Detailed information for compound 212484

Basic information

Technical information
  • TDR Targets ID: 212484
  • Name: N,N-dimethyl-4-propan-2-ylpyrimidin-2-amine
  • MW: 165.235 | Formula: C9H15N3
  • H donors: 0 H acceptors: 2 LogP: 1.82 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccnc(n1)N(C)C)C
  • InChi: 1S/C9H15N3/c1-7(2)8-5-6-10-9(11-8)12(3)4/h5-7H,1-4H3
  • InChiKey: ZWNNPHVZQXVVBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-isopropyl-N,N-dimethyl-pyrimidin-2-amine
  • 4-isopropyl-N,N-dimethyl-2-pyrimidinamine
  • N,N-dimethyl-4-propan-2-yl-pyrimidin-2-amine
  • (4-isopropylpyrimidin-2-yl)-dimethyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rotamase 0.0035 0.0132 0.1223
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0092 0.0739
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0145 0.1082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0359 0.3588
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0151 0.1407
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.011 0.1076
Brugia malayi Bromodomain containing protein 0.0031 0.0106 0.076
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0151 0.1486
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0151 0.1126
Brugia malayi nuclear receptor NHR-67 0.0018 0.0029 0.0137
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0098
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0151 0.0871
Loa Loa (eye worm) hypothetical protein 0.0039 0.0159 0.1281
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0106 0.085
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.011 0.1076
Schistosoma mansoni lamin 0.0028 0.0092 0.0808
Loa Loa (eye worm) hypothetical protein 0.0127 0.0687 0.5538
Echinococcus granulosus lamin dm0 0.0028 0.0092 0.0892
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0144 0.1345
Onchocerca volvulus 0.0038 0.0151 0.0871
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0303 0.2437
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0526 0.5272
Echinococcus multilocularis dna polymerase kappa 0.0065 0.0314 0.3131
Schistosoma mansoni hypothetical protein 0.0073 0.0359 0.3529
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0128 0.4025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0151 0.1407
Loa Loa (eye worm) hypothetical protein 0.0037 0.0145 0.117
Schistosoma mansoni zinc finger protein 0.0018 0.0029 0.0172
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.008 0.2518
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0151 0.1126
Schistosoma mansoni hypothetical protein 0.0132 0.0719 0.719
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0151 0.1407
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0151 0.1126
Loa Loa (eye worm) hypothetical protein 0.0048 0.021 0.1693
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0314 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0117 0.3699
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Schistosoma mansoni ap endonuclease 0.0021 0.005 0.0384
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0144 0.1424
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Loa Loa (eye worm) hypothetical protein 0.0079 0.0398 0.3208
Echinococcus multilocularis geminin 0.0178 0.0996 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0128 0.4025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0151 0.1126
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0029 0.0261
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0019 0.0037 0.0205
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0314 1
Schistosoma mansoni nuclear receptor 0.0018 0.0029 0.0172
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0301
Entamoeba histolytica hypothetical protein 0.0073 0.0359 1
Brugia malayi nuclear receptor RXR 0.002 0.0042 0.0243
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0151 0.1486
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0012 0.0098
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.1668 1 1
Schistosoma mansoni hypothetical protein 0.0054 0.0249 0.2405
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0151 0.1486
Echinococcus multilocularis expressed protein 0.0035 0.0132 0.1303
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0103 0.1006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0151 0.1213
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0128 1
Leishmania major hypothetical protein, conserved 0.0026 0.008 0.4245
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0012 0.0091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.005 0.1539
Brugia malayi hypothetical protein 0.0028 0.0088 0.0613
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0339
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0012 0.0098
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.005 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0955
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0151 0.1126
Loa Loa (eye worm) hypothetical protein 0.0129 0.0698 0.5623
Brugia malayi nuclear receptor RXR 0.0018 0.0029 0.0137
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0314 1
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0314 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0151 0.1126
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0359 0.3529
Leishmania major DNA polymerase kappa, putative 0.0044 0.0187 1
Brugia malayi ecdysone receptor 0.0018 0.0029 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0151 0.1126
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0151 0.1126
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0339
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0151 0.1486
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0029 0.0234
Echinococcus multilocularis thyroid hormone receptor alpha 0.017 0.0949 0.9533
Brugia malayi Pre-SET motif family protein 0.0219 0.1241 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.008 0.2518
Brugia malayi polk-prov protein 0.0039 0.0159 0.1195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0314 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0151 0.1486
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0151 0.1126
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0119 0.0865
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0151 0.1486
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0151 0.1407
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.1668 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0151 0.1486
Echinococcus multilocularis GPCR, family 2 0.0015 0.0012 0.0091
Echinococcus granulosus dna polymerase eta 0.0037 0.0145 0.1431
Brugia malayi PHD-finger family protein 0.0031 0.0106 0.076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Echinococcus granulosus peregrin 0.0031 0.0106 0.1032
Brugia malayi steroid hormone receptor 0.0038 0.0151 0.1126
Onchocerca volvulus 0.0031 0.011 0.058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0151 0.1407
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.1668 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0151 0.1407
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0151 0.1486
Onchocerca volvulus Huntingtin homolog 0.0129 0.0698 0.4796
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0073 0.0494
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0144 0.1424
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0106 0.1032
Schistosoma mansoni hypothetical protein 0.0178 0.0996 1
Brugia malayi hypothetical protein 0.0129 0.0698 0.558
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0012 0.0091
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0886
Schistosoma mansoni hypothetical protein 0.0031 0.0106 0.0949
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0106 0.7912
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.1241 1
Brugia malayi hypothetical protein 0.0019 0.0037 0.0205
Brugia malayi nuclear hormone receptor 0.0018 0.0029 0.0137
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.011 0.8333
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.008 0.6589
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0106 0.9488
Echinococcus granulosus expressed protein 0.0035 0.0132 0.1303
Brugia malayi hypothetical protein 0.0064 0.0306 0.2393
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.011 0.1076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0029 0.0261
Schistosoma mansoni thyroid hormone receptor 0.017 0.0949 0.9529
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0151 0.0871
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0151 0.1126
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0128 0.6784
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0145 0.1431
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0151 0.1486
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0029 0.0137
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0151 0.1486
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0145 0.4008
Schistosoma mansoni ap endonuclease 0.0021 0.005 0.0384
Onchocerca volvulus Protein cycle homolog 0.0019 0.0037 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0151 0.1126
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0029 0.0261
Echinococcus granulosus intermediate filament protein 0.0028 0.0092 0.0892
Brugia malayi bZIP transcription factor family protein 0.0081 0.0412 0.3251
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0151 0.1486
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0151 0.1126
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.1081
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.005 0.3053
Onchocerca volvulus 0.0028 0.0092 0.0449
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0019 0.0037 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0151 0.1213
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.008 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0132 0.0918
Loa Loa (eye worm) hypothetical protein 0.0028 0.0092 0.0739
Schistosoma mansoni nuclear receptor 0.0018 0.0029 0.0172
Echinococcus multilocularis aryl hydrocarbon receptor 0.0028 0.0088 0.085
Brugia malayi nuclear receptor NHR-88 0.0018 0.0029 0.0137
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0029 0.0261
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0044 0.0187 0.0138
Schistosoma mansoni lamin 0.0028 0.0092 0.0808
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0019 0.0037 0.0301
Schistosoma mansoni jun-related protein 0.0066 0.032 0.3126
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0054 0.0004
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.1668 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0145 0.0096
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0151 0.1486
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0145 0.1352
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0106 0.0949
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0301
Entamoeba histolytica hypothetical protein 0.0073 0.0359 1
Schistosoma mansoni coup transcription factor 0.0038 0.0151 0.1407
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0994
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0151 0.0871
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0042 0.0243
Entamoeba histolytica hypothetical protein 0.0073 0.0359 1
Echinococcus multilocularis lamin 0.0028 0.0092 0.0892
Loa Loa (eye worm) RecQ helicase 0.0025 0.0073 0.0587
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.005 0.0471
Echinococcus multilocularis lamin dm0 0.0028 0.0092 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0151 0.1126
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0029 0.0172
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.1668 1 0.5
Brugia malayi hypothetical protein 0.0026 0.008 0.0556
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0994
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0151 0.1126
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0029 0.0261
Trypanosoma brucei unspecified product 0.0026 0.0075 0.2357
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.0314 0.2194
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0151 0.1486
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0412 0.4116
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0029 0.0137
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0106 0.7912
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0159 0.5035
Trichomonas vaginalis set domain proteins, putative 0.0249 0.1424 1
Brugia malayi intermediate filament protein 0.0028 0.0092 0.0647
Schistosoma mansoni thyroid hormone receptor 0.017 0.0949 0.9529
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0412 0.4116
Echinococcus multilocularis musashi 0.0028 0.0092 0.0892
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.005 0.2593
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0012 0.0091
Echinococcus multilocularis dna polymerase eta 0.0037 0.0145 0.1431
Giardia lamblia DINP protein human, muc B family 0.0044 0.0187 1
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0029 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Brugia malayi hypothetical protein 0.0018 0.0029 0.0137
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.005 0.1343
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0145 0.4591
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0339
Echinococcus granulosus lamin 0.0028 0.0092 0.0892
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0042 0.0304
Brugia malayi hypothetical protein 0.0017 0.0024 0.0095
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.005 0.1539
Entamoeba histolytica hypothetical protein 0.0073 0.0359 1
Echinococcus granulosus aryl hydrocarbon receptor 0.0028 0.0088 0.085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0151 0.1213
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0145 0.1431
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.005 0.1539
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.085
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0019 0.0037 0.0205
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0029 0.0261
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0272 0.8658
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0132 0.0979
Trypanosoma brucei unspecified product 0.0058 0.0272 0.8658
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0144 0.1345
Echinococcus multilocularis jun protein 0.0081 0.0412 0.4116
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0029 0.0261
Onchocerca volvulus Huntingtin homolog 0.0129 0.0698 0.4796
Loa Loa (eye worm) hypothetical protein 0.0052 0.0238 0.1915
Trichomonas vaginalis rotamase, putative 0.0034 0.0128 0.0883
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0029 0.0261
Brugia malayi hypothetical protein 0.0018 0.0029 0.0137
Onchocerca volvulus 0.0249 0.1424 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0151 0.1213
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0029 0.0234
Schistosoma mansoni hypothetical protein 0.0178 0.0996 1
Trypanosoma brucei unspecified product 0.0026 0.0075 0.2357
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0151 0.1486
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0314 1
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0151 0.1213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0301
Echinococcus multilocularis peregrin 0.0031 0.0106 0.1032
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0073 0.0499
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.008 0.2518
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Trichomonas vaginalis rotamase, putative 0.0035 0.0132 0.0918
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.005 0.0307
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0145 0.117
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0151 0.1407
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.0314 0.2194
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0106 0.1032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0151 0.1486
Toxoplasma gondii exonuclease III APE 0.0021 0.005 0.2625
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0159 0.5035
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0526 0.5272
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0187 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0151 0.1486
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0314 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.008 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0151 0.1213
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0092 0.0647
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0042 0.0392
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0301
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0117 0.3699
Brugia malayi nuclear hormone receptor 0.0038 0.0151 0.1126
Giardia lamblia PHD finger protein 15 0.0031 0.0106 0.4057
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0029 0.0261
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.0719 0.7216
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0029 0.0172
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.005 0.0402
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.005 0.0338
Brugia malayi hypothetical protein 0.0073 0.0359 0.2824
Leishmania major DNA polymerase eta, putative 0.0037 0.0145 0.7738
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0178 0.1762
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Plasmodium vivax SET domain protein, putative 0.0031 0.011 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0128 0.4025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0151 0.1213
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0042 0.0339
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.011 0.0994
Brugia malayi hypothetical protein 0.0019 0.0037 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0032 0.0931
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0151 0.1407
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0713
Brugia malayi hypothetical protein 0.002 0.0042 0.0243
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0649
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0073 0.0703
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.1668 1 1
Brugia malayi conserved hypotetical protein 0.0018 0.0029 0.0137
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0151 0.1407
Loa Loa (eye worm) hypothetical protein 0.0129 0.0698 0.5623
Loa Loa (eye worm) hypothetical protein 0.0028 0.0088 0.0705
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0145 0.1082
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0145 0.1352
Onchocerca volvulus 0.0028 0.0092 0.0449
Echinococcus granulosus dna polymerase kappa 0.0065 0.0314 0.3131
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0128 0.3514
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0178 0.1762
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0151 0.1213
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.005 0.0471
Brugia malayi Pre-SET motif family protein 0.0031 0.011 0.0796
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0019 0.0037 0.0256
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0151 0.1486
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0359 0.3588
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0132 0.1067
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0041 0.0291
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0029 0.0172
Brugia malayi jmjC domain containing protein 0.01 0.0526 0.4184
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Brugia malayi jmjC domain containing protein 0.0037 0.0144 0.1076
Plasmodium falciparum phd finger protein, putative 0.0031 0.0106 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0994
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0029 0.0172
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0029 0.0137
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0029 0.0261
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0028 0.0088 0.0705
Echinococcus granulosus bloom syndrome protein 0.0025 0.0073 0.0703
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0042 0.0304
Echinococcus granulosus jun protein 0.0081 0.0412 0.4116
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0029 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0151 0.1126
Onchocerca volvulus 0.0064 0.0306 0.1987
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0314 1
Schistosoma mansoni hypothetical protein 0.0066 0.032 0.3126
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.021 0.1611
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0073 0.0499
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0029 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0187 0.5933
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.021 0.1611
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0144 0.1164
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.0719 0.7216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0151 0.1126
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0042 0.0392
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0117 0.3699
Brugia malayi tailless protein 0.0018 0.0029 0.0137
Schistosoma mansoni DNA polymerase eta 0.0037 0.0145 0.1352
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0339
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0029 0.0261
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0092 0.0739
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0042 0.0243
Brugia malayi hypothetical protein 0.002 0.0042 0.0243
Schistosoma mansoni jumonji domain containing protein 0.008 0.0402 0.3962
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Brugia malayi nuclear receptor NHR-88 0.0038 0.0151 0.1126
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0029 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.021 0.1693
Trypanosoma brucei DNA polymerase eta, putative 0.0037 0.0145 0.4591
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0029 0.0261
Echinococcus granulosus geminin 0.0178 0.0996 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0151 0.1407
Onchocerca volvulus Alhambra homolog 0.0031 0.0106 0.0548
Brugia malayi ecdysteroid receptor 0.0038 0.0151 0.1126
Echinococcus granulosus GPCR family 2 0.0015 0.0012 0.0091
Loa Loa (eye worm) DR-78 0.0018 0.0029 0.0234
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0029 0.0172
Onchocerca volvulus 0.0028 0.0088 0.0419
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0339
Schistosoma mansoni intermediate filament proteins 0.0028 0.0092 0.0808
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0012 0.0091
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.008 0.553

Activities

Activity type Activity value Assay description Source Reference
Variation (functional) = -100 % Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-3 M ChEMBL. 8809156
Variation (functional) = -100 % Effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-3 M ChEMBL. 8809156
Variation (functional) = -86.36 % Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 3 x 10E-4 M ChEMBL. 8809156
Variation (functional) = -68.77 % Effect on the contractile force of spontaneously beating atria from Reserpine treated guinea pigs as percentage variation from the control at concentration of 10E-4 M ChEMBL. 8809156
Variation (functional) = -41.66 % Effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-4 M ChEMBL. 8809156
Variation (functional) = -41.66 % Compound was evaluated for its effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 3 x 10E-4 M ChEMBL. 8809156
Variation (functional) = -28.95 % Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 3 x 10E-5 M ChEMBL. 8809156
Variation (functional) = -17.26 % Compound was evaluated for its effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 3 x 10E-5 M ChEMBL. 8809156
Variation (functional) = -8.84 % Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-5 M ChEMBL. 8809156
Variation (functional) = -5.15 % Compound was evaluated for its effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 3 x 10E-6 M ChEMBL. 8809156
Variation (functional) = -5.15 % Effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-5 M ChEMBL. 8809156
Variation (functional) = 0 % Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-6 M ChEMBL. 8809156
Variation (functional) = 0 % Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 3 x 10E-6 M ChEMBL. 8809156
Variation (functional) = 0 % Effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-6 M ChEMBL. 8809156

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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