Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0291 | 0.1234 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.355 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.355 | 0.7839 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0404 | 0.3902 | 0.3902 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0291 | 0.1234 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0259 | 0.0494 | 0.0494 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.355 | 0.5 |
Onchocerca volvulus | 0.0389 | 0.355 | 0.5 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 0.355 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0317 | 0.1861 | 0.1861 |
Brugia malayi | thymidylate synthase | 0.0389 | 0.355 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 0.355 | 0.355 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0663 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 0.355 | 0.355 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0291 | 0.1234 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.355 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 0.355 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0259 | 0.0494 | 0.0494 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.355 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0317 | 0.1861 | 0.1861 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0431 | 0.4529 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0.355 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.355 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0.355 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0291 | 0.1234 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 0.355 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.8 nM | Cytotoxicity against human W1L2 cells | ChEMBL. | 21080724 |
EC50 (functional) | = 2.8 nM | Cytotoxicity against human W1L2 cells | ChEMBL. | 23679915 |
IC50 (functional) | = 2.2 nM | Growth inhibitory activity against human lymphoblastoid W1L2 cell line in presence of 10 microM thymidine/50 microM hypoxanthine | ChEMBL. | 12166942 |
IC50 (functional) | = 2.2 nM | Growth inhibitory activity against human lymphoblastoid W1L2 cell line in presence of 10 microM thymidine/50 microM hypoxanthine | ChEMBL. | 12166942 |
IC50 (functional) | = 2.8 nM | Growth inhibitory activity against human lymphoblastoid W1L2 cell line | ChEMBL. | 12166942 |
IC50 (functional) | = 2.8 nM | Growth inhibitory activity against human lymphoblastoid W1L2 cell line | ChEMBL. | 12166942 |
IC50 (binding) | = 156 nM | Growth inhibitory activity against mouse lymphoblastoid L1210TS cell line was determined as inhibition of thymidylate synthase | ChEMBL. | 12166942 |
IC50 (binding) | = 156 nM | Growth inhibitory activity against mouse lymphoblastoid L1210TS cell line was determined as inhibition of thymidylate synthase | ChEMBL. | 12166942 |
IC50 (binding) | = 156 nM | Inhibition of thymidylate synthase | ChEMBL. | 21080724 |
IC50 (functional) | = 610 nM | Growth inhibitory activity against human lymphoblastoid W1L2:R865 cell line | ChEMBL. | 12166942 |
Solubility | < 1 uM | Solubility at pH 6.0 | ChEMBL. | 12166942 |
Solubility | = 2.3 uM | Solubility at pH 7.4 | ChEMBL. | 12166942 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12166942 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.