Detailed information for compound 212447

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 894.998 | Formula: C51H58O14
  • H donors: 7 H acceptors: 11 LogP: 9.42 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC(=O)CCC(C1CCC2[C@@]1(C)[C@H](OC(=O)/C=C\c1ccc(c(c1)O)O)CC1C2[C@@H](OC(=O)/C=C\c2ccc(c(c2)O)O)CC2[C@@]1(C)CC[C@H](C2)OC(=O)/C=C\c1ccc(c(c1)O)O)C
  • InChi: 1S/C51H58O14/c1-28(4-16-45(58)59)34-11-12-35-49-36(27-44(51(34,35)3)65-48(62)19-10-31-7-15-39(54)42(57)24-31)50(2)21-20-33(63-46(60)17-8-29-5-13-37(52)40(55)22-29)25-32(50)26-43(49)64-47(61)18-9-30-6-14-38(53)41(56)23-30/h5-10,13-15,17-19,22-24,28,32-36,43-44,49,52-57H,4,11-12,16,20-21,25-27H2,1-3H3,(H,58,59)/b17-8+,18-9+,19-10+/t28?,32?,33-,34?,35?,36?,43-,44+,49?,50+,51-/m1/s1
  • InChiKey: IVYNKQOIDZJJMP-ZSPKFBQISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi CHE-14 protein 0.0042 0.0332 0.0602
Loa Loa (eye worm) melatonin receptor type 1A 0.0062 0.0586 0.1062
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.041 0.0675
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0586 0.0586
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0182 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0182 0.033
Entamoeba histolytica thymidine kinase, putative 0.0273 0.33 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0062 0.0586 0.0964
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0182 0.0299
Brugia malayi hypothetical protein 0.005 0.0433 0.0785
Brugia malayi hypothetical protein 0.0062 0.0586 0.1062
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.0586 0.0964
Onchocerca volvulus 0.0062 0.0586 0.0837
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0062 0.0586 0.0837
Echinococcus granulosus dna polymerase eta 0.0064 0.0621 0.1022
Giardia lamblia Kinase, PLK 0.0095 0.1012 0.2686
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0182 0.033
Echinococcus multilocularis JmjC domain containing protein 4 0.004 0.0314 0.0314
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0062 0.0586 0.1062
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0318 0.0524
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0062 0.0586 0.0586
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0586 0.0964
Trichomonas vaginalis thymidine kinase, putative 0.0273 0.33 0.9956
Echinococcus granulosus 7tm_1 domain containing protein 0.0062 0.0586 0.0964
Trichomonas vaginalis thymidine kinase, putative 0.0273 0.33 0.9956
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Echinococcus multilocularis dna polymerase eta 0.0064 0.0621 0.0621
Brugia malayi Dopamine receptor protein 2 0.0062 0.0586 0.1062
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1044 0.1893
Brugia malayi neuropeptide F receptor 0.0062 0.0586 0.1062
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Trypanosoma cruzi thymidine kinase, putative 0.0273 0.33 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni cpg binding protein 0.0029 0.0166 0.0273
Loa Loa (eye worm) hypothetical protein 0.003 0.0182 0.033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.0586 0.0964
Echinococcus granulosus g protein coupled receptor 0.0062 0.0586 0.0964
Echinococcus multilocularis dro:myosuppressin receptor 0.0062 0.0586 0.0586
Echinococcus granulosus biogenic amine 5HT receptor 0.0062 0.0586 0.0964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0586 0.0586
Schistosoma mansoni jumonji domain containing protein 0.004 0.0314 0.0516
Schistosoma mansoni protein phosphatase 2C 0.004 0.0314 0.0516
Brugia malayi hypothetical protein 0.0062 0.0586 0.1062
Onchocerca volvulus Huntingtin homolog 0.0121 0.1349 0.2255
Echinococcus multilocularis serotonin receptor 0.0062 0.0586 0.0586
Echinococcus granulosus neuropeptide s receptor 0.0062 0.0586 0.0964
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0062 0.0586 0.0964
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0293 0.0111
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0515
Echinococcus multilocularis G protein coupled receptor 139 0.0062 0.0586 0.0586
Echinococcus granulosus phd:f box containing protein 0.004 0.0314 0.0516
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Plasmodium vivax JmjC domain containing protein 0.004 0.0314 0.5433
Brugia malayi hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni ap endonuclease 0.0037 0.0271 0.0447
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0062 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0475
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0293 0.0531
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0135 0.1531 0.2521
Schistosoma mansoni biogenic amine (5HT) receptor 0.0062 0.0586 0.0964
Schistosoma mansoni hypothetical protein 0.0022 0.0082 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0293 0.0488
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0262 0.0431
Echinococcus granulosus 7TM GPCR rhodopsin 0.0062 0.0586 0.0964
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0195 0.0321
Schistosoma mansoni coup transcription factor 0.003 0.0182 0.0299
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0433 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0398 0.0447
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0293 0.0488
Brugia malayi jmjC domain containing protein 0.004 0.0314 0.0569
Schistosoma mansoni hypothetical protein 0.0336 0.4109 0.6765
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0586 0.0586
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0182 0.033
Echinococcus granulosus intermediate filament protein 0.0026 0.0136 0.0224
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0062 0.0586 0.0586
Brugia malayi Serotonin receptor 0.0062 0.0586 0.1062
Schistosoma mansoni DNA polymerase eta 0.0064 0.0621 0.1022
Echinococcus granulosus neuropeptide receptor 0.0062 0.0586 0.0964
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.004 0.0314 0.0171
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0293 0.0103
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0314 0.0569
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0195 0.0195
Brugia malayi hypothetical protein 0.0062 0.0586 0.1062
Echinococcus granulosus geminin 0.0336 0.4109 0.6765
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0182 0.033
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0278 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0293 0.0488
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0293 0.0488
Echinococcus multilocularis muscleblind protein 0.0148 0.1689 0.1689
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0195 0.0353
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0293 0.0488
Schistosoma mansoni hypothetical protein 0.0298 0.3623 0.5966
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0433 0.0564
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0259 0.0427
Brugia malayi G protein-coupled receptor 0.0062 0.0586 0.1062
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0586 0.0964
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0571 0.1035
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Onchocerca volvulus 0.003 0.0182 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0586 0.0586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0182 0.033
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0082 0.0082
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0172 0.0282
Loa Loa (eye worm) hypothetical protein 0.003 0.0182 0.033
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.0586 0.0964
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0433 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0271 0.0419
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0259 0.0427
Echinococcus granulosus dro:myosuppressin receptor 0.0062 0.0586 0.0964
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0271 0.0271
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0271 0.0319
Schistosoma mansoni histamine h1 receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) TYRA-2 protein 0.0062 0.0586 0.1062
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0032 0.0058
Loa Loa (eye worm) hypothetical protein 0.0148 0.1689 0.3064
Schistosoma mansoni thyroid hormone receptor 0.003 0.0182 0.0299
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.0586 0.0964
Schistosoma mansoni hypothetical protein 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.003 0.0182 0.033
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.041 0.041
Giardia lamblia DINP protein human, muc B family 0.0039 0.0293 0.0388
Echinococcus multilocularis Eukaryotic translation initiation factor 4H 0.0135 0.1531 0.1531
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0372 0.0613
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0489 0.6073 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0271 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0182 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0182 0.033
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0489 0.6073 0.6073
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0495 0.0898
Toxoplasma gondii exonuclease III APE 0.0037 0.0271 0.3073
Trypanosoma cruzi thymidine kinase, putative 0.0273 0.33 1
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0433 0.8047
Brugia malayi Serotonin receptor 0.0062 0.0586 0.1062
Echinococcus granulosus muscleblind protein 0.0148 0.1689 0.2781
Brugia malayi jmjC domain containing protein 0.004 0.0314 0.0569
Echinococcus multilocularis lamin dm0 0.0026 0.0136 0.0136
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0182 0.033
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0271 0.0032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0586 0.0586
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.0586 0.0964
Brugia malayi Bromodomain containing protein 0.0029 0.0172 0.0311
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0293 0.0071
Echinococcus granulosus orexin receptor type 2 0.0062 0.0586 0.0964
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0293 0.0102
Loa Loa (eye worm) hypothetical protein 0.0054 0.0495 0.0898
Schistosoma mansoni lamin 0.0026 0.0136 0.0224
Schistosoma mansoni lamin 0.0026 0.0136 0.0224
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0062 0.0586 0.1062
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0062 0.0586 0.0586
Echinococcus granulosus jumonji domain containing 1A 0.004 0.0314 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0293 0.0488
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0212 0.251 0.251
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Echinococcus granulosus neuropeptide FF receptor 2 0.0062 0.0586 0.0964
Schistosoma mansoni adenoreceptor 0.0062 0.0586 0.0964
Leishmania major thymidine kinase, putative 0.0273 0.33 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0372 0.0613
Echinococcus granulosus expressed conserved protein 0.0091 0.0968 0.1594
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0293 0.0103
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0136 0.0246
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.0586 0.1062
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0042 0.0335 0.0335
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0293 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0332 0.0332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0586 0.0586
Schistosoma mansoni glutaminase 0.0274 0.3314 0.5456
Loa Loa (eye worm) hypothetical protein 0.0067 0.0657 0.1192
Echinococcus multilocularis GPCR, family 2 0.0031 0.0195 0.0195
Brugia malayi hypothetical protein 0.0062 0.0586 0.1062
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0586 0.0964
Onchocerca volvulus 0.0029 0.0166 0.0056
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0062 0.0586 0.1062
Brugia malayi Muscleblind-like protein 0.0148 0.1689 0.3064
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.0586 0.0586
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0195 0.0195
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0262 0.0288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0586 0.0964
Echinococcus granulosus biogenic amine 5HT receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0314 0.0569
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0182 0.033
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0062 0.0586 0.0586
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0586 0.0586
Echinococcus granulosus cpg binding protein 0.003 0.0187 0.0308
Trypanosoma brucei thymidine kinase 0.0273 0.33 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.2311 0.2311
Echinococcus multilocularis sex peptide receptor 0.0062 0.0586 0.0586
Brugia malayi nuclear hormone receptor 0.003 0.0182 0.033
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0586 0.0964
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0489 0.6073 0.6073
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0278 0.3286
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0195 0.0353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0586 0.0964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0586 0.0586
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0433 1
Echinococcus multilocularis fmrfamide receptor 0.0062 0.0586 0.0586
Brugia malayi RNA binding protein 0.0135 0.1531 0.2776
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0293 0.0488
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0182 0.0085
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0182 0.033
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0062 0.0586 0.1062
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0262 0.0431
Loa Loa (eye worm) hypothetical protein 0.003 0.0182 0.033
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.0586 0.1062
Echinococcus granulosus FTZ F1 alpha 0.003 0.0182 0.0299
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0195 0.0321
Brugia malayi GnHR receptor homolog 0.0062 0.0586 0.1062
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1579 0.26
Brugia malayi hypothetical protein 0.0062 0.0586 0.1062
Echinococcus granulosus peregrin 0.0029 0.0172 0.0282
Schistosoma mansoni biogenic amine receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1012 0.1835
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0182 0.033
Schistosoma mansoni amine GPCR 0.0062 0.0586 0.0964
Brugia malayi Tachykinin-like peptides receptor 99D 0.0062 0.0586 0.1062
Schistosoma mansoni amine GPCR 0.0062 0.0586 0.0964
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0182 0.033
Loa Loa (eye worm) MBCTL1 0.0054 0.0495 0.0898
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Brugia malayi Dopamine receptor 0.0062 0.0586 0.1062
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0172 0.0282
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Toxoplasma gondii histone lysine demethylase JMJD6a 0.004 0.0314 0.4372
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0182 0.033
Schistosoma mansoni hypothetical protein 0.0062 0.0586 0.0964
Echinococcus granulosus serotonin receptor 0.0062 0.0586 0.0964
Schistosoma mansoni cpg binding protein 0.003 0.0187 0.0308
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0182 0.0299
Echinococcus multilocularis cpg binding protein 0.003 0.0187 0.0187
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0262 0.0475
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0153 0.1757 0.2893
Schistosoma mansoni thyroid hormone receptor 0.003 0.0182 0.0299
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0372 0.0675
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0621 0.1126
Echinococcus granulosus sex peptide receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Brugia malayi jmjC domain containing protein 0.004 0.0314 0.0569
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0062 0.0586 0.0964
Onchocerca volvulus 0.0062 0.0586 0.0837
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0135 0.1531 0.2521
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0182 0.0299
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.041 0.041
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0293 0.0488
Onchocerca volvulus 0.0062 0.0586 0.0837
Echinococcus granulosus G protein coupled receptor 139 0.0062 0.0586 0.0964
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0031 0.0195 0.0353
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni amine GPCR 0.0062 0.0586 0.0964
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0495 0.0815
Brugia malayi hypothetical protein 0.0062 0.0586 0.1062
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0293 0.0483
Loa Loa (eye worm) glutaminase 2 0.0274 0.3314 0.6009
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0062 0.0586 0.1062
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Onchocerca volvulus 0.0062 0.0586 0.0837
Brugia malayi G-protein coupled receptor 0.0062 0.0586 0.1062
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0182 0.0299
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0182 0.0299
Echinococcus granulosus dna polymerase kappa 0.0039 0.0293 0.0483
Echinococcus granulosus lysine specific demethylase 6a 0.004 0.0314 0.0516
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0657 0.1192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0372 0.0613
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0586 0.0964
Onchocerca volvulus 0.0446 0.5514 1
Brugia malayi intermediate filament protein 0.0026 0.0136 0.0246
Brugia malayi jmjC domain containing protein 0.004 0.0314 0.0569
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0212 0.251 0.4133
Schistosoma mansoni neuropeptide f receptor 76f 0.0062 0.0586 0.0964
Echinococcus multilocularis lamin 0.0026 0.0136 0.0136
Brugia malayi Melatonin receptor type 1A 0.0062 0.0586 0.1062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0182 0.0299
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1055 0.1914
Trypanosoma brucei polo-like protein kinase 0.0095 0.1012 0.2761
Brugia malayi Dopamine receptor protein 1 0.0062 0.0586 0.1062
Echinococcus granulosus lysine specific demethylase 5A 0.0153 0.1757 0.2893
Onchocerca volvulus Neuropeptide F receptor homolog 0.0062 0.0586 0.0837
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.0586 0.1062
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0153 0.1757 0.2893
Brugia malayi PHD-finger family protein 0.0029 0.0172 0.0311
Echinococcus granulosus intestinal type alkaline phosphatase 0.0489 0.6073 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0262 0.0262
Brugia malayi hypothetical protein 0.0062 0.0586 0.1062
Echinococcus multilocularis peregrin 0.0029 0.0172 0.0172
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1012 0.2468
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.0586 0.0964
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0062 0.0586 0.0964
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0586 0.0964
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0271 0.0032
Loa Loa (eye worm) hypothetical protein 0.004 0.0314 0.0569
Schistosoma mansoni myosin xvIII 0.0062 0.0586 0.0964
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0372 0.0613
Echinococcus multilocularis neuropeptide s receptor 0.0062 0.0586 0.0586
Brugia malayi ORL1-like opioid receptor 0.0062 0.0586 0.1062
Echinococcus granulosus neuropeptide receptor 0.0062 0.0586 0.0964
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0495 0.0815
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0182 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0182 0.033
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0062 0.0586 0.0964
Echinococcus multilocularis expressed conserved protein 0.0091 0.0968 0.0968
Schistosoma mansoni hypothetical protein 0.0062 0.0586 0.0964
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0332 0.0546
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0062 0.0586 0.0964
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0182 0.0299
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0332 0.0602
Schistosoma mansoni hypothetical protein 0.0036 0.0259 0.0427
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0271 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0293 0.0488
Schistosoma mansoni patched 1 0.0042 0.0332 0.0546
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1579 0.1579
Leishmania major DNA polymerase kappa, putative 0.0039 0.0293 0.0103
Echinococcus granulosus g-protein coupled receptor 0.0062 0.0586 0.0964
Brugia malayi glutaminase DH11.1 0.0274 0.3314 0.6009
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0293 0.0293
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1055 0.1914
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0062 0.0586 0.0964
Brugia malayi hypothetical protein 0.0446 0.5514 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.004 0.0314 0.0553
Echinococcus granulosus dnaJ subfamily B 0.041 0.5059 0.833
Echinococcus multilocularis neuropeptide receptor 0.0062 0.0586 0.0586
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0062 0.0586 0.0586
Echinococcus granulosus alkaline phosphatase 0.0489 0.6073 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.1055 0.1914
Loa Loa (eye worm) hypothetical protein 0.0148 0.1689 0.3064
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1012 0.1629
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0182 0.0299
Loa Loa (eye worm) hypothetical protein 0.0042 0.0332 0.0602
Echinococcus granulosus JmjC domain containing protein 4 0.004 0.0314 0.0516
Echinococcus granulosus peptide allatostatin:somatostatin 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.003 0.0182 0.033
Brugia malayi hypothetical protein 0.0032 0.0207 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0372 0.0372
Echinococcus multilocularis neuropeptide receptor 0.0062 0.0586 0.0586
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0182 0.0299
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0062 0.0586 0.1062
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1012 0.2458
Loa Loa (eye worm) hypothetical protein 0.0135 0.1531 0.2776
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1044 0.258
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0262 0.0262
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0062 0.0586 0.0964
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.0586 0.0586
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.041 0.051
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.041 0.0675
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0182 0.033
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1012 0.2468
Echinococcus granulosus neuropeptide receptor A26 0.0062 0.0586 0.0964
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0293 0.0488
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0293 0.0531
Echinococcus multilocularis G-protein coupled receptor, putative 0.0062 0.0586 0.0586
Schistosoma mansoni alkaline phosphatase 0.0489 0.6073 1
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0293 0.0293
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0586 0.0964
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.0586 0.0586
Onchocerca volvulus 0.0062 0.0586 0.0837
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0062 0.0586 0.0586
Echinococcus multilocularis fmrfamide receptor 0.0062 0.0586 0.0586
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0433 0.0564
Mycobacterium ulcerans glutaminase 0.0274 0.3314 1
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0293 0.0071
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0293 0.0102
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0262 0.0431
Loa Loa (eye worm) hypothetical protein 0.0064 0.0621 0.1126
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0136 0.0246
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0586 0.0586
Echinococcus multilocularis lysine specific demethylase 6a 0.004 0.0314 0.0314
Giardia lamblia Thymidine kinase 0.0273 0.33 1
Leishmania major DNA polymerase eta, putative 0.0064 0.0621 0.1182
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0182 0.0299
Plasmodium falciparum JmjC domain-containing protein, putative 0.004 0.0314 0.5433
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0172 0.0311
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0586 0.0964
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0062 0.0586 0.1062
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1063 0.1751
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0433 0.093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0182 0.033
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0621 0.1524
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0515
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0293 0.0483
Trichomonas vaginalis thymidine kinase, putative 0.0273 0.33 0.9956
Brugia malayi putative neuropeptide receptor NPR1 0.0062 0.0586 0.1062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0182 0.033
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Brugia malayi RE15519p 0.0062 0.0586 0.1062
Echinococcus multilocularis somatostatin receptor 0.0062 0.0586 0.0586
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0586 0.0964
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0062 0.0586 0.1062
Echinococcus granulosus somatostatin receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0062 0.0586 0.0964
Onchocerca volvulus 0.0062 0.0586 0.0837
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni alkaline phosphatase 0.0489 0.6073 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni hypothetical protein 0.0031 0.0195 0.0321
Schistosoma mansoni growth hormone secretagogue receptor 0.0062 0.0586 0.0964
Brugia malayi mbt repeat family protein 0.0048 0.041 0.0744
Schistosoma mansoni nuclear hormone receptor 0.003 0.0182 0.0299
Schistosoma mansoni neuropeptide receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Loa Loa (eye worm) hypothetical protein 0.003 0.0182 0.033
Brugia malayi steroid hormone receptor 0.003 0.0182 0.033
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0318 0.0318
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0489 0.6073 0.6073
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0172 0.0172
Onchocerca volvulus 0.0062 0.0586 0.0837
Echinococcus granulosus alpha 1A adrenergic receptor 0.0062 0.0586 0.0964
Echinococcus multilocularis lysine specific demethylase 5A 0.0151 0.1736 0.1736
Schistosoma mansoni biogenic amine receptor 0.0062 0.0586 0.0964
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0586 0.0964
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.058 0.0955
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0293 0.0103
Schistosoma mansoni phosphatidylserine receptor 0.004 0.0314 0.0516
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1012 0.1666
Echinococcus multilocularis dnaJ subfamily B 0.041 0.5059 0.5059
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Loa Loa (eye worm) hypothetical protein 0.003 0.0182 0.033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0182 0.033
Onchocerca volvulus 0.0062 0.0586 0.0837
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0515
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.041 0.0675
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1012 0.1666
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) glutaminase 0.0274 0.3314 0.6009
Echinococcus granulosus lamin dm0 0.0026 0.0136 0.0224
Brugia malayi ecdysteroid receptor 0.003 0.0182 0.033
Echinococcus multilocularis neuropeptide FF receptor 2 0.0062 0.0586 0.0586
Brugia malayi jmjC domain containing protein 0.0153 0.1757 0.3186
Echinococcus granulosus g protein coupled receptor 0.0062 0.0586 0.0964
Echinococcus multilocularis allatostatin A receptor 0.0062 0.0586 0.0586
Echinococcus multilocularis jumonji domain containing 1A 0.004 0.0314 0.0314
Onchocerca volvulus 0.0062 0.0586 0.0837
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0182 0.033
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1012 0.2458
Brugia malayi follicle stimulating hormone receptor 0.0062 0.0586 0.1062
Echinococcus granulosus tachykinin peptides receptor 99D 0.0062 0.0586 0.0964
Schistosoma mansoni hypothetical protein 0.0031 0.0195 0.0321
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0182 0.0085
Loa Loa (eye worm) hypothetical protein 0.005 0.0433 0.0785
Onchocerca volvulus 0.0062 0.0586 0.0837
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0262 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0586 0.0586
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0262 0.0431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1055 0.1914
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1012 0.2458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0586 0.0586
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.0586 0.0586
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1012 0.1012
Schistosoma mansoni hypothetical protein 0.0125 0.14 0.2304
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0497 1
Schistosoma mansoni jumonji domain containing protein 0.0192 0.2258 0.3718
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0372 0.0613
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0372 0.0372
Echinococcus multilocularis orexin receptor type 2 0.0062 0.0586 0.0586
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1012 0.2474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0586 0.0964
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.0586 0.1062
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0182 0.033
Schistosoma mansoni biogenic amine receptor 0.0062 0.0586 0.0964
Schistosoma mansoni neuropeptide receptor 0.0062 0.0586 0.0964
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0182 0.033
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Brugia malayi nuclear receptor NHR-88 0.003 0.0182 0.033
Schistosoma mansoni kinase 0.0048 0.0414 0.0682
Brugia malayi G-protein coupled receptor 0.0062 0.0586 0.1062
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0271 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0586 0.0586
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0182 0.0182
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.004 0.0314 0.4372
Echinococcus granulosus lamin 0.0026 0.0136 0.0224
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0262 0.0431
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0097 0.1044 0.1893
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0586 0.0586
Echinococcus granulosus Eukaryotic translation initiation factor 4H 0.0135 0.1531 0.2521
Schistosoma mansoni opsin-like receptor 0.0062 0.0586 0.0964
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0293 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0182 0.033
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0293 0.0483
Schistosoma mansoni neuropeptide receptor 0.0062 0.0586 0.0964
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1012 0.2468
Onchocerca volvulus 0.0062 0.0586 0.0837
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0398 0.0447
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0293 0.0488
Echinococcus granulosus hypothetical protein 0.0062 0.0586 0.0964
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1012 0.2458
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0062 0.0586 0.0586
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0136 0.0246
Brugia malayi putative neuropeptide receptor 0.0062 0.0586 0.1062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0586 0.0964
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0182 0.033
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1012 0.2458
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.041 0.0675
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0166 0.0301
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni hypothetical protein 0.0031 0.0195 0.0321
Echinococcus multilocularis serotonin receptor 0.0062 0.0586 0.0586
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.0586 0.0964
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0182 0.0299
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0271 0.0492
Loa Loa (eye worm) hypothetical protein 0.0446 0.5514 1
Schistosoma mansoni hypothetical protein 0.0336 0.4109 0.6765
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0262 0.0389
Onchocerca volvulus 0.0062 0.0586 0.0837
Schistosoma mansoni opsin-like receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0314 0.0569
Echinococcus multilocularis phd:f box containing protein 0.004 0.0314 0.0314
Echinococcus granulosus g protein coupled receptor 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.003 0.0182 0.033
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.041 0.0675
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0182 0.0299
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.2311 0.3805
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0182 0.0182
Echinococcus granulosus allatostatin A receptor 0.0062 0.0586 0.0964
Schistosoma mansoni hypothetical protein 0.041 0.5059 0.833
Echinococcus multilocularis musashi 0.0026 0.0136 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0293 0.0488
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0182 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0332 0.0229
Schistosoma mansoni hypothetical protein 0.0067 0.0657 0.1082
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0182 0.033
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.0121 0.1349 0.2446
Brugia malayi hypothetical protein 0.0062 0.0586 0.1062
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1012 0.2458
Loa Loa (eye worm) hypothetical protein 0.0121 0.1349 0.2446
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0271 0.0492
Leishmania major DNA polymerase eta, putative 0.0038 0.0278 0.0054
Schistosoma mansoni hypothetical protein 0.0062 0.0586 0.0964
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.004 0.0314 0.0171
Brugia malayi G protein-coupled receptor F59B2.13 0.0062 0.0586 0.1062
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0271 0.0447
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0586 0.0586
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0062 0.0586 0.0964
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0586 0.0964
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0515
Schistosoma mansoni intermediate filament proteins 0.0026 0.0136 0.0224
Onchocerca volvulus 0.0062 0.0586 0.0837
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0182 0.033
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0135 0.1531 0.2521
Brugia malayi hypothetical protein 0.0036 0.0259 0.047
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0182 0.0299
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Echinococcus multilocularis g-protein coupled receptor 0.0062 0.0586 0.0586
Brugia malayi jmjC domain containing protein 0.0212 0.251 0.4553
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0062 0.0586 0.0964
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0182 0.0182
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0293 0.0488
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0293 0.0103
Schistosoma mansoni hypothetical protein 0.0031 0.0195 0.0321
Echinococcus granulosus fmrfamide receptor 0.0062 0.0586 0.0964
Schistosoma mansoni alpha-1 adrenergic receptor 0.0062 0.0586 0.0964
Leishmania major hypothetical protein, conserved 0.005 0.0433 0.0564
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0062 0.0586 0.0964
Schistosoma mansoni amine GPCR 0.0062 0.0586 0.0964
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0293 0.0103
Brugia malayi hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni hypothetical protein 0.0254 0.3058 0.5035
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0271 0.0032
Loa Loa (eye worm) hypothetical protein 0.004 0.0314 0.0569
Schistosoma mansoni biogenic amine (5HT) receptor 0.0062 0.0586 0.0964
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0744
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0182 0.0299
Echinococcus multilocularis protein patched 0.0042 0.0332 0.0332
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0042 0.0335 0.0551
Echinococcus multilocularis alkaline phosphatase 0.0489 0.6073 0.6073
Trypanosoma brucei unspecified product 0.0039 0.0293 0.0488
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1012 0.1835
Onchocerca volvulus 0.0062 0.0586 0.0837
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0495 0.0815
Trypanosoma brucei RNA helicase, putative 0.0125 0.14 0.3988
Loa Loa (eye worm) jmjC domain-containing protein 0.0153 0.1757 0.3186
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0311
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0182 0.0182
Brugia malayi sulfakinin receptor protein 0.0062 0.0586 0.1062
Echinococcus multilocularis geminin 0.0336 0.4109 0.4109
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1044 0.1044
Brugia malayi CXXC zinc finger family protein 0.0029 0.0166 0.0301
Brugia malayi larval opioid receptor 0.0062 0.0586 0.1062
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0195 0.0353
Brugia malayi neuropeptide F receptor 0.0062 0.0586 0.1062
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0271 0.3819
Echinococcus granulosus GPCR family 2 0.0031 0.0195 0.0321
Echinococcus multilocularis protein dispatched 1 0.0048 0.0407 0.0407
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0062 0.0586 0.1062
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.041 0.0744
Brugia malayi mbt repeat family protein 0.0048 0.041 0.0744
Loa Loa (eye worm) hypothetical protein 0.0026 0.013 0.0235
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0271 0.3819
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0182 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0586 0.0964
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0062 0.0586 0.1062
Trichomonas vaginalis glutaminase, putative 0.0274 0.3314 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0011 0.0018
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0271 0.5
Onchocerca volvulus 0.0062 0.0586 0.0837
Onchocerca volvulus Huntingtin homolog 0.0121 0.1349 0.2255
Brugia malayi AKH receptor 0.0062 0.0586 0.1062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0372 0.0675
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0182 0.0182
Schistosoma mansoni amine GPCR 0.0062 0.0586 0.0964
Brugia malayi hypothetical protein 0.0121 0.1349 0.2446
Loa Loa (eye worm) hypothetical protein 0.0051 0.0452 0.082
Onchocerca volvulus 0.0048 0.041 0.051
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0489 0.6073 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0029 0.0172 0.0282
Onchocerca volvulus 0.0062 0.0586 0.0837
Schistosoma mansoni phd/f-box containing protein 0.004 0.0314 0.0516
Leishmania major hypothetical protein, conserved 0.004 0.0314 0.0171
Loa Loa (eye worm) hypothetical protein 0.0026 0.0136 0.0246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0586 0.0964
Schistosoma mansoni opsin-like receptor 0.0062 0.0586 0.0964
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.0586 0.0586
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0182 0.0182
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.0586 0.0964
Loa Loa (eye worm) hypothetical protein 0.0081 0.0836 0.1515
Schistosoma mansoni cpg binding protein 0.003 0.0187 0.0308
Onchocerca volvulus 0.0062 0.0586 0.0837
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0182 0.0182
Echinococcus multilocularis neuropeptide receptor A26 0.0062 0.0586 0.0586
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0621 0.1182
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0082 0.0135
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0332 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1012 0.2458
Loa Loa (eye worm) hypothetical protein 0.0062 0.0586 0.1062
Schistosoma mansoni ap endonuclease 0.0037 0.0271 0.0447
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.004 0.0314 0.0516
Schistosoma mansoni neuropeptide receptor 0.0062 0.0586 0.0964
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1044 0.1719
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0271 0.0032
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1689 0.1689
Onchocerca volvulus Alhambra homolog 0.0029 0.0172 0.0066
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0062 0.0586 0.0586

Activities

Activity type Activity value Assay description Source Reference
CT5 (functional) = 11.4 uM Inhibition of MT-2 cell growth by 5% or less over a 72 h time period. ChEMBL. 12166940
ED50 (functional) > 140 uM Inhibition of HIV replication by 50%. ChEMBL. 12166940
IC50 (functional) = 0.75 uM Inhibition of 50% of the integrase-mediated catalysis of the Y-oligo substrate with 95% confidence interval ChEMBL. 12166940
IC50 (functional) = 0.97 uM Inhibition of 50% of the integrase-mediated catalysis of the V1/V2 substrate with 95% confidence interval ChEMBL. 12166940
TI (functional) < 1 Therapeutic index (ratio of CT5 to ED50). ChEMBL. 12166940

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.