Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.63 | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 5.99 | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 0.3 uM | Inhibitory concentration against Dihydrofolate reductase from Mycobacterium avium (M. avium) | ChEMBL. | 15214795 |
IC50 (binding) | = 0.3 uM | Inhibitory concentration against Dihydrofolate reductase from Mycobacterium avium (M. avium) | ChEMBL. | 15214795 |
IC50 (binding) | = 1.02 uM | Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (T. gondii) | ChEMBL. | 15214795 |
IC50 (binding) | = 1.02 uM | Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (T. gondii) | ChEMBL. | 15214795 |
IC50 (binding) | = 1.02 uM | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 2.32 uM | Inhibitory concentration against Dihydrofolate reductase from rat liver | ChEMBL. | 15214795 |
IC50 (binding) | = 2.32 uM | Inhibitory concentration against Dihydrofolate reductase from rat liver | ChEMBL. | 15214795 |
IC50 (binding) | = 2.32 uM | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 22 uM | Inhibition of Dihydrofolate reductase from Pneumocystis carinii (P. carinii) | ChEMBL. | 15214795 |
IC50 (binding) | = 22 uM | Inhibition of Dihydrofolate reductase from Pneumocystis carinii (P. carinii) | ChEMBL. | 15214795 |
Selectivity ratio (binding) | = 0.11 | Selectivity ratio [(IC50 rlDHFR)/(IC50 pcDHFR) | ChEMBL. | 15214795 |
Selectivity ratio (binding) | = 2.27 | Selectivity ratio (IC50rlDHFR)/(IC50 tgDHFR) | ChEMBL. | 15214795 |
Selectivity ratio (binding) | = 6.82 | Selectivity ratio (IC50 rlDHFR)/(IC50 maDHFR) | ChEMBL. | 15214795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.