Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid sulfatase (microsomal), isozyme S | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_130476 | All targets in OG5_130476 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | arylsulfatase AtsB | steroid sulfatase (microsomal), isozyme S | 583 aa | 470 aa | 23.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 1.5821 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.5821 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.8565 | 0.5119 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 1.5821 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.5821 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.5821 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 1.5821 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 1.5821 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 1.5821 | 1 | 0.5 |
Onchocerca volvulus | 0.201 | 0.0709 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0956 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.201 | 0.0709 | 0.0709 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8565 | 0.5119 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.5821 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.8565 | 0.5119 | 0.5 |
Brugia malayi | thymidylate synthase | 0.201 | 0.0709 | 0.0709 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8565 | 0.5119 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.8565 | 0.5119 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.8565 | 0.5119 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16.6 uM | Inhibitory activity against purified human Steroid sulfatase | ChEMBL. | 14552755 |
IC50 (binding) | = 16.6 uM | Inhibitory activity against purified human Steroid sulfatase | ChEMBL. | 14552755 |
IC50 (binding) | = 37.1 uM | Inhibitory activity against Steroid sulfatase expressed in CHO cells | ChEMBL. | 14552755 |
IC50 (binding) | = 37.1 uM | Inhibitory activity against Steroid sulfatase expressed in CHO cells | ChEMBL. | 14552755 |
Ki (binding) | ND 0 uM | Inhibitory constant against purified human Steroid sulfatase; ND= not done | ChEMBL. | 14552755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.