Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | SWIB complex protein | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0291 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0291 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0291 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0291 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0291 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0291 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0291 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0291 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0291 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0291 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0138 | 0.4245 | 0.4245 |
Onchocerca volvulus | 0.0291 | 1 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0138 | 0.4245 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0026 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0291 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0291 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0291 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.