Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily D, polypeptide 6 | References | |
Homo sapiens | estrogen receptor 1 | References | |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 9 | References | |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | References | |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily D, polypeptide 6 | 497 aa | 425 aa | 32.0 % |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 490 aa | 441 aa | 21.8 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.3572 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0016 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0023 | 0.3572 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.3572 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0016 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.3572 | 0.3572 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0023 | 0.3572 | 0.3572 |
Trypanosoma brucei | cytochrome P450, putative | 0.0023 | 0.3572 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0023 | 0.3572 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0016 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.3572 | 0.3572 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.3572 | 0.3572 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.3572 | 0.3572 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 363 nM | Inhibition of CYP3A4 (unknown origin) | ChEMBL. | 26897089 |
IC50 (ADMET) | = 397 nM | Inhibition of CYP2C9 (unknown origin) | ChEMBL. | 26897089 |
IC50 (binding) | = 651 nM | Inhibition of GST-tagged human glucocorticoid receptor LBD domain expressed in insect cells at by Gal4-based fluorescence polarization assay | ChEMBL. | 26897089 |
IC50 (binding) | > 2000 nM | Inhibition of estrogen receptor (unknown origin) by Gal4-based luciferase assay | ChEMBL. | 26897089 |
IC50 (ADMET) | = 4100 nM | Inhibition of CYP2D6 (unknown origin) | ChEMBL. | 26897089 |
Inhibition (binding) | = 33 % | Inhibition of histamine H1 receptor (unknown origin) at 10 uM | ChEMBL. | 26897089 |
Inhibition (binding) | = 71 % | Inhibition of serotonin 5H2B receptor (unknown origin) at 10 uM | ChEMBL. | 26897089 |
Inhibition (binding) | = 85 % | Inhibition of adrenergic alpha2A receptor (unknown origin) at 10 uM | ChEMBL. | 26897089 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.