Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Rattus norvegicus | Plasminogen | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.5922 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.068 | 0.1148 |
Brugia malayi | Trypsin family protein | 0.012 | 0.5207 | 0.8793 |
Onchocerca volvulus | 0.012 | 0.5207 | 0.6031 | |
Brugia malayi | thymidylate synthase | 0.013 | 0.5922 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5207 | 0.8793 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.5922 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.5207 | 0.8793 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.5922 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5207 | 0.8793 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.068 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Onchocerca volvulus | 0.013 | 0.5922 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.5207 | 0.8793 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0053 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.5922 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.068 | 0.1148 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.5922 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.5922 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.5922 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.56 nM | In vitro inhibitory activity of the compound was evaluated against FIIa serine protease | ChEMBL. | 9934495 |
IC50 (binding) | = 135 nM | In vitro inhibitory activity of the compound was evaluated against human trypsin | ChEMBL. | 9934495 |
IC50 (binding) | = 135 nM | In vitro inhibitory activity of the compound was evaluated against human trypsin | ChEMBL. | 9934495 |
IC50 (binding) | = 627 nM | In vitro inhibitory activity of the compound was evaluated against Coagulation factor X | ChEMBL. | 9934495 |
IC50 (binding) | = 627 nM | In vitro inhibitory activity of the compound was evaluated against Coagulation factor X | ChEMBL. | 9934495 |
IC50 (binding) | = 1760 nM | In vitro inhibitory activity of the compound was evaluated against thrombolytic enzyme plasmin | ChEMBL. | 9934495 |
IC50 (binding) | = 1760 nM | In vitro inhibitory activity of the compound was evaluated against thrombolytic enzyme plasmin | ChEMBL. | 9934495 |
Ratio (binding) | = 241.1 | In vitro inhibitory activity of the compound was evaluated as ratio of trypsin by FIIa serine protease | ChEMBL. | 9934495 |
Ratio (binding) | = 241.1 | In vitro inhibitory activity of the compound was evaluated as ratio of trypsin by FIIa serine protease | ChEMBL. | 9934495 |
Ratio (binding) | = 1119.6 | In vitro inhibitory activity of the compound was evaluated as ratio of FIIa serine protease by FXa serine protease | ChEMBL. | 9934495 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.