TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 602.392 | Formula: C18H24N10O10P2
H donors: 6 H acceptors: 12 LogP: -4.79 Rotable bonds: 11
Rule of 5 violations (Lipinski): 4
SMILES: Nc1ncnc2c1ncn2C1OC([C@H]([C@@H]1O)OP(=O)(COCCn1cnc2c1c(N)ncn2)O)COP(=O)(O)O
InChi: 1S/C18H24N10O10P2/c19-14-10-17(24-5-21-14)28(7-25-10)18-12(29)13(9(37-18)3-36-40(32,33)34)38-39(30,31)8-35-2-1-27-6-26-16-11(27)15(20)22-4-23-16/h4-7,9,12-13,18,29H,1-3,8H2,(H,30,31)(H2,19,21,24)(H2,20,22,23)(H2,32,33,34)/t9?,12?,13-,18?/m0/s1
InChiKey: HZMBALOCWYVVPP-IMRODOBOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	neuropeptide F receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0132	0.018
Echinococcus granulosus	neuropeptide receptor	0.0417	0.0328	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0005	0.0003
Onchocerca volvulus		0.0267	0.0193	0.0255
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.0028	0.0036
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.7978	0.7118	0.9841
Echinococcus granulosus	epidermal growth factor receptor	0.0086	0.0031	0.0039
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.017	0.0106	0.0144
Mycobacterium ulcerans	adenylylate/guanylate cyclase	0.0141	0.0081	0.0102
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0267	0.0193	0.0264
Toxoplasma gondii	hypothetical protein	0.0199	0.0132	0.0125
Schistosoma mansoni	tyrosine kinase	0.0054	0.0002	0.0003
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0087	0.0032	0.0041
Toxoplasma gondii	microneme protein MIC17B	0.0199	0.0132	0.0125
Onchocerca volvulus		0.0083	0.0028	0.0026
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.017	0.0106	0.0144
Brugia malayi	hypothetical protein	0.0083	0.0028	0.0036
Brugia malayi	G-protein coupled receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Echinococcus multilocularis	glycine receptor subunit beta	0.017	0.0106	0.0144
Schistosoma mansoni	tyrosine kinase	0.007	0.0017	0.0023
Onchocerca volvulus		0.0199	0.0132	0.017
Brugia malayi	hypothetical protein	0.0062	0.0009	0.001
Onchocerca volvulus		0.017	0.0106	0.0134
Mycobacterium ulcerans	folylpolyglutamate synthase protein FolC	0.0323	0.0244	0.0328
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0087	0.0032	0.0041
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0267	0.0193	0.0264
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.7978	0.7118	0.9841
Mycobacterium ulcerans	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	0.0235	0.0165	0.0218
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0087	0.0032	0.0044
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.017	0.0106	0.0144
Onchocerca volvulus		0.0214	0.0146	0.0189
Echinococcus granulosus	kinesin family 1	0.046	0.0367	0.0505
Onchocerca volvulus		0.0678	0.0563	0.0766
Echinococcus granulosus	enteropeptidase	0.0197	0.0131	0.0178
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Echinococcus multilocularis	folylpolyglutamate synthase, mitochondrial	0.0323	0.0244	0.0335
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	1.1187	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.0028	0.0036
Onchocerca volvulus		0.0199	0.0132	0.017
Brugia malayi	PAN domain containing protein	0.0199	0.0132	0.018
Schistosoma mansoni	nAChR subunit	0.017	0.0106	0.0147
Mycobacterium tuberculosis	Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transfo	0.0235	0.0165	0.0218
Echinococcus multilocularis	glycoprotein Antigen 5	0.0197	0.0131	0.0178
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.017	0.0106	0.0144
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0132	0.0072	0.0097
Toxoplasma gondii	PAN domain-containing protein	0.0199	0.0132	0.0125
Onchocerca volvulus		0.0678	0.0563	0.0766
Onchocerca volvulus		0.0087	0.0032	0.0031
Onchocerca volvulus		0.0267	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0009	0.001
Echinococcus granulosus	biogenic amine 5HT receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	nAChR subunit	0.017	0.0106	0.0147
Brugia malayi	Trypsin family protein	0.0197	0.0131	0.0178
Brugia malayi	Cation transporter family protein	0.017	0.0106	0.0144
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0267	0.0193	0.0267
Brugia malayi	FolC bifunctional protein	0.0323	0.0244	0.0335
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0267	0.0193	0.0264
Echinococcus multilocularis	nAChR subunit	0.0087	0.0032	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0132	0.018
Schistosoma mansoni	tyrosine kinase	0.007	0.0017	0.0023
Schistosoma mansoni	folylpolyglutamate synthase	0.0323	0.0244	0.0338
Onchocerca volvulus		0.0083	0.0028	0.0026
Echinococcus granulosus	g protein coupled receptor	0.0267	0.0193	0.0264
Brugia malayi	Furin-like cysteine rich region family protein	0.0153	0.0091	0.0123
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0267	0.0193	0.0264
Echinococcus multilocularis		0.0123	0.0064	0.0085
Onchocerca volvulus		0.0267	0.0193	0.0255
Echinococcus multilocularis	tissue type plasminogen activator	0.0289	0.0214	0.0292
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0267	0.0193	0.0264
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Brugia malayi	hypothetical protein	0.0083	0.0028	0.0036
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0197	0.0131	0.018
Schistosoma mansoni	apoptosis regulator bax	0.0087	0.0032	0.0044
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0083	0.0028	0.0036
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0032	0.0041
Loa Loa (eye worm)	LGC-31 protein	0.017	0.0106	0.0144
Echinococcus granulosus	thymidylate synthase	0.8106	0.7233	1
Brugia malayi	PAN domain containing protein	0.0199	0.0132	0.018
Loa Loa (eye worm)	glutamate receptor	0.0062	0.0009	0.001
Brugia malayi	Receptor family ligand binding region containing protein	0.0211	0.0144	0.0196
Loa Loa (eye worm)	kinesin-like protein KLP2	0.006	0.0007	0.0007
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0062	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Wolbachia endosymbiont of Brugia malayi	AICAR transformylase/IMP cyclohydrolase PurH	0.0235	0.0165	0.1109
Echinococcus multilocularis	neuropeptide receptor	0.0417	0.0328	0.0451
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Brugia malayi	selenium donor protein	0.0123	0.0064	0.0085
Echinococcus granulosus	sex peptide receptor	0.0267	0.0193	0.0264
Echinococcus multilocularis	G protein coupled receptor 139	0.0417	0.0328	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0032	0.0041
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.017	0.0106	0.0144
Brugia malayi	PAN domain containing protein	0.0199	0.0132	0.018
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0132	0.0072	0.0097
Echinococcus granulosus	tissue type plasminogen activator	0.0289	0.0214	0.0292
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.009	0.0035	0.0028
Schistosoma mansoni	jumonji domain containing protein	0.0078	0.0024	0.0033
Onchocerca volvulus		0.0267	0.0193	0.0255
Loa Loa (eye worm)	dihydrofolate reductase	0.7978	0.7118	0.9841
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.017	0.0106	0.0144
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0199	0.0132	0.0125
Loa Loa (eye worm)	hypothetical protein	0.1271	0.1095	0.1512
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Onchocerca volvulus		0.0267	0.0193	0.0255
Onchocerca volvulus		0.0087	0.0032	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Brugia malayi	ORL1-like opioid receptor	0.0267	0.0193	0.0264
Toxoplasma gondii	hypothetical protein	0.0199	0.0132	0.0125
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.8106	0.7233	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.017	0.0106	0.0144
Brugia malayi	dihydrofolate reductase family protein	0.7978	0.7118	0.9841
Loa Loa (eye worm)	TYRA-2 protein	0.0267	0.0193	0.0264
Brugia malayi	RE15519p	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.017	0.0106	0.0144
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Schistosoma mansoni	hypothetical protein	0.0093	0.0038	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0032	0.0041
Onchocerca volvulus		0.0199	0.0132	0.017
Toxoplasma gondii	bifunctional protein FolC subfamily protein	0.0323	0.0244	0.0237
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0019	0.0024
Brugia malayi	hypothetical protein	0.0083	0.0028	0.0036
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.007	0.0017	0.002
Brugia malayi	sulfakinin receptor protein	0.0267	0.0193	0.0264
Schistosoma mansoni	hypothetical protein	0.0267	0.0193	0.0267
Echinococcus multilocularis	neuropeptide Y receptor	0.0267	0.0193	0.0264
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0087	0.0032	0.0041
Brugia malayi	follicle stimulating hormone receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	opsin-like receptor	0.0267	0.0193	0.0267
Brugia malayi	Cation transporter family protein	0.017	0.0106	0.0144
Brugia malayi	Trypsin family protein	0.1271	0.1095	0.1512
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0267	0.0193	0.0264
Schistosoma mansoni	biogenic amine receptor	0.0267	0.0193	0.0267
Schistosoma mansoni	protein kinase	0.0211	0.0144	0.0198
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0062	0.0009	0.001
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0083	0.0028	0.0036
Onchocerca volvulus		0.017	0.0106	0.0134
Echinococcus granulosus	neuropeptide FF receptor 2	0.0267	0.0193	0.0264
Schistosoma mansoni	metabotropic glutamate receptor	0.0062	0.0009	0.0013
Schistosoma mansoni	nAChR subunit	0.017	0.0106	0.0147
Schistosoma mansoni	hypothetical protein	0.0197	0.0131	0.018
Toxoplasma gondii	selenide, water dikinase	0.0123	0.0064	0.0057
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0062	0.0009	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0267	0.0193	0.0267
Echinococcus granulosus	epidermal growth factor receptor	0.0153	0.0091	0.0123
Echinococcus multilocularis	somatostatin receptor	0.0267	0.0193	0.0264
Echinococcus granulosus	serotonin receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1271	0.1095	0.1514
Schistosoma mansoni	neurotransmitter gated ion channel	0.0087	0.0032	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.017	0.0106	0.0144
Schistosoma mansoni	voltage-gated potassium channel	0.053	0.043	0.0594
Loa Loa (eye worm)	DOMON domain-containing protein	0.0214	0.0146	0.0198
Echinococcus multilocularis	sex peptide receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0062	0.0009	0.001
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus granulosus	neuropeptide Y receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0062	0.0009	0.001
Onchocerca volvulus		0.0267	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Brugia malayi	larval opioid receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0197	0.0131	0.0178
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0083	0.0028	0.0026
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.017	0.0106	0.0144
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0267	0.0193	0.0267
Echinococcus granulosus	folylpolyglutamate synthase mitochondrial	0.0323	0.0244	0.0335
Schistosoma mansoni	hypothetical protein	0.0401	0.0314	0.0433
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.017	0.0106	0.0144
Onchocerca volvulus	Putative nachr subunit	0.017	0.0106	0.0134
Echinococcus granulosus	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.017	0.0106	0.0144
Mycobacterium ulcerans	phosphoribosylaminoimidazole synthetase	0.0362	0.0279	0.0376
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0211	0.0144	0.0196
Echinococcus multilocularis	voltage dependent calcium channel	0.0132	0.0072	0.0097
Echinococcus multilocularis	g protein coupled receptor	0.0267	0.0193	0.0264
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Brugia malayi	jmjC domain containing protein	0.0098	0.0042	0.0055
Mycobacterium leprae	PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS)	0.0323	0.0244	0.0311
Brugia malayi	Serotonin receptor	0.0267	0.0193	0.0264
Echinococcus multilocularis	integrin beta 2	0.0727	0.0606	0.0836
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0267	0.0193	0.0255
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0197	0.0131	0.018
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.017	0.0106	0.0144
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	serine-type protease inhibitor	0.5544	0.4933	0.682
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0032	0.0041
Brugia malayi	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Onchocerca volvulus	Putative folylpolyglutamate synthase	0.0323	0.0244	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0132	0.018
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0197	0.0131	0.0178
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.7978	0.7118	0.9841
Onchocerca volvulus		0.0289	0.0214	0.0283
Onchocerca volvulus		0.0267	0.0193	0.0255
Echinococcus granulosus	sodium channel protein	0.0108	0.005	0.0067
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0093	0.0037	0.0049
Brugia malayi	Muscle positioning protein 4	0.0218	0.0149	0.0204
Brugia malayi	hypothetical protein	0.0197	0.0131	0.0178
Echinococcus granulosus	neuropeptide receptor A26	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0678	0.0563	0.0775
Schistosoma mansoni	neuropeptide receptor	0.0267	0.0193	0.0267
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0267	0.0193	0.0267
Entamoeba histolytica	hypothetical protein	0.0087	0.0032	1
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	PAN domain-containing protein	0.0199	0.0132	0.018
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.8106	0.7233	1
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0108	0.005	0.0043
Mycobacterium tuberculosis	Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II)	0.0123	0.0064	0.0078
Schistosoma mansoni	methionyl-tRNA formyltransferase	0.006	0.0007	0.001
Loa Loa (eye worm)	G-protein coupled receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0267	0.0193	0.0267
Treponema pallidum	folylpolyglutamate synthetase (folC)	0.0323	0.0244	1
Loa Loa (eye worm)	FolC protein	0.0323	0.0244	0.0335
Echinococcus granulosus	glycine receptor subunit beta	0.017	0.0106	0.0144
Brugia malayi	Dopamine receptor protein 1	0.0267	0.0193	0.0264
Brugia malayi	PAN domain containing protein	0.0199	0.0132	0.018
Schistosoma mansoni	glutamate receptor NMDA	0.0062	0.0009	0.0013
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.017	0.0106	0.0147
Plasmodium vivax	selenophosphate synthetase, putative	0.0123	0.0064	0.0057
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.053	0.043	0.0592
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0267	0.0193	0.0267
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.017	0.0106	0.0144
Echinococcus multilocularis	neuropeptides capa receptor	0.0267	0.0193	0.0264
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0087	0.0032	0.0041
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.017	0.0106	0.0147
Onchocerca volvulus		0.0214	0.0146	0.0189
Trypanosoma cruzi	folylpolyglutamate synthetase	0.0323	0.0244	0.0237
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.017	0.0106	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus multilocularis	epidermal growth factor receptor	0.0153	0.0091	0.0123
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0197	0.0131	0.0178
Toxoplasma gondii	microneme protein, putative	0.0199	0.0132	0.0125
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0267	0.0193	0.0267
Schistosoma mansoni	neuropeptide f receptor 76f	0.0267	0.0193	0.0267
Mycobacterium tuberculosis	Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt	0.0239	0.0169	0.0224
Wolbachia endosymbiont of Brugia malayi	phosphoribosylformylglycinamidine synthase domain-containing protein	0.0123	0.0064	0.0399
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0132	0.0072	0.0097
Onchocerca volvulus		0.0267	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus granulosus	glutamate receptor 2	0.0062	0.0009	0.001
Brugia malayi	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus granulosus	folylpolyglutamate synthase, mitochondrial	0.0323	0.0244	0.0335
Echinococcus multilocularis	dro:myosuppressin receptor	0.0267	0.0193	0.0264
Trypanosoma cruzi	selenophosphate synthetase, putative	0.0123	0.0064	0.0057
Onchocerca volvulus		0.0199	0.0132	0.017
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0132	0.018
Loa Loa (eye worm)	G-protein coupled receptor	0.0267	0.0193	0.0264
Brugia malayi	Protein kinase domain containing protein	0.0298	0.0221	0.0303
Echinococcus multilocularis	kinesin family 1	0.046	0.0367	0.0505
Loa Loa (eye worm)	integrin beta-2	0.0885	0.0749	0.1032
Onchocerca volvulus		0.0214	0.0146	0.0189
Plasmodium falciparum	dihydrofolate synthase/folylpolyglutamate synthase	0.0323	0.0244	0.0237
Entamoeba histolytica	hypothetical protein	0.0062	0.0009	0.0702
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Echinococcus granulosus	g protein coupled receptor	0.0267	0.0193	0.0264
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0186	0.012	0.0164
Onchocerca volvulus		0.0197	0.0131	0.0168
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0062	0.0009	0.001
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0267	0.0193	0.0264
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	1.1187	1	1
Brugia malayi	Kelch motif family protein	0.0183	0.0118	0.0161
Brugia malayi	hypothetical protein	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0199	0.0132	0.017
Echinococcus granulosus	selenide water dikinase	0.0123	0.0064	0.0085
Trypanosoma cruzi	folylpolyglutamate synthase, putative	0.0323	0.0244	0.0237
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Onchocerca volvulus		0.0267	0.0193	0.0255
Brugia malayi	G protein-coupled receptor	0.0267	0.0193	0.0264
Toxoplasma gondii	microneme protein MIC4	0.0199	0.0132	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Onchocerca volvulus		0.0267	0.0193	0.0255
Mycobacterium tuberculosis	Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS)	0.0323	0.0244	0.0328
Schistosoma mansoni	voltage-gated potassium channel	0.053	0.043	0.0594
Trypanosoma brucei	folylpolyglutamate synthase, putative	0.0323	0.0244	0.0237
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0267	0.0193	0.0264
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0132	0.0072	0.01
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.017	0.0106	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0132	0.018
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0019	0.0024
Schistosoma mansoni	adenoreceptor	0.0267	0.0193	0.0267
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0032	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0132	0.018
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Echinococcus multilocularis	glutamate receptor 2	0.0062	0.0009	0.001
Loa Loa (eye worm)	TK/ROR protein kinase	0.0298	0.0221	0.0303
Echinococcus granulosus	kelch ECH associated protein 1	0.0093	0.0037	0.0049
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0062	0.0009	0.001
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0062	0.0009	0.001
Brugia malayi	Receptor family ligand binding region containing protein	0.0062	0.0009	0.001
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0267	0.0193	0.0264
Onchocerca volvulus		0.8106	0.7233	1
Onchocerca volvulus		0.0362	0.0279	0.0373
Onchocerca volvulus		0.0678	0.0563	0.0766
Loa Loa (eye worm)	thymidylate synthase	0.8106	0.7233	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Echinococcus granulosus	fmrfamide receptor	0.0267	0.0193	0.0264
Mycobacterium tuberculosis	Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase)	0.0362	0.0279	0.0376
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0267	0.0193	0.0267
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0083	0.0028	0.0036
Echinococcus multilocularis	thymidylate synthase	0.8106	0.7233	1
Brugia malayi	Trypsin family protein	0.0197	0.0131	0.0178
Schistosoma mansoni	tyrosine kinase	0.0086	0.0031	0.0042
Schistosoma mansoni	dihydrofolate reductase	0.7978	0.7118	0.9841
Onchocerca volvulus		0.0267	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Echinococcus multilocularis	transmembrane protease serine 3	0.0197	0.0131	0.0178
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.017	0.0106	0.0144
Schistosoma mansoni	neuropeptide F-like receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0062	0.0009	0.001
Echinococcus granulosus	somatostatin receptor	0.0267	0.0193	0.0264
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	1.1187	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.017	0.0106	0.0147
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0199	0.0132	0.017
Echinococcus granulosus	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0267	0.0193	0.0264
Echinococcus multilocularis	nmda type glutamate receptor	0.0062	0.0009	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Schistosoma mansoni	neuropeptide F-like receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Brugia malayi	Dopamine receptor protein 2	0.0267	0.0193	0.0264
Brugia malayi	G protein-coupled receptor F59B2.13	0.0267	0.0193	0.0264
Echinococcus multilocularis	Kelch repeat type 1	0.0093	0.0038	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Brugia malayi	GnHR receptor homolog	0.0267	0.0193	0.0264
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0093	0.0037	0.0049
Brugia malayi	Kringle domain containing protein	0.0289	0.0214	0.0292
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0098	0.0042	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0009	0.001
Echinococcus granulosus	neuropeptide receptor	0.0267	0.0193	0.0264
Brugia malayi	PAN domain containing protein	0.0199	0.0132	0.018
Loa Loa (eye worm)	hypothetical protein	0.0197	0.0131	0.0178
Toxoplasma gondii	PAN domain-containing protein	0.2202	0.1931	0.1925
Leishmania major	pteridine reductase 1	0.0222	0.0153	0.0146
Mycobacterium leprae	PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE)	0.0362	0.0279	0.0359
Toxoplasma gondii	microneme protein MIC17C	0.0199	0.0132	0.0125
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0087	0.0032	0.0041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Echinococcus granulosus	transmembrane protease serine 3	0.0197	0.0131	0.0178
Echinococcus granulosus	allatostatin A receptor	0.0267	0.0193	0.0264
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.015	0.0089	0.012
Onchocerca volvulus		0.0267	0.0193	0.0255
Wolbachia endosymbiont of Brugia malayi	phosphoribosylamine--glycine ligase	0.164	0.1427	1
Onchocerca volvulus		0.0197	0.0131	0.0168
Echinococcus granulosus	nAChR subunit	0.0087	0.0032	0.0041
Echinococcus multilocularis	serotonin receptor	0.0267	0.0193	0.0264
Echinococcus granulosus	glycine receptor subunit alpha 1	0.017	0.0106	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0009	0.001
Echinococcus granulosus	biogenic amine 5HT receptor	0.0267	0.0193	0.0264
Mycobacterium tuberculosis	Hypothetical protein	0.3856	0.3417	0.4718
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus granulosus	receptor type guanylyl cyclase	0.0211	0.0144	0.0196
Onchocerca volvulus		0.0197	0.0131	0.0168
Onchocerca volvulus		0.0197	0.0131	0.0168
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0267	0.0193	0.0264
Echinococcus multilocularis	serotonin receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0267	0.0193	0.0267
Echinococcus multilocularis	sodium channel protein	0.015	0.0089	0.012
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0062	0.0009	0.001
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0086	0.0031	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0197	0.0131	0.0178
Onchocerca volvulus		0.1271	0.1095	0.1504
Schistosoma mansoni	amine GPCR	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0032	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Brugia malayi	PAN domain containing protein	0.0199	0.0132	0.018
Mycobacterium ulcerans	thymidylate synthase	0.8106	0.7233	1
Schistosoma mansoni	hypothetical protein	0.0087	0.0032	0.0044
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.017	0.0106	0.0144
Schistosoma mansoni	hypothetical protein	0.0267	0.0193	0.0267
Schistosoma mansoni	voltage-gated cation channel	0.0132	0.0072	0.01
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0197	0.0131	0.018
Loa Loa (eye worm)	trypsin family protein	0.0197	0.0131	0.0178
Leishmania major	hypothetical protein, conserved	0.0289	0.0214	0.0207
Schistosoma mansoni	tyrosine kinase	0.0054	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Brugia malayi	putative neuropeptide receptor NPR1	0.0267	0.0193	0.0264
Loa Loa (eye worm)	melatonin receptor type 1A	0.0267	0.0193	0.0264
Echinococcus multilocularis	g protein coupled receptor	0.0267	0.0193	0.0264
Echinococcus granulosus	neuropeptides capa receptor	0.0267	0.0193	0.0264
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.017	0.0106	0.0144
Chlamydia trachomatis	dihydrofolate reductase	0.7978	0.7118	1
Schistosoma mansoni	hypothetical protein	0.0214	0.0146	0.0201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0267	0.0193	0.0267
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0009	0.001
Echinococcus granulosus	nmda type glutamate receptor	0.0062	0.0009	0.001
Loa Loa (eye worm)	PAN domain-containing protein	0.0199	0.0132	0.018
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0183	0.0118	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus granulosus	neuropeptide Y receptor	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0267	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.017	0.0106	0.0144
Echinococcus multilocularis	nAChR subunit	0.017	0.0106	0.0144
Echinococcus multilocularis	potassium voltage gated channel protein	0.053	0.043	0.0592
Echinococcus multilocularis	allatostatin A receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Mycobacterium leprae	Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transf	0.0235	0.0165	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0132	0.018
Loa Loa (eye worm)	hypothetical protein	0.053	0.043	0.0592
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.017	0.0106	0.0144
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Brugia malayi	Trypsin-like protease protein 5	0.0197	0.0131	0.0178
Echinococcus multilocularis	epidermal growth factor receptor	0.0086	0.0031	0.0039
Loa Loa (eye worm)	PAN domain-containing protein	0.0199	0.0132	0.018
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0132	0.0072	0.0097
Schistosoma mansoni	amine GPCR	0.0267	0.0193	0.0267
Brugia malayi	PAN domain containing protein	0.0199	0.0132	0.018
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus multilocularis	kelch ECH associated protein 1	0.0093	0.0037	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Trypanosoma cruzi	hypothetical protein, conserved	0.0289	0.0214	0.0207
Schistosoma mansoni	growth hormone secretagogue receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0062	0.0009	0.001
Onchocerca volvulus		0.0214	0.0146	0.0189
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0005	0.0003
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0267	0.0193	0.0264
Brugia malayi	PAN domain containing protein	0.0199	0.0132	0.018
Schistosoma mansoni	biogenic amine receptor	0.0267	0.0193	0.0267
Echinococcus granulosus	7TM GPCR rhodopsin	0.0267	0.0193	0.0264
Echinococcus multilocularis	glutamate receptor 2	0.0062	0.0009	0.001
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.017	0.0106	0.0144
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0009	0.001
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.8106	0.7233	1
Brugia malayi	G-protein coupled receptor	0.0267	0.0193	0.0264
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.017	0.0106	0.0144
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0087	0.0032	0.0042
Plasmodium vivax	dihydrofolate synthase/folylpolyglutamate synthase, putative	0.0323	0.0244	0.0237
Brugia malayi	AKH receptor	0.0267	0.0193	0.0264
Echinococcus granulosus	g-protein coupled receptor	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0267	0.0193	0.0255
Echinococcus granulosus	integrin beta 2	0.0727	0.0606	0.0836
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0087	0.0032	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Wolbachia endosymbiont of Brugia malayi	phosphoribosylaminoimidazole synthetase	0.0362	0.0279	0.1914
Toxoplasma gondii	kringle domain-containing protein	0.0289	0.0214	0.0207
Brugia malayi	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus multilocularis	fmrfamide receptor	0.0267	0.0193	0.0264
Brugia malayi	Integrin beta pat-3 precursor	0.0885	0.0749	0.1032
Schistosoma mansoni	neuropeptide receptor	0.0267	0.0193	0.0267
Trypanosoma cruzi	extracellular receptor, putative	0.0062	0.0009	0.0002
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0087	0.0032	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Schistosoma mansoni	nAChR subunit	0.0083	0.0028	0.0039
Schistosoma mansoni	integrin beta subunit	0.0578	0.0473	0.0653
Brugia malayi	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0267	0.0193	0.0264
Onchocerca volvulus		0.017	0.0106	0.0134
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.017	0.0106	0.0144
Echinococcus multilocularis	g-protein coupled receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0072	0.0097
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.017	0.0106	0.0144
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.017	0.0106	0.0144
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0083	0.0028	0.0036
Brugia malayi	hypothetical protein	0.0149	0.0088	0.0118
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.017	0.0106	0.0144
Echinococcus multilocularis	neuropeptide receptor	0.0267	0.0193	0.0264
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.053	0.043	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0083	0.0028	0.0036
Loa Loa (eye worm)	ACC-1 protein	0.017	0.0106	0.0144
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0267	0.0193	0.0267
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0211	0.0144	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Onchocerca volvulus		0.1074	0.0919	0.1259
Onchocerca volvulus		0.0267	0.0193	0.0255
Trypanosoma cruzi	selenophosphate synthetase, putative	0.0123	0.0064	0.0057
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	1.1187	1	1
Echinococcus granulosus	nAChR subunit	0.017	0.0106	0.0144
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0132	0.0072	0.0097
Toxoplasma gondii	PAN domain-containing protein	0.2202	0.1931	0.1925
Echinococcus multilocularis	kelch ECH associated protein 1	0.0093	0.0037	0.0049
Echinococcus granulosus	dro:myosuppressin receptor	0.0267	0.0193	0.0264
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0267	0.0193	0.0264
Schistosoma mansoni	kinesin eg-5	0.006	0.0007	0.001
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0197	0.0131	0.0178
Schistosoma mansoni	amine GPCR	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0267	0.0193	0.0264
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0267	0.0193	0.0267
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0678	0.0563	0.0778
Schistosoma mansoni	tyrosine kinase	0.0086	0.0031	0.0042
Schistosoma mansoni	nAChR subunit	0.017	0.0106	0.0147
Brugia malayi	excitatory GABA receptor EXP-1A	0.017	0.0106	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Schistosoma mansoni	hypothetical protein	0.0267	0.0193	0.0267
Loa Loa (eye worm)	GABA receptor subunit	0.0087	0.0032	0.0041
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0289	0.0214	0.0207
Schistosoma mansoni	nAChR subunit	0.017	0.0106	0.0147
Brugia malayi	hypothetical protein	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0199	0.0132	0.017
Schistosoma mansoni	serine-type protease inhibitor	0.5544	0.4933	0.682
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	neuropeptide F receptor	0.0267	0.0193	0.0264
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0062	0.0009	0.001
Schistosoma mansoni	metabotropic glutamate receptor	0.0062	0.0009	0.0013
Echinococcus granulosus	tm gpcr rhodopsin	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0199	0.0132	0.017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0678	0.0563	0.0775
Echinococcus multilocularis	voltage dependent calcium channel	0.0132	0.0072	0.0097
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.017	0.0106	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0153	0.0091	0.0123
Schistosoma mansoni	tyrosine kinase	0.0153	0.0091	0.0126
Mycobacterium ulcerans	thiamine monophosphate kinase	0.0074	0.002	0.0018
Schistosoma mansoni	opsin-like receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Echinococcus granulosus	7tm_1 domain containing protein	0.0267	0.0193	0.0264
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0132	0.0072	0.0097
Loa Loa (eye worm)	PAN domain-containing protein	0.0199	0.0132	0.018
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus granulosus	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Mycobacterium leprae	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II)	0.0123	0.0064	0.0061
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0087	0.0032	0.0041
Echinococcus granulosus	glutamate receptor 2	0.0062	0.0009	0.001
Loa Loa (eye worm)	ACC-1 protein	0.017	0.0106	0.0144
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0267	0.0193	0.0267
Echinococcus multilocularis	g protein coupled receptor	0.0267	0.0193	0.0264
Brugia malayi	SEA domain containing protein	0.0214	0.0146	0.0198
Brugia malayi	putative neuropeptide receptor	0.0267	0.0193	0.0264
Brugia malayi	Serotonin receptor	0.0267	0.0193	0.0264
Echinococcus multilocularis	neuropeptides capa receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0289	0.0214	0.0292
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.009	0.0035	0.0028
Brugia malayi	hypothetical protein	0.0267	0.0193	0.0264
Schistosoma mansoni	nAChR subunit	0.0083	0.0028	0.0039
Schistosoma mansoni	biogenic amine receptor	0.0267	0.0193	0.0267
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0083	0.0028	0.0036
Brugia malayi	thymidylate synthase	0.8106	0.7233	1
Echinococcus granulosus	potassium voltage gated channel protein	0.053	0.043	0.0592
Onchocerca volvulus		0.0199	0.0132	0.017
Onchocerca volvulus		0.0199	0.0132	0.017
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.017	0.0106	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0028	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus multilocularis	tyrosine kinase	0.007	0.0017	0.002
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Brugia malayi	hypothetical protein	0.0267	0.0193	0.0264
Schistosoma mansoni	acetylcholine receptor-related	0.0083	0.0028	0.0039
Brugia malayi	Cation transporter family protein	0.0678	0.0563	0.0775
Schistosoma mansoni	tyrosine kinase	0.0077	0.0023	0.0032
Echinococcus granulosus	voltage dependent calcium channel	0.0132	0.0072	0.0097
Brugia malayi	neuropeptide F receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	neuropeptide receptor	0.0267	0.0193	0.0267
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0267	0.0193	0.0264
Loa Loa (eye worm)	apoptosis regulator protein	0.0087	0.0032	0.0041
Onchocerca volvulus		0.0267	0.0193	0.0255
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.017	0.0106	0.0144
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.017	0.0106	0.0144
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.017	0.0106	0.0144
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.017	0.0106	0.0144
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.017	0.0106	0.0144
Schistosoma mansoni	opsin-like receptor	0.0267	0.0193	0.0267
Toxoplasma gondii	PAN domain-containing protein	0.0199	0.0132	0.0125
Loa Loa (eye worm)	calcium channel	0.0132	0.0072	0.0097
Echinococcus granulosus	tm gpcr rhodopsin	0.0267	0.0193	0.0264
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0062	0.0009	0.001
Loa Loa (eye worm)	selenium donor protein	0.0123	0.0064	0.0085
Schistosoma mansoni	hypothetical protein	0.0087	0.0032	0.0044
Schistosoma mansoni	hypothetical protein	0.0087	0.0032	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0149	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0197	0.0131	0.0178
Echinococcus multilocularis	dihydrofolate reductase	0.7978	0.7118	0.9841
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0211	0.0144	0.0196
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Echinococcus granulosus	glycine receptor subunit alpha 1	0.017	0.0106	0.0144
Mycobacterium ulcerans	hypothetical protein	0.0197	0.0131	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0595	0.0489	0.0673
Schistosoma mansoni	nAChR subunit	0.017	0.0106	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0062	0.0009	0.001
Brugia malayi	PAN domain containing protein	0.0199	0.0132	0.018
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0197	0.0131	0.018
Loa Loa (eye worm)	PAN domain-containing protein	0.0199	0.0132	0.018
Schistosoma mansoni	hypothetical protein	0.0289	0.0214	0.0295
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.017	0.0106	0.0144
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0087	0.0032	0.0044
Brugia malayi	Melatonin receptor type 1A	0.0267	0.0193	0.0264
Mycobacterium leprae	PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT	0.164	0.1427	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0267	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.1271	0.1095	0.1512
Trypanosoma brucei	pteridine reductase 1	0.0219	0.015	0.0143
Echinococcus granulosus	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Schistosoma mansoni	hypothetical protein	0.0197	0.0131	0.018
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0197	0.0131	0.018
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0083	0.0028	0.0036
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0211	0.0144	0.0196
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0267	0.0193	0.0255
Brugia malayi	Guanylyl cyclase protein 23	0.0087	0.0032	0.0042
Onchocerca volvulus		0.0087	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus granulosus	G protein coupled receptor 139	0.0267	0.0193	0.0264
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.017	0.0106	0.0144
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0087	0.0032	0.0041
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0083	0.0028	0.0036
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0267	0.0193	0.0264
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.017	0.0106	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0032	0.0041
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0098	0.0042	0.0055
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0267	0.0193	0.0267
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0083	0.0028	0.0036
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0678	0.0563	0.0778
Brugia malayi	hypothetical protein	0.0083	0.0028	0.0036
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.3856	0.3417	0.3412
Echinococcus granulosus	tyrosine kinase	0.007	0.0017	0.002
Toxoplasma gondii	subtilisin SUB12	0.0199	0.0132	0.0125
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	1.1187	1	1
Loa Loa (eye worm)	hypothetical protein	0.0214	0.0146	0.0198
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.017	0.0106	0.0144
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.0028	0.0036
Plasmodium falciparum	selenide water dikinase, putative	0.0123	0.0064	0.0057
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0132	0.0072	0.0097
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0231	0.0161	0.0223
Schistosoma mansoni	neuropeptide receptor	0.0417	0.0328	0.0454
Echinococcus granulosus	tm gpcr rhodopsin	0.0267	0.0193	0.0264
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0083	0.0028	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Schistosoma mansoni	cercarial elastase (S01 family)	0.0197	0.0131	0.018
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0083	0.0028	0.0036
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0197	0.0131	0.0178
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0267	0.0193	0.0267
Echinococcus granulosus	orexin receptor type 2	0.0267	0.0193	0.0264
Echinococcus granulosus	g protein coupled receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0267	0.0193	0.0267
Brugia malayi	hypothetical protein	0.3856	0.3417	0.4722
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0009	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0267	0.0193	0.0267
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0267	0.0193	0.0264
Echinococcus granulosus	glycine receptor subunit beta	0.017	0.0106	0.0144
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0087	0.0032	0.0044
Echinococcus multilocularis	neuropeptide receptor A26	0.0267	0.0193	0.0264
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Leishmania major	folylpolyglutamate synthetase	0.0323	0.0244	0.0237
Schistosoma mansoni	myosin xvIII	0.0267	0.0193	0.0267
Schistosoma mansoni	hypothetical protein	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Echinococcus granulosus	neuropeptides capa receptor	0.0267	0.0193	0.0264
Mycobacterium ulcerans	phosphoribosylamine--glycine ligase	0.164	0.1427	0.1965
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1344	0.1161	0.1605
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0288	0.0213	0.0282
Brugia malayi	Kinesin motor domain containing protein	0.006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Schistosoma mansoni	histamine h1 receptor	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0009	0.001
Echinococcus granulosus	Mastin	0.0197	0.0131	0.0178
Trypanosoma brucei	Selenophosphate synthetase 2	0.0123	0.0064	0.0057
Schistosoma mansoni	amine GPCR	0.0267	0.0193	0.0267
Toxoplasma gondii	microneme protein MIC17A	0.0199	0.0132	0.0125
Echinococcus granulosus	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Echinococcus multilocularis	folylpolyglutamate synthase, mitochondrial	0.0323	0.0244	0.0335
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0009	0.001
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0267	0.0193	0.0264
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0267	0.0193	0.0264
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0267	0.0193	0.0264
Leishmania major	extracellular receptor, putative	0.0062	0.0009	0.0002
Schistosoma mansoni	amine GPCR	0.0267	0.0193	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0088	0.0118
Brugia malayi	hypothetical protein	0.0267	0.0193	0.0264
Toxoplasma gondii	PAN domain-containing protein	0.0199	0.0132	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0132	0.0072	0.01
Schistosoma mansoni	selinide water dikinase	0.0123	0.0064	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.3856	0.3417	1
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0199	0.0132	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0009	0.001
Echinococcus multilocularis	fmrfamide receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	neurotransmitter gated ion channel	0.0083	0.0028	0.0039
Onchocerca volvulus		0.0199	0.0132	0.017
Brugia malayi	hypothetical protein	0.0083	0.0028	0.0036
Brugia malayi	Dihydrofolate reductase	0.7978	0.7118	0.9841
Mycobacterium ulcerans	phosphoribosylformylglycinamidine synthase II	0.0123	0.0064	0.0078
Schistosoma mansoni	nAChR subunit	0.017	0.0106	0.0147
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0062	0.0009	0.001
Brugia malayi	metabotropic glutamate receptor type 2	0.0062	0.0009	0.001
Echinococcus multilocularis	neuropeptide Y receptor	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0218	0.0149	0.0194
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0186	0.012	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0197	0.0131	0.0178
Plasmodium falciparum	cysteine repeat modular protein 1	0.0289	0.0214	0.0207
Echinococcus multilocularis	Mastin	0.0197	0.0131	0.0178
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0267	0.0193	0.0264
Giardia lamblia	Kinesin-5	0.006	0.0007	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0267	0.0193	0.0264
Schistosoma mansoni	tyrosine kinase	0.0077	0.0023	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0193	0.0264
Onchocerca volvulus		0.0197	0.0131	0.0168
Brugia malayi	PAN domain containing protein	0.0199	0.0132	0.018
Brugia malayi	Trypsin family protein	0.0197	0.0131	0.0178
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0132	0.0072	0.0097
Toxoplasma gondii	PAN domain-containing protein	0.0199	0.0132	0.0125
Echinococcus granulosus	dihydrofolate reductase	0.7978	0.7118	0.9841
Echinococcus multilocularis	neuropeptide s receptor	0.0267	0.0193	0.0264
Leishmania major	selenophosphate synthetase, putative	0.0123	0.0064	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0032	0.0041
Echinococcus multilocularis	glycine receptor subunit beta	0.017	0.0106	0.0144
Schistosoma mansoni	neurotransmitter gated ion channel	0.0083	0.0028	0.0039
Schistosoma mansoni	tyrosine kinase	0.0077	0.0023	0.0032
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0267	0.0193	0.0264
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.017	0.0106	0.0144
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0508	0.041	0.0563
Brugia malayi	Dopamine receptor	0.0267	0.0193	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0032	0.0041
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0062	0.0009	0.001
Loa Loa (eye worm)	acetylcholine receptor protein	0.0083	0.0028	0.0036
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.017	0.0106	0.0144
Loa Loa (eye worm)	hypothetical protein	0.017	0.0106	0.0144
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0005	0.0003
Echinococcus granulosus	glycoprotein Antigen 5	0.0197	0.0131	0.0178
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0267	0.0193	0.0264
Echinococcus granulosus	neuropeptide s receptor	0.0267	0.0193	0.0264
Echinococcus granulosus	glycine receptor subunit alpha 1	0.017	0.0106	0.0144
Brugia malayi	CUB domain containing protein	0.0073	0.0019	0.0024
Echinococcus multilocularis	orexin receptor type 2	0.0267	0.0193	0.0264
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0197	0.0131	0.0178
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0062	0.0009	0.001
Echinococcus multilocularis	enteropeptidase	0.0197	0.0131	0.0178
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0267	0.0193	0.0264
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.017	0.0106	0.0144
Brugia malayi	hypothetical protein	0.0267	0.0193	0.0264

Activities

Activity type	Activity value	Assay description	Source	Reference
Animal death (functional)	= 19.5 %	Inhibitory effects on HSV-1 induced mortality in NMRI mice upon (ip) administration at a dose of 150 mk/kg/day	ChEMBL.	11606136
Animal death (functional)	> 21 %	Inhibitory effects on HSV-1 induced mortality in NMRI mice upon (ip) administration at a dose of 250 mk/kg/day	ChEMBL.	11606136
Animal death (functional)	> 21 %	Inhibitory effects on HSV-1 induced mortality in NMRI mice upon (ip) administration at a dose of 100 mk/kg/day	ChEMBL.	11606136
IC50 (functional)	= 5.9 ug ml-1	Inhibition of cytopathogenicity against human HIV-1(IIIB) in MT-4 cells	ChEMBL.	11606136
IC50 (functional)	= 6.4 ug ml-1	Inhibition of cytopathogenicity against human HIV-2(LAV-2) in MT-4 cells	ChEMBL.	11606136
IC50 (functional)	= 17 ug ml-1	Inhibition of antiviral activity against moloney murine sarcoma virus(MSV)in CEM cells in cell protection assay	ChEMBL.	11606136
IC50 (functional)	= 298 ug ml-1	Cellular toxic effect was determined in MT-4 cells	ChEMBL.	11606136
IC50 (functional)	> 300 ug ml-1	Cellular toxic effect was determined in CEM cells	ChEMBL.	11606136
Ki (binding)	= 0.0001 M	Inhibitory activity against adenosine deaminase	ChEMBL.	11606136
Ki (binding)	= 0.79 mM	Inhibitory activity against PRPP synthetase	ChEMBL.	11606136
Km (binding)	= 0.00016 M	Michaelis rate constant is determined by the Lineweaver and Burk method against adenosine deaminase	ChEMBL.	11606136
Km (binding)	= 0.57 mM	Michaelis rate constant is determined by the Lineweaver and Burk method against PRPP synthetase	ChEMBL.	11606136
Relative Vmax (binding)	= 9.8	Maximum velocity constant of the rate of deamination was determined against adenosine deaminase	ChEMBL.	11606136
Relative Vmax (binding)	= 12	Maximum velocity constant of the rate of phosphorylation was determined against PRPP synthetase	ChEMBL.	11606136
Symptom initiation (functional)	= 16 %	Inhibitory effects on HSV-1 induced mortality in NMRI mice upon (ip) administration at a dose of 100 mk/kg/day	ChEMBL.	11606136
Symptom initiation (functional)	= 19.3 %	Inhibitory effects on HSV-1 induced mortality in NMRI mice upon (ip) administration at a dose of 150 mk/kg/day	ChEMBL.	11606136
Symptom initiation (functional)	> 21 %	Inhibitory effects on HSV-1 induced mortality in NMRI mice upon (ip) administration at a dose of 250 mk/kg/day	ChEMBL.	11606136

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 301581

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 211656