Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0088 | 0.3091 | 0.5018 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0075 | 0.2386 | 0.2755 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0074 | 0.237 | 0.2704 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0074 | 0.237 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0119 | 0.4643 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0061 | 0.1685 | 0.0504 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 1 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0088 | 0.3091 | 0.5018 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0074 | 0.237 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0047 | 0.098 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0105 | 0.3938 | 0.7736 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0119 | 0.4643 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0088 | 0.3091 | 0.4646 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0119 | 0.4643 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0088 | 0.3091 | 0.5018 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 1 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0119 | 0.4643 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0074 | 0.237 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0074 | 0.237 | 0.2704 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 1 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0088 | 0.3091 | 0.5018 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0074 | 0.237 | 0.2704 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0075 | 0.2386 | 0.2755 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0047 | 0.098 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 1 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0119 | 0.4643 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 1 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 1 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0119 | 0.4643 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0105 | 0.3922 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0074 | 0.237 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0061 | 0.1685 | 0.0504 |
Schistosoma mansoni | glutamate receptor kainate | 0.0105 | 0.3922 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
log(1/MIC) (functional) | = -2.415 | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by two-fold serial dilution method | ChEMBL. | 817022 |
MIC (functional) | = 40.33 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis | ChEMBL. | 24246731 |
MIC (functional) | = 2.578 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by BACTEC 960 assay | ChEMBL. | 24836065 |
MIC (functional) | = 260 umol/L | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by two-fold serial dilution method | ChEMBL. | 817022 |
pMIC (functional) | = 3.4 | Minimum inhibitory concentration against Mycobacterium tuberculosis var. bovis strain at 310K, with value expressed as pMIC i.e. -log of MIC (ug/mL). | ChEMBL. | 15239654 |
pMIC (functional) | = 3.4 | Minimum inhibitory concentration against Mycobacterium tuberculosis var. bovis strain at 310K, with value expressed as pMIC i.e. -log of MIC (ug/mL). | ChEMBL. | 15239654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium tuberculosis | 6263 | |
Annotator: | crowther@u.washington.edu | Comment: | 2007-12-07 | References: | 15239654 |
1 literature reference was collected for this gene.