Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0066 | 0 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0148 | 0.221 | 0.6554 |
Plasmodium falciparum | thioredoxin reductase | 0.0192 | 0.3372 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0148 | 0.221 | 0.6554 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0066 | 0 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0148 | 0.221 | 0.6554 |
Brugia malayi | glutathione reductase | 0.0192 | 0.3372 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0066 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0192 | 0.3372 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0148 | 0.221 | 0.6554 |
Trypanosoma brucei | trypanothione reductase | 0.0192 | 0.3372 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0066 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0066 | 0 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0148 | 0.221 | 0.6554 |
Plasmodium falciparum | glutathione reductase | 0.0192 | 0.3372 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0148 | 0.221 | 0.6554 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0192 | 0.3372 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0148 | 0.221 | 0.6554 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0148 | 0.221 | 0.221 |
Toxoplasma gondii | thioredoxin reductase | 0.0192 | 0.3372 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0148 | 0.221 | 0.6554 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0148 | 0.221 | 1 |
Leishmania major | trypanothione reductase | 0.0192 | 0.3372 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0066 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0192 | 0.3372 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0192 | 0.3372 | 1 |
Treponema pallidum | NADH oxidase | 0.0066 | 0 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0192 | 0.3372 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0066 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0192 | 0.3372 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0148 | 0.221 | 0.6554 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0066 | 0 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0192 | 0.3372 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0438 | 1 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0148 | 0.221 | 0.6554 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0192 | 0.3372 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0192 | 0.3372 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (functional) | = 85 % | In vitro maximal vasorelaxing effect evoked on endothelium-denuded rat aortic rings in the presence of 1 uM glibenclamide | ChEMBL. | 12904071 |
Log IC50 (functional) | = 5.36 | In vitro vasorelaxant effect on denuded rat aortic rings. | ChEMBL. | 12904071 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.