Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) | Human herpes virus 5 capsid protein P40 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0266 | 0.2592 | 1 |
Treponema pallidum | NADH oxidase | 0.0092 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0266 | 0.2592 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0266 | 0.2592 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0092 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0266 | 0.2592 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0259 | 0.2483 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0259 | 0.2483 | 0.9582 |
Brugia malayi | Thioredoxin reductase | 0.0266 | 0.2592 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0259 | 0.2483 | 0.9582 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0266 | 0.2592 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0762 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0266 | 0.2592 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0092 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0259 | 0.2483 | 0.9582 |
Plasmodium vivax | glutathione reductase, putative | 0.0266 | 0.2592 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0092 | 0 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0259 | 0.2483 | 0.9582 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0266 | 0.2592 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0092 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.0266 | 0.2592 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0092 | 0 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0259 | 0.2483 | 0.9582 |
Plasmodium falciparum | plasmepsin IV | 0.0259 | 0.2483 | 0.9582 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0259 | 0.2483 | 0.9582 |
Plasmodium falciparum | thioredoxin reductase | 0.0266 | 0.2592 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0092 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0266 | 0.2592 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0259 | 0.2483 | 0.2483 |
Plasmodium falciparum | plasmepsin VI | 0.0259 | 0.2483 | 0.9582 |
Plasmodium falciparum | plasmepsin I | 0.0259 | 0.2483 | 0.9582 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0266 | 0.2592 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0266 | 0.2592 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0092 | 0 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0259 | 0.2483 | 0.9582 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0092 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0266 | 0.2592 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 uM | Inhibitory activity of the compound against human cytomegalovirus (HCMV) protease was evaluated | ChEMBL. | 9934494 |
IC50 (binding) | = 0.2 uM | Inhibitory activity of the compound against human cytomegalovirus (HCMV) protease was evaluated | ChEMBL. | 9934494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.