Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | References | |
Homo sapiens | free fatty acid receptor 1 | References | |
Mus musculus | free fatty acid receptor 4 | References | |
Homo sapiens | free fatty acid receptor 4 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0015 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0015 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 61 % | Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay relative to basal level | LITERATURE. | 27815121 |
Activity (binding) | = 73 % | Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay relative to basal level | LITERATURE. | 27815121 |
EC50 (binding) | = 16 nM | Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay | LITERATURE. | 27815121 |
EC50 (binding) | = 16 nM | Agonist activity at mouse GPR120 assessed as induction of IP1 accumulation | LITERATURE. | 28105274 |
EC50 (binding) | = 35 nM | Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment | LITERATURE. | 28105274 |
EC50 (binding) | = 94 nM | Agonist activity at human GPR120 assessed as induction of IP1 accumulation | LITERATURE. | 28105274 |
EC50 (binding) | = 94 nM | Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay | LITERATURE. | 27815121 |
EC50 (binding) | = 1100 nM | Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitment | LITERATURE. | 28105274 |
EC50 (binding) | > 9950 nM | Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay | LITERATURE. | 27815121 |
EC50 (binding) | > 10000 nM | Agonist activity at human GPR40 assessed as induction of IP1 accumulation | LITERATURE. | 28105274 |
IC50 (ADMET) | = 3280 nM | Inhibition of CYP3A4 (unknown origin) | LITERATURE. | 27815121 |
IC50 (ADMET) | > 50000 nM | Inhibition of CYP2C9 (unknown origin) | LITERATURE. | 27815121 |
IC50 (ADMET) | > 50000 nM | Inhibition of CYP2D6 (unknown origin) | LITERATURE. | 27815121 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.