Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0053 | 0.2077 | 0.1613 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0024 | 0.0553 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0781 | 0.1298 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2746 | 0.279 |
Onchocerca volvulus | 0.0028 | 0.0781 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.2746 | 0.5167 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0053 | 0.2077 | 0.1613 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.5315 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.7828 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.7828 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.5315 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.7828 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0781 | 0.0967 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.2077 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0053 | 0.2077 | 0.3908 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.2746 | 0.3487 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.2746 | 0.5071 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0553 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.2746 | 0.5071 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0024 | 0.0553 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0206 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0053 | 0.2077 | 0.1613 |
Onchocerca volvulus | 0.0028 | 0.0781 | 0.5 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.2077 | 0.1613 |
Brugia malayi | RNA binding protein | 0.0066 | 0.2746 | 0.5071 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2746 | 0.279 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0027 | 0.005 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.2077 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.2746 | 0.3487 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2746 | 0.279 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0053 | 0.2077 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0206 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.5315 | 1 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0024 | 0.0553 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0781 | 0.1469 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0053 | 0.2077 | 0.1613 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0781 | 0.1469 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.7828 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0104 | 0.0196 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0053 | 0.2077 | 0.2628 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0781 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0754 | 0.1419 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0053 | 0.2077 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0781 | 0.1298 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0781 | 0.0967 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0024 | 0.0553 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0206 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.0781 | 0.0967 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0053 | 0.2077 | 0.2628 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2746 | 0.279 |
Brugia malayi | MAP kinase sur-1 | 0.0053 | 0.2077 | 0.3786 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.2077 | 1 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0781 | 0.0967 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.2746 | 0.5167 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0781 | 0.1469 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.2077 | 0.1613 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.2746 | 0.5167 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0024 | 0.0553 | 0.0675 |
Mycobacterium tuberculosis | Conserved protein | 0.0024 | 0.0553 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0053 | 0.2077 | 0.2628 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.2077 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0781 | 0.0967 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2746 | 0.279 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0553 | 0.5 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0024 | 0.0553 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.2077 | 0.1839 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0053 | 0.2077 | 0.2628 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (functional) | = 96 % | In vitro maximal vasorelaxation of endothelium-denuded rat aortic rings, expressed as percentage contractile tension. | ChEMBL. | 12904071 |
Log IC50 (functional) | = 5.24 | In vitro vasorelaxant effect on denuded rat aortic rings. | ChEMBL. | 12904071 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.