Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 4 | References | |
Homo sapiens | nuclear receptor subfamily 1, group I, member 2 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | nuclear receptor subfamily 1, group H, member 4 | 476 aa | 402 aa | 28.1 % |
Brugia malayi | ecdysteroid receptor | nuclear receptor subfamily 1, group I, member 2 | 434 aa | 427 aa | 25.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.5 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0024 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | Agonist activity at human LXRbeta transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay | ChEMBL. | 26905831 | |
EC50 (binding) | = 0.88 uM | Agonist activity at human PXR transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay | ChEMBL. | 26905831 |
EC50 (binding) | = 11 uM | Partial agonist activity at human FXR transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay | ChEMBL. | 26905831 |
Efficacy (binding) | = 23 % | Partial agonist activity at human FXR transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay relative to T0901317 | ChEMBL. | 26905831 |
Efficacy (binding) | = 61 % | Agonist activity at human PXR transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay relative to T0901317 | ChEMBL. | 26905831 |
IC50 (binding) | = 43 uM | Inverse agonist activity at human RORgamma transfected in HEK293 cells after 24 hrs by beta galactosidase luciferase reporter gene assay | ChEMBL. | 26905831 |
IC50 (binding) | = 53 uM | Inverse agonist activity at human RORalpha transfected in HEK293 cells after 24 hrs by beta galactosidase luciferase reporter gene assay | ChEMBL. | 26905831 |
IC50 (binding) | = 60 uM | Inverse agonist activity at human RORbeta transfected in HEK293 cells after 24 hrs by beta galactosidase luciferase reporter gene assay | ChEMBL. | 26905831 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.