Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Concentration of the compound required to inhibit the mutant alpha-Ala HCMV protease by 50% was determined | ChEMBL. | 9871686 |
IC50 (binding) | > 100 uM | Concentration of the compound required to inhibit the mutant alpha-Ala HCMV protease by 50% was determined | ChEMBL. | 9871686 |
Inhibition (functional) | = 48 % | Compound was evaluated for antiviral activity measured as percentage inhibition determined at a concentration of 100 (microM) against mutant alpha-Ala HCMV protease | ChEMBL. | 9871686 |
T1/2 | = 1.4 hr | Compound was tested for its stability by HPLC method, value expressed as half life | ChEMBL. | 9871686 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.