Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | protein kinase C II. | 0.1528 | 0.3142 | 0.2971 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0245 | 0.0242 | 0.0242 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.2963 | 0.6386 | 0.963 |
Echinococcus granulosus | nervana 2 | 0.293 | 0.6312 | 0.9513 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.1528 | 0.3142 | 0.4545 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.3067 | 0.6622 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.4562 | 1 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0245 | 0.0242 | 0.0242 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.3067 | 0.6622 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.1528 | 0.3142 | 0.4545 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.1528 | 0.3142 | 0.4545 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.293 | 0.6312 | 0.9513 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.1528 | 0.3142 | 0.2971 |
Trichomonas vaginalis | AGC family protein kinase | 0.1632 | 0.3378 | 0.3378 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.1528 | 0.3142 | 0.4545 |
Echinococcus multilocularis | nervana 2 | 0.293 | 0.6312 | 0.9513 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.4562 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.4562 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.1528 | 0.3142 | 0.2971 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.293 | 0.6312 | 0.9513 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0245 | 0.0242 | 0.038 |
Trichomonas vaginalis | AGC family protein kinase | 0.1528 | 0.3142 | 0.3142 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.1495 | 0.3067 | 0.3067 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1528 | 0.3142 | 0.4545 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.1528 | 0.3142 | 0.2971 |
Entamoeba histolytica | protein kinase, putative | 0.1528 | 0.3142 | 0.3142 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0245 | 0.0242 | 0.0366 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.1528 | 0.3142 | 0.2971 |
Echinococcus granulosus | protein kinase c iota type | 0.1528 | 0.3142 | 0.4545 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.2963 | 0.6386 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1528 | 0.3142 | 0.3142 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.1528 | 0.3142 | 0.4545 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1528 | 0.3142 | 0.4545 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0245 | 0.0242 | 0.038 |
Trichomonas vaginalis | AGC family protein kinase | 0.4562 | 1 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.2963 | 0.6386 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1528 | 0.3142 | 0.3142 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.1528 | 0.3142 | 0.4545 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.1528 | 0.3142 | 0.4545 |
Brugia malayi | Protein kinase domain containing protein | 0.1528 | 0.3142 | 0.2971 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.1528 | 0.3142 | 0.4545 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1528 | 0.3142 | 0.4545 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.2963 | 0.6386 | 0.963 |
Brugia malayi | Protein kinase domain containing protein | 0.1528 | 0.3142 | 0.2971 |
Trypanosoma cruzi | Protein kinase B | 0.3067 | 0.6622 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.293 | 0.6312 | 0.9513 |
Trichomonas vaginalis | AGC family protein kinase | 0.4562 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.4458 | 0.9764 | 0.9764 |
Loa Loa (eye worm) | hypothetical protein | 0.1528 | 0.3142 | 0.2971 |
Echinococcus granulosus | nervana 2 | 0.293 | 0.6312 | 0.9513 |
Giardia lamblia | Kinase, AGC PKA | 0.2963 | 0.6386 | 0.5 |
Schistosoma mansoni | serine/threonine kinase | 0.1528 | 0.3142 | 0.4545 |
Entamoeba histolytica | protein kinase 2, putative | 0.2963 | 0.6386 | 0.6386 |
Echinococcus multilocularis | nervana 2 | 0.293 | 0.6312 | 0.9513 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1528 | 0.3142 | 0.4545 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0245 | 0.0242 | 0.0242 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1528 | 0.3142 | 0.4545 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1528 | 0.3142 | 0.4545 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1528 | 0.3142 | 0.4545 |
Echinococcus granulosus | NDR protein kinase | 0.1528 | 0.3142 | 0.4545 |
Echinococcus granulosus | protein kinase C gamma type | 0.1528 | 0.3142 | 0.4545 |
Trichomonas vaginalis | AGC family protein kinase | 0.4562 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.4562 | 1 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.3067 | 0.6622 | 0.6622 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.1528 | 0.3142 | 0.4545 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.1528 | 0.3142 | 0.2971 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.4458 | 0.9764 | 0.9758 |
Echinococcus granulosus | serine/threonine protein kinase | 0.3067 | 0.6622 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.4458 | 0.9764 | 0.9758 |
Entamoeba histolytica | protein kinase, putative | 0.4562 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.1528 | 0.3142 | 0.4545 |
Trichomonas vaginalis | AGC family protein kinase | 0.4562 | 1 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.1528 | 0.3142 | 0.4545 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.1528 | 0.3142 | 0.2971 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0245 | 0.0242 | 0.0366 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0245 | 0.0242 | 1 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.1528 | 0.3142 | 0.4545 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.1528 | 0.3142 | 0.4545 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.3067 | 0.6622 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.1528 | 0.3142 | 0.4545 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.2963 | 0.6386 | 0.963 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.3067 | 0.6622 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.1528 | 0.3142 | 0.4545 |
Trichomonas vaginalis | AGC family protein kinase | 0.4562 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.2963 | 0.6386 | 0.9644 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.4562 | 1 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.3067 | 0.6622 | 0.6622 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0245 | 0.0242 | 0.0242 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1528 | 0.3142 | 0.4545 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.293 | 0.6312 | 0.9513 |
Brugia malayi | Hr1 repeat family protein | 0.1528 | 0.3142 | 0.2971 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0245 | 0.0242 | 0.0248 |
Schistosoma mansoni | atypical protein kinase C | 0.1528 | 0.3142 | 0.4545 |
Toxoplasma gondii | AGC kinase | 0.4458 | 0.9764 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 100 ug ml-1 | Cytotoxic concentration required to inhibit NC-37 cells by 50% | ChEMBL. | No reference |
EC50 (functional) | > 100 ug ml-1 | Concentration required to reduce HSV-1 (KOS strain) induced cytopathogenicity in NC-37 cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.