Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | BC026374 protein S09 family | 0.0187 | 0.141 | 0.1376 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.0039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.141 | 0.1376 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0039 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0088 | 0.0488 | 0.0451 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1105 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0488 | 0.0451 |
Brugia malayi | Carboxylesterase family protein | 0.1105 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0488 | 0.0451 |
Echinococcus granulosus | serotonin transporter | 0.0088 | 0.0488 | 0.0451 |
Schistosoma mansoni | gliotactin | 0.0187 | 0.141 | 0.1376 |
Onchocerca volvulus | 0.0187 | 0.141 | 1 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0088 | 0.0488 | 0.0451 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0187 | 0.141 | 0.1376 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.141 | 0.1376 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0187 | 0.141 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0187 | 0.141 | 0.1376 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0187 | 0.141 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.0039 | 0.5 |
Brugia malayi | hypothetical protein | 0.0187 | 0.141 | 0.1376 |
Schistosoma mansoni | acetylcholinesterase | 0.0187 | 0.141 | 0.1376 |
Echinococcus granulosus | neuroligin | 0.0187 | 0.141 | 0.1376 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0187 | 0.141 | 0.1376 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.141 | 0.1376 |
Echinococcus granulosus | acetylcholinesterase | 0.1105 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.141 | 0.1376 |
Loa Loa (eye worm) | carboxylesterase | 0.1105 | 1 | 1 |
Onchocerca volvulus | 0.0187 | 0.141 | 1 | |
Onchocerca volvulus | 0.0187 | 0.141 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.141 | 0.1376 |
Echinococcus granulosus | carboxylesterase 5A | 0.1105 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0187 | 0.141 | 0.1376 |
Loa Loa (eye worm) | serotonin transporter b | 0.0088 | 0.0488 | 0.0451 |
Echinococcus multilocularis | acetylcholinesterase | 0.1105 | 1 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0187 | 0.141 | 0.1376 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0039 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0187 | 0.141 | 0.1376 |
Echinococcus multilocularis | serotonin transporter | 0.0088 | 0.0488 | 0.0451 |
Onchocerca volvulus | 0.0187 | 0.141 | 1 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0088 | 0.0488 | 0.0451 |
Loa Loa (eye worm) | carboxylesterase | 0.0187 | 0.141 | 0.1376 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.141 | 0.1376 |
Onchocerca volvulus | 0.0187 | 0.141 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.141 | 0.1376 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0088 | 0.0488 | 0.0451 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0187 | 0.141 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1105 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0187 | 0.141 | 0.1376 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0039 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.0039 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.141 | 0.1376 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0088 | 0.0488 | 0.0451 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1105 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0187 | 0.141 | 0.1376 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0187 | 0.141 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0187 | 0.141 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0187 | 0.141 | 0.1376 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1105 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1105 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1105 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0488 | 0.0451 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0187 | 0.141 | 0.1376 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.141 | 0.1376 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0039 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0187 | 0.141 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1105 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0187 | 0.141 | 0.1376 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.141 | 0.1376 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.141 | 0.1376 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0187 | 0.141 | 0.1376 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0088 | 0.0488 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.05 uM | Effective concentration (EC50) required to inhibit UT7/TPO Cell Proliferation | ChEMBL. | 11606138 |
EC50 (binding) | = 0.1 uM | Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells | ChEMBL. | 11606138 |
Efficacy (binding) | = 39 % | Thrombopoietin luciferase activity in BAF-3 cells | ChEMBL. | 11606138 |
Efficacy (functional) | = 100 % | Compound tested for UT7/TPO cell proliferation activity (%TPO) using proliferation assay. | ChEMBL. | 11606138 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.