Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 10 (sodium/bile acid cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0247 | 0.2779 | 0.2696 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0315 | 0.0315 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.2779 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.2779 | 0.2779 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0228 | 0.2539 | 0.2454 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.2779 | 0.0321 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.2779 | 0.0321 |
Schistosoma mansoni | dihydrofolate reductase | 0.0823 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.06 | 0.7207 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0228 | 0.2539 | 0.2539 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0113 | 0.0113 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0315 | 0.0315 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0247 | 0.2779 | 0.2779 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0113 | 0.0113 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.06 | 0.7207 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.2779 | 0.0321 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.01 | 0.0935 | 0.0832 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0147 | 0.1522 | 0.1424 |
Brugia malayi | hypothetical protein | 0.0109 | 0.1039 | 0.1039 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.2779 | 0.0321 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0823 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.2779 | 0.0321 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0315 | 0.0315 |
Brugia malayi | Dihydrofolate reductase | 0.0823 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0823 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0823 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0315 | 0.0315 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0823 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0823 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0109 | 0.1039 | 0.1442 |
Onchocerca volvulus | 0.0247 | 0.2779 | 1 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.06 | 0.7207 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0228 | 0.2539 | 0.1674 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.06 | 0.7207 | 1 |
Brugia malayi | thymidylate synthase | 0.0228 | 0.2539 | 0.2539 |
Echinococcus granulosus | dihydrofolate reductase | 0.0823 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.06 | 0.7207 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0109 | 0.1039 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.06 | 0.7207 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1200 nM | In vitro inhibitory activity against uptake of [14C]-taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codependent Bile Acid Transporter | ChEMBL. | 14552767 |
IC50 (binding) | = 1200 nM | In vitro inhibitory activity against uptake of [14C]-taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codependent Bile Acid Transporter | ChEMBL. | 14552767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.