Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.482 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 6.644 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 7.523 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 30 nM | Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii. | ChEMBL. | 7658454 |
IC50 (binding) | = 30 nM | Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii. | ChEMBL. | 7658454 |
IC50 (binding) | = 227 nM | Inhibitory activity against purified dihydrofolate reductase from rat | ChEMBL. | 7658454 |
IC50 (binding) | = 227 nM | Inhibitory activity against purified dihydrofolate reductase from rat | ChEMBL. | 7658454 |
IC50 (binding) | = 330 nM | Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii. | ChEMBL. | 7658454 |
IC50 (binding) | = 330 nM | Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii. | ChEMBL. | 7658454 |
IC50 (binding) | = 0.03 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.03 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.227 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.227 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.33 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.33 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 6.4815 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 6.644 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 7.5229 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
Selectivity (binding) | = 0.7 | Ratio of IC50 evaluated towards DHFR of rat liver to P. cainii | ChEMBL. | 7658454 |
Selectivity (binding) | = 7.6 | Ratio of IC50 evaluated towards DHFR of rat liver to T. gondii | ChEMBL. | 7658454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.