Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, alpha | No references | |
Homo sapiens | retinoic acid receptor, gamma | No references | |
Homo sapiens | retinoic acid receptor, beta | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Brugia malayi | nuclear hormone receptor | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0787 | 0.9749 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.9524 | 0.977 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0787 | 0.9749 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 0.25 nM | Activation of RARgamma (unknown origin) expressed in human HeLa cells co-expressing ERE-beta-Glob-Luc-SV-Neo incubated for 18 hrs by luciferase reporter gene assay | PATENT. | No reference |
Kd (binding) | = 8 nM | Activation of RARbeta (unknown origin) expressed in human HeLa cells co-expressing ERE-beta-Glob-Luc-SV-Neo incubated for 18 hrs by luciferase reporter gene assay | PATENT. | No reference |
Kd (binding) | = 60 nM | Activation of RARalpha (unknown origin) expressed in human HeLa cells co-expressing ERE-beta-Glob-Luc-SV-Neo incubated for 18 hrs by luciferase reporter gene assay | PATENT. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.