TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 491.198 | Formula: C25H33NO7S
H donors: 0 H acceptors: 3 LogP: 4.03 Rotable bonds: 12
Rule of 5 violations (Lipinski): 0
SMILES: COc1cc(CCCOC(=O)[C@H]2CCCCN2S(=O)(=O)Cc2ccccc2)cc(c1OC)OC
InChi: InChI=1S/C25H33NO7S/c1-30-22-16-20(17-23(31-2)24(22)32-3)12-9-15-33-25(27)21-13-7-8-14-26(21)34(28,29)18-19-10-5-4-6-11-19/h4-6,10-11,16-17,21H,7-9,12-15,18H2,1-3H3/t21-/m1/s1
InChiKey: WUVVOAPMLQTLBJ-OAQYLSRUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Legionella pneumophila	Outer membrane protein MIP		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	immunophilin	Get druggable targets OG5_126727	All targets in OG5_126727
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	Get druggable targets OG5_126727	All targets in OG5_126727
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	Get druggable targets OG5_126727	All targets in OG5_126727
Leishmania mexicana	fk506-binding protein 1-like protein	Get druggable targets OG5_126727	All targets in OG5_126727
Leishmania donovani	peptidylprolyl isomerase-like protein	Get druggable targets OG5_126727	All targets in OG5_126727
Candida albicans	hypothetical protein	Get druggable targets OG5_126727	All targets in OG5_126727
Trypanosoma congolense	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Leishmania major	peptidylprolyl isomerase-like protein	Get druggable targets OG5_126727	All targets in OG5_126727
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	Get druggable targets OG5_126727	All targets in OG5_126727
Leishmania infantum	fk506-binding protein 1-like protein	Get druggable targets OG5_126727	All targets in OG5_126727
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	Get druggable targets OG5_126727	All targets in OG5_126727
Trypanosoma brucei gambiense	peptidylprolyl isomerase-like protein, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Candida albicans	one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes	Get druggable targets OG5_126727	All targets in OG5_126727
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	Get druggable targets OG5_126727	All targets in OG5_126727
Trichomonas vaginalis	peptidylprolyl isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Theileria parva	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Candida albicans	one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes	Get druggable targets OG5_126727	All targets in OG5_126727
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	Get druggable targets OG5_126727	All targets in OG5_126727
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Trichomonas vaginalis	immunophilin, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	Get druggable targets OG5_126727	All targets in OG5_126727
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126727	All targets in OG5_126727
Trichomonas vaginalis	fk506-binding protein, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	Get druggable targets OG5_126727	All targets in OG5_126727
Neospora caninum	Peptidylprolyl isomerase D (Cyclophilin D), related	Get druggable targets OG5_126727	All targets in OG5_126727
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Leishmania major	fk506-binding protein 1-like protein	Get druggable targets OG5_126727	All targets in OG5_126727
Leishmania donovani	fk506-binding protein 1-like protein	Get druggable targets OG5_126727	All targets in OG5_126727
Leishmania mexicana	peptidylprolyl isomerase-like protein	Get druggable targets OG5_126727	All targets in OG5_126727
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	Get druggable targets OG5_126727	All targets in OG5_126727
Schistosoma japonicum	ko:K09571 FK506-binding protein 4/5, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Candida albicans	one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes	Get druggable targets OG5_126727	All targets in OG5_126727
Leishmania braziliensis	fk506-binding protein 1-like protein	Get druggable targets OG5_126727	All targets in OG5_126727
Echinococcus multilocularis	fk506 binding protein	Get druggable targets OG5_126727	All targets in OG5_126727
Schistosoma mansoni	immunophilin	Get druggable targets OG5_126727	All targets in OG5_126727
Plasmodium berghei	peptidyl-prolyl cis-trans isomerase FKBP35, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Loa Loa (eye worm)	FKBP5 protein	Get druggable targets OG5_126727	All targets in OG5_126727
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	Get druggable targets OG5_126727	All targets in OG5_126727
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Plasmodium knowlesi	peptidyl-prolyl cis-trans isomerase FKBP35, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	Get druggable targets OG5_126727	All targets in OG5_126727
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	Get druggable targets OG5_126727	All targets in OG5_126727
Schistosoma mansoni	immunophilin	Get druggable targets OG5_126727	All targets in OG5_126727
Trichomonas vaginalis	peptidylprolyl isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Leishmania infantum	peptidylprolyl isomerase-like protein	Get druggable targets OG5_126727	All targets in OG5_126727
Schistosoma japonicum	ko:K09568 FK506-binding protein 1, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Plasmodium yoelii	FK506-binding protein	Get druggable targets OG5_126727	All targets in OG5_126727
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	Get druggable targets OG5_126727	All targets in OG5_126727
Candida albicans	one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes	Get druggable targets OG5_126727	All targets in OG5_126727
Leishmania braziliensis	peptidylprolyl isomerase-like protein	Get druggable targets OG5_126727	All targets in OG5_126727
Trypanosoma brucei gambiense	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Trypanosoma congolense	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Schistosoma japonicum	FK506-binding protein 1A, putative	Get druggable targets OG5_126727	All targets in OG5_126727
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	Get druggable targets OG5_126727	All targets in OG5_126727
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_126727	All targets in OG5_126727

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	Outer membrane protein MIP	233 aa	187 aa	28.3 %
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	Outer membrane protein MIP	233 aa	204 aa	35.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0026	0.0274	0.0698
Echinococcus granulosus	multidrug resistance protein 1	0.0021	0.001	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0151	0.5833	1
Schistosoma mansoni	immunophilin	0.0094	0.3263	0.8307
Trypanosoma brucei	epsilon tubulin	0.0047	0.1178	0.1455
Echinococcus granulosus	tubulin gamma 1 chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0053	0.1458	0.3713
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.1458	0.3713
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0109	0.3928	0.4851
Echinococcus multilocularis	tubulin alpha chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0677	0.1724
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Leishmania major	cathepsin L-like protease	0.0053	0.1458	0.1801
Trypanosoma cruzi	cysteine peptidase, putative	0.0202	0.8097	1
Schistosoma mansoni	tubulin subunit beta	0.0076	0.2486	0.6329
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1178	0.2999
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.1458	0.3713
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Schistosoma mansoni	multidrug resistance protein	0.0021	0.001	0.0026
Schistosoma mansoni	tubulin subunit gamma	0.0047	0.1178	0.2999
Loa Loa (eye worm)	tubulin beta chain	0.0076	0.2486	0.6329
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0021	0.001	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Echinococcus multilocularis	tubulin alpha 1C chain	0.0047	0.1178	0.2999
Trypanosoma brucei	alpha tubulin, putative	0.0026	0.0274	0.0338
Plasmodium vivax	vivapain-1	0.0027	0.0313	0.0797
Echinococcus granulosus	tubulin alpha chain	0.0047	0.1178	0.2999
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0109	0.3928	1
Onchocerca volvulus		0.0053	0.1458	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0313	0.0386
Echinococcus multilocularis	peroxisome assembly protein 26	0.0047	0.1178	0.2999
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0109	0.3928	1
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0313	0.0772
Echinococcus granulosus	Tubulin alpha 1 chain	0.0047	0.1178	0.2999
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0313	0.0386
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0109	0.3928	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0021	0.001	0.0026
Echinococcus multilocularis	tubulin alpha	0.0047	0.1178	0.2999
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Trichomonas vaginalis	tubulin beta chain, putative	0.0076	0.2486	0.6329
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Giardia lamblia	Beta tubulin	0.0076	0.2486	0.6329
Brugia malayi	Cathepsin L-like precursor	0.0053	0.1458	0.3713
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0021	0.001	0.0026
Giardia lamblia	Alpha-tubulin	0.0047	0.1178	0.2999
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0026	0.0274	0.0698
Loa Loa (eye worm)	beta-tubulin	0.0076	0.2486	0.6329
Echinococcus multilocularis	Tubulin beta 2C chain	0.0076	0.2486	0.6329
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0109	0.3928	0.4851
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Brugia malayi	Tubulin gamma chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	tubulin alpha chain, putative	0.0076	0.2486	0.6329
Echinococcus granulosus	beta tubulin	0.0076	0.2486	0.6329
Brugia malayi	Tubulin alpha-2 chain	0.0047	0.1178	0.2999
Brugia malayi	tubulin alpha chain - mouse	0.0047	0.1178	0.2999
Echinococcus granulosus	cathepsin L cysteine protease	0.0027	0.0313	0.0797
Toxoplasma gondii	beta-tubulin, putative	0.0076	0.2486	0.4263
Loa Loa (eye worm)	alpha-tubulin	0.0047	0.1178	0.2999
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.1178	0.2999
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0021	0.001	0.0026
Echinococcus granulosus	multidrug resistance protein 1	0.0021	0.001	0.0026
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0109	0.3928	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0021	0.001	0.0026
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0109	0.3928	0.4851
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Onchocerca volvulus		0.0026	0.0274	0.1821
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0677	0.1724
Brugia malayi	Tubulin alpha chain	0.0047	0.1178	0.2999
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0021	0.001	0.0026
Echinococcus granulosus	beta tubulin	0.0076	0.2486	0.6329
Loa Loa (eye worm)	tubulin alpha 2	0.0026	0.0274	0.0698
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.1458	0.3713
Plasmodium vivax	vivapain-2	0.0053	0.1458	0.3713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0021	0.001	0.0026
Trichomonas vaginalis	tubulin gamma chain, putative	0.0076	0.2486	0.6329
Brugia malayi	cathepsin L-like precursor	0.0036	0.0677	0.1724
Plasmodium vivax	tubulin alpha chain, putative	0.0047	0.1178	0.2999
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.1458	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0026	0.0274	0.0698
Schistosoma mansoni	alpha tubulin	0.0047	0.1178	0.2999
Trichomonas vaginalis	abcb9, putative	0.0021	0.001	0.0026
Echinococcus multilocularis	tubulin epsilon chain	0.0047	0.1178	0.2999
Loa Loa (eye worm)	FKBP5 protein	0.0109	0.3928	1
Trichomonas vaginalis	tubulin, putative	0.0076	0.2486	0.6329
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Echinococcus granulosus	cysteine protease	0.0027	0.0313	0.0797
Leishmania major	cathepsin L-like protease	0.0053	0.1458	0.1801
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0109	0.3928	1
Echinococcus multilocularis	tubulin alpha chain	0.0047	0.1178	0.2999
Echinococcus granulosus	tubulin alpha	0.0047	0.1178	0.2999
Leishmania major	cysteine peptidase A (CPA)	0.0053	0.1458	0.1801
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0021	0.001	0.0026
Echinococcus granulosus	tubulin beta 4A class IVa	0.0076	0.2486	0.6329
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0677	0.1724
Loa Loa (eye worm)	multidrug resistance protein 3	0.0021	0.001	0.0026
Onchocerca volvulus		0.0053	0.1458	1
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0021	0.001	0.0018
Leishmania major	cathepsin L-like protease	0.0202	0.8097	1
Trichomonas vaginalis	fk506-binding protein, putative	0.0109	0.3928	1
Brugia malayi	Cathepsin L-like precursor	0.0053	0.1458	0.3713
Toxoplasma gondii	beta tubulin	0.0076	0.2486	0.4263
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0021	0.001	0.0026
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0021	0.001	0.0026
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0109	0.3928	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.1458	0.3713
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0109	0.3928	1
Echinococcus multilocularis	cysteine protease	0.0053	0.1458	0.3713
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0053	0.1458	0.3713
Loa Loa (eye worm)	tubulin gamma chain	0.0047	0.1178	0.2999
Entamoeba histolytica	tubulin family protein	0.0076	0.2486	0.6319
Leishmania major	cathepsin L-like protease	0.0202	0.8097	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0021	0.001	0.0026
Trypanosoma cruzi	alpha tubulin, putative	0.0047	0.1178	0.1455
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.1458	0.3713
Trypanosoma cruzi	tubulin gamma chain	0.0047	0.1178	0.1455
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0021	0.001	0.0026
Trichomonas vaginalis	ABC transporter, putative	0.0021	0.001	0.0026
Mycobacterium leprae	cell division protein FtsZ	0.002	0	0.5
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Echinococcus multilocularis	tubulin beta 1 chain	0.0076	0.2486	0.6329
Echinococcus granulosus	Tubulin beta 2C chain	0.0076	0.2486	0.6329
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0076	0.2486	0.6329
Echinococcus granulosus	tubulin alpha chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0053	0.1458	0.3713
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0021	0.001	0.0026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.1458	0.3713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0313	0.0797
Schistosoma mansoni	alpha tubulin	0.0047	0.1178	0.2999
Echinococcus granulosus	cathepsin l1	0.0036	0.0677	0.1724
Schistosoma mansoni	tubulin subunit beta	0.0076	0.2486	0.6329
Echinococcus multilocularis	tubulin alpha chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0021	0.001	0.0026
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Echinococcus multilocularis	tubulin alpha 3 chain	0.0047	0.1178	0.2999
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0109	0.3928	0.4851
Trypanosoma brucei	beta tubulin	0.0076	0.2486	0.3071
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0109	0.3928	0.4851
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Echinococcus multilocularis	beta tubulin	0.0076	0.2486	0.6329
Trypanosoma brucei	alpha tubulin	0.0047	0.1178	0.1455
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0109	0.3928	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0313	0.0386
Echinococcus granulosus	Tubulin beta 2C chain	0.0076	0.2486	0.6329
Brugia malayi	Tubulin beta-1 chain	0.0076	0.2486	0.6329
Echinococcus granulosus	tubulin beta 1 chain	0.0076	0.2486	0.6329
Schistosoma mansoni	alpha tubulin	0.0047	0.1178	0.2999
Echinococcus multilocularis	Tubulin beta 2C chain	0.0076	0.2486	0.6329
Schistosoma mansoni	tubulin subunit alpha	0.0047	0.1178	0.2999
Plasmodium falciparum	multidrug resistance protein 1	0.0021	0.001	0.0026
Plasmodium vivax	vivapain-2	0.0053	0.1458	0.3713
Leishmania major	cathepsin L-like protease	0.0053	0.1458	0.1801
Toxoplasma gondii	cathepsin CPL	0.0053	0.1458	0.2501
Echinococcus granulosus	tubulin alpha chain	0.0047	0.1178	0.2999
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.1458	0.1801
Trypanosoma cruzi	cysteine peptidase, putative	0.0202	0.8097	1
Trypanosoma cruzi	beta tubulin, putative	0.0076	0.2486	0.3071
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.1458	0.3713
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0677	0.1724
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.0313	0.0797
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0076	0.2486	0.6329
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.1458	0.3713
Plasmodium vivax	tubulin beta chain, putative	0.0076	0.2486	0.6329
Trichomonas vaginalis	ABC transporter, putative	0.0021	0.001	0.0026
Echinococcus multilocularis	multidrug resistance protein 1	0.0021	0.001	0.0026
Echinococcus multilocularis	ATP binding cassette sub family B	0.002	0	0.0001
Leishmania major	fk506-binding protein 1-like protein	0.0109	0.3928	0.4851
Toxoplasma gondii	alpha-tubulin I, putative	0.0047	0.1178	0.202
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0053	0.1458	0.3713
Loa Loa (eye worm)	tubulin alpha 2	0.0026	0.0274	0.0698
Loa Loa (eye worm)	cysteine protease	0.0053	0.1458	0.3713
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0021	0.001	0.0026
Brugia malayi	Tubulin alpha-2 chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0047	0.1178	0.2999
Plasmodium falciparum	tubulin gamma chain	0.0047	0.1178	0.2999
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0053	0.1458	0.3713
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0109	0.3928	0.4851
Echinococcus multilocularis	Tubulin beta 2C chain	0.0076	0.2486	0.6329
Trypanosoma brucei	epsilon tubulin	0.0047	0.1178	0.1455
Onchocerca volvulus		0.0053	0.1458	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0021	0.001	0.0026
Brugia malayi	ABC transporter family protein	0.0021	0.001	0.0026
Echinococcus granulosus	tubulin epsilon chain	0.0047	0.1178	0.2999
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0021	0.001	0.0026
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0076	0.2486	0.6329
Giardia lamblia	Beta tubulin	0.0076	0.2486	0.6329
Brugia malayi	Tubulin beta chain	0.0026	0.0274	0.0698
Echinococcus granulosus	Tubulin beta 2C chain	0.0076	0.2486	0.6329
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.0313	0.0797
Entamoeba histolytica	tubulin gamma chain	0.0047	0.1178	0.2981
Echinococcus multilocularis	cathepsin L cysteine protease	0.0053	0.1458	0.3713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Trypanosoma cruzi	major cysteine proteinase, putative	0.0159	0.6171	0.7621
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0021	0.001	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0021	0.001	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0021	0.001	0.0026
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0021	0.001	0.0026
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0109	0.3928	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.1458	0.3713
Trypanosoma brucei	beta tubulin	0.0076	0.2486	0.3071
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0313	0.0772
Echinococcus granulosus	tubulin alpha 3 chain	0.0047	0.1178	0.2999
Echinococcus multilocularis	tubulin subunit TubB	0.0047	0.1178	0.2999
Loa Loa (eye worm)	tubulin alpha chain	0.0047	0.1178	0.2999
Loa Loa (eye worm)	hypothetical protein	0.0021	0.001	0.0026
Echinococcus multilocularis	tubulin gamma 1 chain	0.0047	0.1178	0.2999
Leishmania major	gamma-tubulin	0.0047	0.1178	0.1455
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0053	0.1458	0.3713
Onchocerca volvulus		0.0053	0.1458	1
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.002	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.0053	0.1458	0.3713
Trypanosoma brucei	beta tubulin	0.0076	0.2486	0.3071
Trypanosoma brucei	alpha tubulin	0.0047	0.1178	0.1455
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Loa Loa (eye worm)	alpha-tubulin	0.0047	0.1178	0.2999
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0185	0.7316	0.9035
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Leishmania major	p-glycoprotein	0.0021	0.001	0.0013
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Echinococcus granulosus	tubulin alpha 1C chain	0.0047	0.1178	0.2999
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0677	0.1724
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.1178	0.2999
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0021	0.001	0.0026
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0021	0.001	0.0026
Entamoeba histolytica	cysteine proteinase 1, putative	0.0027	0.0313	0.0772
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0021	0.001	0.0018
Plasmodium vivax	unspecified product	0.0027	0.0313	0.0797
Loa Loa (eye worm)	hypothetical protein	0.002	0	0.0001
Brugia malayi	Cathepsin L-like precursor	0.0053	0.1458	0.3713
Loa Loa (eye worm)	BEN-1 protein	0.0076	0.2486	0.6329
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Giardia lamblia	Gamma tubulin	0.0047	0.1178	0.2999
Loa Loa (eye worm)	tubulin beta-4 chain	0.0076	0.2486	0.6329
Schistosoma mansoni	cathepsin F (C01 family)	0.0053	0.1458	0.3713
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.1458	0.3713
Brugia malayi	Cathepsin L-like precursor	0.0053	0.1458	0.3713
Entamoeba histolytica	tubulin family protein	0.0076	0.2486	0.6319
Trypanosoma cruzi	cysteine protease, putative	0.0027	0.0313	0.0386
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0109	0.3928	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0021	0.001	0.0026
Echinococcus multilocularis	tubulin subunit beta	0.0076	0.2486	0.6329
Echinococcus granulosus	cathepsin L	0.0027	0.0313	0.0797
Plasmodium falciparum	alpha tubulin 2	0.0047	0.1178	0.2999
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0313	0.0772
Trypanosoma cruzi	cysteine peptidase, putative	0.0202	0.8097	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0047	0.1178	0.2999
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0021	0.001	0.0026
Schistosoma mansoni	immunophilin	0.0109	0.3928	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0047	0.1178	0.2999
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Trichomonas vaginalis	tubulin, putative	0.0026	0.0274	0.0698
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0027	0.0313	0.0386
Leishmania major	epsilon tubulin, putative	0.0047	0.1178	0.1455
Trichomonas vaginalis	tubulin gamma chain, putative	0.0047	0.1178	0.2999
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0021	0.001	0.0026
Trichomonas vaginalis	tubulin alpha chain, putative	0.0047	0.1178	0.2999
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0677	0.1724
Onchocerca volvulus		0.0053	0.1458	1
Plasmodium vivax	tubulin gamma chain, putative	0.0047	0.1178	0.2999
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0047	0.1178	0.202
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0021	0.001	0.0026
Onchocerca volvulus	Cathepsin F homolog	0.0053	0.1458	1
Plasmodium vivax	multidrug resistance protein 1, putative	0.0021	0.001	0.0026
Schistosoma mansoni	cathepsin F (C01 family)	0.0053	0.1458	0.3713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.0151	0.5833	1
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0021	0.001	0.0026
Trypanosoma brucei	epsilon tubulin	0.0047	0.1178	0.1455
Trypanosoma brucei	alpha tubulin	0.0047	0.1178	0.1455
Schistosoma mansoni	smdr2	0.0021	0.001	0.0026
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0677	0.1724
Echinococcus multilocularis	beta tubulin	0.0076	0.2486	0.6329
Leishmania major	peptidylprolyl isomerase-like protein	0.0109	0.3928	0.4851
Trichomonas vaginalis	tubulin beta chain, putative	0.0026	0.0274	0.0698
Echinococcus multilocularis	tubulin alpha chain	0.0047	0.1178	0.2999
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0047	0.1178	0.2999
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0313	0.0797
Brugia malayi	beta-tubulin, identical	0.0076	0.2486	0.6329
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0109	0.3928	1
Loa Loa (eye worm)	tubulin alpha chain	0.0047	0.1178	0.2999
Schistosoma mansoni	tubulin subunit beta	0.0076	0.2486	0.6329
Echinococcus granulosus	Tubulin beta 2C chain	0.0076	0.2486	0.6329
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0109	0.3928	1
Leishmania major	cathepsin L-like protease	0.0202	0.8097	1
Schistosoma mansoni	tubulin subunit alpha	0.0047	0.1178	0.2999
Plasmodium vivax	tubulin epsilon chain, putative	0.0047	0.1178	0.2999
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0021	0.001	0.0013
Trichomonas vaginalis	ABC transporter, putative	0.0021	0.001	0.0026
Trypanosoma cruzi	epsilon tubulin, putative	0.0047	0.1178	0.1455
Leishmania major	cathepsin L-like protease	0.0053	0.1458	0.1801
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0036	0.0677	0.1724
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0053	0.1458	0.3713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Plasmodium vivax	vivapain-3	0.0027	0.0313	0.0797
Loa Loa (eye worm)	tubulin beta-2A chain	0.0076	0.2486	0.6329
Echinococcus granulosus	Tubulin alpha 1 chain	0.0047	0.1178	0.2999
Loa Loa (eye worm)	ctsf protein	0.0053	0.1458	0.3713
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.1458	0.3696
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0021	0.001	0.0026
Echinococcus granulosus	multidrug resistance protein 1	0.0021	0.001	0.0026
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1458	0.3713
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0047	0.1178	0.2999
Onchocerca volvulus		0.0036	0.0677	0.4606
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.1458	0.3713
Trichomonas vaginalis	tubulin, putative	0.0026	0.0274	0.0698
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0047	0.1178	0.2999
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0313	0.0797
Schistosoma mansoni	tubulin subunit beta	0.0076	0.2486	0.6329
Echinococcus granulosus	alpha tubulin	0.0047	0.1178	0.2999
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0021	0.001	0.0026
Schistosoma mansoni	multidrug resistance protein	0.0021	0.001	0.0026
Plasmodium vivax	tubulin alpha chain, putative	0.0047	0.1178	0.2999
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Brugia malayi	multidrug resistance protein 3	0.0021	0.001	0.0026
Brugia malayi	alpha-tubulin	0.0047	0.1178	0.2999
Schistosoma mansoni	tubulin subunit beta	0.0076	0.2486	0.6329
Plasmodium falciparum	tubulin beta chain	0.0076	0.2486	0.6329
Trichomonas vaginalis	ABC transporter, putative	0.0021	0.001	0.0026
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0021	0.001	0.0026
Loa Loa (eye worm)	fibroinase	0.0053	0.1458	0.3713
Loa Loa (eye worm)	tubulin beta-1 chain	0.0076	0.2486	0.6329
Loa Loa (eye worm)	hypothetical protein	0.0094	0.3263	0.8307
Trypanosoma cruzi	cysteine proteinase, putative	0.0027	0.0313	0.0386
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0677	0.1724
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0047	0.1178	0.2999
Trypanosoma brucei	beta tubulin	0.0076	0.2486	0.3071
Schistosoma mansoni	multidrug resistance protein	0.0021	0.001	0.0026
Echinococcus multilocularis	cathepsin L cysteine protease	0.0053	0.1458	0.3713
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0109	0.3928	1
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0094	0.3263	0.8307
Entamoeba histolytica	tubulin alpha chain, putative	0.0047	0.1178	0.2981
Trichomonas vaginalis	taga, putative	0.0021	0.001	0.0026
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Echinococcus granulosus	tubulin subunit TubB	0.0047	0.1178	0.2999
Echinococcus granulosus	tubulin subunit beta	0.0076	0.2486	0.6329
Plasmodium falciparum	tubulin epsilon chain, putative	0.0047	0.1178	0.2999
Echinococcus granulosus	cathepsin l1	0.0053	0.1458	0.3713
Echinococcus multilocularis	cathepsin L	0.0027	0.0313	0.0797
Echinococcus granulosus	Tubulin alpha 1 chain	0.0047	0.1178	0.2999
Echinococcus granulosus	peroxisome assembly protein 26	0.0047	0.1178	0.2999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Echinococcus granulosus	tubulin alpha chain	0.0047	0.1178	0.2999
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0313	0.0797
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0109	0.3928	1
Brugia malayi	Cathepsin L-like precursor	0.0053	0.1458	0.3713
Echinococcus multilocularis	cysteine protease	0.0053	0.1458	0.3713
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0313	0.0772
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0021	0.001	0.0026
Giardia lamblia	Alpha-tubulin	0.0047	0.1178	0.2999
Trichomonas vaginalis	tubulin alpha chain, putative	0.0026	0.0274	0.0698
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Plasmodium falciparum	alpha tubulin 1	0.0047	0.1178	0.2999
Leishmania major	cathepsin L-like protease	0.0053	0.1458	0.1801
Trichomonas vaginalis	immunophilin, putative	0.0109	0.3928	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Onchocerca volvulus		0.0053	0.1458	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0053	0.1458	0.3713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.8097	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0021	0.001	0.0026
Toxoplasma gondii	alpha tubulin TUBA1	0.0047	0.1178	0.202
Toxoplasma gondii	beta-1 tubulin, putative	0.0076	0.2486	0.4263
Echinococcus granulosus	tubulin alpha chain	0.0047	0.1178	0.2999
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.1458	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0202	0.8097	1
Schistosoma mansoni	tubulin subunit epsilon	0.0047	0.1178	0.2999
Echinococcus multilocularis	fk506 binding protein	0.0109	0.3928	1
Trichomonas vaginalis	abcb9, putative	0.0021	0.001	0.0026
Giardia lamblia	Beta tubulin	0.0076	0.2486	0.6329
Trypanosoma brucei	tubulin gamma chain	0.0047	0.1178	0.1455
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.1178	0.2999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0027	0.0313	0.0797
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0021	0.001	0.0026
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0094	0.3263	0.8307
Echinococcus multilocularis	Tubulin beta 2C chain	0.0076	0.2486	0.6329
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0047	0.1178	0.2999
Echinococcus granulosus	Tubulin beta 2C chain	0.0076	0.2486	0.6329
Schistosoma mansoni	tubulin subunit beta	0.0076	0.2486	0.6329
Echinococcus multilocularis	Tubulin beta 2C chain	0.0076	0.2486	0.6329
Brugia malayi	tubulin alpha-2 chain	0.0047	0.1178	0.2999
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.0313	0.0797
Trypanosoma cruzi	cysteine proteinase, putative	0.0027	0.0313	0.0386
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Trypanosoma brucei	alpha tubulin	0.0047	0.1178	0.1455
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0053	0.1458	0.3713
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.1458	0.3713
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0026	0.0274	0.0698
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.1178	0.2999
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Loa Loa (eye worm)	BEN-1 protein	0.0076	0.2486	0.6329
Echinococcus multilocularis	hypothetical protein	0.0047	0.1178	0.2999
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.002	0	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0274	0.0698
Entamoeba histolytica	cysteine protease, putative	0.0053	0.1458	0.3696
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0021	0.001	0.0026
Echinococcus multilocularis	tubulin alpha chain	0.0047	0.1178	0.2999
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.1458	0.3696
Schistosoma mansoni	immunophilin	0.0109	0.3928	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0053	0.1458	0.3713
Onchocerca volvulus		0.0053	0.1458	1
Leishmania major	alpha tubulin	0.0047	0.1178	0.1455
Trypanosoma brucei	beta tubulin	0.0047	0.1178	0.1455
Trypanosoma cruzi	epsilon tubulin, putative	0.0047	0.1178	0.1455
Schistosoma mansoni	tubulin subunit alpha	0.0047	0.1178	0.2999
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Trichomonas vaginalis	tubulin alpha chain, putative	0.0026	0.0274	0.0698
Trichomonas vaginalis	abcb9, putative	0.0021	0.001	0.0026
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0677	0.1703
Leishmania major	beta tubulin	0.0076	0.2486	0.3071
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.1178	0.2999
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0109	0.3928	1
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0109	0.3928	1
Entamoeba histolytica	cysteine proteinase 2	0.0027	0.0313	0.0772
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0313	0.0772
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.1178	0.2999
Entamoeba histolytica	tubulin alpha-1 chain	0.0047	0.1178	0.2981
Leishmania major	beta tubulin	0.0076	0.2486	0.3071

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.89	Inhibition of Mip PPIase activity in Legionella pneumophila	LITERATURE.	27591009
IC50 (binding)	= 12.8 uM	Inhibition of Mip PPIase activity in Legionella pneumophila	LITERATURE.	27591009
IC50	= 66.9 uM	Cytotoxicity against mouse J774	LITERATURE.	27591009

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3936855

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2120702