Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 3 (5-HT3) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.0352 | 1 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0352 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0352 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0352 | 1 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.3547 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.3547 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Echinococcus granulosus | dihydrofolate reductase | 0.0352 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.3547 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0352 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0352 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.3547 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.3547 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0352 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.0352 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Onchocerca volvulus | Putative nachr subunit | 0.0015 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0135 | 0.3547 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.64 nM | Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes | ChEMBL. | 8246239 |
Ki (binding) | = 0.64 nM | Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes | ChEMBL. | 8246239 |
Ki (binding) | = 0.75 nM | Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes | ChEMBL. | 8246239 |
Ki (binding) | = 0.75 nM | Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes | ChEMBL. | 8246239 |
Ki (binding) | = 0.93 nM | Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes | ChEMBL. | 8246239 |
Ki (binding) | = 0.93 nM | Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes | ChEMBL. | 8246239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.