Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.0012 | 0.0008 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0005 | 0.0002 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0014 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0032 | 0.0029 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0009 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0009 | 0.0009 |
Onchocerca volvulus | 0.0245 | 0.0129 | 0.0552 | |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0009 | 0.0013 |
Leishmania major | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0004 | 0.0000088881 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0012 | 0.0011 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.8086 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0004 | 0.0000088881 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0009 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0011 | 0.0008 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0011 | 0.0008 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0019 | 0.0004 | 0.0005 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0011 | 0.001 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0005 | 0.2525 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0004 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0004 | 0.0001 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0005 | 0.0003 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0019 | 0.0004 | 0.0000088881 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0011 | 0.0008 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0006 | 0.0004 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0019 | 0.0004 | 0.0003 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0004 | 0.0000088881 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0012 | 0.0011 |
Onchocerca volvulus | 0.0031 | 0.0011 | 0.0008 | |
Echinococcus multilocularis | snurportin 1 | 0.0308 | 0.0164 | 0.0163 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0019 | 0.0018 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0019 | 0.0004 | 0.0000088881 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0011 | 0.0008 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0019 | 0.0004 | 0.0003 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0011 | 0.001 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1886 | 0.1037 | 0.1034 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0019 | 0.0004 | 0.0005 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0014 | 0.0011 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0019 | 0.0017 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0019 | 0.0004 | 0.0005 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0012 | 0.0011 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0009 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0009 | 0.0009 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0011 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0014 | 0.0011 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.2878 | 0.7118 | 1 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0019 | 0.0004 | 0.0003 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0019 | 0.0004 | 0.0062 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0004 | 0.0001 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Echinococcus granulosus | lamin | 0.0028 | 0.0009 | 0.0008 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0248 | 0.0131 | 0.0131 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0005 | 0.0002 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0019 | 0.0018 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0009 | 0.0009 |
Echinococcus multilocularis | thymidylate synthase | 0.3965 | 0.2187 | 0.2186 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0019 | 0.0004 | 0.0000088881 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0019 | 0.0004 | 0.0062 |
Echinococcus granulosus | Smad4 | 0.0017 | 0.0003 | 0.0002 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0004 | 0.0004 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0011 | 0.001 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0011 | 0.0011 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0014 | 0.0013 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0004 | 0.0003 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0005 | 0.0007 |
Brugia malayi | Smad1 | 0.0017 | 0.0003 | 0.0001 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0009 | 0.0009 |
Brugia malayi | hypothetical protein | 0.1886 | 0.1037 | 0.1035 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0004 | 0.0002 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.0039 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0011 | 0.0011 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0008 | 0.0075 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0009 | 0.0007 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0017 | 0.0003 | 0.0004 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0011 | 0.0011 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | Smad1 | 0.0017 | 0.0003 | 0.0003 |
Mycobacterium ulcerans | thymidylate synthase | 0.3965 | 0.2187 | 0.2184 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0009 | 0.0009 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0017 | 0.0003 | 0.0002 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.001 | 0.0009 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0019 | 0.0004 | 0.0004 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0004 | 0.0037 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0019 | 0.0004 | 0.0002 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0022 | 0.0006 | 0.0003 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0019 | 0.0004 | 0.0000088881 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0004 | 0.1038 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0019 | 0.0004 | 0.0000088881 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0011 | 0.001 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0009 | 0.0009 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0004 | 0.0005 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0003 | 0.0002 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0012 | 0.0012 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0017 | 0.0003 | 0.0002 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0004 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 1.8086 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.8086 | 1 | 1 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0005 | 0.005 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.0006 | 0.0006 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0014 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0012 | 0.0011 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0003 | 0.0001 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.0012 | 0.0017 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0005 | 0.1309 |
Mycobacterium ulcerans | pyruvate kinase | 0.0033 | 0.0012 | 0.0008 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0014 | 1 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0005 | 0.0004 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3965 | 0.2187 | 0.2185 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1886 | 0.1037 | 0.1452 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0026 | 0.0008 | 0.0006 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0005 | 0.0004 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0006 | 0.0004 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0004 | 0.0001 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0009 | 0.0013 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0012 | 0.0017 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0026 | 0.0008 | 0.0006 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0004 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0006 | 0.0006 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0019 | 0.0018 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0017 | 0.0003 | 0.0003 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0019 | 0.0004 | 0.0001 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0003 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0006 | 0.0006 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0019 | 0.0016 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0003 | 0.0001 |
Echinococcus multilocularis | smad | 0.0017 | 0.0003 | 0.0002 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0215 | 0.0113 | 0.0113 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0019 | 0.0018 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0017 | 0.0003 | 0.0002 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0009 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0011 | 0.0011 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0019 | 0.0004 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0026 | 0.0008 | 0.0011 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0014 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0248 | 0.0131 | 0.0131 |
Toxoplasma gondii | FATC domain-containing protein | 0.0026 | 0.0008 | 0.0011 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0003 | 0.0001 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0006 | 0.2479 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3965 | 0.2187 | 0.2178 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0003 | 0.0002 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3965 | 0.2187 | 0.2184 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0003 | 0.0001 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0012 | 0.0014 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.0008 | 0.0007 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0011 | 0.0015 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0012 | 0.0011 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0012 | 0.0014 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0017 | 0.0003 | 0.0002 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0011 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0011 | 0.0008 |
Trichomonas vaginalis | set domain proteins, putative | 0.0245 | 0.0129 | 0.1245 |
Echinococcus granulosus | serine protein kinase ATM | 0.0026 | 0.0008 | 0.0007 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0019 | 0.0004 | 0.0003 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0003 | 0.0002 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0005 | 0.0003 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0019 | 0.0016 |
Echinococcus multilocularis | Smad4 | 0.0017 | 0.0003 | 0.0002 |
Echinococcus multilocularis | dihydrofolate reductase | 1.8086 | 1 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0009 | 0.0008 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0004 | 0.0037 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0005 | 0.0007 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0011 | 0.0009 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0009 | 0.0006 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0002 | 0.0002 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0009 | 0.0008 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0004 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0032 | 0.0032 |
Schistosoma mansoni | lamin | 0.0028 | 0.0009 | 0.0006 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0012 | 0.0013 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0011 | 0.0008 |
Brugia malayi | MH2 domain containing protein | 0.0248 | 0.0131 | 0.0129 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0026 | 0.0008 | 0.0005 |
Schistosoma mansoni | lamin | 0.0028 | 0.0009 | 0.0006 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0009 | 0.0008 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0308 | 0.0164 | 0.0164 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0009 | 0.0008 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0006 | 0.0061 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0011 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0012 | 0.0012 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.0012 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0001 | 0.0001 |
Echinococcus granulosus | dihydrofolate reductase | 1.8086 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0019 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0009 | 0.0009 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.0032 | 0.003 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Schistosoma mansoni | ran | 0.0021 | 0.0005 | 0.0002 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0005 | 0.0003 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0012 | 0.0011 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0005 | 0.0002 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0012 | 0.0013 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0017 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.005 | 0.005 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0011 | 0.001 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Brugia malayi | thymidylate synthase | 0.3965 | 0.2187 | 0.2186 |
Brugia malayi | Pre-SET motif family protein | 0.0215 | 0.0113 | 0.0111 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0003 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.0308 | 0.0164 | 0.0161 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0023 | 0.0006 | 0.2416 |
Loa Loa (eye worm) | thymidylate synthase | 0.3965 | 0.2187 | 0.2187 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0009 | 0.0008 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0004 | 0.0001 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0012 | 0.0114 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0011 | 0.0008 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0026 | 0.0008 | 0.0007 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0004 | 0.0005 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0012 | 0.001 |
Echinococcus granulosus | thymidylate synthase | 0.3965 | 0.2187 | 0.2186 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0009 | 0.0008 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0005 | 0.0005 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0012 | 0.0009 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0011 | 0.0009 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.0019 | 0.0004 | 0.0000088881 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0019 | 0.0004 | 0.0005 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.8086 | 1 | 1 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0019 | 0.0004 | 0.0000088881 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.8086 | 1 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0012 | 0.001 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0012 | 0.0011 |
Echinococcus granulosus | smad | 0.0017 | 0.0003 | 0.0002 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.2878 | 0.7118 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0008 | 0.3892 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0003 | 0.0002 |
Schistosoma mansoni | ran | 0.0021 | 0.0005 | 0.0002 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0011 | 0.001 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.0012 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0019 | 0.0016 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0012 | 0.0012 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0012 | 0.0014 |
Echinococcus granulosus | snurportin 1 | 0.0308 | 0.0164 | 0.0163 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0011 | 0.001 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.005 | 0.0048 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0014 | 0.0013 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0019 | 0.0004 | 0.0005 |
Giardia lamblia | GTOR | 0.0019 | 0.0004 | 0.1108 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.2878 | 0.7118 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0012 | 0.0012 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0006 | 0.0061 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0006 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.005 | 0.005 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0019 | 0.0019 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0011 | 0.0008 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.005 | 0.0048 |
Schistosoma mansoni | dihydrofolate reductase | 1.8086 | 1 | 1 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0019 | 0.0004 | 0.0001 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.2878 | 0.7118 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 1.2878 | 0.7118 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0001 | 0.0001 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0012 | 0.0009 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0009 | 0.0013 |
Onchocerca volvulus | 0.3965 | 0.2187 | 1 | |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0012 | 0.0114 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0004 | 0.0037 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.2878 | 0.7118 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1886 | 0.1037 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0012 | 0.0011 |
Chlamydia trachomatis | dihydrofolate reductase | 1.8086 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 283.8 uM | Indirect antitumour effect was measured as cytotoxicity with murine macrophages pretreated with compounds | ChEMBL. | 12904070 |
IC50 (functional) | = 283.8 uM | Indirect antitumour effect was measured as cytotoxicity with murine macrophages pretreated with compounds | ChEMBL. | 12904070 |
IC50 (functional) | = 604.9 uM | In vitro cytotoxicity against the selected tumour cell line LoVoS arising from human colon adenocarcinoma was determined | ChEMBL. | 12904070 |
IC50 (functional) | = 604.9 uM | In vitro cytotoxicity against the selected tumour cell line LoVoS arising from human colon adenocarcinoma was determined | ChEMBL. | 12904070 |
IC50 (functional) | = 780.3 uM | Invitro cytotoxicity against the selected tumour cell line LoVoR arising from human colon adenocarcinoma was determined | ChEMBL. | 12904070 |
IC50 (functional) | = 780.3 uM | Invitro cytotoxicity against the selected tumour cell line LoVoR arising from human colon adenocarcinoma was determined | ChEMBL. | 12904070 |
ND (functional) | 0 | Direct cytotoxicity against the selected tumour cell line 2008 was determined especially on ovarian adenocarcinoma derived cells; not detected | ChEMBL. | 12904070 |
ND (functional) | 0 | Direct cytotoxicity against the selected tumour cell line c13* was determined especially on ovarian adenocarcinoma derived cells; not detected | ChEMBL. | 12904070 |
ND (functional) | 0 | Indirect antitumour effect was measured as cytotoxicity against human monocytes; not detected | ChEMBL. | 12904070 |
Potency ratio (functional) | = 0.5 | Potency ratio was determined against LoVoR versus FAA (Flavone acetic acid); less potent | ChEMBL. | 12904070 |
Potency ratio (functional) | = 0.9 | Potency ratio was determined against LoVoS versus FAA (Flavone acetic acid) | ChEMBL. | 12904070 |
Potency ratio (functional) | = 1 | Potency ratio was determined against murine macrophages versus FAA (Flavone acetic acid) | ChEMBL. | 12904070 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.