Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | References | |
Ovis aries | Cyclooxygenase-1 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0079 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antiinflammatory activity in carrageenan-induced BALB/c mouse peritonitis model assessed as decrease in nitric oxide level in peritoneal exudates at 10 to 20 mg/kg administered via oral gavage 30 mins prior to carrageenan challenge measured after 4 hrs by Griess method | ChEMBL. | 26850006 | |
Activity (functional) | Antiinflammatory activity in carrageenan-induced BALB/c mouse peritonitis model assessed as decrease in number of leukocytes in peritoneal exudates administered via oral gavage 30 mins prior to carrageenan challenge measured after 4 hrs | ChEMBL. | 26850006 | |
Activity (functional) | Antiinflammatory activity in carrageenan-induced BALB/c mouse paw edema model assessed as decrease in paw volume administered orally 30 mins prior to carrageenan challenge measured after 1 to 6 hrs by plethysmometric analysis | ChEMBL. | 26850006 | |
Activity (functional) | = 59 % | Antiinflammatory activity in carrageenan-induced BALB/c mouse paw edema model assessed as decrease in paw volume at 10 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 6 hrs by plethysmometric analysis relative to control | ChEMBL. | 26850006 |
Activity (functional) | = 60 % | Antiinflammatory activity in BALB/c mouse paw edema model assessed as decrease in myeloperoxidase activity in paw exudates at 20 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 4 hrs by microplate reader analysis relative to control | ChEMBL. | 26850006 |
Activity (functional) | = 60 % | Antiinflammatory activity in BALB/c mouse paw edema model assessed as decrease in myeloperoxidase activity in paw exudates at 10 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 4 hrs by microplate reader analysis relative to control | ChEMBL. | 26850006 |
Activity (functional) | = 74 % | Antiinflammatory activity in carrageenan-induced BALB/c mouse paw edema model assessed as decrease in paw volume at 20 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 6 hrs by plethysmometric analysis relative to control | ChEMBL. | 26850006 |
IC50 (binding) | = 1 uM | Inhibition of human recombinant COX-2 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition incubated for 2 mins by ELISA | ChEMBL. | 26850006 |
IC50 (binding) | = 4.1 uM | Inhibition of ovine COX-1 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition incubated for 2 mins by ELISA | ChEMBL. | 26850006 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.