Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0457 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0457 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0457 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0077 | 0 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.0245 | 0.4421 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0457 | 1 | 1 |
Trypanosoma brucei | squalene synthase, putative | 0.0245 | 0.4421 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0077 | 0 | 0.5 |
Leishmania major | squalene synthase, putative | 0.0245 | 0.4421 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0457 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0457 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0457 | 1 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0245 | 0.4421 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0457 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0457 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0077 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0457 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0077 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0224 | 0.3852 | 0.3852 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0077 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3 ug kg-1 | Effective dose after subcutaneous administration to TPTX rats for 50% reduction of hypercalcemia | ChEMBL. | 12166945 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.