Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 1 | No references | |
Homo sapiens | Janus kinase 2 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.001 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.001 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.001 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.001 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.001 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.001 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 24 nM | HTRF Biochemical Assay | BINDINGDB. | No reference |
IC50 (binding) | = 814 nM | HTRF Biochemical Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.