Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Dihydrofolate reductase | References | |
Homo sapiens | dihydrofolate reductase | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 0.5 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 0.5 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against Escherichia coli harboring acrF gene deletion mutant by alamar blue reagent based micro dilution broth assay | ChEMBL. | 27437079 | |
Activity (functional) | Antibacterial activity against Escherichia coli JW0451 harboring AcrB gene deletion mutant by alamar blue reagent based micro dilution broth assay | ChEMBL. | 27437079 | |
Activity (functional) | Antibacterial activity against Escherichia coli harboring emrB gene deletion mutant by alamar blue reagent based micro dilution broth assay | ChEMBL. | 27437079 | |
Activity (functional) | Antibacterial activity against Escherichia coli harboring macB gene deletion mutant by alamar blue reagent based micro dilution broth assay | ChEMBL. | 27437079 | |
INH (ADMET) | > 50 uM | Inhibition of human CYP3A4 using BQ as substrate assessed as reduction in 7-hydroxyquinoline metabolite formation incubated for 30 mins by high throughput assay | ChEMBL. | 27437079 |
INH (ADMET) | > 50 uM | Inhibition of human CYP2D6 using AMMC as substrate assessed as reduction in 3-[-2-(N,Ndiethylamino)ethyl]-7-hydroxy-4-methylcoumarin hydrochloride metabolite formation incubated for 30 mins by high throughput assay | ChEMBL. | 27437079 |
Ki (binding) | = 4.77 nM | Inhibition of recombinant Staphylococcus aureus DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition | ChEMBL. | 27437079 |
Ki (binding) | = 200.77 nM | Inhibition of recombinant human DHFR assessed as reduction in NADPH oxidation using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition | ChEMBL. | 27437079 |
MIC (functional) | = 0.0098 ug ml-1 | Antibacterial activity against Escherichia coli NR698 harboring imp gene deletion mutant by alamar blue reagent based micro dilution broth assay | ChEMBL. | 27437079 |
MIC (functional) | > 20 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 by alamar blue reagent based micro dilution broth assay | ChEMBL. | 27437079 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.