Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0012 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Agonist activity at VDR in human HaCaT cells assessed as increase in CAMP gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 | |
Activity (binding) | = 0 % | Agonist activity at VDR in human A549 cells assessed as increase in CAMP gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 7 % | Displacement of [3H]-1,25(OH)2D3 from recombinant human VDR ligand binding domain relative to 1,25(OH)2D3 | ChEMBL. | 26613420 |
Activity (binding) | = 11 % | Displacement of [3H]-1,25(OH)2D3 from recombinant human VDR ligand binding domain relative to vitamin D | ChEMBL. | 26613420 |
Activity (binding) | = 15 % | Agonist activity at VDR in human HEK293 cells assessed as increase in CYP24A1 gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 15 % | Agonist activity at VDR in human MG63 cells assessed as increase in CYP24A1 gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 18 % | Agonist activity at VDR in human H292 cells assessed as increase in CAMP gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 19 % | Agonist activity at VDR in human HaCaT cells assessed as increase in CYP24A1 gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 21 % | Agonist activity at VDR in human U937 cells assessed as increase in CYP24A1 gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 24 % | Agonist activity at VDR in human THP1 cells assessed as increase in CYP24A1 gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 36 % | Agonist activity at VDR in human SW480 cells assessed as increase in CYP24A1 gene expression at 100 nM after 24 hrs by RT-PCR analysis relative to 1,25(OH)2D3 | ChEMBL. | 26613420 |
Activity (binding) | = 36 % | Agonist activity at VDR in human SW480 cells assessed as increase in E-cadherin gene expression at 100 nM after 24 hrs by RT-PCR analysis relative to 1,25(OH)2D3 | ChEMBL. | 26613420 |
Activity (binding) | = 45 % | Agonist activity at VDR in human MG63 cells assessed as increase in OCN gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 47 % | Agonist activity at VDR in human THP1 cells assessed as increase in CAMP expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 48 % | Agonist activity at VDR in human U937 cells assessed as increase in CAMP expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 51 % | Agonist activity at VDR in human H292 cells assessed as increase in CYP24A1 gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 52 % | Agonist activity at VDR in human SW480 cells assessed as increase in TRPV6 gene expression at 100 nM after 24 hrs by RT-PCR analysis relative to 1,25(OH)2D3 | ChEMBL. | 26613420 |
Activity (binding) | = 55 % | Agonist activity at VDR in human A549 cells assessed as increase in CYP24A1 gene expression at 100 nM after 24 hrs by RT-PCR analysis | ChEMBL. | 26613420 |
Activity (binding) | = 87 % | Agonist activity at VDR in human MG63 cells assessed as increase in OCN expression at 100 nM after 96 hrs by ELISA relative to 1,25(OH)2D3 | ChEMBL. | 26613420 |
EC50 (binding) | = 0.7 nM | Agonist activity at VDR (unknown origin) expressed in HEK293 cells cotransfected with RXRalpha assessed as RXRalpha recruitment by two-hybrid assay | ChEMBL. | 26613420 |
EC50 (binding) | = 1.5 nM | Agonist activity at VDR in human HEK293 cells assessed as transcriptional activity after 16 to 24 hrs by luciferase reporter gene assay | ChEMBL. | 26613420 |
EC50 (binding) | = 4.5 nM | Agonist activity at VDR (unknown origin) expressed in HEK293 cells cotransfected with SRC1 assessed as SRC1 recruitment by two-hybrid assay | ChEMBL. | 26613420 |
Efficacy (binding) | = 86 % | Partial agonist activity at VDR in human HEK293 cells assessed as transcriptional activity after 16 to 24 hrs by luciferase reporter gene assay relative to 1,25(OH)2D3 | ChEMBL. | 26613420 |
IC50 (binding) | = 0.09 nM | Agonist activity at VDR (unknown origin) expressed in HEK293 cells cotransfected with NCoR assessed as decrease in NCoR recruitment by two-hybrid assay | ChEMBL. | 26613420 |
IC50 (binding) | = 5 nM | Displacement of [3H]-1,25(OH)2D3 from recombinant human VDR ligand binding domain | ChEMBL. | 26613420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.