Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | References | |
Homo sapiens | matrix metallopeptidase 8 (neutrophil collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.2107 | 0.2566 |
Echinococcus granulosus | carboxylesterase 5A | 0.0408 | 0.8211 | 0.8579 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.8211 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0147 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0408 | 0.8211 | 0.8579 |
Mycobacterium ulcerans | hydrolase | 0.0147 | 0 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0293 | 0.4577 | 0.5574 |
Brugia malayi | Carboxylesterase family protein | 0.0408 | 0.8211 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.2107 | 0.2566 |
Echinococcus granulosus | acetylcholinesterase | 0.0408 | 0.8211 | 0.8579 |
Brugia malayi | Carboxylesterase family protein | 0.0408 | 0.8211 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0408 | 0.8211 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0408 | 0.8211 | 0.8063 |
Loa Loa (eye worm) | carboxylesterase | 0.0408 | 0.8211 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0408 | 0.8211 | 0.8579 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.044 | 0.9222 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.8211 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0268 | 0.3814 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.2107 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0408 | 0.8211 | 0.8579 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0147 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.2107 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.2107 | 0.1455 |
Brugia malayi | Hemopexin family protein | 0.0172 | 0.0763 | 0.0929 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.044 | 0.9222 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0408 | 0.8211 | 0.8579 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.2107 | 0.2566 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.2107 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0268 | 0.3814 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0268 | 0.3814 | 0.4645 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.2107 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.2107 | 0.1455 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.2107 | 0.2566 |
Loa Loa (eye worm) | matrixin family protein | 0.0293 | 0.4577 | 0.5574 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.28 | Inhibition of MMP1 (unknown origin) | ChEMBL. | 17275314 |
Ki (binding) | = 7.51 | Inhibition of MMP9 (unknown origin) | ChEMBL. | 17275314 |
Ki (binding) | = 7.92 | Inhibition of MMP2 (unknown origin) | ChEMBL. | 17275314 |
Ki (binding) | = 12 nM | Inhibitory activity against Matrix metalloproteinase-2 | ChEMBL. | 11020282 |
Ki (binding) | = 12 nM | Inhibitory activity against Matrix metalloproteinase-2 | ChEMBL. | 11020282 |
Ki (binding) | = 22 nM | Inhibitory activity against Clostridium histolyticum collagenase (ChC) was determined | ChEMBL. | 11020282 |
Ki (binding) | = 22 nM | Inhibitory activity against Clostridium histolyticum collagenase (ChC) was determined | ChEMBL. | 11020282 |
Ki (binding) | = 27 nM | Inhibitory activity against Matrix metalloproteinase-8 | ChEMBL. | 11020282 |
Ki (binding) | = 27 nM | Inhibitory activity against Matrix metalloproteinase-8 | ChEMBL. | 11020282 |
Ki (binding) | = 31 nM | Inhibitory activity against Matrix metalloproteinase-9 | ChEMBL. | 11020282 |
Ki (binding) | = 31 nM | Inhibitory activity against Matrix metalloproteinase-9 | ChEMBL. | 11020282 |
Ki (binding) | = 53 nM | Inhibitory activity against matrix metalloproteinase-1 | ChEMBL. | 11020282 |
Ki (binding) | = 53 nM | Inhibitory activity against matrix metalloproteinase-1 | ChEMBL. | 11020282 |
Ki (binding) | > 200 nM | Inhibitory activity against human isoenzyme Carbonic anhydrase I | ChEMBL. | 11020282 |
Ki (binding) | > 200 nM | Inhibitory activity against human isoenzyme Carbonic anhydrase II | ChEMBL. | 11020282 |
Ki (binding) | > 200 nM | Inhibitory activity against bCA -IV | ChEMBL. | 11020282 |
Ki (binding) | > 200 nM | Inhibitory activity against human isoenzyme Carbonic anhydrase I | ChEMBL. | 11020282 |
Ki (binding) | > 200 nM | Inhibitory activity against human isoenzyme Carbonic anhydrase II | ChEMBL. | 11020282 |
Ki (binding) | > 200 nM | Inhibitory activity against bCA -IV | ChEMBL. | 11020282 |
log(1/IC50) (binding) | = 7.28 | Inhibition of MMP1 (unknown origin) | ChEMBL. | 17275314 |
log(1/Ki) (binding) | = 7.51 | Inhibition of MMP9 (unknown origin) | ChEMBL. | 17275314 |
log(1/Ki) (binding) | = 7.92 | Inhibition of MMP2 (unknown origin) | ChEMBL. | 17275314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.