinococcus granulosus tyrosine protein kinase ABL1 0.0233 0.087 0.0853
Echinococcus granulosus neuropeptide receptor A26 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Schistosoma mansoni tyrosine kinase 0.002 0.0018 0.0001
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0407 0.1571 0.1798
Loa Loa (eye worm) hypothetical protein 0.0095 0.0316 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0256 0.0238
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.06 0.2344 1
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.06 0.2344 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis neuropeptide s receptor 0.008 0.0256 0.0238
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0256 0.0239
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.049 0.1904 0.1889
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0085 0.0067
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Onchocerca volvulus 0.008 0.0256 0.1021
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0057 0.0166 0.0148
Echinococcus granulosus tyrosine protein kinase Src64B 0.0057 0.0166 0.0148
Loa Loa (eye worm) TYRA-2 protein 0.008 0.0256 0.0238
Onchocerca volvulus 0.008 0.0256 0.1021
Echinococcus granulosus biogenic amine 5HT receptor 0.008 0.0256 0.0238
Echinococcus multilocularis g-protein coupled receptor 0.008 0.0256 0.0238
Schistosoma mansoni biogenic amine receptor 0.008 0.0256 0.0239
Trypanosoma cruzi protein farnesyltransferase, putative 0.049 0.1904 0.4309
Echinococcus multilocularis orexin receptor type 2 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.06 0.2344 0.233
Schistosoma mansoni hypothetical protein 0.008 0.0256 0.0239
Onchocerca volvulus 0.008 0.0256 0.1021
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0057 0.0166 0.0148
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.2508 1 1
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.2508 1 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0057 0.0166 0.0148
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0057 0.0166 0.0148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0256 0.0239
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0256 0.0238
Schistosoma mansoni amine GPCR 0.008 0.0256 0.0239
Onchocerca volvulus 0.008 0.0256 0.1021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0256 0.0239
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.06 0.2344 0.233
Brugia malayi sulfakinin receptor protein 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Schistosoma mansoni hypothetical protein 0.008 0.0256 0.0239
Leishmania major protein farnesyltransferase alpha subunit, putative 0.06 0.2344 1
Onchocerca volvulus 0.008 0.0256 0.1021
Onchocerca volvulus Neuropeptide F receptor homolog 0.008 0.0256 0.1021
Echinococcus granulosus peptide allatostatin:somatostatin 0.008 0.0256 0.0238
Brugia malayi hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0057 0.0166 0.0148
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0256 0.0238
Onchocerca volvulus 0.008 0.0256 0.1021
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.008 0.0256 0.0238
Brugia malayi G-protein coupled receptor 0.008 0.0256 0.0238
Giardia lamblia Rab geranylgeranyltransferase 0.2193 0.8737 1
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0256 0.0238
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0256 0.0238
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0256 0.0238
Echinococcus granulosus serotonin receptor 0.008 0.0256 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0256 0.0239
Brugia malayi hypothetical protein 0.008 0.0256 0.0238
Echinococcus multilocularis neuropeptide receptor A26 0.008 0.0256 0.0238
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0256 0.0238
Schistosoma mansoni tyrosine kinase 0.0027 0.0046 0.0028
Schistosoma mansoni biogenic amine receptor 0.008 0.0256 0.0239
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.008 0.0256 0.0238
Brugia malayi Tachykinin-like peptides receptor 99D 0.008 0.0256 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0256 0.0238
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.06 0.2344 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.008 0.0256 0.0239
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.049 0.1904 0.0395
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0256 0.0238
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.2508 1 1
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0407 0.1571 0.1555
Brugia malayi hypothetical protein 0.008 0.0256 0.0238
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0256 0.0238
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.008 0.0256 0.0238
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0083 0.027 0.0309
Schistosoma mansoni hypothetical protein 0.008 0.0256 0.0239
Echinococcus multilocularis fmrfamide receptor 0.008 0.0256 0.0238
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.06 0.2344 0.2683
Brugia malayi putative neuropeptide receptor NPR1 0.008 0.0256 0.0238
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0139 0.0121
Leishmania major geranylgeranyltransferase, putative 0.0407 0.1571 0.6189
Echinococcus granulosus tyrosine kinase 0.005 0.0139 0.0121
Echinococcus granulosus orexin receptor type 2 0.008 0.0256 0.0238
Brugia malayi follicle stimulating hormone receptor 0.008 0.0256 0.0238

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 88 nM Displacement of [3H]-clonidine from alpha2-adrenergic receptor of calf neocortical membrane ChEMBL. 6298426
Kd (binding) = 250 nM Displacement of [3H]-prazosin from alpha1-adrenergic receptor of calf neocortical membrane ChEMBL. 6298426
Ratio (binding) = 2.8 Relative affinity for alpha-1 and alpha-2 adrenergic receptors ChEMBL. 6298426

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.