Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.016 | 0.0556 | 0.165 |
Toxoplasma gondii | thioredoxin reductase | 0.0353 | 0.3372 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0353 | 0.3372 | 1 |
Brugia malayi | glutathione reductase | 0.0353 | 0.3372 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0353 | 0.3372 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0353 | 0.3372 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0353 | 0.3372 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0353 | 0.3372 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.016 | 0.0556 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0273 | 0.221 | 0.6554 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.016 | 0.0556 | 1 |
Leishmania major | trypanothione reductase | 0.0353 | 0.3372 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0353 | 0.3372 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0273 | 0.221 | 0.6554 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0122 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0353 | 0.3372 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0178 | 0.0818 | 0.2426 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0122 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0353 | 0.3372 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0178 | 0.0818 | 0.0818 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0353 | 0.3372 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0353 | 0.3372 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0273 | 0.221 | 0.6554 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0353 | 0.3372 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0806 | 1 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0273 | 0.221 | 0.6554 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.016 | 0.0556 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.016 | 0.0556 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.016 | 0.0556 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0273 | 0.221 | 0.6554 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0273 | 0.221 | 0.6554 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0273 | 0.221 | 0.221 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0273 | 0.221 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0307 | 0.2697 | 0.7998 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0178 | 0.0818 | 0.2426 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0307 | 0.2697 | 0.7998 |
Plasmodium falciparum | plasmepsin II | 0.0273 | 0.221 | 0.6554 |
Plasmodium vivax | plasmepsin IV, putative | 0.0273 | 0.221 | 0.6554 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0122 | 0 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0273 | 0.221 | 0.6554 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0223 | 0.1471 | 0.4362 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0178 | 0.0821 | 0.0821 |
Plasmodium falciparum | plasmepsin IV | 0.0273 | 0.221 | 0.6554 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0353 | 0.3372 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 44 uM | Concentration required to inhibit proliferation of cultured lymphoid leukemia L1210 cells to 50% growth over 48 hours | ChEMBL. | 1433180 |
IC50 (functional) | = 44 uM | Concentration required to inhibit proliferation of cultured lymphoid leukemia L1210 cells to 50% growth over 48 hours | ChEMBL. | 1433180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.